Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP-ribosyltransferase toxin AexT

Gene

aexT

Organism
Aeromonas salmonicida
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Directly involved in the toxicity for RTG-2 (rainbow trout gonad) fish cells.

GO - Molecular functioni

  1. GTPase activator activity Source: InterPro
  2. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Toxin, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosyltransferase toxin AexT (EC:2.4.2.-)
Alternative name(s):
Exoenzyme T
Gene namesi
Name:aexT
OrganismiAeromonas salmonicida
Taxonomic identifieri645 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

Subcellular locationi

Secreted
Note: Translocated into the cytosol of fish cells via a type III secretion system.

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475ADP-ribosyltransferase toxin AexTPRO_0000064470Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ93Q17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YopE family.Curated

Family and domain databases

Gene3Di1.20.120.260. 1 hit.
InterProiIPR003540. ADP-ribosyltransferase.
IPR014773. Uncharacterised_dom_YopE.
IPR003537. Vir_YopE.
[Graphical view]
PfamiPF03496. ADPrib_exo_Tox. 1 hit.
PF03545. YopE. 1 hit.
[Graphical view]
PRINTSiPR01372. YERSINIAYOPE.
SUPFAMiSSF47233. SSF47233. 1 hit.

Sequencei

Sequence statusi: Complete.

Q93Q17-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQIQANTVGT QAVAHHSDAT TGVGRMGQME ARQVATGQDA ILLGSRSEPQ
60 70 80 90 100
KGQGLLSRLG AQLARPFVAI KEWISNLLGT DKRAAAPKAQ TAVSPEDLQR
110 120 130 140 150
LMKQAAFGSS LGGFAKADVL NNITGEQLGK DHASLATGNG PLRSLCTALQ
160 170 180 190 200
AVVIGSQQPQ LRELATGLLA RPIAGIPLQQ WGSVGGKVTE LLTSAPPELL
210 220 230 240 250
KEAMSQLHTA MGEVADLQRA VKAEVAGEPA RSATTAAAVA PLQSGESEVN
260 270 280 290 300
VEPADKALAE GLQEQFGLEA EQYLGEQPHG TYSDAEVMAL GLYTNGEYQH
310 320 330 340 350
LNRSLRQEKQ LDAGQALIDQ GMSTAFEKST PTEQLIKTFR GTHGGDAFNE
360 370 380 390 400
VAEGQVGHDV AYLSTSRDPK VATNFGGSGS ISTIFGRSGI DVSDISVEGD
410 420 430 440 450
EQEILYNKET DMRVLLSAKD ERGVTRRVLE EASLGEQSGH SKGLLDGLDL
460 470
ARGAGGADKP QEQDIRLKMR GLDLA
Length:475
Mass (Da):50,105
Last modified:December 1, 2001 - v1
Checksum:i95069F91E8820877
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288366 Genomic DNA. Translation: AAK83052.1.
AJ578475 Genomic DNA. Translation: CAE17664.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288366 Genomic DNA. Translation: AAK83052.1.
AJ578475 Genomic DNA. Translation: CAE17664.1.

3D structure databases

ProteinModelPortaliQ93Q17.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.120.260. 1 hit.
InterProiIPR003540. ADP-ribosyltransferase.
IPR014773. Uncharacterised_dom_YopE.
IPR003537. Vir_YopE.
[Graphical view]
PfamiPF03496. ADPrib_exo_Tox. 1 hit.
PF03545. YopE. 1 hit.
[Graphical view]
PRINTSiPR01372. YERSINIAYOPE.
SUPFAMiSSF47233. SSF47233. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Characterization of an ADP-ribosyltransferase toxin (AexT) from Aeromonas salmonicida subsp. salmonicida."
    Braun M., Stuber K., Schlatter Y., Wahli T., Kuhnert P., Frey J.
    J. Bacteriol. 184:1851-1858(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOXICITY.
    Strain: ATCC 33658 / DSM 19634 / JCM 7874 / NCIMB 1102 and JF2267.
  2. "The ADP-ribosylating toxin, AexT, from Aeromonas salmonicida subsp. salmonicida is translocated via a type III secretion pathway."
    Burr S.E., Stuber K., Frey J.
    J. Bacteriol. 185:6583-6591(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SECRETION VIA TYPE III SECRETION PATHWAY.

Entry informationi

Entry nameiAEXT_AERSA
AccessioniPrimary (citable) accession number: Q93Q17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Although the gene exists in strain ATCC 33658, it is not expressed.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.