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Protein

Bacterioferritin

Gene

bfr

Organism
Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23Iron 11
Metal bindingi56Iron 11
Metal bindingi56Iron 21
Metal bindingi57Iron (Fe-coproporphyrin III axial ligand); shared with dimeric partner1
Metal bindingi59Iron 11
Metal bindingi99Iron 21
Metal bindingi132Iron 11
Metal bindingi132Iron 21
Metal bindingi135Iron 21

GO - Molecular functioni

GO - Biological processi

  • intracellular sequestering of iron ion Source: UniProtKB
  • iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.16.3.1. 1905.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterioferritin (EC:1.16.3.1)
Short name:
BFR
Gene namesi
Name:bfr
Ordered Locus Names:Ddes_1387
OrganismiDesulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Taxonomic identifieri525146 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002598 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001925911 – 179BacterioferritinAdd BLAST179

Interactioni

Subunit structurei

Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.1 Publication

Protein-protein interaction databases

STRINGi525146.Ddes_1387.

Structurei

Secondary structure

1179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 39Combined sources35
Helixi43 – 69Combined sources27
Helixi88 – 115Combined sources28
Helixi119 – 149Combined sources31
Helixi151 – 157Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NF4X-ray2.05A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-179[»]
1NF6X-ray2.35A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-179[»]
1NFVX-ray1.95A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-179[»]
ProteinModelPortaliQ93PP9.
SMRiQ93PP9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93PP9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 150Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the bacterioferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotationCurated

Phylogenomic databases

eggNOGiENOG4108UQY. Bacteria.
COG2193. LUCA.
HOGENOMiHOG000262383.
KOiK03594.
OMAiFHFHCDD.
OrthoDBiPOG091H0B0I.

Family and domain databases

CDDicd00907. Bacterioferritin. 1 hit.
Gene3Di1.20.1260.10. 1 hit.
InterProiIPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF002560. Bacterioferritin. 1 hit.
PRINTSiPR00601. BACFERRITIN.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93PP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNREDRKA KVIEVLNKAR AMELHAIHQY MNQHYSLDDM DYGELAANMK
60 70 80 90 100
LIAIDEMRHA ENFAERIKEL GGEPTTQKEG KVVTGQAVPV IYESDADQED
110 120 130 140 150
ATIEAYSQFL KVCKEQGDIV TARLFERIIE EEQAHLTYYE NIGSHIKNLG
160 170
DTYLAKIAGT PSSTGTASKG FVTATPAAE
Length:179
Mass (Da):19,881
Last modified:December 1, 2001 - v1
Checksum:i09E3387462FED3A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321851 Genomic DNA. Translation: AAK60120.1.
CP001358 Genomic DNA. Translation: ACL49289.1.
RefSeqiWP_012625013.1. NC_011883.1.

Genome annotation databases

EnsemblBacteriaiACL49289; ACL49289; Ddes_1387.
KEGGidds:Ddes_1387.
PATRICi21736512. VBIDesDes50650_1607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321851 Genomic DNA. Translation: AAK60120.1.
CP001358 Genomic DNA. Translation: ACL49289.1.
RefSeqiWP_012625013.1. NC_011883.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NF4X-ray2.05A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-179[»]
1NF6X-ray2.35A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-179[»]
1NFVX-ray1.95A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-179[»]
ProteinModelPortaliQ93PP9.
SMRiQ93PP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi525146.Ddes_1387.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL49289; ACL49289; Ddes_1387.
KEGGidds:Ddes_1387.
PATRICi21736512. VBIDesDes50650_1607.

Phylogenomic databases

eggNOGiENOG4108UQY. Bacteria.
COG2193. LUCA.
HOGENOMiHOG000262383.
KOiK03594.
OMAiFHFHCDD.
OrthoDBiPOG091H0B0I.

Enzyme and pathway databases

BRENDAi1.16.3.1. 1905.

Miscellaneous databases

EvolutionaryTraceiQ93PP9.

Family and domain databases

CDDicd00907. Bacterioferritin. 1 hit.
Gene3Di1.20.1260.10. 1 hit.
InterProiIPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF002560. Bacterioferritin. 1 hit.
PRINTSiPR00601. BACFERRITIN.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBFR_DESDA
AccessioniPrimary (citable) accession number: Q93PP9
Secondary accession number(s): B8J0L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.