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Q93Q17 (AEXT_AERSA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP-ribosyltransferase toxin AexT

EC=2.4.2.-
Alternative name(s):
Exoenzyme T
Gene names
Name:aexT
OrganismAeromonas salmonicida
Taxonomic identifier645 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Directly involved in the toxicity for RTG-2 (rainbow trout gonad) fish cells.

Subcellular location

Secreted. Note: Translocated into the cytosol of fish cells via a type III secretion system.

Miscellaneous

Although the gene exists in strain ATCC 33658, it is not expressed.

Sequence similarities

Belongs to the YopE family.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionGlycosyltransferase
Toxin
Transferase
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTPase activator activity

Inferred from electronic annotation. Source: InterPro

transferase activity, transferring glycosyl groups

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 475475ADP-ribosyltransferase toxin AexT
PRO_0000064470

Sequences

Sequence LengthMass (Da)Tools
Q93Q17 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 95069F91E8820877

FASTA47550,105
        10         20         30         40         50         60 
MQIQANTVGT QAVAHHSDAT TGVGRMGQME ARQVATGQDA ILLGSRSEPQ KGQGLLSRLG 

        70         80         90        100        110        120 
AQLARPFVAI KEWISNLLGT DKRAAAPKAQ TAVSPEDLQR LMKQAAFGSS LGGFAKADVL 

       130        140        150        160        170        180 
NNITGEQLGK DHASLATGNG PLRSLCTALQ AVVIGSQQPQ LRELATGLLA RPIAGIPLQQ 

       190        200        210        220        230        240 
WGSVGGKVTE LLTSAPPELL KEAMSQLHTA MGEVADLQRA VKAEVAGEPA RSATTAAAVA 

       250        260        270        280        290        300 
PLQSGESEVN VEPADKALAE GLQEQFGLEA EQYLGEQPHG TYSDAEVMAL GLYTNGEYQH 

       310        320        330        340        350        360 
LNRSLRQEKQ LDAGQALIDQ GMSTAFEKST PTEQLIKTFR GTHGGDAFNE VAEGQVGHDV 

       370        380        390        400        410        420 
AYLSTSRDPK VATNFGGSGS ISTIFGRSGI DVSDISVEGD EQEILYNKET DMRVLLSAKD 

       430        440        450        460        470 
ERGVTRRVLE EASLGEQSGH SKGLLDGLDL ARGAGGADKP QEQDIRLKMR GLDLA 

« Hide

References

[1]"Characterization of an ADP-ribosyltransferase toxin (AexT) from Aeromonas salmonicida subsp. salmonicida."
Braun M., Stuber K., Schlatter Y., Wahli T., Kuhnert P., Frey J.
J. Bacteriol. 184:1851-1858(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOXICITY.
Strain: ATCC 33658 / DSM 19634 / JCM 7874 / NCIMB 1102 and JF2267.
[2]"The ADP-ribosylating toxin, AexT, from Aeromonas salmonicida subsp. salmonicida is translocated via a type III secretion pathway."
Burr S.E., Stuber K., Frey J.
J. Bacteriol. 185:6583-6591(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SECRETION VIA TYPE III SECRETION PATHWAY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF288366 Genomic DNA. Translation: AAK83052.1.
AJ578475 Genomic DNA. Translation: CAE17664.1.

3D structure databases

ProteinModelPortalQ93Q17.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.120.260. 1 hit.
InterProIPR003540. ADP-ribosyltransferase.
IPR014773. Uncharacterised_dom_YopE.
IPR003537. Vir_YopE.
[Graphical view]
PfamPF03496. ADPrib_exo_Tox. 1 hit.
PF03545. YopE. 1 hit.
[Graphical view]
PRINTSPR01372. YERSINIAYOPE.
SUPFAMSSF47233. SSF47233. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAEXT_AERSA
AccessionPrimary (citable) accession number: Q93Q17
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families