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Q93NX9

- Q93NX9_9ACTO

UniProt

Q93NX9 - Q93NX9_9ACTO

Protein
Submitted name:

AmphI

Gene

amphI

Organism
Streptomyces nodosus
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei4589 – 45891NADPImported
    Binding sitei4626 – 46261NADPImported
    Binding sitei4655 – 46551NADP; via amide nitrogenImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4487 – 44893NADPImported
    Nucleotide bindingi4509 – 45113NADPImported
    Nucleotide bindingi4538 – 45403NADPImported
    Nucleotide bindingi4565 – 45673NADPImported

    GO - Molecular functioni

    1. cofactor binding Source: InterPro
    2. nucleotide binding Source: UniProtKB-KW
    3. oxidoreductase activity Source: InterPro
    4. phosphopantetheine binding Source: InterPro
    5. transferase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    TransferaseUniRule annotation

    Keywords - Ligandi

    NADPImported, Nucleotide-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    AmphIImported
    Gene namesi
    Name:amphIImported
    OrganismiStreptomyces nodosusImported
    Taxonomic identifieri40318 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Keywords - PTMi

    PhosphopantetheineUniRule annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4L4XX-ray2.55A4200-4759[»]
    ProteinModelPortaliQ93NX9.
    SMRiQ93NX9. Positions 1662-1752, 6281-6371.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.1200.10. 6 hits.
    3.40.366.10. 12 hits.
    3.40.47.10. 12 hits.
    3.40.50.720. 7 hits.
    InterProiIPR001227. Ac_transferase_dom.
    IPR009081. Acyl_carrier_prot-like.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR020842. PKS/FAS_KR.
    IPR020801. PKS_acyl_transferase.
    IPR020841. PKS_Beta-ketoAc_synthase_dom.
    IPR020807. PKS_dehydratase.
    IPR013968. PKS_KR.
    IPR020806. PKS_PP-bd.
    IPR015083. Polyketide_synth_docking.
    IPR006162. PPantetheine_attach_site.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 6 hits.
    PF00106. adh_short. 2 hits.
    PF08990. Docking. 1 hit.
    PF00109. ketoacyl-synt. 6 hits.
    PF02801. Ketoacyl-synt_C. 6 hits.
    PF08659. KR. 4 hits.
    PF00550. PP-binding. 6 hits.
    [Graphical view]
    SMARTiSM00827. PKS_AT. 6 hits.
    SM00826. PKS_DH. 1 hit.
    SM00822. PKS_KR. 6 hits.
    SM00825. PKS_KS. 6 hits.
    SM00823. PKS_PP. 6 hits.
    [Graphical view]
    SUPFAMiSSF47336. SSF47336. 6 hits.
    SSF52151. SSF52151. 12 hits.
    SSF53901. SSF53901. 6 hits.
    SSF55048. SSF55048. 6 hits.
    PROSITEiPS50075. ACP_DOMAIN. 6 hits.
    PS00606. B_KETOACYL_SYNTHASE. 6 hits.
    PS00012. PHOSPHOPANTETHEINE. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q93NX9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNEQKLRDY LKLATADLRR ARRRVGELES ASQEPIAIVG MTCRYPGGVS     50
    SPEDLWRMVE AGENGVTPFP TDRGWDLEAL ASSPTSRGGF LHDAPEFDAD 100
    FFGISPREAV AMDPQQRVVL ESAWEAFERA GINPTSVKGS RTGVFIGAMA 150
    QDYRVGPADG AEGFQLTGNT GSVLSGRISY TFGTVGPAVT VDTACSSSLV 200
    AVHLATQALR AGECTLALAG GVTVMSGPGT FIEMGRQGGL SVDGRCRSFG 250
    DTADGTGWAE GVGILVLERL SDAIRNGREI LAVVRGTAVN QDGASNGLTA 300
    PNGPSQQAVI EQALVNARLS AGDIDVVEAH GTGTTLGDPV EAQALLATYG 350
    QQRDEDKPLL LGSVKSNISH TQAAAGVAGV IKMVMAMRHG VLPRTLLADE 400
    PTRHVDWSQG AVRVLTENTE WPATGAPRRA AVSSFGISGT NAHTIVEQAP 450
    EPEPADPEDD APSTPAAVTG VLPVLLSGRS PEVLRAQAAA LLTTLGTGTP 500
    PAPADLAYSL ATTRTAFEHR AVLLASDLPE LTGRLTAIAE GTDPAVLADT 550
    VTGTARTETR LAVLFTGQGA QRLGAGRELA ARFPVFAAAL DAALDAFTPH 600
    LDVPLRKVLW GEDADRLDRT EYAQPALFAV EVALYRLLES FEVKPDHLAG 650
    HSVGEIAAAH VAGVFSLDDA ATLVAARGRL MQALPEGGAM VAVQASEDEV 700
    APLLAGHEDL VSLAAVNGPS AVVLSGDETT VTELAARLAA DGRKTSRLRV 750
    SHAFHSPLMA PMLDEFRNVV EGLTLHSPLL PVVSDVTGEP ATVAQLTSPD 800
    YWVDHVRQAV RFADGIDWLA RHDVTAFLEL GPDSVLSAMA QNCLDAAGSD 850
    ALTVPALREG RPEDHTFTAA LAALHTQGTA LHWDACFTGT GARRTDLPTY 900
    TFQRRRYWPR AVQGGAADLR SVGLGAAHHP LLSAAVSLAD SEGALLTGRI 950
    SLLSHPWLAD HTVRGATLLP GTAFLELAVR AGDEVGCDRV DELTLAAPLV 1000
    LPEQGGVQVQ LWIGNPDASG RRSVTVYGRP DADEDAPWTS HATGVLSASR 1050
    TTSDFDATVW PPADAETLPV DGLYERLAEG GFGYGPLFQG LRAAWRRGDE 1100
    VFAEVVLPES GHTDAESFGL HPALLDSALH AASFVDLDER AAGGLPFSWE 1150
    GVSLHASGAT TLRVRLAPAA GDAVAIAVAD DSGQLVLSAD SLILRAVAAR 1200
    EIDAAAALVR DALFRLDWVP VTAVAASGTA AALVGEDPFG LRALPQFGDL 1250
    AVHPDLADLA AADGAVPDTV LLPLTGTGPD ADPVTAAHRA ATEALAAVRT 1300
    WLEQDERFAA SRLALVTRGA TTGHDPAAAA VWGLVRSAQS ENPGRFLLVD 1350
    LDADQDTPAL PAAALTSEEP QLAVRGEELR AARLVRRPAS TAEAVPAFGG 1400
    EGAVLVTGGT GGLGAVLARH LVAEHGVREL VLVSRRGGAA AGAAELVAEL 1450
    AESGARATVV ACDVTDRAAV AELVAAHPVS AVVHSAGVLD DGMVGTLTPE 1500
    RLTTVLRPKV DAAWNLHEAT RDLDLKAFVL FSSVAGVLGS PGQANYAAGN 1550
    AFLDALAAHR RAAGLPGLSL AWGPWEQTGG MTGGISEDDL RRMARAGTPA 1600
    LTVEQGLALL DAALDGDDAA LAPVRLDLSV LRAQGEVPPL LRSLIRGRSR 1650
    RAAVAGSATA GGLAQRLARL DAESRDELVL DLVRGQVALV LGHATGAEID 1700
    AGRAFRELGF DSLTAVELRN RLNTVTGLRL PATLVFDYPT VSHLASYVLD 1750
    ELLGTEVEAE VVQRGTAAVA DDPIVIVGMA CRYPGGVTSP EDLWRLVTEG 1800
    TDAVSGFPVN RGWDVENLYH PDPDHPGTAY TRSGGFLHEA GEFDPGFFGM 1850
    SPREALATDS QQRLLLEASW EAIERAGIDP VGLRGSATGV FAGVMYSDYS 1900
    AMLGSPEFEG FQGSGSSPSL ASGRVSYTLG LEGPAVTVDT ACSSSLVAMH 1950
    WAMQALRSGE ISLALAGGVT VMSTPAVFVD FARQRGLSPD GRCKAFSDSA 2000
    DGVGWSEGVG MLVLERQSDA IRNGHQILAV VRGSAVNQDG ASNGLTAPNG 2050
    PSQQRVIRQA LASGGLSAGD VDVVEAHGTG TTLGDPIEAQ ALLATYGRDR 2100
    DPEQPLLLGS VKSNIGHTQA AAGVAGVIKM VMSMRHGVLP RTLHVDAPSS 2150
    HVDWTEGAVE LLTEQTAWPE TGRPRRAAVS SFGISGTNVH TVLEQAPGTT 2200
    VPAPAAPERT AGAVPLLLSG RTRDALRAQA ARLLTHLQNH PEPSLADLGH 2250
    SLATTRSRFE RRAAVIAQDR EGLLASLGSL AAGRPDPAVV EGEAAGRARV 2300
    AVMFSGQGSQ RAAMGRELYE TQPRFAAAFD EVCAALDPLL DRPLREVVFA 2350
    AEGSEEAALL DRTGWTQPAL FAVEVALYRL VESWGVRADF VTGHSIGEIA 2400
    AAHIAGVFTL QDAARLVAAR ATLMEALPSG GAMVAVQATE EEVAPLLGEG 2450
    LSVAAVNGPT SVVVSGDEDP AVELAAEFSG RGRRTKRLRV SHAFHSPHMD 2500
    AMLDAFRTVA ETLSYAAPRI PLVSDLTGRR ADDAEVRTAD YWVRHVREAV 2550
    RFADCVRTLR DAGATLFLEL GPDGLLTAMA EDTLGDERYD HNTALVPLLR 2600
    ADRPEESAAA TAAARLQIHG VDLDWTAYLA GTGARRVDLP TYAFQHAHYW 2650
    PQLPSAAPSP AGDPADQKLW AAVERGDAAE LAAVLGLDED SLTPLDSLLP 2700
    ALSSWRRGNQ EKALLDTLRY RVEWTRLSKP AAPVLDGTWL LVSSDATADD 2750
    ETELLDGLAE ALGAHGARVR RLVLDADCAD RAVLGARLAD TENADNTAQV 2800
    LSVLPLDERP TDGPAGFTQG LALTIALVQA LADTGAHGRL WTATRGAVST 2850
    GPADPVTHPA QATAWGMGRG VALEHPRLWG GLVDLPADFD RGAGQRLAEV 2900
    LAVKDAPDGE DQVALRATGV HGRRLVRHIV DELPSADQFT ASGSVLITGG 2950
    TGGLGAETAR WLARSGAAHL VLTSRRGPDA PGAAELRAEL EQSGASVSIV 3000
    ACDVADRDAL AAVLDGLSAD QPLTGVVHTA GVGHYGPLDA LTPAEFAGLT 3050
    AAKLAGAAHL DNLLGDRELD FFILFGSIAG VWGSGDQSAY GAANAYLDAL 3100
    ALARRARGLA ATSIAWGPWG GTGMAADDAV SGTLRRQGLG LLDPAPALTE 3150
    MRRAVVRQDV TVTVADVDWT RYAPLFTSAR PSALISDLPE VRALAAENTP 3200
    ADTGDASEIV QRVRSLSEPE QLRLLTDLVR TEAATVLGHS SAGAVPEDRA 3250
    FREIGFDSLT AVELRKHLGA ATGLSLPSTM VFDYPTPLEL AQYLRAEMVG 3300
    SVLEVAGPVA TGGTDDEPIA IIGMSCRYPG GVSSPEQLWD LVLSGTDAIT 3350
    DFPVNRGWNT AGLYDPDPDH PGTTYSTQGG FLHEADEFDP MFFGISPREA 3400
    LVMDPQQRLL LETTWEAFER AGLTPDTLRG SLTGTFIGSS YQEYGMGAGD 3450
    GAEGHLVTGT SPSVLSGRLA YVFGLEGPAV TVDTACSSSL VALHLACQAL 3500
    RNGESNLAVA GGATVMTTPN AFVAFSRQRA LAQDGRCKAF SESADGMTLA 3550
    EGVGIVLVER LSDARRNGHP VLAVIRGSAI NQDGASNGLS APNGPSQQRV 3600
    IRQALANARV APGEIDLLEA HGTGTPLGDP IEAQALFATY GRTRTPETAL 3650
    LLGSVKSNIG HSQSAAGVAS IIKMVMALRH GVMPQTLHAD EPSSHVDWSP 3700
    GTVRLLGENT DWPQTGRPRR AAVSSFGISG TNAHVILEQE TEAPAAEDEQ 3750
    LAPAPLPVAA GVVPWLLSAR GAAALREQAD RLLTHLVTAD PAARPIDIGL 3800
    SLATSRALFE HRAVVVPPAG TDPLEALRAV AADGPSGVVA RGVADVAGRT 3850
    VFVFPGQGSQ WAGMGAQLLD ESPVFAERIA ECAAALAEFT DWNLIDVLRG 3900
    AEGAPTLERV DVVQPASFAV MVSLAAVWRA QGVEPDAVVG HSQGEIAAAV 3950
    VSGALSLRDG ARVVTLRAQA IGRSLAGRGG MMSVALPVAE VEARLEAFEG 4000
    RVSVAAENGP RSSVVAGEPE ALDELHAQLT AEEIRARRVA VDYASHSPHV 4050
    EDLHDEILEL LAEVAPRTSE IPFFSTVTGD WLDTTVMDAG YWYRSLRGRV 4100
    LFADAVRDLI AADHRAFIEV SSHPVLAMSV QDMIDDAGVA GVASGTLRRD 4150
    NGGLDRFLLS AAEVFVRGVQ VDWAAVFEGT GASRVDLPTY AFQHENLWAM 4200
    AAAPEAVTAA DPEDAAFWTA VEDGDVSALT AALGTDEDSV AAVLPALSSW 4250
    RRARKERSTV DSWRYRPTWK PVTKLPQRTL DGTWLLVSAD GVDDTDVAEA 4300
    LETGGAEVRR LVLDESCTDR AVLRERLTDA DGLTGIVSVL AGAERTGAVP 4350
    GTGLVLGVAL TVALVQALGD AGIDTPLWAL TRGAVSTGRS DKVTAPVQAQ 4400
    VTGIGWTAAL ECPGRWGGVV DLPETLDARA GQRLAAVLAG ALGDDDQIAL 4450
    RSSGVFTRRI VRADAAPDGS ARDWKPRGTT LVTGGSGTLA PHLARWLAEQ 4500
    GAEHLVLVSR RGPEAPGAAE LRAELAERGT ETTLAACDIT DRDAVAALLE 4550
    SLKAEGRTVR TVVHTAATIE LHTLDATTLD DFDRVLAAKV TGAQILDELL 4600
    DDEELDDFVL YSSTAGMWGS GAHAAYVAGN AYLAALAEHR RARGLTALSL 4650
    SWGIWADDLQ LGRVDPQMIR RSGLEFMDPQ LALSGLKRAL DDDEQVIAVA 4700
    DVDWETYHPV YTSARPTPLF DEVPEVQRLT AAAEQSAGDP ARGEFAAALL 4750
    ALPAAEQHRK LLETVRTEAA SVLGLSSAED LTDQRAFRDV GFDSLTAVGL 4800
    RNRLASVTGL TLPSTMVFDY PNPAALAGFL HSELADVHSA GAVAVTAGAP 4850
    VDDDPIAIVG MSCRYPGGIT SAEQLWRVSL EEVDAVSVFP ADRGWDAEAL 4900
    YDPDPDASGR TYSVQGGFLR DVADFDPGFF GISPREALSM DPQQRLLLET 4950
    AWEVFENAGL DPVAQRGSRT GTFIGASYQD YGAAVPGSEG SEGHMITGSL 5000
    PSVLSGRVSY LFGLEGPAVT LDTACSSSLV AIHLACQSLR NGESTLALAG 5050
    GASIMSTPMS FIGFSRQRAL AEDGRCKAYA EGADGMTLAE GVGLILLERL 5100
    SDARRNGHEV LAVIRGSAVN QDGASNGLTA PNGPSQQRVI RQALANAGVE 5150
    ANDIDVLEGH GTGTALGDPI EAQALFATYG KDRDPERPVL LGSVKSNIGH 5200
    TQMASGVASI IKLVHALREG VAPKSLHIDQ PSTHVDWSSG TIQLLTERTE 5250
    WPETGRPRRA AVSSFGLSGT NVHTVLEQAP AADAPAAEDT PAPRDALVPV 5300
    LVSGRGEAAL RAQAGALLDL LAERPGIHPT DLAFSLATSR AALEHRAAVV 5350
    ADDHEALVRG LTALRDGLPG AGLVQGRTGR GRTAFLFTGQ GSQRLGMGRE 5400
    LYERHPVFAD ALDAVLARID GTTERPLRDV LFAAEGSQDA ALLHRTGYAQ 5450
    PALFALEVAL FRLLESWGVT PDYLAGHSVG EIAAAHVAGV LDLDDACTLV 5500
    AARGRLMQAL PEGGAMVALE AAEDEVLPHL EGLADQVSVA AVNGPRSVVV 5550
    AGEEEPVLAL AAHFAEQGRR TKRLRVSHAF HSPLMDPMLD DFAAVARALT 5600
    YHAPSIPFVS NVTGTLAAPE QVCTADYWVS HVRSAVRFAD GIGWLSTQGG 5650
    VQTFLELGPD GVLSGMARES LTDASRTALL PTLRGDRPEE QALVTAVAAA 5700
    HAHGFDVDWT AWFQGSGARR VALPTYAFQR ERYWPDTTAA GITAPAPGSA 5750
    LDAEFWAAVE HADVASLTAS LGLDDATVTA MVPALTAWRQ RRGEQSALDS 5800
    WRYRVTWKPR GGAPGAAPTG RWLVLVPAEH RDEATAAWAA DVEAALATAT 5850
    VRVEVTGTDR AALAARLTEA ADGDTFQGVL SLLALAPGDA GHPGAPAALT 5900
    LTATALQALG DARIDAPLWN ITRGAVAVGR SEQVTAPEQA AVWGLFRAAA 5950
    LELPARVGGS VDLPEDLDTQ AARRLRGILA AADGEDAVAV RASGVFLRRL 6000
    AHSPAADTVG SAFDPAAGTV LITGGTGGIG GHLARRLARD GAAHLLLTSR 6050
    RGPDAPGAGE LRAELEESGA RVTIAACDAA DRDALAALLA TVPEDAPLTA 6100
    VFHTAGVVDD HVVDELTPES FATVLHAKTV AARHLHDLTA GHDLAAFVLF 6150
    SSTAGLIGAA GQGNYAAANS QLDALAEQRR AQGLPALSVA WGPWAGSGMV 6200
    ADAAEIAARV RRGGFEPLDP ASGVAALLRA VDNGDTSVAV ADIDWERFLR 6250
    AFASARPLPL VADLPETAGA NAPAAAAGTG SGLREQLAGL PAEERHAHVL 6300
    DLLRTQVAAV LGHSDARTVD DDLAFRDLGF DSLTVLELRN ALNALTGLSL 6350
    PASLVYDHPT PREMADFLLA ELLGSLPEST RHAVATRAVD EDPIAVVGLA 6400
    CRFPGGVSTP EELWQLLAEG RDGITGFPDD RNWDIAALGA GASDTLHGGF 6450
    LAQVADFDAR FFGISPREAL AMDPQQRLLL ETTWEALERA GIDPAALRGS 6500
    TTGVFVGTNG QDYPNLLRRS TSDVSGYVAT GNTASVMSGR LSYALGLEGP 6550
    AVTIDTACSS SLVALHWAGH ALSAGECDLV VAGGVSVMST PDSFVEFSTQ 6600
    GGLAPDGHCK PFSDDADGTA WSEGVGILVL ERLSDAIRNG HEVRGIIRGT 6650
    AVNQDGASNG LTAPNGPSQQ RVIRQALADA RLAPSEIDAV EAHGTGTTLG 6700
    DPIEAQALLN TYGPGRDTDQ PLLLGTVKSN IGHTQAAAGV AGVIKMLLAM 6750
    QHGTLPRTLH VTSPTSHVDW SSGAVSLLTE ERDWPETGRP RRAGVSAFGV 6800
    SGTNAHVIVE QAPIDEPVVE PTEEPAPAAE VTTVPWIVSG RSREALQDQV 6850
    DRLTAYAAAR PELSPLDVGR SLATDRTLFP HRAVLLAGPD GVREAARSVA 6900
    SRTRGRTAFL FSGQGAQRAL MGRELYERYP AFADALDTVL AQFDTALDFS 6950
    LREVLFAEPG TPEAERLNET GWTQPALFAV EVALHRLVES WGLTPDQVAG 7000
    HSIGEIAAAH VAGVFSLEDA CALVAARASL MQELPRGGAM LAVRATEEEV 7050
    APHLTERVSV AAVNGPSAVV VAGDEAEVAA IAAHFEAQDR KTTRLRVSHA 7100
    FHSPLMDPML TAFARVAESL TYHEPVIPLV STVTGVPAGA ELLTPGYWVR 7150
    HVRETVRFAD GVRALREDGV TTFVEIGPDG QLTAAAQQTL DASGDEAPAT 7200
    VVALQRRDRS EETTLLEGLA TLHTQGAGPD WTAWFAGTGG HRVELPTYAF 7250
    QRERYWPEPA APGATGVQDP VDAAFWAAVE REDLESLTAS LGLDGDTVTT 7300
    MVPALSAWRR RTDARSTARD WRYHESWTAL GTPAHSAGAG RVLALVPAEH 7350
    AGTDWAETLV AALGADPLVV DGTSGSLARE LADLVPQQAT FAPSRRPART 7400
    LAAPAESPST SSTGTSGRHT ESTHRTPLLD GQTSPAGTLD PAGWTVVVSL 7450
    LAAGTGTLPA PDAAPAAVLE ALEAAGVDAP LWCVTRGAVS VAGEAPAAVG 7500
    QAALWGMGRV AALEHPERFG GLADLAPDAD AATAALLAAH LAEPGGEDQI 7550
    AVRATGLFGR RLVRTAVAPG DSGWRPHGTV LVVGGTRAMG ARAARWLARE 7600
    GAARLVLTTS PADSATDTEE LRAELGRLGA EVTVAPYDGG DRDAARALLD 7650
    GLTGLTAVVY ADDTPADGPA AALAPVDTLA EAATGRSLDA FVLFGSVAGV 7700
    WGVRGHTDEA AEGAYVDALA RALRAEGTPA LAVSWNAWAE LTDPSTTRHL 7750
    RMNGLPVMDA DAALTALAGA VADGSAAVTV ADVRWDTFAP AHHETRPTAL 7800
    FDGLPEARTA LAGAARDRAE GATASDGYGR WLLEQPAADR DDILLALVSE 7850
    KAALVLGHAD TTLVEPDLPF RDLGFDSLTA VDLRNQLTAA TGITLPATLV 7900
    FDHPNPAALA AHLRTELLGG ATDTAAPVAA PAATGDDPIV IVGMACRFPG 7950
    GVNSPEDLWQ LVLDEVDAVG DFPADRGWDL DALAGDGPGR SATDQGGFLY 8000
    DATDFDPGLF GVSPREAMVM DPQQRILLEA SWEALERAGI DPGTLRGSGT 8050
    TGVFVGGGSG DYRPPAEYGQ WQTAQSASLL SGRLAYTFGI QGPTVSVDTA 8100
    CSSSLVALHL AAQALRSGEC SIALAGGVTV MATPVGFVEF SAQGALSPDG 8150
    RCRAFSEDAN GTGWSEGVGM LVVERLSDAR RNGHRVLAVL RGSAINQDGA 8200
    SNGLTAPSGP AQQRVIRQAL ANARLEAADV DAVEAHGTGT KLGDPIEAQA 8250
    LLATYGQDRE RPVLVGSLKA NIGHTQAASG VGGVIKMVLA MQHGLLPRSL 8300
    YTENPSSHVD WTAGNARLLT ELTPWPESER VRRAAVSSFG ASGTNAHLIL 8350
    EQPEPVRQPV EGARPAEDGS PVPVLLSGRS QNALRAQARK LLAHVAGHPE 8400
    ETVTDLARTL ATTRAVFEHR AAVTAADRDA LIAGLTAVAE GTTAAHIVEH 8450
    QVERTGKHAV LFSGQGSQQL GMGRDLYERF PAFAEAFDAV LARLDGHLGA 8500
    SLRDVVWHGD QETLNETGHT QPALFAFEVA LYRLVESWGV TPDFVAGHSV 8550
    GEIAAAHVAG VLSLDDACRL VAARARLMQD LPRGGAMVAV EATEQEVAAE 8600
    LTEAVSIAAV NGPTSVVLAG AEDAVLAVAA VLAERGRRTS RLKVSHAFHS 8650
    VLMDPMLAEF RKVAESLRYE APRIAVVSNV TGDVAGADEL CDADYWVRHV 8700
    RGTVRFADGV TALAGRGVRV LLELGPDAVL SALAEQSAPD TVSIPAQRRN 8750
    RDEVETLVAA LGRLHVHAAG PRWDAFFDAA PGSWLDLPTY AFQRGRFWPD 8800
    TLPTAPQGGA TAGEADGTDS AFWDAVAQED FGSLESVLDV EGDALSKVLP 8850
    ALLDWRRRTS EETQLDSWRH RIVWKRLTGA AMAHRKPLTG TWLAVVPEGL 8900
    GEDPWVTTAL DALGTRVVRA EVGADGREAM AATLREAAGE GTRFGGVVSL 8950
    LALRETVHGD VPEGVALTGT LLQALGDAGI EAPLWCVTRS AVSANRSDRP 9000
    RRPLQAAVWG LGRVAALEYP NRWGGLVDLP ERADERAAAG LAAVLAGLDG 9050
    EDQVAVRGSA VLARRLVPAP DRGQSGAWDP TGTVLITGGT GAIGAHVARR 9100
    LAKDGVQHLV LLSRRGAEAP GATALRDELQ TLGAGVTLAA CDASDRGQLA 9150
    AVLDAIPDDR PLTAVLHAAG VLDDGVIDRL TPERYQKVFR AKVTSALLLD 9200
    ELTRDLDLAA FVLFSSASSA VGNPGQANYA AANAVLDALA EARRVQNLPA 9250
    TSVSWGAWGG GGMADGHGAD DAARRAGVAA MDPDLAVESL LRLVTGKEPT 9300
    AVVAEVDLDR FASAFGGARP SALLREFPGY RETVAAAAPA SPEGTLADRL 9350
    AGMAPARRLD TVVDLVRTRA AQVLGYPDID AVGAERSFRD LGVDSLGAVE 9400
    LRNQLGAETG LSLPATLVFD HPTPLALGEF VLARLAPEEA GPAVSDEETE 9450
    IRAVLASVPL DRLREIGVLE PLLQLAGRGG GAGDDEDGES VDSMTVADLV 9500
    RAALNGQSDL 9510
    Length:9,510
    Mass (Da):992,847
    Last modified:December 1, 2001 - v1
    Checksum:i1A8E003A15D478CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF357202 Genomic DNA. Translation: AAK73501.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF357202 Genomic DNA. Translation: AAK73501.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4L4X X-ray 2.55 A 4200-4759 [» ]
    ProteinModelPortali Q93NX9.
    SMRi Q93NX9. Positions 1662-1752, 6281-6371.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1200.10. 6 hits.
    3.40.366.10. 12 hits.
    3.40.47.10. 12 hits.
    3.40.50.720. 7 hits.
    InterProi IPR001227. Ac_transferase_dom.
    IPR009081. Acyl_carrier_prot-like.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR020842. PKS/FAS_KR.
    IPR020801. PKS_acyl_transferase.
    IPR020841. PKS_Beta-ketoAc_synthase_dom.
    IPR020807. PKS_dehydratase.
    IPR013968. PKS_KR.
    IPR020806. PKS_PP-bd.
    IPR015083. Polyketide_synth_docking.
    IPR006162. PPantetheine_attach_site.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 6 hits.
    PF00106. adh_short. 2 hits.
    PF08990. Docking. 1 hit.
    PF00109. ketoacyl-synt. 6 hits.
    PF02801. Ketoacyl-synt_C. 6 hits.
    PF08659. KR. 4 hits.
    PF00550. PP-binding. 6 hits.
    [Graphical view ]
    SMARTi SM00827. PKS_AT. 6 hits.
    SM00826. PKS_DH. 1 hit.
    SM00822. PKS_KR. 6 hits.
    SM00825. PKS_KS. 6 hits.
    SM00823. PKS_PP. 6 hits.
    [Graphical view ]
    SUPFAMi SSF47336. SSF47336. 6 hits.
    SSF52151. SSF52151. 12 hits.
    SSF53901. SSF53901. 6 hits.
    SSF55048. SSF55048. 6 hits.
    PROSITEi PS50075. ACP_DOMAIN. 6 hits.
    PS00606. B_KETOACYL_SYNTHASE. 6 hits.
    PS00012. PHOSPHOPANTETHEINE. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes."
      Caffrey P., Lynch S., Flood E., Finnan S., Oliynyk M.
      Chem. Biol. 8:713-723(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups."
      Carmody M., Murphy B., Byrne B., Power P., Rai D., Rawlings B., Caffrey P.
      J. Biol. Chem. 280:34420-34426(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Structural studies of an A2-type modular polyketide synthase ketoreductase reveal features controlling ?-substituent stereochemistry."
      Zheng J., Piasecki S.K., Keatinge-Clay A.T.
      ACS Chem. Biol. 8:1964-1971(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 4200-4759 IN COMPLEX WITH NADP.

    Entry informationi

    Entry nameiQ93NX9_9ACTO
    AccessioniPrimary (citable) accession number: Q93NX9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

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