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Q93NX9

- Q93NX9_9ACTO

UniProt

Q93NX9 - Q93NX9_9ACTO

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Protein
Submitted name:

AmphI

Gene

amphI

Organism
Streptomyces nodosus
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei4589 – 45891NADPImported
Binding sitei4626 – 46261NADPImported
Binding sitei4655 – 46551NADP; via amide nitrogenImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4487 – 44893NADPImported
Nucleotide bindingi4509 – 45113NADPImported
Nucleotide bindingi4538 – 45403NADPImported
Nucleotide bindingi4565 – 45673NADPImported

GO - Molecular functioni

  1. cofactor binding Source: InterPro
  2. nucleotide binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: InterPro
  4. phosphopantetheine binding Source: InterPro
  5. transferase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Ligandi

NADPImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
AmphIImported
Gene namesi
Name:amphIImported
OrganismiStreptomyces nodosusImported
Taxonomic identifieri40318 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Keywords - PTMi

PhosphopantetheineUniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4L4XX-ray2.55A4200-4759[»]
ProteinModelPortaliQ93NX9.
SMRiQ93NX9. Positions 1662-1752, 6281-6371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di1.10.1200.10. 6 hits.
3.40.366.10. 12 hits.
3.40.47.10. 12 hits.
3.40.50.720. 7 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 6 hits.
PF00106. adh_short. 2 hits.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 6 hits.
PF02801. Ketoacyl-synt_C. 6 hits.
PF08659. KR. 4 hits.
PF00550. PP-binding. 6 hits.
[Graphical view]
SMARTiSM00827. PKS_AT. 6 hits.
SM00826. PKS_DH. 1 hit.
SM00822. PKS_KR. 6 hits.
SM00825. PKS_KS. 6 hits.
SM00823. PKS_PP. 6 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 6 hits.
SSF52151. SSF52151. 12 hits.
SSF53901. SSF53901. 6 hits.
SSF55048. SSF55048. 6 hits.
PROSITEiPS50075. ACP_DOMAIN. 6 hits.
PS00606. B_KETOACYL_SYNTHASE. 6 hits.
PS00012. PHOSPHOPANTETHEINE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93NX9-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MDNEQKLRDY LKLATADLRR ARRRVGELES ASQEPIAIVG MTCRYPGGVS
60 70 80 90 100
SPEDLWRMVE AGENGVTPFP TDRGWDLEAL ASSPTSRGGF LHDAPEFDAD
110 120 130 140 150
FFGISPREAV AMDPQQRVVL ESAWEAFERA GINPTSVKGS RTGVFIGAMA
160 170 180 190 200
QDYRVGPADG AEGFQLTGNT GSVLSGRISY TFGTVGPAVT VDTACSSSLV
210 220 230 240 250
AVHLATQALR AGECTLALAG GVTVMSGPGT FIEMGRQGGL SVDGRCRSFG
260 270 280 290 300
DTADGTGWAE GVGILVLERL SDAIRNGREI LAVVRGTAVN QDGASNGLTA
310 320 330 340 350
PNGPSQQAVI EQALVNARLS AGDIDVVEAH GTGTTLGDPV EAQALLATYG
360 370 380 390 400
QQRDEDKPLL LGSVKSNISH TQAAAGVAGV IKMVMAMRHG VLPRTLLADE
410 420 430 440 450
PTRHVDWSQG AVRVLTENTE WPATGAPRRA AVSSFGISGT NAHTIVEQAP
460 470 480 490 500
EPEPADPEDD APSTPAAVTG VLPVLLSGRS PEVLRAQAAA LLTTLGTGTP
510 520 530 540 550
PAPADLAYSL ATTRTAFEHR AVLLASDLPE LTGRLTAIAE GTDPAVLADT
560 570 580 590 600
VTGTARTETR LAVLFTGQGA QRLGAGRELA ARFPVFAAAL DAALDAFTPH
610 620 630 640 650
LDVPLRKVLW GEDADRLDRT EYAQPALFAV EVALYRLLES FEVKPDHLAG
660 670 680 690 700
HSVGEIAAAH VAGVFSLDDA ATLVAARGRL MQALPEGGAM VAVQASEDEV
710 720 730 740 750
APLLAGHEDL VSLAAVNGPS AVVLSGDETT VTELAARLAA DGRKTSRLRV
760 770 780 790 800
SHAFHSPLMA PMLDEFRNVV EGLTLHSPLL PVVSDVTGEP ATVAQLTSPD
810 820 830 840 850
YWVDHVRQAV RFADGIDWLA RHDVTAFLEL GPDSVLSAMA QNCLDAAGSD
860 870 880 890 900
ALTVPALREG RPEDHTFTAA LAALHTQGTA LHWDACFTGT GARRTDLPTY
910 920 930 940 950
TFQRRRYWPR AVQGGAADLR SVGLGAAHHP LLSAAVSLAD SEGALLTGRI
960 970 980 990 1000
SLLSHPWLAD HTVRGATLLP GTAFLELAVR AGDEVGCDRV DELTLAAPLV
1010 1020 1030 1040 1050
LPEQGGVQVQ LWIGNPDASG RRSVTVYGRP DADEDAPWTS HATGVLSASR
1060 1070 1080 1090 1100
TTSDFDATVW PPADAETLPV DGLYERLAEG GFGYGPLFQG LRAAWRRGDE
1110 1120 1130 1140 1150
VFAEVVLPES GHTDAESFGL HPALLDSALH AASFVDLDER AAGGLPFSWE
1160 1170 1180 1190 1200
GVSLHASGAT TLRVRLAPAA GDAVAIAVAD DSGQLVLSAD SLILRAVAAR
1210 1220 1230 1240 1250
EIDAAAALVR DALFRLDWVP VTAVAASGTA AALVGEDPFG LRALPQFGDL
1260 1270 1280 1290 1300
AVHPDLADLA AADGAVPDTV LLPLTGTGPD ADPVTAAHRA ATEALAAVRT
1310 1320 1330 1340 1350
WLEQDERFAA SRLALVTRGA TTGHDPAAAA VWGLVRSAQS ENPGRFLLVD
1360 1370 1380 1390 1400
LDADQDTPAL PAAALTSEEP QLAVRGEELR AARLVRRPAS TAEAVPAFGG
1410 1420 1430 1440 1450
EGAVLVTGGT GGLGAVLARH LVAEHGVREL VLVSRRGGAA AGAAELVAEL
1460 1470 1480 1490 1500
AESGARATVV ACDVTDRAAV AELVAAHPVS AVVHSAGVLD DGMVGTLTPE
1510 1520 1530 1540 1550
RLTTVLRPKV DAAWNLHEAT RDLDLKAFVL FSSVAGVLGS PGQANYAAGN
1560 1570 1580 1590 1600
AFLDALAAHR RAAGLPGLSL AWGPWEQTGG MTGGISEDDL RRMARAGTPA
1610 1620 1630 1640 1650
LTVEQGLALL DAALDGDDAA LAPVRLDLSV LRAQGEVPPL LRSLIRGRSR
1660 1670 1680 1690 1700
RAAVAGSATA GGLAQRLARL DAESRDELVL DLVRGQVALV LGHATGAEID
1710 1720 1730 1740 1750
AGRAFRELGF DSLTAVELRN RLNTVTGLRL PATLVFDYPT VSHLASYVLD
1760 1770 1780 1790 1800
ELLGTEVEAE VVQRGTAAVA DDPIVIVGMA CRYPGGVTSP EDLWRLVTEG
1810 1820 1830 1840 1850
TDAVSGFPVN RGWDVENLYH PDPDHPGTAY TRSGGFLHEA GEFDPGFFGM
1860 1870 1880 1890 1900
SPREALATDS QQRLLLEASW EAIERAGIDP VGLRGSATGV FAGVMYSDYS
1910 1920 1930 1940 1950
AMLGSPEFEG FQGSGSSPSL ASGRVSYTLG LEGPAVTVDT ACSSSLVAMH
1960 1970 1980 1990 2000
WAMQALRSGE ISLALAGGVT VMSTPAVFVD FARQRGLSPD GRCKAFSDSA
2010 2020 2030 2040 2050
DGVGWSEGVG MLVLERQSDA IRNGHQILAV VRGSAVNQDG ASNGLTAPNG
2060 2070 2080 2090 2100
PSQQRVIRQA LASGGLSAGD VDVVEAHGTG TTLGDPIEAQ ALLATYGRDR
2110 2120 2130 2140 2150
DPEQPLLLGS VKSNIGHTQA AAGVAGVIKM VMSMRHGVLP RTLHVDAPSS
2160 2170 2180 2190 2200
HVDWTEGAVE LLTEQTAWPE TGRPRRAAVS SFGISGTNVH TVLEQAPGTT
2210 2220 2230 2240 2250
VPAPAAPERT AGAVPLLLSG RTRDALRAQA ARLLTHLQNH PEPSLADLGH
2260 2270 2280 2290 2300
SLATTRSRFE RRAAVIAQDR EGLLASLGSL AAGRPDPAVV EGEAAGRARV
2310 2320 2330 2340 2350
AVMFSGQGSQ RAAMGRELYE TQPRFAAAFD EVCAALDPLL DRPLREVVFA
2360 2370 2380 2390 2400
AEGSEEAALL DRTGWTQPAL FAVEVALYRL VESWGVRADF VTGHSIGEIA
2410 2420 2430 2440 2450
AAHIAGVFTL QDAARLVAAR ATLMEALPSG GAMVAVQATE EEVAPLLGEG
2460 2470 2480 2490 2500
LSVAAVNGPT SVVVSGDEDP AVELAAEFSG RGRRTKRLRV SHAFHSPHMD
2510 2520 2530 2540 2550
AMLDAFRTVA ETLSYAAPRI PLVSDLTGRR ADDAEVRTAD YWVRHVREAV
2560 2570 2580 2590 2600
RFADCVRTLR DAGATLFLEL GPDGLLTAMA EDTLGDERYD HNTALVPLLR
2610 2620 2630 2640 2650
ADRPEESAAA TAAARLQIHG VDLDWTAYLA GTGARRVDLP TYAFQHAHYW
2660 2670 2680 2690 2700
PQLPSAAPSP AGDPADQKLW AAVERGDAAE LAAVLGLDED SLTPLDSLLP
2710 2720 2730 2740 2750
ALSSWRRGNQ EKALLDTLRY RVEWTRLSKP AAPVLDGTWL LVSSDATADD
2760 2770 2780 2790 2800
ETELLDGLAE ALGAHGARVR RLVLDADCAD RAVLGARLAD TENADNTAQV
2810 2820 2830 2840 2850
LSVLPLDERP TDGPAGFTQG LALTIALVQA LADTGAHGRL WTATRGAVST
2860 2870 2880 2890 2900
GPADPVTHPA QATAWGMGRG VALEHPRLWG GLVDLPADFD RGAGQRLAEV
2910 2920 2930 2940 2950
LAVKDAPDGE DQVALRATGV HGRRLVRHIV DELPSADQFT ASGSVLITGG
2960 2970 2980 2990 3000
TGGLGAETAR WLARSGAAHL VLTSRRGPDA PGAAELRAEL EQSGASVSIV
3010 3020 3030 3040 3050
ACDVADRDAL AAVLDGLSAD QPLTGVVHTA GVGHYGPLDA LTPAEFAGLT
3060 3070 3080 3090 3100
AAKLAGAAHL DNLLGDRELD FFILFGSIAG VWGSGDQSAY GAANAYLDAL
3110 3120 3130 3140 3150
ALARRARGLA ATSIAWGPWG GTGMAADDAV SGTLRRQGLG LLDPAPALTE
3160 3170 3180 3190 3200
MRRAVVRQDV TVTVADVDWT RYAPLFTSAR PSALISDLPE VRALAAENTP
3210 3220 3230 3240 3250
ADTGDASEIV QRVRSLSEPE QLRLLTDLVR TEAATVLGHS SAGAVPEDRA
3260 3270 3280 3290 3300
FREIGFDSLT AVELRKHLGA ATGLSLPSTM VFDYPTPLEL AQYLRAEMVG
3310 3320 3330 3340 3350
SVLEVAGPVA TGGTDDEPIA IIGMSCRYPG GVSSPEQLWD LVLSGTDAIT
3360 3370 3380 3390 3400
DFPVNRGWNT AGLYDPDPDH PGTTYSTQGG FLHEADEFDP MFFGISPREA
3410 3420 3430 3440 3450
LVMDPQQRLL LETTWEAFER AGLTPDTLRG SLTGTFIGSS YQEYGMGAGD
3460 3470 3480 3490 3500
GAEGHLVTGT SPSVLSGRLA YVFGLEGPAV TVDTACSSSL VALHLACQAL
3510 3520 3530 3540 3550
RNGESNLAVA GGATVMTTPN AFVAFSRQRA LAQDGRCKAF SESADGMTLA
3560 3570 3580 3590 3600
EGVGIVLVER LSDARRNGHP VLAVIRGSAI NQDGASNGLS APNGPSQQRV
3610 3620 3630 3640 3650
IRQALANARV APGEIDLLEA HGTGTPLGDP IEAQALFATY GRTRTPETAL
3660 3670 3680 3690 3700
LLGSVKSNIG HSQSAAGVAS IIKMVMALRH GVMPQTLHAD EPSSHVDWSP
3710 3720 3730 3740 3750
GTVRLLGENT DWPQTGRPRR AAVSSFGISG TNAHVILEQE TEAPAAEDEQ
3760 3770 3780 3790 3800
LAPAPLPVAA GVVPWLLSAR GAAALREQAD RLLTHLVTAD PAARPIDIGL
3810 3820 3830 3840 3850
SLATSRALFE HRAVVVPPAG TDPLEALRAV AADGPSGVVA RGVADVAGRT
3860 3870 3880 3890 3900
VFVFPGQGSQ WAGMGAQLLD ESPVFAERIA ECAAALAEFT DWNLIDVLRG
3910 3920 3930 3940 3950
AEGAPTLERV DVVQPASFAV MVSLAAVWRA QGVEPDAVVG HSQGEIAAAV
3960 3970 3980 3990 4000
VSGALSLRDG ARVVTLRAQA IGRSLAGRGG MMSVALPVAE VEARLEAFEG
4010 4020 4030 4040 4050
RVSVAAENGP RSSVVAGEPE ALDELHAQLT AEEIRARRVA VDYASHSPHV
4060 4070 4080 4090 4100
EDLHDEILEL LAEVAPRTSE IPFFSTVTGD WLDTTVMDAG YWYRSLRGRV
4110 4120 4130 4140 4150
LFADAVRDLI AADHRAFIEV SSHPVLAMSV QDMIDDAGVA GVASGTLRRD
4160 4170 4180 4190 4200
NGGLDRFLLS AAEVFVRGVQ VDWAAVFEGT GASRVDLPTY AFQHENLWAM
4210 4220 4230 4240 4250
AAAPEAVTAA DPEDAAFWTA VEDGDVSALT AALGTDEDSV AAVLPALSSW
4260 4270 4280 4290 4300
RRARKERSTV DSWRYRPTWK PVTKLPQRTL DGTWLLVSAD GVDDTDVAEA
4310 4320 4330 4340 4350
LETGGAEVRR LVLDESCTDR AVLRERLTDA DGLTGIVSVL AGAERTGAVP
4360 4370 4380 4390 4400
GTGLVLGVAL TVALVQALGD AGIDTPLWAL TRGAVSTGRS DKVTAPVQAQ
4410 4420 4430 4440 4450
VTGIGWTAAL ECPGRWGGVV DLPETLDARA GQRLAAVLAG ALGDDDQIAL
4460 4470 4480 4490 4500
RSSGVFTRRI VRADAAPDGS ARDWKPRGTT LVTGGSGTLA PHLARWLAEQ
4510 4520 4530 4540 4550
GAEHLVLVSR RGPEAPGAAE LRAELAERGT ETTLAACDIT DRDAVAALLE
4560 4570 4580 4590 4600
SLKAEGRTVR TVVHTAATIE LHTLDATTLD DFDRVLAAKV TGAQILDELL
4610 4620 4630 4640 4650
DDEELDDFVL YSSTAGMWGS GAHAAYVAGN AYLAALAEHR RARGLTALSL
4660 4670 4680 4690 4700
SWGIWADDLQ LGRVDPQMIR RSGLEFMDPQ LALSGLKRAL DDDEQVIAVA
4710 4720 4730 4740 4750
DVDWETYHPV YTSARPTPLF DEVPEVQRLT AAAEQSAGDP ARGEFAAALL
4760 4770 4780 4790 4800
ALPAAEQHRK LLETVRTEAA SVLGLSSAED LTDQRAFRDV GFDSLTAVGL
4810 4820 4830 4840 4850
RNRLASVTGL TLPSTMVFDY PNPAALAGFL HSELADVHSA GAVAVTAGAP
4860 4870 4880 4890 4900
VDDDPIAIVG MSCRYPGGIT SAEQLWRVSL EEVDAVSVFP ADRGWDAEAL
4910 4920 4930 4940 4950
YDPDPDASGR TYSVQGGFLR DVADFDPGFF GISPREALSM DPQQRLLLET
4960 4970 4980 4990 5000
AWEVFENAGL DPVAQRGSRT GTFIGASYQD YGAAVPGSEG SEGHMITGSL
5010 5020 5030 5040 5050
PSVLSGRVSY LFGLEGPAVT LDTACSSSLV AIHLACQSLR NGESTLALAG
5060 5070 5080 5090 5100
GASIMSTPMS FIGFSRQRAL AEDGRCKAYA EGADGMTLAE GVGLILLERL
5110 5120 5130 5140 5150
SDARRNGHEV LAVIRGSAVN QDGASNGLTA PNGPSQQRVI RQALANAGVE
5160 5170 5180 5190 5200
ANDIDVLEGH GTGTALGDPI EAQALFATYG KDRDPERPVL LGSVKSNIGH
5210 5220 5230 5240 5250
TQMASGVASI IKLVHALREG VAPKSLHIDQ PSTHVDWSSG TIQLLTERTE
5260 5270 5280 5290 5300
WPETGRPRRA AVSSFGLSGT NVHTVLEQAP AADAPAAEDT PAPRDALVPV
5310 5320 5330 5340 5350
LVSGRGEAAL RAQAGALLDL LAERPGIHPT DLAFSLATSR AALEHRAAVV
5360 5370 5380 5390 5400
ADDHEALVRG LTALRDGLPG AGLVQGRTGR GRTAFLFTGQ GSQRLGMGRE
5410 5420 5430 5440 5450
LYERHPVFAD ALDAVLARID GTTERPLRDV LFAAEGSQDA ALLHRTGYAQ
5460 5470 5480 5490 5500
PALFALEVAL FRLLESWGVT PDYLAGHSVG EIAAAHVAGV LDLDDACTLV
5510 5520 5530 5540 5550
AARGRLMQAL PEGGAMVALE AAEDEVLPHL EGLADQVSVA AVNGPRSVVV
5560 5570 5580 5590 5600
AGEEEPVLAL AAHFAEQGRR TKRLRVSHAF HSPLMDPMLD DFAAVARALT
5610 5620 5630 5640 5650
YHAPSIPFVS NVTGTLAAPE QVCTADYWVS HVRSAVRFAD GIGWLSTQGG
5660 5670 5680 5690 5700
VQTFLELGPD GVLSGMARES LTDASRTALL PTLRGDRPEE QALVTAVAAA
5710 5720 5730 5740 5750
HAHGFDVDWT AWFQGSGARR VALPTYAFQR ERYWPDTTAA GITAPAPGSA
5760 5770 5780 5790 5800
LDAEFWAAVE HADVASLTAS LGLDDATVTA MVPALTAWRQ RRGEQSALDS
5810 5820 5830 5840 5850
WRYRVTWKPR GGAPGAAPTG RWLVLVPAEH RDEATAAWAA DVEAALATAT
5860 5870 5880 5890 5900
VRVEVTGTDR AALAARLTEA ADGDTFQGVL SLLALAPGDA GHPGAPAALT
5910 5920 5930 5940 5950
LTATALQALG DARIDAPLWN ITRGAVAVGR SEQVTAPEQA AVWGLFRAAA
5960 5970 5980 5990 6000
LELPARVGGS VDLPEDLDTQ AARRLRGILA AADGEDAVAV RASGVFLRRL
6010 6020 6030 6040 6050
AHSPAADTVG SAFDPAAGTV LITGGTGGIG GHLARRLARD GAAHLLLTSR
6060 6070 6080 6090 6100
RGPDAPGAGE LRAELEESGA RVTIAACDAA DRDALAALLA TVPEDAPLTA
6110 6120 6130 6140 6150
VFHTAGVVDD HVVDELTPES FATVLHAKTV AARHLHDLTA GHDLAAFVLF
6160 6170 6180 6190 6200
SSTAGLIGAA GQGNYAAANS QLDALAEQRR AQGLPALSVA WGPWAGSGMV
6210 6220 6230 6240 6250
ADAAEIAARV RRGGFEPLDP ASGVAALLRA VDNGDTSVAV ADIDWERFLR
6260 6270 6280 6290 6300
AFASARPLPL VADLPETAGA NAPAAAAGTG SGLREQLAGL PAEERHAHVL
6310 6320 6330 6340 6350
DLLRTQVAAV LGHSDARTVD DDLAFRDLGF DSLTVLELRN ALNALTGLSL
6360 6370 6380 6390 6400
PASLVYDHPT PREMADFLLA ELLGSLPEST RHAVATRAVD EDPIAVVGLA
6410 6420 6430 6440 6450
CRFPGGVSTP EELWQLLAEG RDGITGFPDD RNWDIAALGA GASDTLHGGF
6460 6470 6480 6490 6500
LAQVADFDAR FFGISPREAL AMDPQQRLLL ETTWEALERA GIDPAALRGS
6510 6520 6530 6540 6550
TTGVFVGTNG QDYPNLLRRS TSDVSGYVAT GNTASVMSGR LSYALGLEGP
6560 6570 6580 6590 6600
AVTIDTACSS SLVALHWAGH ALSAGECDLV VAGGVSVMST PDSFVEFSTQ
6610 6620 6630 6640 6650
GGLAPDGHCK PFSDDADGTA WSEGVGILVL ERLSDAIRNG HEVRGIIRGT
6660 6670 6680 6690 6700
AVNQDGASNG LTAPNGPSQQ RVIRQALADA RLAPSEIDAV EAHGTGTTLG
6710 6720 6730 6740 6750
DPIEAQALLN TYGPGRDTDQ PLLLGTVKSN IGHTQAAAGV AGVIKMLLAM
6760 6770 6780 6790 6800
QHGTLPRTLH VTSPTSHVDW SSGAVSLLTE ERDWPETGRP RRAGVSAFGV
6810 6820 6830 6840 6850
SGTNAHVIVE QAPIDEPVVE PTEEPAPAAE VTTVPWIVSG RSREALQDQV
6860 6870 6880 6890 6900
DRLTAYAAAR PELSPLDVGR SLATDRTLFP HRAVLLAGPD GVREAARSVA
6910 6920 6930 6940 6950
SRTRGRTAFL FSGQGAQRAL MGRELYERYP AFADALDTVL AQFDTALDFS
6960 6970 6980 6990 7000
LREVLFAEPG TPEAERLNET GWTQPALFAV EVALHRLVES WGLTPDQVAG
7010 7020 7030 7040 7050
HSIGEIAAAH VAGVFSLEDA CALVAARASL MQELPRGGAM LAVRATEEEV
7060 7070 7080 7090 7100
APHLTERVSV AAVNGPSAVV VAGDEAEVAA IAAHFEAQDR KTTRLRVSHA
7110 7120 7130 7140 7150
FHSPLMDPML TAFARVAESL TYHEPVIPLV STVTGVPAGA ELLTPGYWVR
7160 7170 7180 7190 7200
HVRETVRFAD GVRALREDGV TTFVEIGPDG QLTAAAQQTL DASGDEAPAT
7210 7220 7230 7240 7250
VVALQRRDRS EETTLLEGLA TLHTQGAGPD WTAWFAGTGG HRVELPTYAF
7260 7270 7280 7290 7300
QRERYWPEPA APGATGVQDP VDAAFWAAVE REDLESLTAS LGLDGDTVTT
7310 7320 7330 7340 7350
MVPALSAWRR RTDARSTARD WRYHESWTAL GTPAHSAGAG RVLALVPAEH
7360 7370 7380 7390 7400
AGTDWAETLV AALGADPLVV DGTSGSLARE LADLVPQQAT FAPSRRPART
7410 7420 7430 7440 7450
LAAPAESPST SSTGTSGRHT ESTHRTPLLD GQTSPAGTLD PAGWTVVVSL
7460 7470 7480 7490 7500
LAAGTGTLPA PDAAPAAVLE ALEAAGVDAP LWCVTRGAVS VAGEAPAAVG
7510 7520 7530 7540 7550
QAALWGMGRV AALEHPERFG GLADLAPDAD AATAALLAAH LAEPGGEDQI
7560 7570 7580 7590 7600
AVRATGLFGR RLVRTAVAPG DSGWRPHGTV LVVGGTRAMG ARAARWLARE
7610 7620 7630 7640 7650
GAARLVLTTS PADSATDTEE LRAELGRLGA EVTVAPYDGG DRDAARALLD
7660 7670 7680 7690 7700
GLTGLTAVVY ADDTPADGPA AALAPVDTLA EAATGRSLDA FVLFGSVAGV
7710 7720 7730 7740 7750
WGVRGHTDEA AEGAYVDALA RALRAEGTPA LAVSWNAWAE LTDPSTTRHL
7760 7770 7780 7790 7800
RMNGLPVMDA DAALTALAGA VADGSAAVTV ADVRWDTFAP AHHETRPTAL
7810 7820 7830 7840 7850
FDGLPEARTA LAGAARDRAE GATASDGYGR WLLEQPAADR DDILLALVSE
7860 7870 7880 7890 7900
KAALVLGHAD TTLVEPDLPF RDLGFDSLTA VDLRNQLTAA TGITLPATLV
7910 7920 7930 7940 7950
FDHPNPAALA AHLRTELLGG ATDTAAPVAA PAATGDDPIV IVGMACRFPG
7960 7970 7980 7990 8000
GVNSPEDLWQ LVLDEVDAVG DFPADRGWDL DALAGDGPGR SATDQGGFLY
8010 8020 8030 8040 8050
DATDFDPGLF GVSPREAMVM DPQQRILLEA SWEALERAGI DPGTLRGSGT
8060 8070 8080 8090 8100
TGVFVGGGSG DYRPPAEYGQ WQTAQSASLL SGRLAYTFGI QGPTVSVDTA
8110 8120 8130 8140 8150
CSSSLVALHL AAQALRSGEC SIALAGGVTV MATPVGFVEF SAQGALSPDG
8160 8170 8180 8190 8200
RCRAFSEDAN GTGWSEGVGM LVVERLSDAR RNGHRVLAVL RGSAINQDGA
8210 8220 8230 8240 8250
SNGLTAPSGP AQQRVIRQAL ANARLEAADV DAVEAHGTGT KLGDPIEAQA
8260 8270 8280 8290 8300
LLATYGQDRE RPVLVGSLKA NIGHTQAASG VGGVIKMVLA MQHGLLPRSL
8310 8320 8330 8340 8350
YTENPSSHVD WTAGNARLLT ELTPWPESER VRRAAVSSFG ASGTNAHLIL
8360 8370 8380 8390 8400
EQPEPVRQPV EGARPAEDGS PVPVLLSGRS QNALRAQARK LLAHVAGHPE
8410 8420 8430 8440 8450
ETVTDLARTL ATTRAVFEHR AAVTAADRDA LIAGLTAVAE GTTAAHIVEH
8460 8470 8480 8490 8500
QVERTGKHAV LFSGQGSQQL GMGRDLYERF PAFAEAFDAV LARLDGHLGA
8510 8520 8530 8540 8550
SLRDVVWHGD QETLNETGHT QPALFAFEVA LYRLVESWGV TPDFVAGHSV
8560 8570 8580 8590 8600
GEIAAAHVAG VLSLDDACRL VAARARLMQD LPRGGAMVAV EATEQEVAAE
8610 8620 8630 8640 8650
LTEAVSIAAV NGPTSVVLAG AEDAVLAVAA VLAERGRRTS RLKVSHAFHS
8660 8670 8680 8690 8700
VLMDPMLAEF RKVAESLRYE APRIAVVSNV TGDVAGADEL CDADYWVRHV
8710 8720 8730 8740 8750
RGTVRFADGV TALAGRGVRV LLELGPDAVL SALAEQSAPD TVSIPAQRRN
8760 8770 8780 8790 8800
RDEVETLVAA LGRLHVHAAG PRWDAFFDAA PGSWLDLPTY AFQRGRFWPD
8810 8820 8830 8840 8850
TLPTAPQGGA TAGEADGTDS AFWDAVAQED FGSLESVLDV EGDALSKVLP
8860 8870 8880 8890 8900
ALLDWRRRTS EETQLDSWRH RIVWKRLTGA AMAHRKPLTG TWLAVVPEGL
8910 8920 8930 8940 8950
GEDPWVTTAL DALGTRVVRA EVGADGREAM AATLREAAGE GTRFGGVVSL
8960 8970 8980 8990 9000
LALRETVHGD VPEGVALTGT LLQALGDAGI EAPLWCVTRS AVSANRSDRP
9010 9020 9030 9040 9050
RRPLQAAVWG LGRVAALEYP NRWGGLVDLP ERADERAAAG LAAVLAGLDG
9060 9070 9080 9090 9100
EDQVAVRGSA VLARRLVPAP DRGQSGAWDP TGTVLITGGT GAIGAHVARR
9110 9120 9130 9140 9150
LAKDGVQHLV LLSRRGAEAP GATALRDELQ TLGAGVTLAA CDASDRGQLA
9160 9170 9180 9190 9200
AVLDAIPDDR PLTAVLHAAG VLDDGVIDRL TPERYQKVFR AKVTSALLLD
9210 9220 9230 9240 9250
ELTRDLDLAA FVLFSSASSA VGNPGQANYA AANAVLDALA EARRVQNLPA
9260 9270 9280 9290 9300
TSVSWGAWGG GGMADGHGAD DAARRAGVAA MDPDLAVESL LRLVTGKEPT
9310 9320 9330 9340 9350
AVVAEVDLDR FASAFGGARP SALLREFPGY RETVAAAAPA SPEGTLADRL
9360 9370 9380 9390 9400
AGMAPARRLD TVVDLVRTRA AQVLGYPDID AVGAERSFRD LGVDSLGAVE
9410 9420 9430 9440 9450
LRNQLGAETG LSLPATLVFD HPTPLALGEF VLARLAPEEA GPAVSDEETE
9460 9470 9480 9490 9500
IRAVLASVPL DRLREIGVLE PLLQLAGRGG GAGDDEDGES VDSMTVADLV
9510
RAALNGQSDL
Length:9,510
Mass (Da):992,847
Last modified:December 1, 2001 - v1
Checksum:i1A8E003A15D478CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357202 Genomic DNA. Translation: AAK73501.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357202 Genomic DNA. Translation: AAK73501.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4L4X X-ray 2.55 A 4200-4759 [» ]
ProteinModelPortali Q93NX9.
SMRi Q93NX9. Positions 1662-1752, 6281-6371.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1200.10. 6 hits.
3.40.366.10. 12 hits.
3.40.47.10. 12 hits.
3.40.50.720. 7 hits.
InterProi IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 6 hits.
PF00106. adh_short. 2 hits.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 6 hits.
PF02801. Ketoacyl-synt_C. 6 hits.
PF08659. KR. 4 hits.
PF00550. PP-binding. 6 hits.
[Graphical view ]
SMARTi SM00827. PKS_AT. 6 hits.
SM00826. PKS_DH. 1 hit.
SM00822. PKS_KR. 6 hits.
SM00825. PKS_KS. 6 hits.
SM00823. PKS_PP. 6 hits.
[Graphical view ]
SUPFAMi SSF47336. SSF47336. 6 hits.
SSF52151. SSF52151. 12 hits.
SSF53901. SSF53901. 6 hits.
SSF55048. SSF55048. 6 hits.
PROSITEi PS50075. ACP_DOMAIN. 6 hits.
PS00606. B_KETOACYL_SYNTHASE. 6 hits.
PS00012. PHOSPHOPANTETHEINE. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes."
    Caffrey P., Lynch S., Flood E., Finnan S., Oliynyk M.
    Chem. Biol. 8:713-723(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups."
    Carmody M., Murphy B., Byrne B., Power P., Rai D., Rawlings B., Caffrey P.
    J. Biol. Chem. 280:34420-34426(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Structural studies of an A2-type modular polyketide synthase ketoreductase reveal features controlling ?-substituent stereochemistry."
    Zheng J., Piasecki S.K., Keatinge-Clay A.T.
    ACS Chem. Biol. 8:1964-1971(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 4200-4759 IN COMPLEX WITH NADP.

Entry informationi

Entry nameiQ93NX9_9ACTO
AccessioniPrimary (citable) accession number: Q93NX9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3