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Q93NX9

- Q93NX9_9ACTO

UniProt

Q93NX9 - Q93NX9_9ACTO

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Protein
Submitted name: AmphI
Gene
amphI
Organism
Streptomyces nodosus
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei4589 – 45891NADPImported
Binding sitei4626 – 46261NADPImported
Binding sitei4655 – 46551NADP; via amide nitrogenImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4487 – 44893NADPImported
Nucleotide bindingi4509 – 45113NADPImported
Nucleotide bindingi4538 – 45403NADPImported
Nucleotide bindingi4565 – 45673NADPImported

GO - Molecular functioni

  1. cofactor binding Source: InterPro
  2. nucleotide binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: InterPro
  4. phosphopantetheine binding Source: InterPro
  5. transferase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Ligandi

NADPImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
AmphIImported
Gene namesi
Name:amphIImported
OrganismiStreptomyces nodosusImported
Taxonomic identifieri40318 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Keywords - PTMi

PhosphopantetheineUniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4L4XX-ray2.55A4200-4759[»]
ProteinModelPortaliQ93NX9.
SMRiQ93NX9. Positions 1662-1752, 6281-6371.

Family & Domainsi

Family and domain databases

Gene3Di1.10.1200.10. 6 hits.
3.40.366.10. 12 hits.
3.40.47.10. 12 hits.
3.40.50.720. 7 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 6 hits.
PF00106. adh_short. 2 hits.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 6 hits.
PF02801. Ketoacyl-synt_C. 6 hits.
PF08659. KR. 4 hits.
PF00550. PP-binding. 6 hits.
[Graphical view]
SMARTiSM00827. PKS_AT. 6 hits.
SM00826. PKS_DH. 1 hit.
SM00822. PKS_KR. 6 hits.
SM00825. PKS_KS. 6 hits.
SM00823. PKS_PP. 6 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 6 hits.
SSF52151. SSF52151. 12 hits.
SSF53901. SSF53901. 6 hits.
SSF55048. SSF55048. 6 hits.
PROSITEiPS50075. ACP_DOMAIN. 6 hits.
PS00606. B_KETOACYL_SYNTHASE. 6 hits.
PS00012. PHOSPHOPANTETHEINE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93NX9-1 [UniParc]FASTAAdd to Basket

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MDNEQKLRDY LKLATADLRR ARRRVGELES ASQEPIAIVG MTCRYPGGVS     50
SPEDLWRMVE AGENGVTPFP TDRGWDLEAL ASSPTSRGGF LHDAPEFDAD 100
FFGISPREAV AMDPQQRVVL ESAWEAFERA GINPTSVKGS RTGVFIGAMA 150
QDYRVGPADG AEGFQLTGNT GSVLSGRISY TFGTVGPAVT VDTACSSSLV 200
AVHLATQALR AGECTLALAG GVTVMSGPGT FIEMGRQGGL SVDGRCRSFG 250
DTADGTGWAE GVGILVLERL SDAIRNGREI LAVVRGTAVN QDGASNGLTA 300
PNGPSQQAVI EQALVNARLS AGDIDVVEAH GTGTTLGDPV EAQALLATYG 350
QQRDEDKPLL LGSVKSNISH TQAAAGVAGV IKMVMAMRHG VLPRTLLADE 400
PTRHVDWSQG AVRVLTENTE WPATGAPRRA AVSSFGISGT NAHTIVEQAP 450
EPEPADPEDD APSTPAAVTG VLPVLLSGRS PEVLRAQAAA LLTTLGTGTP 500
PAPADLAYSL ATTRTAFEHR AVLLASDLPE LTGRLTAIAE GTDPAVLADT 550
VTGTARTETR LAVLFTGQGA QRLGAGRELA ARFPVFAAAL DAALDAFTPH 600
LDVPLRKVLW GEDADRLDRT EYAQPALFAV EVALYRLLES FEVKPDHLAG 650
HSVGEIAAAH VAGVFSLDDA ATLVAARGRL MQALPEGGAM VAVQASEDEV 700
APLLAGHEDL VSLAAVNGPS AVVLSGDETT VTELAARLAA DGRKTSRLRV 750
SHAFHSPLMA PMLDEFRNVV EGLTLHSPLL PVVSDVTGEP ATVAQLTSPD 800
YWVDHVRQAV RFADGIDWLA RHDVTAFLEL GPDSVLSAMA QNCLDAAGSD 850
ALTVPALREG RPEDHTFTAA LAALHTQGTA LHWDACFTGT GARRTDLPTY 900
TFQRRRYWPR AVQGGAADLR SVGLGAAHHP LLSAAVSLAD SEGALLTGRI 950
SLLSHPWLAD HTVRGATLLP GTAFLELAVR AGDEVGCDRV DELTLAAPLV 1000
LPEQGGVQVQ LWIGNPDASG RRSVTVYGRP DADEDAPWTS HATGVLSASR 1050
TTSDFDATVW PPADAETLPV DGLYERLAEG GFGYGPLFQG LRAAWRRGDE 1100
VFAEVVLPES GHTDAESFGL HPALLDSALH AASFVDLDER AAGGLPFSWE 1150
GVSLHASGAT TLRVRLAPAA GDAVAIAVAD DSGQLVLSAD SLILRAVAAR 1200
EIDAAAALVR DALFRLDWVP VTAVAASGTA AALVGEDPFG LRALPQFGDL 1250
AVHPDLADLA AADGAVPDTV LLPLTGTGPD ADPVTAAHRA ATEALAAVRT 1300
WLEQDERFAA SRLALVTRGA TTGHDPAAAA VWGLVRSAQS ENPGRFLLVD 1350
LDADQDTPAL PAAALTSEEP QLAVRGEELR AARLVRRPAS TAEAVPAFGG 1400
EGAVLVTGGT GGLGAVLARH LVAEHGVREL VLVSRRGGAA AGAAELVAEL 1450
AESGARATVV ACDVTDRAAV AELVAAHPVS AVVHSAGVLD DGMVGTLTPE 1500
RLTTVLRPKV DAAWNLHEAT RDLDLKAFVL FSSVAGVLGS PGQANYAAGN 1550
AFLDALAAHR RAAGLPGLSL AWGPWEQTGG MTGGISEDDL RRMARAGTPA 1600
LTVEQGLALL DAALDGDDAA LAPVRLDLSV LRAQGEVPPL LRSLIRGRSR 1650
RAAVAGSATA GGLAQRLARL DAESRDELVL DLVRGQVALV LGHATGAEID 1700
AGRAFRELGF DSLTAVELRN RLNTVTGLRL PATLVFDYPT VSHLASYVLD 1750
ELLGTEVEAE VVQRGTAAVA DDPIVIVGMA CRYPGGVTSP EDLWRLVTEG 1800
TDAVSGFPVN RGWDVENLYH PDPDHPGTAY TRSGGFLHEA GEFDPGFFGM 1850
SPREALATDS QQRLLLEASW EAIERAGIDP VGLRGSATGV FAGVMYSDYS 1900
AMLGSPEFEG FQGSGSSPSL ASGRVSYTLG LEGPAVTVDT ACSSSLVAMH 1950
WAMQALRSGE ISLALAGGVT VMSTPAVFVD FARQRGLSPD GRCKAFSDSA 2000
DGVGWSEGVG MLVLERQSDA IRNGHQILAV VRGSAVNQDG ASNGLTAPNG 2050
PSQQRVIRQA LASGGLSAGD VDVVEAHGTG TTLGDPIEAQ ALLATYGRDR 2100
DPEQPLLLGS VKSNIGHTQA AAGVAGVIKM VMSMRHGVLP RTLHVDAPSS 2150
HVDWTEGAVE LLTEQTAWPE TGRPRRAAVS SFGISGTNVH TVLEQAPGTT 2200
VPAPAAPERT AGAVPLLLSG RTRDALRAQA ARLLTHLQNH PEPSLADLGH 2250
SLATTRSRFE RRAAVIAQDR EGLLASLGSL AAGRPDPAVV EGEAAGRARV 2300
AVMFSGQGSQ RAAMGRELYE TQPRFAAAFD EVCAALDPLL DRPLREVVFA 2350
AEGSEEAALL DRTGWTQPAL FAVEVALYRL VESWGVRADF VTGHSIGEIA 2400
AAHIAGVFTL QDAARLVAAR ATLMEALPSG GAMVAVQATE EEVAPLLGEG 2450
LSVAAVNGPT SVVVSGDEDP AVELAAEFSG RGRRTKRLRV SHAFHSPHMD 2500
AMLDAFRTVA ETLSYAAPRI PLVSDLTGRR ADDAEVRTAD YWVRHVREAV 2550
RFADCVRTLR DAGATLFLEL GPDGLLTAMA EDTLGDERYD HNTALVPLLR 2600
ADRPEESAAA TAAARLQIHG VDLDWTAYLA GTGARRVDLP TYAFQHAHYW 2650
PQLPSAAPSP AGDPADQKLW AAVERGDAAE LAAVLGLDED SLTPLDSLLP 2700
ALSSWRRGNQ EKALLDTLRY RVEWTRLSKP AAPVLDGTWL LVSSDATADD 2750
ETELLDGLAE ALGAHGARVR RLVLDADCAD RAVLGARLAD TENADNTAQV 2800
LSVLPLDERP TDGPAGFTQG LALTIALVQA LADTGAHGRL WTATRGAVST 2850
GPADPVTHPA QATAWGMGRG VALEHPRLWG GLVDLPADFD RGAGQRLAEV 2900
LAVKDAPDGE DQVALRATGV HGRRLVRHIV DELPSADQFT ASGSVLITGG 2950
TGGLGAETAR WLARSGAAHL VLTSRRGPDA PGAAELRAEL EQSGASVSIV 3000
ACDVADRDAL AAVLDGLSAD QPLTGVVHTA GVGHYGPLDA LTPAEFAGLT 3050
AAKLAGAAHL DNLLGDRELD FFILFGSIAG VWGSGDQSAY GAANAYLDAL 3100
ALARRARGLA ATSIAWGPWG GTGMAADDAV SGTLRRQGLG LLDPAPALTE 3150
MRRAVVRQDV TVTVADVDWT RYAPLFTSAR PSALISDLPE VRALAAENTP 3200
ADTGDASEIV QRVRSLSEPE QLRLLTDLVR TEAATVLGHS SAGAVPEDRA 3250
FREIGFDSLT AVELRKHLGA ATGLSLPSTM VFDYPTPLEL AQYLRAEMVG 3300
SVLEVAGPVA TGGTDDEPIA IIGMSCRYPG GVSSPEQLWD LVLSGTDAIT 3350
DFPVNRGWNT AGLYDPDPDH PGTTYSTQGG FLHEADEFDP MFFGISPREA 3400
LVMDPQQRLL LETTWEAFER AGLTPDTLRG SLTGTFIGSS YQEYGMGAGD 3450
GAEGHLVTGT SPSVLSGRLA YVFGLEGPAV TVDTACSSSL VALHLACQAL 3500
RNGESNLAVA GGATVMTTPN AFVAFSRQRA LAQDGRCKAF SESADGMTLA 3550
EGVGIVLVER LSDARRNGHP VLAVIRGSAI NQDGASNGLS APNGPSQQRV 3600
IRQALANARV APGEIDLLEA HGTGTPLGDP IEAQALFATY GRTRTPETAL 3650
LLGSVKSNIG HSQSAAGVAS IIKMVMALRH GVMPQTLHAD EPSSHVDWSP 3700
GTVRLLGENT DWPQTGRPRR AAVSSFGISG TNAHVILEQE TEAPAAEDEQ 3750
LAPAPLPVAA GVVPWLLSAR GAAALREQAD RLLTHLVTAD PAARPIDIGL 3800
SLATSRALFE HRAVVVPPAG TDPLEALRAV AADGPSGVVA RGVADVAGRT 3850
VFVFPGQGSQ WAGMGAQLLD ESPVFAERIA ECAAALAEFT DWNLIDVLRG 3900
AEGAPTLERV DVVQPASFAV MVSLAAVWRA QGVEPDAVVG HSQGEIAAAV 3950
VSGALSLRDG ARVVTLRAQA IGRSLAGRGG MMSVALPVAE VEARLEAFEG 4000
RVSVAAENGP RSSVVAGEPE ALDELHAQLT AEEIRARRVA VDYASHSPHV 4050
EDLHDEILEL LAEVAPRTSE IPFFSTVTGD WLDTTVMDAG YWYRSLRGRV 4100
LFADAVRDLI AADHRAFIEV SSHPVLAMSV QDMIDDAGVA GVASGTLRRD 4150
NGGLDRFLLS AAEVFVRGVQ VDWAAVFEGT GASRVDLPTY AFQHENLWAM 4200
AAAPEAVTAA DPEDAAFWTA VEDGDVSALT AALGTDEDSV AAVLPALSSW 4250
RRARKERSTV DSWRYRPTWK PVTKLPQRTL DGTWLLVSAD GVDDTDVAEA 4300
LETGGAEVRR LVLDESCTDR AVLRERLTDA DGLTGIVSVL AGAERTGAVP 4350
GTGLVLGVAL TVALVQALGD AGIDTPLWAL TRGAVSTGRS DKVTAPVQAQ 4400
VTGIGWTAAL ECPGRWGGVV DLPETLDARA GQRLAAVLAG ALGDDDQIAL 4450
RSSGVFTRRI VRADAAPDGS ARDWKPRGTT LVTGGSGTLA PHLARWLAEQ 4500
GAEHLVLVSR RGPEAPGAAE LRAELAERGT ETTLAACDIT DRDAVAALLE 4550
SLKAEGRTVR TVVHTAATIE LHTLDATTLD DFDRVLAAKV TGAQILDELL 4600
DDEELDDFVL YSSTAGMWGS GAHAAYVAGN AYLAALAEHR RARGLTALSL 4650
SWGIWADDLQ LGRVDPQMIR RSGLEFMDPQ LALSGLKRAL DDDEQVIAVA 4700
DVDWETYHPV YTSARPTPLF DEVPEVQRLT AAAEQSAGDP ARGEFAAALL 4750
ALPAAEQHRK LLETVRTEAA SVLGLSSAED LTDQRAFRDV GFDSLTAVGL 4800
RNRLASVTGL TLPSTMVFDY PNPAALAGFL HSELADVHSA GAVAVTAGAP 4850
VDDDPIAIVG MSCRYPGGIT SAEQLWRVSL EEVDAVSVFP ADRGWDAEAL 4900
YDPDPDASGR TYSVQGGFLR DVADFDPGFF GISPREALSM DPQQRLLLET 4950
AWEVFENAGL DPVAQRGSRT GTFIGASYQD YGAAVPGSEG SEGHMITGSL 5000
PSVLSGRVSY LFGLEGPAVT LDTACSSSLV AIHLACQSLR NGESTLALAG 5050
GASIMSTPMS FIGFSRQRAL AEDGRCKAYA EGADGMTLAE GVGLILLERL 5100
SDARRNGHEV LAVIRGSAVN QDGASNGLTA PNGPSQQRVI RQALANAGVE 5150
ANDIDVLEGH GTGTALGDPI EAQALFATYG KDRDPERPVL LGSVKSNIGH 5200
TQMASGVASI IKLVHALREG VAPKSLHIDQ PSTHVDWSSG TIQLLTERTE 5250
WPETGRPRRA AVSSFGLSGT NVHTVLEQAP AADAPAAEDT PAPRDALVPV 5300
LVSGRGEAAL RAQAGALLDL LAERPGIHPT DLAFSLATSR AALEHRAAVV 5350
ADDHEALVRG LTALRDGLPG AGLVQGRTGR GRTAFLFTGQ GSQRLGMGRE 5400
LYERHPVFAD ALDAVLARID GTTERPLRDV LFAAEGSQDA ALLHRTGYAQ 5450
PALFALEVAL FRLLESWGVT PDYLAGHSVG EIAAAHVAGV LDLDDACTLV 5500
AARGRLMQAL PEGGAMVALE AAEDEVLPHL EGLADQVSVA AVNGPRSVVV 5550
AGEEEPVLAL AAHFAEQGRR TKRLRVSHAF HSPLMDPMLD DFAAVARALT 5600
YHAPSIPFVS NVTGTLAAPE QVCTADYWVS HVRSAVRFAD GIGWLSTQGG 5650
VQTFLELGPD GVLSGMARES LTDASRTALL PTLRGDRPEE QALVTAVAAA 5700
HAHGFDVDWT AWFQGSGARR VALPTYAFQR ERYWPDTTAA GITAPAPGSA 5750
LDAEFWAAVE HADVASLTAS LGLDDATVTA MVPALTAWRQ RRGEQSALDS 5800
WRYRVTWKPR GGAPGAAPTG RWLVLVPAEH RDEATAAWAA DVEAALATAT 5850
VRVEVTGTDR AALAARLTEA ADGDTFQGVL SLLALAPGDA GHPGAPAALT 5900
LTATALQALG DARIDAPLWN ITRGAVAVGR SEQVTAPEQA AVWGLFRAAA 5950
LELPARVGGS VDLPEDLDTQ AARRLRGILA AADGEDAVAV RASGVFLRRL 6000
AHSPAADTVG SAFDPAAGTV LITGGTGGIG GHLARRLARD GAAHLLLTSR 6050
RGPDAPGAGE LRAELEESGA RVTIAACDAA DRDALAALLA TVPEDAPLTA 6100
VFHTAGVVDD HVVDELTPES FATVLHAKTV AARHLHDLTA GHDLAAFVLF 6150
SSTAGLIGAA GQGNYAAANS QLDALAEQRR AQGLPALSVA WGPWAGSGMV 6200
ADAAEIAARV RRGGFEPLDP ASGVAALLRA VDNGDTSVAV ADIDWERFLR 6250
AFASARPLPL VADLPETAGA NAPAAAAGTG SGLREQLAGL PAEERHAHVL 6300
DLLRTQVAAV LGHSDARTVD DDLAFRDLGF DSLTVLELRN ALNALTGLSL 6350
PASLVYDHPT PREMADFLLA ELLGSLPEST RHAVATRAVD EDPIAVVGLA 6400
CRFPGGVSTP EELWQLLAEG RDGITGFPDD RNWDIAALGA GASDTLHGGF 6450
LAQVADFDAR FFGISPREAL AMDPQQRLLL ETTWEALERA GIDPAALRGS 6500
TTGVFVGTNG QDYPNLLRRS TSDVSGYVAT GNTASVMSGR LSYALGLEGP 6550
AVTIDTACSS SLVALHWAGH ALSAGECDLV VAGGVSVMST PDSFVEFSTQ 6600
GGLAPDGHCK PFSDDADGTA WSEGVGILVL ERLSDAIRNG HEVRGIIRGT 6650
AVNQDGASNG LTAPNGPSQQ RVIRQALADA RLAPSEIDAV EAHGTGTTLG 6700
DPIEAQALLN TYGPGRDTDQ PLLLGTVKSN IGHTQAAAGV AGVIKMLLAM 6750
QHGTLPRTLH VTSPTSHVDW SSGAVSLLTE ERDWPETGRP RRAGVSAFGV 6800
SGTNAHVIVE QAPIDEPVVE PTEEPAPAAE VTTVPWIVSG RSREALQDQV 6850
DRLTAYAAAR PELSPLDVGR SLATDRTLFP HRAVLLAGPD GVREAARSVA 6900
SRTRGRTAFL FSGQGAQRAL MGRELYERYP AFADALDTVL AQFDTALDFS 6950
LREVLFAEPG TPEAERLNET GWTQPALFAV EVALHRLVES WGLTPDQVAG 7000
HSIGEIAAAH VAGVFSLEDA CALVAARASL MQELPRGGAM LAVRATEEEV 7050
APHLTERVSV AAVNGPSAVV VAGDEAEVAA IAAHFEAQDR KTTRLRVSHA 7100
FHSPLMDPML TAFARVAESL TYHEPVIPLV STVTGVPAGA ELLTPGYWVR 7150
HVRETVRFAD GVRALREDGV TTFVEIGPDG QLTAAAQQTL DASGDEAPAT 7200
VVALQRRDRS EETTLLEGLA TLHTQGAGPD WTAWFAGTGG HRVELPTYAF 7250
QRERYWPEPA APGATGVQDP VDAAFWAAVE REDLESLTAS LGLDGDTVTT 7300
MVPALSAWRR RTDARSTARD WRYHESWTAL GTPAHSAGAG RVLALVPAEH 7350
AGTDWAETLV AALGADPLVV DGTSGSLARE LADLVPQQAT FAPSRRPART 7400
LAAPAESPST SSTGTSGRHT ESTHRTPLLD GQTSPAGTLD PAGWTVVVSL 7450
LAAGTGTLPA PDAAPAAVLE ALEAAGVDAP LWCVTRGAVS VAGEAPAAVG 7500
QAALWGMGRV AALEHPERFG GLADLAPDAD AATAALLAAH LAEPGGEDQI 7550
AVRATGLFGR RLVRTAVAPG DSGWRPHGTV LVVGGTRAMG ARAARWLARE 7600
GAARLVLTTS PADSATDTEE LRAELGRLGA EVTVAPYDGG DRDAARALLD 7650
GLTGLTAVVY ADDTPADGPA AALAPVDTLA EAATGRSLDA FVLFGSVAGV 7700
WGVRGHTDEA AEGAYVDALA RALRAEGTPA LAVSWNAWAE LTDPSTTRHL 7750
RMNGLPVMDA DAALTALAGA VADGSAAVTV ADVRWDTFAP AHHETRPTAL 7800
FDGLPEARTA LAGAARDRAE GATASDGYGR WLLEQPAADR DDILLALVSE 7850
KAALVLGHAD TTLVEPDLPF RDLGFDSLTA VDLRNQLTAA TGITLPATLV 7900
FDHPNPAALA AHLRTELLGG ATDTAAPVAA PAATGDDPIV IVGMACRFPG 7950
GVNSPEDLWQ LVLDEVDAVG DFPADRGWDL DALAGDGPGR SATDQGGFLY 8000
DATDFDPGLF GVSPREAMVM DPQQRILLEA SWEALERAGI DPGTLRGSGT 8050
TGVFVGGGSG DYRPPAEYGQ WQTAQSASLL SGRLAYTFGI QGPTVSVDTA 8100
CSSSLVALHL AAQALRSGEC SIALAGGVTV MATPVGFVEF SAQGALSPDG 8150
RCRAFSEDAN GTGWSEGVGM LVVERLSDAR RNGHRVLAVL RGSAINQDGA 8200
SNGLTAPSGP AQQRVIRQAL ANARLEAADV DAVEAHGTGT KLGDPIEAQA 8250
LLATYGQDRE RPVLVGSLKA NIGHTQAASG VGGVIKMVLA MQHGLLPRSL 8300
YTENPSSHVD WTAGNARLLT ELTPWPESER VRRAAVSSFG ASGTNAHLIL 8350
EQPEPVRQPV EGARPAEDGS PVPVLLSGRS QNALRAQARK LLAHVAGHPE 8400
ETVTDLARTL ATTRAVFEHR AAVTAADRDA LIAGLTAVAE GTTAAHIVEH 8450
QVERTGKHAV LFSGQGSQQL GMGRDLYERF PAFAEAFDAV LARLDGHLGA 8500
SLRDVVWHGD QETLNETGHT QPALFAFEVA LYRLVESWGV TPDFVAGHSV 8550
GEIAAAHVAG VLSLDDACRL VAARARLMQD LPRGGAMVAV EATEQEVAAE 8600
LTEAVSIAAV NGPTSVVLAG AEDAVLAVAA VLAERGRRTS RLKVSHAFHS 8650
VLMDPMLAEF RKVAESLRYE APRIAVVSNV TGDVAGADEL CDADYWVRHV 8700
RGTVRFADGV TALAGRGVRV LLELGPDAVL SALAEQSAPD TVSIPAQRRN 8750
RDEVETLVAA LGRLHVHAAG PRWDAFFDAA PGSWLDLPTY AFQRGRFWPD 8800
TLPTAPQGGA TAGEADGTDS AFWDAVAQED FGSLESVLDV EGDALSKVLP 8850
ALLDWRRRTS EETQLDSWRH RIVWKRLTGA AMAHRKPLTG TWLAVVPEGL 8900
GEDPWVTTAL DALGTRVVRA EVGADGREAM AATLREAAGE GTRFGGVVSL 8950
LALRETVHGD VPEGVALTGT LLQALGDAGI EAPLWCVTRS AVSANRSDRP 9000
RRPLQAAVWG LGRVAALEYP NRWGGLVDLP ERADERAAAG LAAVLAGLDG 9050
EDQVAVRGSA VLARRLVPAP DRGQSGAWDP TGTVLITGGT GAIGAHVARR 9100
LAKDGVQHLV LLSRRGAEAP GATALRDELQ TLGAGVTLAA CDASDRGQLA 9150
AVLDAIPDDR PLTAVLHAAG VLDDGVIDRL TPERYQKVFR AKVTSALLLD 9200
ELTRDLDLAA FVLFSSASSA VGNPGQANYA AANAVLDALA EARRVQNLPA 9250
TSVSWGAWGG GGMADGHGAD DAARRAGVAA MDPDLAVESL LRLVTGKEPT 9300
AVVAEVDLDR FASAFGGARP SALLREFPGY RETVAAAAPA SPEGTLADRL 9350
AGMAPARRLD TVVDLVRTRA AQVLGYPDID AVGAERSFRD LGVDSLGAVE 9400
LRNQLGAETG LSLPATLVFD HPTPLALGEF VLARLAPEEA GPAVSDEETE 9450
IRAVLASVPL DRLREIGVLE PLLQLAGRGG GAGDDEDGES VDSMTVADLV 9500
RAALNGQSDL 9510
Length:9,510
Mass (Da):992,847
Last modified:December 1, 2001 - v1
Checksum:i1A8E003A15D478CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF357202 Genomic DNA. Translation: AAK73501.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF357202 Genomic DNA. Translation: AAK73501.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4L4X X-ray 2.55 A 4200-4759 [» ]
ProteinModelPortali Q93NX9.
SMRi Q93NX9. Positions 1662-1752, 6281-6371.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1200.10. 6 hits.
3.40.366.10. 12 hits.
3.40.47.10. 12 hits.
3.40.50.720. 7 hits.
InterProi IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 6 hits.
PF00106. adh_short. 2 hits.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 6 hits.
PF02801. Ketoacyl-synt_C. 6 hits.
PF08659. KR. 4 hits.
PF00550. PP-binding. 6 hits.
[Graphical view ]
SMARTi SM00827. PKS_AT. 6 hits.
SM00826. PKS_DH. 1 hit.
SM00822. PKS_KR. 6 hits.
SM00825. PKS_KS. 6 hits.
SM00823. PKS_PP. 6 hits.
[Graphical view ]
SUPFAMi SSF47336. SSF47336. 6 hits.
SSF52151. SSF52151. 12 hits.
SSF53901. SSF53901. 6 hits.
SSF55048. SSF55048. 6 hits.
PROSITEi PS50075. ACP_DOMAIN. 6 hits.
PS00606. B_KETOACYL_SYNTHASE. 6 hits.
PS00012. PHOSPHOPANTETHEINE. 6 hits.
[Graphical view ]
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Publicationsi

  1. "Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes."
    Caffrey P., Lynch S., Flood E., Finnan S., Oliynyk M.
    Chem. Biol. 8:713-723(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups."
    Carmody M., Murphy B., Byrne B., Power P., Rai D., Rawlings B., Caffrey P.
    J. Biol. Chem. 280:34420-34426(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Structural studies of an A2-type modular polyketide synthase ketoreductase reveal features controlling ?-substituent stereochemistry."
    Zheng J., Piasecki S.K., Keatinge-Clay A.T.
    ACS Chem. Biol. 8:1964-1971(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 4200-4759 IN COMPLEX WITH NADP.

Entry informationi

Entry nameiQ93NX9_9ACTO
AccessioniPrimary (citable) accession number: Q93NX9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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