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Q93Q17

- AEXT_AERSA

UniProt

Q93Q17 - AEXT_AERSA

Protein

ADP-ribosyltransferase toxin AexT

Gene

aexT

Organism
Aeromonas salmonicida
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Directly involved in the toxicity for RTG-2 (rainbow trout gonad) fish cells.

    GO - Molecular functioni

    1. GTPase activator activity Source: InterPro
    2. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Toxin, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosyltransferase toxin AexT (EC:2.4.2.-)
    Alternative name(s):
    Exoenzyme T
    Gene namesi
    Name:aexT
    OrganismiAeromonas salmonicida
    Taxonomic identifieri645 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

    Subcellular locationi

    Secreted
    Note: Translocated into the cytosol of fish cells via a type III secretion system.

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 475475ADP-ribosyltransferase toxin AexTPRO_0000064470Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ93Q17.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the YopE family.Curated

    Family and domain databases

    Gene3Di1.20.120.260. 1 hit.
    InterProiIPR003540. ADP-ribosyltransferase.
    IPR014773. Uncharacterised_dom_YopE.
    IPR003537. Vir_YopE.
    [Graphical view]
    PfamiPF03496. ADPrib_exo_Tox. 1 hit.
    PF03545. YopE. 1 hit.
    [Graphical view]
    PRINTSiPR01372. YERSINIAYOPE.
    SUPFAMiSSF47233. SSF47233. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q93Q17-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQIQANTVGT QAVAHHSDAT TGVGRMGQME ARQVATGQDA ILLGSRSEPQ    50
    KGQGLLSRLG AQLARPFVAI KEWISNLLGT DKRAAAPKAQ TAVSPEDLQR 100
    LMKQAAFGSS LGGFAKADVL NNITGEQLGK DHASLATGNG PLRSLCTALQ 150
    AVVIGSQQPQ LRELATGLLA RPIAGIPLQQ WGSVGGKVTE LLTSAPPELL 200
    KEAMSQLHTA MGEVADLQRA VKAEVAGEPA RSATTAAAVA PLQSGESEVN 250
    VEPADKALAE GLQEQFGLEA EQYLGEQPHG TYSDAEVMAL GLYTNGEYQH 300
    LNRSLRQEKQ LDAGQALIDQ GMSTAFEKST PTEQLIKTFR GTHGGDAFNE 350
    VAEGQVGHDV AYLSTSRDPK VATNFGGSGS ISTIFGRSGI DVSDISVEGD 400
    EQEILYNKET DMRVLLSAKD ERGVTRRVLE EASLGEQSGH SKGLLDGLDL 450
    ARGAGGADKP QEQDIRLKMR GLDLA 475
    Length:475
    Mass (Da):50,105
    Last modified:December 1, 2001 - v1
    Checksum:i95069F91E8820877
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288366 Genomic DNA. Translation: AAK83052.1.
    AJ578475 Genomic DNA. Translation: CAE17664.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288366 Genomic DNA. Translation: AAK83052.1 .
    AJ578475 Genomic DNA. Translation: CAE17664.1 .

    3D structure databases

    ProteinModelPortali Q93Q17.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.120.260. 1 hit.
    InterProi IPR003540. ADP-ribosyltransferase.
    IPR014773. Uncharacterised_dom_YopE.
    IPR003537. Vir_YopE.
    [Graphical view ]
    Pfami PF03496. ADPrib_exo_Tox. 1 hit.
    PF03545. YopE. 1 hit.
    [Graphical view ]
    PRINTSi PR01372. YERSINIAYOPE.
    SUPFAMi SSF47233. SSF47233. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of an ADP-ribosyltransferase toxin (AexT) from Aeromonas salmonicida subsp. salmonicida."
      Braun M., Stuber K., Schlatter Y., Wahli T., Kuhnert P., Frey J.
      J. Bacteriol. 184:1851-1858(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TOXICITY.
      Strain: ATCC 33658 / DSM 19634 / JCM 7874 / NCIMB 1102 and JF2267.
    2. "The ADP-ribosylating toxin, AexT, from Aeromonas salmonicida subsp. salmonicida is translocated via a type III secretion pathway."
      Burr S.E., Stuber K., Frey J.
      J. Bacteriol. 185:6583-6591(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SECRETION VIA TYPE III SECRETION PATHWAY.

    Entry informationi

    Entry nameiAEXT_AERSA
    AccessioniPrimary (citable) accession number: Q93Q17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Although the gene exists in strain ATCC 33658, it is not expressed.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3