Q93NX9 (Q93NX9_9ACTO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
AmphI EMBL AAK73501.1

Gene names

Name:

amphI EMBL AAK73501.1

Organism

Streptomyces nodosus EMBL AAK73501.1

Taxonomic identifier

40318 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	9510 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Molecular function	Transferase RuleBase RU000693
Technical term	3D-structure PDB 4DI7
Gene Ontology (GO)
Biological_process	oxidation-reduction process Inferred from electronic annotation. Source: GOC
Molecular_function	cofactor binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q93NX9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 1A8E003A15D478CF	FASTA	9,510	992,847
	10 20 30 40 50 60 MDNEQKLRDY LKLATADLRR ARRRVGELES ASQEPIAIVG MTCRYPGGVS SPEDLWRMVE 70 80 90 100 110 120 AGENGVTPFP TDRGWDLEAL ASSPTSRGGF LHDAPEFDAD FFGISPREAV AMDPQQRVVL 130 140 150 160 170 180 ESAWEAFERA GINPTSVKGS RTGVFIGAMA QDYRVGPADG AEGFQLTGNT GSVLSGRISY 190 200 210 220 230 240 TFGTVGPAVT VDTACSSSLV AVHLATQALR AGECTLALAG GVTVMSGPGT FIEMGRQGGL 250 260 270 280 290 300 SVDGRCRSFG DTADGTGWAE GVGILVLERL SDAIRNGREI LAVVRGTAVN QDGASNGLTA 310 320 330 340 350 360 PNGPSQQAVI EQALVNARLS AGDIDVVEAH GTGTTLGDPV EAQALLATYG QQRDEDKPLL 370 380 390 400 410 420 LGSVKSNISH TQAAAGVAGV IKMVMAMRHG VLPRTLLADE PTRHVDWSQG AVRVLTENTE 430 440 450 460 470 480 WPATGAPRRA AVSSFGISGT NAHTIVEQAP EPEPADPEDD APSTPAAVTG VLPVLLSGRS 490 500 510 520 530 540 PEVLRAQAAA LLTTLGTGTP PAPADLAYSL ATTRTAFEHR AVLLASDLPE LTGRLTAIAE 550 560 570 580 590 600 GTDPAVLADT VTGTARTETR LAVLFTGQGA QRLGAGRELA ARFPVFAAAL DAALDAFTPH 610 620 630 640 650 660 LDVPLRKVLW GEDADRLDRT EYAQPALFAV EVALYRLLES FEVKPDHLAG HSVGEIAAAH 670 680 690 700 710 720 VAGVFSLDDA ATLVAARGRL MQALPEGGAM VAVQASEDEV APLLAGHEDL VSLAAVNGPS 730 740 750 760 770 780 AVVLSGDETT VTELAARLAA DGRKTSRLRV SHAFHSPLMA PMLDEFRNVV EGLTLHSPLL 790 800 810 820 830 840 PVVSDVTGEP ATVAQLTSPD YWVDHVRQAV RFADGIDWLA RHDVTAFLEL GPDSVLSAMA 850 860 870 880 890 900 QNCLDAAGSD ALTVPALREG RPEDHTFTAA LAALHTQGTA LHWDACFTGT GARRTDLPTY 910 920 930 940 950 960 TFQRRRYWPR AVQGGAADLR SVGLGAAHHP LLSAAVSLAD SEGALLTGRI SLLSHPWLAD 970 980 990 1000 1010 1020 HTVRGATLLP GTAFLELAVR AGDEVGCDRV DELTLAAPLV LPEQGGVQVQ LWIGNPDASG 1030 1040 1050 1060 1070 1080 RRSVTVYGRP DADEDAPWTS HATGVLSASR TTSDFDATVW PPADAETLPV DGLYERLAEG 1090 1100 1110 1120 1130 1140 GFGYGPLFQG LRAAWRRGDE VFAEVVLPES GHTDAESFGL HPALLDSALH AASFVDLDER 1150 1160 1170 1180 1190 1200 AAGGLPFSWE GVSLHASGAT TLRVRLAPAA GDAVAIAVAD DSGQLVLSAD SLILRAVAAR 1210 1220 1230 1240 1250 1260 EIDAAAALVR DALFRLDWVP VTAVAASGTA AALVGEDPFG LRALPQFGDL AVHPDLADLA 1270 1280 1290 1300 1310 1320 AADGAVPDTV LLPLTGTGPD ADPVTAAHRA ATEALAAVRT WLEQDERFAA SRLALVTRGA 1330 1340 1350 1360 1370 1380 TTGHDPAAAA VWGLVRSAQS ENPGRFLLVD LDADQDTPAL PAAALTSEEP QLAVRGEELR 1390 1400 1410 1420 1430 1440 AARLVRRPAS TAEAVPAFGG EGAVLVTGGT GGLGAVLARH LVAEHGVREL VLVSRRGGAA 1450 1460 1470 1480 1490 1500 AGAAELVAEL AESGARATVV ACDVTDRAAV AELVAAHPVS AVVHSAGVLD DGMVGTLTPE 1510 1520 1530 1540 1550 1560 RLTTVLRPKV DAAWNLHEAT RDLDLKAFVL FSSVAGVLGS PGQANYAAGN AFLDALAAHR 1570 1580 1590 1600 1610 1620 RAAGLPGLSL AWGPWEQTGG MTGGISEDDL RRMARAGTPA LTVEQGLALL DAALDGDDAA 1630 1640 1650 1660 1670 1680 LAPVRLDLSV LRAQGEVPPL LRSLIRGRSR RAAVAGSATA GGLAQRLARL DAESRDELVL 1690 1700 1710 1720 1730 1740 DLVRGQVALV LGHATGAEID AGRAFRELGF DSLTAVELRN RLNTVTGLRL PATLVFDYPT 1750 1760 1770 1780 1790 1800 VSHLASYVLD ELLGTEVEAE VVQRGTAAVA DDPIVIVGMA CRYPGGVTSP EDLWRLVTEG 1810 1820 1830 1840 1850 1860 TDAVSGFPVN RGWDVENLYH PDPDHPGTAY TRSGGFLHEA GEFDPGFFGM SPREALATDS 1870 1880 1890 1900 1910 1920 QQRLLLEASW EAIERAGIDP VGLRGSATGV FAGVMYSDYS AMLGSPEFEG FQGSGSSPSL 1930 1940 1950 1960 1970 1980 ASGRVSYTLG LEGPAVTVDT ACSSSLVAMH WAMQALRSGE ISLALAGGVT VMSTPAVFVD 1990 2000 2010 2020 2030 2040 FARQRGLSPD GRCKAFSDSA DGVGWSEGVG MLVLERQSDA IRNGHQILAV VRGSAVNQDG 2050 2060 2070 2080 2090 2100 ASNGLTAPNG PSQQRVIRQA LASGGLSAGD VDVVEAHGTG TTLGDPIEAQ ALLATYGRDR 2110 2120 2130 2140 2150 2160 DPEQPLLLGS VKSNIGHTQA AAGVAGVIKM VMSMRHGVLP RTLHVDAPSS HVDWTEGAVE 2170 2180 2190 2200 2210 2220 LLTEQTAWPE TGRPRRAAVS SFGISGTNVH TVLEQAPGTT VPAPAAPERT AGAVPLLLSG 2230 2240 2250 2260 2270 2280 RTRDALRAQA ARLLTHLQNH PEPSLADLGH SLATTRSRFE RRAAVIAQDR EGLLASLGSL 2290 2300 2310 2320 2330 2340 AAGRPDPAVV EGEAAGRARV AVMFSGQGSQ RAAMGRELYE TQPRFAAAFD EVCAALDPLL 2350 2360 2370 2380 2390 2400 DRPLREVVFA AEGSEEAALL DRTGWTQPAL FAVEVALYRL VESWGVRADF VTGHSIGEIA 2410 2420 2430 2440 2450 2460 AAHIAGVFTL QDAARLVAAR ATLMEALPSG GAMVAVQATE EEVAPLLGEG LSVAAVNGPT 2470 2480 2490 2500 2510 2520 SVVVSGDEDP AVELAAEFSG RGRRTKRLRV SHAFHSPHMD AMLDAFRTVA ETLSYAAPRI 2530 2540 2550 2560 2570 2580 PLVSDLTGRR ADDAEVRTAD YWVRHVREAV RFADCVRTLR DAGATLFLEL GPDGLLTAMA 2590 2600 2610 2620 2630 2640 EDTLGDERYD HNTALVPLLR ADRPEESAAA TAAARLQIHG VDLDWTAYLA GTGARRVDLP 2650 2660 2670 2680 2690 2700 TYAFQHAHYW PQLPSAAPSP AGDPADQKLW AAVERGDAAE LAAVLGLDED SLTPLDSLLP 2710 2720 2730 2740 2750 2760 ALSSWRRGNQ EKALLDTLRY RVEWTRLSKP AAPVLDGTWL LVSSDATADD ETELLDGLAE 2770 2780 2790 2800 2810 2820 ALGAHGARVR RLVLDADCAD RAVLGARLAD TENADNTAQV LSVLPLDERP TDGPAGFTQG 2830 2840 2850 2860 2870 2880 LALTIALVQA LADTGAHGRL WTATRGAVST GPADPVTHPA QATAWGMGRG VALEHPRLWG 2890 2900 2910 2920 2930 2940 GLVDLPADFD RGAGQRLAEV LAVKDAPDGE DQVALRATGV HGRRLVRHIV DELPSADQFT 2950 2960 2970 2980 2990 3000 ASGSVLITGG TGGLGAETAR WLARSGAAHL VLTSRRGPDA PGAAELRAEL EQSGASVSIV 3010 3020 3030 3040 3050 3060 ACDVADRDAL AAVLDGLSAD QPLTGVVHTA GVGHYGPLDA LTPAEFAGLT AAKLAGAAHL 3070 3080 3090 3100 3110 3120 DNLLGDRELD FFILFGSIAG VWGSGDQSAY GAANAYLDAL ALARRARGLA ATSIAWGPWG 3130 3140 3150 3160 3170 3180 GTGMAADDAV SGTLRRQGLG LLDPAPALTE MRRAVVRQDV TVTVADVDWT RYAPLFTSAR 3190 3200 3210 3220 3230 3240 PSALISDLPE VRALAAENTP ADTGDASEIV QRVRSLSEPE QLRLLTDLVR TEAATVLGHS 3250 3260 3270 3280 3290 3300 SAGAVPEDRA FREIGFDSLT AVELRKHLGA ATGLSLPSTM VFDYPTPLEL AQYLRAEMVG 3310 3320 3330 3340 3350 3360 SVLEVAGPVA TGGTDDEPIA IIGMSCRYPG GVSSPEQLWD LVLSGTDAIT DFPVNRGWNT 3370 3380 3390 3400 3410 3420 AGLYDPDPDH PGTTYSTQGG FLHEADEFDP MFFGISPREA LVMDPQQRLL LETTWEAFER 3430 3440 3450 3460 3470 3480 AGLTPDTLRG SLTGTFIGSS YQEYGMGAGD GAEGHLVTGT SPSVLSGRLA YVFGLEGPAV 3490 3500 3510 3520 3530 3540 TVDTACSSSL VALHLACQAL RNGESNLAVA GGATVMTTPN AFVAFSRQRA LAQDGRCKAF 3550 3560 3570 3580 3590 3600 SESADGMTLA EGVGIVLVER LSDARRNGHP VLAVIRGSAI NQDGASNGLS APNGPSQQRV 3610 3620 3630 3640 3650 3660 IRQALANARV APGEIDLLEA HGTGTPLGDP IEAQALFATY GRTRTPETAL LLGSVKSNIG 3670 3680 3690 3700 3710 3720 HSQSAAGVAS IIKMVMALRH GVMPQTLHAD EPSSHVDWSP GTVRLLGENT DWPQTGRPRR 3730 3740 3750 3760 3770 3780 AAVSSFGISG TNAHVILEQE TEAPAAEDEQ LAPAPLPVAA GVVPWLLSAR GAAALREQAD 3790 3800 3810 3820 3830 3840 RLLTHLVTAD PAARPIDIGL SLATSRALFE HRAVVVPPAG TDPLEALRAV AADGPSGVVA 3850 3860 3870 3880 3890 3900 RGVADVAGRT VFVFPGQGSQ WAGMGAQLLD ESPVFAERIA ECAAALAEFT DWNLIDVLRG 3910 3920 3930 3940 3950 3960 AEGAPTLERV DVVQPASFAV MVSLAAVWRA QGVEPDAVVG HSQGEIAAAV VSGALSLRDG 3970 3980 3990 4000 4010 4020 ARVVTLRAQA IGRSLAGRGG MMSVALPVAE VEARLEAFEG RVSVAAENGP RSSVVAGEPE 4030 4040 4050 4060 4070 4080 ALDELHAQLT AEEIRARRVA VDYASHSPHV EDLHDEILEL LAEVAPRTSE IPFFSTVTGD 4090 4100 4110 4120 4130 4140 WLDTTVMDAG YWYRSLRGRV LFADAVRDLI AADHRAFIEV SSHPVLAMSV QDMIDDAGVA 4150 4160 4170 4180 4190 4200 GVASGTLRRD NGGLDRFLLS AAEVFVRGVQ VDWAAVFEGT GASRVDLPTY AFQHENLWAM 4210 4220 4230 4240 4250 4260 AAAPEAVTAA DPEDAAFWTA VEDGDVSALT AALGTDEDSV AAVLPALSSW RRARKERSTV 4270 4280 4290 4300 4310 4320 DSWRYRPTWK PVTKLPQRTL DGTWLLVSAD GVDDTDVAEA LETGGAEVRR LVLDESCTDR 4330 4340 4350 4360 4370 4380 AVLRERLTDA DGLTGIVSVL AGAERTGAVP GTGLVLGVAL TVALVQALGD AGIDTPLWAL 4390 4400 4410 4420 4430 4440 TRGAVSTGRS DKVTAPVQAQ VTGIGWTAAL ECPGRWGGVV DLPETLDARA GQRLAAVLAG 4450 4460 4470 4480 4490 4500 ALGDDDQIAL RSSGVFTRRI VRADAAPDGS ARDWKPRGTT LVTGGSGTLA PHLARWLAEQ 4510 4520 4530 4540 4550 4560 GAEHLVLVSR RGPEAPGAAE LRAELAERGT ETTLAACDIT DRDAVAALLE SLKAEGRTVR 4570 4580 4590 4600 4610 4620 TVVHTAATIE LHTLDATTLD DFDRVLAAKV TGAQILDELL DDEELDDFVL YSSTAGMWGS 4630 4640 4650 4660 4670 4680 GAHAAYVAGN AYLAALAEHR RARGLTALSL SWGIWADDLQ LGRVDPQMIR RSGLEFMDPQ 4690 4700 4710 4720 4730 4740 LALSGLKRAL DDDEQVIAVA DVDWETYHPV YTSARPTPLF DEVPEVQRLT AAAEQSAGDP 4750 4760 4770 4780 4790 4800 ARGEFAAALL ALPAAEQHRK LLETVRTEAA SVLGLSSAED LTDQRAFRDV GFDSLTAVGL 4810 4820 4830 4840 4850 4860 RNRLASVTGL TLPSTMVFDY PNPAALAGFL HSELADVHSA GAVAVTAGAP VDDDPIAIVG 4870 4880 4890 4900 4910 4920 MSCRYPGGIT SAEQLWRVSL EEVDAVSVFP ADRGWDAEAL YDPDPDASGR TYSVQGGFLR 4930 4940 4950 4960 4970 4980 DVADFDPGFF GISPREALSM DPQQRLLLET AWEVFENAGL DPVAQRGSRT GTFIGASYQD 4990 5000 5010 5020 5030 5040 YGAAVPGSEG SEGHMITGSL PSVLSGRVSY LFGLEGPAVT LDTACSSSLV AIHLACQSLR 5050 5060 5070 5080 5090 5100 NGESTLALAG GASIMSTPMS FIGFSRQRAL AEDGRCKAYA EGADGMTLAE GVGLILLERL 5110 5120 5130 5140 5150 5160 SDARRNGHEV LAVIRGSAVN QDGASNGLTA PNGPSQQRVI RQALANAGVE ANDIDVLEGH 5170 5180 5190 5200 5210 5220 GTGTALGDPI EAQALFATYG KDRDPERPVL LGSVKSNIGH TQMASGVASI IKLVHALREG 5230 5240 5250 5260 5270 5280 VAPKSLHIDQ PSTHVDWSSG TIQLLTERTE WPETGRPRRA AVSSFGLSGT NVHTVLEQAP 5290 5300 5310 5320 5330 5340 AADAPAAEDT PAPRDALVPV LVSGRGEAAL RAQAGALLDL LAERPGIHPT DLAFSLATSR 5350 5360 5370 5380 5390 5400 AALEHRAAVV ADDHEALVRG LTALRDGLPG AGLVQGRTGR GRTAFLFTGQ GSQRLGMGRE 5410 5420 5430 5440 5450 5460 LYERHPVFAD ALDAVLARID GTTERPLRDV LFAAEGSQDA ALLHRTGYAQ PALFALEVAL 5470 5480 5490 5500 5510 5520 FRLLESWGVT PDYLAGHSVG EIAAAHVAGV LDLDDACTLV AARGRLMQAL PEGGAMVALE 5530 5540 5550 5560 5570 5580 AAEDEVLPHL EGLADQVSVA AVNGPRSVVV AGEEEPVLAL AAHFAEQGRR TKRLRVSHAF 5590 5600 5610 5620 5630 5640 HSPLMDPMLD DFAAVARALT YHAPSIPFVS NVTGTLAAPE QVCTADYWVS HVRSAVRFAD 5650 5660 5670 5680 5690 5700 GIGWLSTQGG VQTFLELGPD GVLSGMARES LTDASRTALL PTLRGDRPEE QALVTAVAAA 5710 5720 5730 5740 5750 5760 HAHGFDVDWT AWFQGSGARR VALPTYAFQR ERYWPDTTAA GITAPAPGSA LDAEFWAAVE 5770 5780 5790 5800 5810 5820 HADVASLTAS LGLDDATVTA MVPALTAWRQ RRGEQSALDS WRYRVTWKPR GGAPGAAPTG 5830 5840 5850 5860 5870 5880 RWLVLVPAEH RDEATAAWAA DVEAALATAT VRVEVTGTDR AALAARLTEA ADGDTFQGVL 5890 5900 5910 5920 5930 5940 SLLALAPGDA GHPGAPAALT LTATALQALG DARIDAPLWN ITRGAVAVGR SEQVTAPEQA 5950 5960 5970 5980 5990 6000 AVWGLFRAAA LELPARVGGS VDLPEDLDTQ AARRLRGILA AADGEDAVAV RASGVFLRRL 6010 6020 6030 6040 6050 6060 AHSPAADTVG SAFDPAAGTV LITGGTGGIG GHLARRLARD GAAHLLLTSR RGPDAPGAGE 6070 6080 6090 6100 6110 6120 LRAELEESGA RVTIAACDAA DRDALAALLA TVPEDAPLTA VFHTAGVVDD HVVDELTPES 6130 6140 6150 6160 6170 6180 FATVLHAKTV AARHLHDLTA GHDLAAFVLF SSTAGLIGAA GQGNYAAANS QLDALAEQRR 6190 6200 6210 6220 6230 6240 AQGLPALSVA WGPWAGSGMV ADAAEIAARV RRGGFEPLDP ASGVAALLRA VDNGDTSVAV 6250 6260 6270 6280 6290 6300 ADIDWERFLR AFASARPLPL VADLPETAGA NAPAAAAGTG SGLREQLAGL PAEERHAHVL 6310 6320 6330 6340 6350 6360 DLLRTQVAAV LGHSDARTVD DDLAFRDLGF DSLTVLELRN ALNALTGLSL PASLVYDHPT 6370 6380 6390 6400 6410 6420 PREMADFLLA ELLGSLPEST RHAVATRAVD EDPIAVVGLA CRFPGGVSTP EELWQLLAEG 6430 6440 6450 6460 6470 6480 RDGITGFPDD RNWDIAALGA GASDTLHGGF LAQVADFDAR FFGISPREAL AMDPQQRLLL 6490 6500 6510 6520 6530 6540 ETTWEALERA GIDPAALRGS TTGVFVGTNG QDYPNLLRRS TSDVSGYVAT GNTASVMSGR 6550 6560 6570 6580 6590 6600 LSYALGLEGP AVTIDTACSS SLVALHWAGH ALSAGECDLV VAGGVSVMST PDSFVEFSTQ 6610 6620 6630 6640 6650 6660 GGLAPDGHCK PFSDDADGTA WSEGVGILVL ERLSDAIRNG HEVRGIIRGT AVNQDGASNG 6670 6680 6690 6700 6710 6720 LTAPNGPSQQ RVIRQALADA RLAPSEIDAV EAHGTGTTLG DPIEAQALLN TYGPGRDTDQ 6730 6740 6750 6760 6770 6780 PLLLGTVKSN IGHTQAAAGV AGVIKMLLAM QHGTLPRTLH VTSPTSHVDW SSGAVSLLTE 6790 6800 6810 6820 6830 6840 ERDWPETGRP RRAGVSAFGV SGTNAHVIVE QAPIDEPVVE PTEEPAPAAE VTTVPWIVSG 6850 6860 6870 6880 6890 6900 RSREALQDQV DRLTAYAAAR PELSPLDVGR SLATDRTLFP HRAVLLAGPD GVREAARSVA 6910 6920 6930 6940 6950 6960 SRTRGRTAFL FSGQGAQRAL MGRELYERYP AFADALDTVL AQFDTALDFS LREVLFAEPG 6970 6980 6990 7000 7010 7020 TPEAERLNET GWTQPALFAV EVALHRLVES WGLTPDQVAG HSIGEIAAAH VAGVFSLEDA 7030 7040 7050 7060 7070 7080 CALVAARASL MQELPRGGAM LAVRATEEEV APHLTERVSV AAVNGPSAVV VAGDEAEVAA 7090 7100 7110 7120 7130 7140 IAAHFEAQDR KTTRLRVSHA FHSPLMDPML TAFARVAESL TYHEPVIPLV STVTGVPAGA 7150 7160 7170 7180 7190 7200 ELLTPGYWVR HVRETVRFAD GVRALREDGV TTFVEIGPDG QLTAAAQQTL DASGDEAPAT 7210 7220 7230 7240 7250 7260 VVALQRRDRS EETTLLEGLA TLHTQGAGPD WTAWFAGTGG HRVELPTYAF QRERYWPEPA 7270 7280 7290 7300 7310 7320 APGATGVQDP VDAAFWAAVE REDLESLTAS LGLDGDTVTT MVPALSAWRR RTDARSTARD 7330 7340 7350 7360 7370 7380 WRYHESWTAL GTPAHSAGAG RVLALVPAEH AGTDWAETLV AALGADPLVV DGTSGSLARE 7390 7400 7410 7420 7430 7440 LADLVPQQAT FAPSRRPART LAAPAESPST SSTGTSGRHT ESTHRTPLLD GQTSPAGTLD 7450 7460 7470 7480 7490 7500 PAGWTVVVSL LAAGTGTLPA PDAAPAAVLE ALEAAGVDAP LWCVTRGAVS VAGEAPAAVG 7510 7520 7530 7540 7550 7560 QAALWGMGRV AALEHPERFG GLADLAPDAD AATAALLAAH LAEPGGEDQI AVRATGLFGR 7570 7580 7590 7600 7610 7620 RLVRTAVAPG DSGWRPHGTV LVVGGTRAMG ARAARWLARE GAARLVLTTS PADSATDTEE 7630 7640 7650 7660 7670 7680 LRAELGRLGA EVTVAPYDGG DRDAARALLD GLTGLTAVVY ADDTPADGPA AALAPVDTLA 7690 7700 7710 7720 7730 7740 EAATGRSLDA FVLFGSVAGV WGVRGHTDEA AEGAYVDALA RALRAEGTPA LAVSWNAWAE 7750 7760 7770 7780 7790 7800 LTDPSTTRHL RMNGLPVMDA DAALTALAGA VADGSAAVTV ADVRWDTFAP AHHETRPTAL 7810 7820 7830 7840 7850 7860 FDGLPEARTA LAGAARDRAE GATASDGYGR WLLEQPAADR DDILLALVSE KAALVLGHAD 7870 7880 7890 7900 7910 7920 TTLVEPDLPF RDLGFDSLTA VDLRNQLTAA TGITLPATLV FDHPNPAALA AHLRTELLGG 7930 7940 7950 7960 7970 7980 ATDTAAPVAA PAATGDDPIV IVGMACRFPG GVNSPEDLWQ LVLDEVDAVG DFPADRGWDL 7990 8000 8010 8020 8030 8040 DALAGDGPGR SATDQGGFLY DATDFDPGLF GVSPREAMVM DPQQRILLEA SWEALERAGI 8050 8060 8070 8080 8090 8100 DPGTLRGSGT TGVFVGGGSG DYRPPAEYGQ WQTAQSASLL SGRLAYTFGI QGPTVSVDTA 8110 8120 8130 8140 8150 8160 CSSSLVALHL AAQALRSGEC SIALAGGVTV MATPVGFVEF SAQGALSPDG RCRAFSEDAN 8170 8180 8190 8200 8210 8220 GTGWSEGVGM LVVERLSDAR RNGHRVLAVL RGSAINQDGA SNGLTAPSGP AQQRVIRQAL 8230 8240 8250 8260 8270 8280 ANARLEAADV DAVEAHGTGT KLGDPIEAQA LLATYGQDRE RPVLVGSLKA NIGHTQAASG 8290 8300 8310 8320 8330 8340 VGGVIKMVLA MQHGLLPRSL YTENPSSHVD WTAGNARLLT ELTPWPESER VRRAAVSSFG 8350 8360 8370 8380 8390 8400 ASGTNAHLIL EQPEPVRQPV EGARPAEDGS PVPVLLSGRS QNALRAQARK LLAHVAGHPE 8410 8420 8430 8440 8450 8460 ETVTDLARTL ATTRAVFEHR AAVTAADRDA LIAGLTAVAE GTTAAHIVEH QVERTGKHAV 8470 8480 8490 8500 8510 8520 LFSGQGSQQL GMGRDLYERF PAFAEAFDAV LARLDGHLGA SLRDVVWHGD QETLNETGHT 8530 8540 8550 8560 8570 8580 QPALFAFEVA LYRLVESWGV TPDFVAGHSV GEIAAAHVAG VLSLDDACRL VAARARLMQD 8590 8600 8610 8620 8630 8640 LPRGGAMVAV EATEQEVAAE LTEAVSIAAV NGPTSVVLAG AEDAVLAVAA VLAERGRRTS 8650 8660 8670 8680 8690 8700 RLKVSHAFHS VLMDPMLAEF RKVAESLRYE APRIAVVSNV TGDVAGADEL CDADYWVRHV 8710 8720 8730 8740 8750 8760 RGTVRFADGV TALAGRGVRV LLELGPDAVL SALAEQSAPD TVSIPAQRRN RDEVETLVAA 8770 8780 8790 8800 8810 8820 LGRLHVHAAG PRWDAFFDAA PGSWLDLPTY AFQRGRFWPD TLPTAPQGGA TAGEADGTDS 8830 8840 8850 8860 8870 8880 AFWDAVAQED FGSLESVLDV EGDALSKVLP ALLDWRRRTS EETQLDSWRH RIVWKRLTGA 8890 8900 8910 8920 8930 8940 AMAHRKPLTG TWLAVVPEGL GEDPWVTTAL DALGTRVVRA EVGADGREAM AATLREAAGE 8950 8960 8970 8980 8990 9000 GTRFGGVVSL LALRETVHGD VPEGVALTGT LLQALGDAGI EAPLWCVTRS AVSANRSDRP 9010 9020 9030 9040 9050 9060 RRPLQAAVWG LGRVAALEYP NRWGGLVDLP ERADERAAAG LAAVLAGLDG EDQVAVRGSA 9070 9080 9090 9100 9110 9120 VLARRLVPAP DRGQSGAWDP TGTVLITGGT GAIGAHVARR LAKDGVQHLV LLSRRGAEAP 9130 9140 9150 9160 9170 9180 GATALRDELQ TLGAGVTLAA CDASDRGQLA AVLDAIPDDR PLTAVLHAAG VLDDGVIDRL 9190 9200 9210 9220 9230 9240 TPERYQKVFR AKVTSALLLD ELTRDLDLAA FVLFSSASSA VGNPGQANYA AANAVLDALA 9250 9260 9270 9280 9290 9300 EARRVQNLPA TSVSWGAWGG GGMADGHGAD DAARRAGVAA MDPDLAVESL LRLVTGKEPT 9310 9320 9330 9340 9350 9360 AVVAEVDLDR FASAFGGARP SALLREFPGY RETVAAAAPA SPEGTLADRL AGMAPARRLD 9370 9380 9390 9400 9410 9420 TVVDLVRTRA AQVLGYPDID AVGAERSFRD LGVDSLGAVE LRNQLGAETG LSLPATLVFD 9430 9440 9450 9460 9470 9480 HPTPLALGEF VLARLAPEEA GPAVSDEETE IRAVLASVPL DRLREIGVLE PLLQLAGRGG 9490 9500 9510 GAGDDEDGES VDSMTVADLV RAALNGQSDL

References

[1]	"Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes." Caffrey P., Lynch S., Flood E., Finnan S., Oliynyk M. Chem. Biol. 8:713-723(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups." Carmody M., Murphy B., Byrne B., Power P., Rai D., Rawlings B., Caffrey P. J. Biol. Chem. 280:34420-34426(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Structure and mutagenesis of A2-type ketoreductase from modular polyketide synthase reveals insights into stereospecificity." Zheng J., Keatinge-Clay A.T. Submitted (JAN-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 4200-4735.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF357202 Genomic DNA. Translation: AAK73501.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4DI7	X-ray	2.45	A	4200-4735	[»]

HSSP

HSSP built from PDB template 1NM2 based on UniProtKB P72391.

ProteinModelPortal

Q93NX9.

SMR

Q93NX9. Positions 1662-1752, 6281-6371.

ModBase

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Protocols and materials databases

StructuralBiologyKnowledgebase

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Family and domain databases

Gene3D

1.10.1200.10. 6 hits.
3.40.366.10. 12 hits.
3.40.47.10. 12 hits.
3.40.50.720. 7 hits.

InterPro

IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]

Pfam

PF00698. Acyl_transf_1. 6 hits.
PF00106. adh_short. 2 hits.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 6 hits.
PF02801. Ketoacyl-synt_C. 6 hits.
PF08659. KR. 4 hits.
PF00550. PP-binding. 6 hits.
[Graphical view]

SMART

SM00827. PKS_AT. 6 hits.
SM00826. PKS_DH. 1 hit.
SM00822. PKS_KR. 6 hits.
SM00825. PKS_KS. 6 hits.
SM00823. PKS_PP. 6 hits.
[Graphical view]

SUPFAM

SSF47336. ACP_like. 6 hits.
SSF52151. Acyl_Trfase/lysoPlipase. 6 hits.
SSF55048. Malonyl_transacylase_ACP-bd. 6 hits.
SSF53901. Thiolase-like. 6 hits.

PROSITE

PS50075. ACP_DOMAIN. 6 hits.
PS00606. B_KETOACYL_SYNTHASE. 6 hits.
PS00012. PHOSPHOPANTETHEINE. 6 hits.
[Graphical view]

ProtoNet

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Entry information

Entry name

Q93NX9_9ACTO

Accession

Primary (citable) accession number: Q93NX9

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)