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Protein

Beta-lactamase

Gene
N/A
Organism
Citrobacter sedlakii
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Antibiotic resistanceUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotationSAAS annotation (EC:3.5.2.6UniRule annotationSAAS annotation)
OrganismiCitrobacter sedlakiiImported
Taxonomic identifieri67826 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCitrobacterCitrobacter freundii complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500432012329 – 295Beta-lactamaseSequence analysisAdd BLAST267

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BFCX-ray2.20A/B/C/D34-295[»]
3BFDX-ray2.00A/B/C/D33-295[»]
3BFEX-ray2.40A/B/C/D34-295[»]
3BFFX-ray1.90A/B/C/D34-295[»]
3BFGX-ray2.00A/B/C/D34-295[»]
ProteinModelPortaliQ93PQ0.
SMRiQ93PQ0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93PQ0.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93PQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKERFRQTV FIAAAVMPFI FSSTSLHAQA TSDVQQVQKK LAALEKQSGG
60 70 80 90 100
RLGVALINTA DNSQVLYRAD ERFAMCSTSK VMTAAAVLKQ SETHDGILQQ
110 120 130 140 150
KMTIKKADLT NWNPVTEKYV GNTMTLAELS AATLQYSDNT AMNKLLAHLG
160 170 180 190 200
GPGNVTAFAR SIGDTTFRLD RKEPELNTAI PGDERDTTSP LAMAKSLRKL
210 220 230 240 250
TLGDALAGPQ RAQLVDWLKG NTTGGQSIRA GLPAHWVVGD KTGAGDYGTT
260 270 280 290
NDIAVIWPED RAPLVLVTYF TQPQQDAKWR KDVLAAAAKI VTEGK
Length:295
Mass (Da):31,934
Last modified:December 1, 2001 - v1
Checksum:i34116ABC373C114E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321608 Genomic DNA. Translation: AAK63223.1.
RefSeqiWP_063864602.1. NG_049979.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321608 Genomic DNA. Translation: AAK63223.1.
RefSeqiWP_063864602.1. NG_049979.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BFCX-ray2.20A/B/C/D34-295[»]
3BFDX-ray2.00A/B/C/D33-295[»]
3BFEX-ray2.40A/B/C/D34-295[»]
3BFFX-ray1.90A/B/C/D34-295[»]
3BFGX-ray2.00A/B/C/D34-295[»]
ProteinModelPortaliQ93PQ0.
SMRiQ93PQ0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ93PQ0.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ93PQ0_9ENTR
AccessioniPrimary (citable) accession number: Q93PQ0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.