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Q93NX9 (Q93NX9_9ACTO) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:amphI EMBL AAK73501.1
OrganismStreptomyces nodosus EMBL AAK73501.1
Taxonomic identifier40318 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length9510 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding4487 – 44893NADP PDB 4L4X
Nucleotide binding4509 – 45113NADP PDB 4L4X
Nucleotide binding4538 – 45403NADP PDB 4L4X
Nucleotide binding4565 – 45673NADP PDB 4L4X

Sites

Binding site45891NADP PDB 4L4X
Binding site46261NADP PDB 4L4X
Binding site46551NADP; via amide nitrogen PDB 4L4X

Sequences

Sequence LengthMass (Da)Tools
Q93NX9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 1A8E003A15D478CF

FASTA9,510992,847
        10         20         30         40         50         60 
MDNEQKLRDY LKLATADLRR ARRRVGELES ASQEPIAIVG MTCRYPGGVS SPEDLWRMVE 

        70         80         90        100        110        120 
AGENGVTPFP TDRGWDLEAL ASSPTSRGGF LHDAPEFDAD FFGISPREAV AMDPQQRVVL 

       130        140        150        160        170        180 
ESAWEAFERA GINPTSVKGS RTGVFIGAMA QDYRVGPADG AEGFQLTGNT GSVLSGRISY 

       190        200        210        220        230        240 
TFGTVGPAVT VDTACSSSLV AVHLATQALR AGECTLALAG GVTVMSGPGT FIEMGRQGGL 

       250        260        270        280        290        300 
SVDGRCRSFG DTADGTGWAE GVGILVLERL SDAIRNGREI LAVVRGTAVN QDGASNGLTA 

       310        320        330        340        350        360 
PNGPSQQAVI EQALVNARLS AGDIDVVEAH GTGTTLGDPV EAQALLATYG QQRDEDKPLL 

       370        380        390        400        410        420 
LGSVKSNISH TQAAAGVAGV IKMVMAMRHG VLPRTLLADE PTRHVDWSQG AVRVLTENTE 

       430        440        450        460        470        480 
WPATGAPRRA AVSSFGISGT NAHTIVEQAP EPEPADPEDD APSTPAAVTG VLPVLLSGRS 

       490        500        510        520        530        540 
PEVLRAQAAA LLTTLGTGTP PAPADLAYSL ATTRTAFEHR AVLLASDLPE LTGRLTAIAE 

       550        560        570        580        590        600 
GTDPAVLADT VTGTARTETR LAVLFTGQGA QRLGAGRELA ARFPVFAAAL DAALDAFTPH 

       610        620        630        640        650        660 
LDVPLRKVLW GEDADRLDRT EYAQPALFAV EVALYRLLES FEVKPDHLAG HSVGEIAAAH 

       670        680        690        700        710        720 
VAGVFSLDDA ATLVAARGRL MQALPEGGAM VAVQASEDEV APLLAGHEDL VSLAAVNGPS 

       730        740        750        760        770        780 
AVVLSGDETT VTELAARLAA DGRKTSRLRV SHAFHSPLMA PMLDEFRNVV EGLTLHSPLL 

       790        800        810        820        830        840 
PVVSDVTGEP ATVAQLTSPD YWVDHVRQAV RFADGIDWLA RHDVTAFLEL GPDSVLSAMA 

       850        860        870        880        890        900 
QNCLDAAGSD ALTVPALREG RPEDHTFTAA LAALHTQGTA LHWDACFTGT GARRTDLPTY 

       910        920        930        940        950        960 
TFQRRRYWPR AVQGGAADLR SVGLGAAHHP LLSAAVSLAD SEGALLTGRI SLLSHPWLAD 

       970        980        990       1000       1010       1020 
HTVRGATLLP GTAFLELAVR AGDEVGCDRV DELTLAAPLV LPEQGGVQVQ LWIGNPDASG 

      1030       1040       1050       1060       1070       1080 
RRSVTVYGRP DADEDAPWTS HATGVLSASR TTSDFDATVW PPADAETLPV DGLYERLAEG 

      1090       1100       1110       1120       1130       1140 
GFGYGPLFQG LRAAWRRGDE VFAEVVLPES GHTDAESFGL HPALLDSALH AASFVDLDER 

      1150       1160       1170       1180       1190       1200 
AAGGLPFSWE GVSLHASGAT TLRVRLAPAA GDAVAIAVAD DSGQLVLSAD SLILRAVAAR 

      1210       1220       1230       1240       1250       1260 
EIDAAAALVR DALFRLDWVP VTAVAASGTA AALVGEDPFG LRALPQFGDL AVHPDLADLA 

      1270       1280       1290       1300       1310       1320 
AADGAVPDTV LLPLTGTGPD ADPVTAAHRA ATEALAAVRT WLEQDERFAA SRLALVTRGA 

      1330       1340       1350       1360       1370       1380 
TTGHDPAAAA VWGLVRSAQS ENPGRFLLVD LDADQDTPAL PAAALTSEEP QLAVRGEELR 

      1390       1400       1410       1420       1430       1440 
AARLVRRPAS TAEAVPAFGG EGAVLVTGGT GGLGAVLARH LVAEHGVREL VLVSRRGGAA 

      1450       1460       1470       1480       1490       1500 
AGAAELVAEL AESGARATVV ACDVTDRAAV AELVAAHPVS AVVHSAGVLD DGMVGTLTPE 

      1510       1520       1530       1540       1550       1560 
RLTTVLRPKV DAAWNLHEAT RDLDLKAFVL FSSVAGVLGS PGQANYAAGN AFLDALAAHR 

      1570       1580       1590       1600       1610       1620 
RAAGLPGLSL AWGPWEQTGG MTGGISEDDL RRMARAGTPA LTVEQGLALL DAALDGDDAA 

      1630       1640       1650       1660       1670       1680 
LAPVRLDLSV LRAQGEVPPL LRSLIRGRSR RAAVAGSATA GGLAQRLARL DAESRDELVL 

      1690       1700       1710       1720       1730       1740 
DLVRGQVALV LGHATGAEID AGRAFRELGF DSLTAVELRN RLNTVTGLRL PATLVFDYPT 

      1750       1760       1770       1780       1790       1800 
VSHLASYVLD ELLGTEVEAE VVQRGTAAVA DDPIVIVGMA CRYPGGVTSP EDLWRLVTEG 

      1810       1820       1830       1840       1850       1860 
TDAVSGFPVN RGWDVENLYH PDPDHPGTAY TRSGGFLHEA GEFDPGFFGM SPREALATDS 

      1870       1880       1890       1900       1910       1920 
QQRLLLEASW EAIERAGIDP VGLRGSATGV FAGVMYSDYS AMLGSPEFEG FQGSGSSPSL 

      1930       1940       1950       1960       1970       1980 
ASGRVSYTLG LEGPAVTVDT ACSSSLVAMH WAMQALRSGE ISLALAGGVT VMSTPAVFVD 

      1990       2000       2010       2020       2030       2040 
FARQRGLSPD GRCKAFSDSA DGVGWSEGVG MLVLERQSDA IRNGHQILAV VRGSAVNQDG 

      2050       2060       2070       2080       2090       2100 
ASNGLTAPNG PSQQRVIRQA LASGGLSAGD VDVVEAHGTG TTLGDPIEAQ ALLATYGRDR 

      2110       2120       2130       2140       2150       2160 
DPEQPLLLGS VKSNIGHTQA AAGVAGVIKM VMSMRHGVLP RTLHVDAPSS HVDWTEGAVE 

      2170       2180       2190       2200       2210       2220 
LLTEQTAWPE TGRPRRAAVS SFGISGTNVH TVLEQAPGTT VPAPAAPERT AGAVPLLLSG 

      2230       2240       2250       2260       2270       2280 
RTRDALRAQA ARLLTHLQNH PEPSLADLGH SLATTRSRFE RRAAVIAQDR EGLLASLGSL 

      2290       2300       2310       2320       2330       2340 
AAGRPDPAVV EGEAAGRARV AVMFSGQGSQ RAAMGRELYE TQPRFAAAFD EVCAALDPLL 

      2350       2360       2370       2380       2390       2400 
DRPLREVVFA AEGSEEAALL DRTGWTQPAL FAVEVALYRL VESWGVRADF VTGHSIGEIA 

      2410       2420       2430       2440       2450       2460 
AAHIAGVFTL QDAARLVAAR ATLMEALPSG GAMVAVQATE EEVAPLLGEG LSVAAVNGPT 

      2470       2480       2490       2500       2510       2520 
SVVVSGDEDP AVELAAEFSG RGRRTKRLRV SHAFHSPHMD AMLDAFRTVA ETLSYAAPRI 

      2530       2540       2550       2560       2570       2580 
PLVSDLTGRR ADDAEVRTAD YWVRHVREAV RFADCVRTLR DAGATLFLEL GPDGLLTAMA 

      2590       2600       2610       2620       2630       2640 
EDTLGDERYD HNTALVPLLR ADRPEESAAA TAAARLQIHG VDLDWTAYLA GTGARRVDLP 

      2650       2660       2670       2680       2690       2700 
TYAFQHAHYW PQLPSAAPSP AGDPADQKLW AAVERGDAAE LAAVLGLDED SLTPLDSLLP 

      2710       2720       2730       2740       2750       2760 
ALSSWRRGNQ EKALLDTLRY RVEWTRLSKP AAPVLDGTWL LVSSDATADD ETELLDGLAE 

      2770       2780       2790       2800       2810       2820 
ALGAHGARVR RLVLDADCAD RAVLGARLAD TENADNTAQV LSVLPLDERP TDGPAGFTQG 

      2830       2840       2850       2860       2870       2880 
LALTIALVQA LADTGAHGRL WTATRGAVST GPADPVTHPA QATAWGMGRG VALEHPRLWG 

      2890       2900       2910       2920       2930       2940 
GLVDLPADFD RGAGQRLAEV LAVKDAPDGE DQVALRATGV HGRRLVRHIV DELPSADQFT 

      2950       2960       2970       2980       2990       3000 
ASGSVLITGG TGGLGAETAR WLARSGAAHL VLTSRRGPDA PGAAELRAEL EQSGASVSIV 

      3010       3020       3030       3040       3050       3060 
ACDVADRDAL AAVLDGLSAD QPLTGVVHTA GVGHYGPLDA LTPAEFAGLT AAKLAGAAHL 

      3070       3080       3090       3100       3110       3120 
DNLLGDRELD FFILFGSIAG VWGSGDQSAY GAANAYLDAL ALARRARGLA ATSIAWGPWG 

      3130       3140       3150       3160       3170       3180 
GTGMAADDAV SGTLRRQGLG LLDPAPALTE MRRAVVRQDV TVTVADVDWT RYAPLFTSAR 

      3190       3200       3210       3220       3230       3240 
PSALISDLPE VRALAAENTP ADTGDASEIV QRVRSLSEPE QLRLLTDLVR TEAATVLGHS 

      3250       3260       3270       3280       3290       3300 
SAGAVPEDRA FREIGFDSLT AVELRKHLGA ATGLSLPSTM VFDYPTPLEL AQYLRAEMVG 

      3310       3320       3330       3340       3350       3360 
SVLEVAGPVA TGGTDDEPIA IIGMSCRYPG GVSSPEQLWD LVLSGTDAIT DFPVNRGWNT 

      3370       3380       3390       3400       3410       3420 
AGLYDPDPDH PGTTYSTQGG FLHEADEFDP MFFGISPREA LVMDPQQRLL LETTWEAFER 

      3430       3440       3450       3460       3470       3480 
AGLTPDTLRG SLTGTFIGSS YQEYGMGAGD GAEGHLVTGT SPSVLSGRLA YVFGLEGPAV 

      3490       3500       3510       3520       3530       3540 
TVDTACSSSL VALHLACQAL RNGESNLAVA GGATVMTTPN AFVAFSRQRA LAQDGRCKAF 

      3550       3560       3570       3580       3590       3600 
SESADGMTLA EGVGIVLVER LSDARRNGHP VLAVIRGSAI NQDGASNGLS APNGPSQQRV 

      3610       3620       3630       3640       3650       3660 
IRQALANARV APGEIDLLEA HGTGTPLGDP IEAQALFATY GRTRTPETAL LLGSVKSNIG 

      3670       3680       3690       3700       3710       3720 
HSQSAAGVAS IIKMVMALRH GVMPQTLHAD EPSSHVDWSP GTVRLLGENT DWPQTGRPRR 

      3730       3740       3750       3760       3770       3780 
AAVSSFGISG TNAHVILEQE TEAPAAEDEQ LAPAPLPVAA GVVPWLLSAR GAAALREQAD 

      3790       3800       3810       3820       3830       3840 
RLLTHLVTAD PAARPIDIGL SLATSRALFE HRAVVVPPAG TDPLEALRAV AADGPSGVVA 

      3850       3860       3870       3880       3890       3900 
RGVADVAGRT VFVFPGQGSQ WAGMGAQLLD ESPVFAERIA ECAAALAEFT DWNLIDVLRG 

      3910       3920       3930       3940       3950       3960 
AEGAPTLERV DVVQPASFAV MVSLAAVWRA QGVEPDAVVG HSQGEIAAAV VSGALSLRDG 

      3970       3980       3990       4000       4010       4020 
ARVVTLRAQA IGRSLAGRGG MMSVALPVAE VEARLEAFEG RVSVAAENGP RSSVVAGEPE 

      4030       4040       4050       4060       4070       4080 
ALDELHAQLT AEEIRARRVA VDYASHSPHV EDLHDEILEL LAEVAPRTSE IPFFSTVTGD 

      4090       4100       4110       4120       4130       4140 
WLDTTVMDAG YWYRSLRGRV LFADAVRDLI AADHRAFIEV SSHPVLAMSV QDMIDDAGVA 

      4150       4160       4170       4180       4190       4200 
GVASGTLRRD NGGLDRFLLS AAEVFVRGVQ VDWAAVFEGT GASRVDLPTY AFQHENLWAM 

      4210       4220       4230       4240       4250       4260 
AAAPEAVTAA DPEDAAFWTA VEDGDVSALT AALGTDEDSV AAVLPALSSW RRARKERSTV 

      4270       4280       4290       4300       4310       4320 
DSWRYRPTWK PVTKLPQRTL DGTWLLVSAD GVDDTDVAEA LETGGAEVRR LVLDESCTDR 

      4330       4340       4350       4360       4370       4380 
AVLRERLTDA DGLTGIVSVL AGAERTGAVP GTGLVLGVAL TVALVQALGD AGIDTPLWAL 

      4390       4400       4410       4420       4430       4440 
TRGAVSTGRS DKVTAPVQAQ VTGIGWTAAL ECPGRWGGVV DLPETLDARA GQRLAAVLAG 

      4450       4460       4470       4480       4490       4500 
ALGDDDQIAL RSSGVFTRRI VRADAAPDGS ARDWKPRGTT LVTGGSGTLA PHLARWLAEQ 

      4510       4520       4530       4540       4550       4560 
GAEHLVLVSR RGPEAPGAAE LRAELAERGT ETTLAACDIT DRDAVAALLE SLKAEGRTVR 

      4570       4580       4590       4600       4610       4620 
TVVHTAATIE LHTLDATTLD DFDRVLAAKV TGAQILDELL DDEELDDFVL YSSTAGMWGS 

      4630       4640       4650       4660       4670       4680 
GAHAAYVAGN AYLAALAEHR RARGLTALSL SWGIWADDLQ LGRVDPQMIR RSGLEFMDPQ 

      4690       4700       4710       4720       4730       4740 
LALSGLKRAL DDDEQVIAVA DVDWETYHPV YTSARPTPLF DEVPEVQRLT AAAEQSAGDP 

      4750       4760       4770       4780       4790       4800 
ARGEFAAALL ALPAAEQHRK LLETVRTEAA SVLGLSSAED LTDQRAFRDV GFDSLTAVGL 

      4810       4820       4830       4840       4850       4860 
RNRLASVTGL TLPSTMVFDY PNPAALAGFL HSELADVHSA GAVAVTAGAP VDDDPIAIVG 

      4870       4880       4890       4900       4910       4920 
MSCRYPGGIT SAEQLWRVSL EEVDAVSVFP ADRGWDAEAL YDPDPDASGR TYSVQGGFLR 

      4930       4940       4950       4960       4970       4980 
DVADFDPGFF GISPREALSM DPQQRLLLET AWEVFENAGL DPVAQRGSRT GTFIGASYQD 

      4990       5000       5010       5020       5030       5040 
YGAAVPGSEG SEGHMITGSL PSVLSGRVSY LFGLEGPAVT LDTACSSSLV AIHLACQSLR 

      5050       5060       5070       5080       5090       5100 
NGESTLALAG GASIMSTPMS FIGFSRQRAL AEDGRCKAYA EGADGMTLAE GVGLILLERL 

      5110       5120       5130       5140       5150       5160 
SDARRNGHEV LAVIRGSAVN QDGASNGLTA PNGPSQQRVI RQALANAGVE ANDIDVLEGH 

      5170       5180       5190       5200       5210       5220 
GTGTALGDPI EAQALFATYG KDRDPERPVL LGSVKSNIGH TQMASGVASI IKLVHALREG 

      5230       5240       5250       5260       5270       5280 
VAPKSLHIDQ PSTHVDWSSG TIQLLTERTE WPETGRPRRA AVSSFGLSGT NVHTVLEQAP 

      5290       5300       5310       5320       5330       5340 
AADAPAAEDT PAPRDALVPV LVSGRGEAAL RAQAGALLDL LAERPGIHPT DLAFSLATSR 

      5350       5360       5370       5380       5390       5400 
AALEHRAAVV ADDHEALVRG LTALRDGLPG AGLVQGRTGR GRTAFLFTGQ GSQRLGMGRE 

      5410       5420       5430       5440       5450       5460 
LYERHPVFAD ALDAVLARID GTTERPLRDV LFAAEGSQDA ALLHRTGYAQ PALFALEVAL 

      5470       5480       5490       5500       5510       5520 
FRLLESWGVT PDYLAGHSVG EIAAAHVAGV LDLDDACTLV AARGRLMQAL PEGGAMVALE 

      5530       5540       5550       5560       5570       5580 
AAEDEVLPHL EGLADQVSVA AVNGPRSVVV AGEEEPVLAL AAHFAEQGRR TKRLRVSHAF 

      5590       5600       5610       5620       5630       5640 
HSPLMDPMLD DFAAVARALT YHAPSIPFVS NVTGTLAAPE QVCTADYWVS HVRSAVRFAD 

      5650       5660       5670       5680       5690       5700 
GIGWLSTQGG VQTFLELGPD GVLSGMARES LTDASRTALL PTLRGDRPEE QALVTAVAAA 

      5710       5720       5730       5740       5750       5760 
HAHGFDVDWT AWFQGSGARR VALPTYAFQR ERYWPDTTAA GITAPAPGSA LDAEFWAAVE 

      5770       5780       5790       5800       5810       5820 
HADVASLTAS LGLDDATVTA MVPALTAWRQ RRGEQSALDS WRYRVTWKPR GGAPGAAPTG 

      5830       5840       5850       5860       5870       5880 
RWLVLVPAEH RDEATAAWAA DVEAALATAT VRVEVTGTDR AALAARLTEA ADGDTFQGVL 

      5890       5900       5910       5920       5930       5940 
SLLALAPGDA GHPGAPAALT LTATALQALG DARIDAPLWN ITRGAVAVGR SEQVTAPEQA 

      5950       5960       5970       5980       5990       6000 
AVWGLFRAAA LELPARVGGS VDLPEDLDTQ AARRLRGILA AADGEDAVAV RASGVFLRRL 

      6010       6020       6030       6040       6050       6060 
AHSPAADTVG SAFDPAAGTV LITGGTGGIG GHLARRLARD GAAHLLLTSR RGPDAPGAGE 

      6070       6080       6090       6100       6110       6120 
LRAELEESGA RVTIAACDAA DRDALAALLA TVPEDAPLTA VFHTAGVVDD HVVDELTPES 

      6130       6140       6150       6160       6170       6180 
FATVLHAKTV AARHLHDLTA GHDLAAFVLF SSTAGLIGAA GQGNYAAANS QLDALAEQRR 

      6190       6200       6210       6220       6230       6240 
AQGLPALSVA WGPWAGSGMV ADAAEIAARV RRGGFEPLDP ASGVAALLRA VDNGDTSVAV 

      6250       6260       6270       6280       6290       6300 
ADIDWERFLR AFASARPLPL VADLPETAGA NAPAAAAGTG SGLREQLAGL PAEERHAHVL 

      6310       6320       6330       6340       6350       6360 
DLLRTQVAAV LGHSDARTVD DDLAFRDLGF DSLTVLELRN ALNALTGLSL PASLVYDHPT 

      6370       6380       6390       6400       6410       6420 
PREMADFLLA ELLGSLPEST RHAVATRAVD EDPIAVVGLA CRFPGGVSTP EELWQLLAEG 

      6430       6440       6450       6460       6470       6480 
RDGITGFPDD RNWDIAALGA GASDTLHGGF LAQVADFDAR FFGISPREAL AMDPQQRLLL 

      6490       6500       6510       6520       6530       6540 
ETTWEALERA GIDPAALRGS TTGVFVGTNG QDYPNLLRRS TSDVSGYVAT GNTASVMSGR 

      6550       6560       6570       6580       6590       6600 
LSYALGLEGP AVTIDTACSS SLVALHWAGH ALSAGECDLV VAGGVSVMST PDSFVEFSTQ 

      6610       6620       6630       6640       6650       6660 
GGLAPDGHCK PFSDDADGTA WSEGVGILVL ERLSDAIRNG HEVRGIIRGT AVNQDGASNG 

      6670       6680       6690       6700       6710       6720 
LTAPNGPSQQ RVIRQALADA RLAPSEIDAV EAHGTGTTLG DPIEAQALLN TYGPGRDTDQ 

      6730       6740       6750       6760       6770       6780 
PLLLGTVKSN IGHTQAAAGV AGVIKMLLAM QHGTLPRTLH VTSPTSHVDW SSGAVSLLTE 

      6790       6800       6810       6820       6830       6840 
ERDWPETGRP RRAGVSAFGV SGTNAHVIVE QAPIDEPVVE PTEEPAPAAE VTTVPWIVSG 

      6850       6860       6870       6880       6890       6900 
RSREALQDQV DRLTAYAAAR PELSPLDVGR SLATDRTLFP HRAVLLAGPD GVREAARSVA 

      6910       6920       6930       6940       6950       6960 
SRTRGRTAFL FSGQGAQRAL MGRELYERYP AFADALDTVL AQFDTALDFS LREVLFAEPG 

      6970       6980       6990       7000       7010       7020 
TPEAERLNET GWTQPALFAV EVALHRLVES WGLTPDQVAG HSIGEIAAAH VAGVFSLEDA 

      7030       7040       7050       7060       7070       7080 
CALVAARASL MQELPRGGAM LAVRATEEEV APHLTERVSV AAVNGPSAVV VAGDEAEVAA 

      7090       7100       7110       7120       7130       7140 
IAAHFEAQDR KTTRLRVSHA FHSPLMDPML TAFARVAESL TYHEPVIPLV STVTGVPAGA 

      7150       7160       7170       7180       7190       7200 
ELLTPGYWVR HVRETVRFAD GVRALREDGV TTFVEIGPDG QLTAAAQQTL DASGDEAPAT 

      7210       7220       7230       7240       7250       7260 
VVALQRRDRS EETTLLEGLA TLHTQGAGPD WTAWFAGTGG HRVELPTYAF QRERYWPEPA 

      7270       7280       7290       7300       7310       7320 
APGATGVQDP VDAAFWAAVE REDLESLTAS LGLDGDTVTT MVPALSAWRR RTDARSTARD 

      7330       7340       7350       7360       7370       7380 
WRYHESWTAL GTPAHSAGAG RVLALVPAEH AGTDWAETLV AALGADPLVV DGTSGSLARE 

      7390       7400       7410       7420       7430       7440 
LADLVPQQAT FAPSRRPART LAAPAESPST SSTGTSGRHT ESTHRTPLLD GQTSPAGTLD 

      7450       7460       7470       7480       7490       7500 
PAGWTVVVSL LAAGTGTLPA PDAAPAAVLE ALEAAGVDAP LWCVTRGAVS VAGEAPAAVG 

      7510       7520       7530       7540       7550       7560 
QAALWGMGRV AALEHPERFG GLADLAPDAD AATAALLAAH LAEPGGEDQI AVRATGLFGR 

      7570       7580       7590       7600       7610       7620 
RLVRTAVAPG DSGWRPHGTV LVVGGTRAMG ARAARWLARE GAARLVLTTS PADSATDTEE 

      7630       7640       7650       7660       7670       7680 
LRAELGRLGA EVTVAPYDGG DRDAARALLD GLTGLTAVVY ADDTPADGPA AALAPVDTLA 

      7690       7700       7710       7720       7730       7740 
EAATGRSLDA FVLFGSVAGV WGVRGHTDEA AEGAYVDALA RALRAEGTPA LAVSWNAWAE 

      7750       7760       7770       7780       7790       7800 
LTDPSTTRHL RMNGLPVMDA DAALTALAGA VADGSAAVTV ADVRWDTFAP AHHETRPTAL 

      7810       7820       7830       7840       7850       7860 
FDGLPEARTA LAGAARDRAE GATASDGYGR WLLEQPAADR DDILLALVSE KAALVLGHAD 

      7870       7880       7890       7900       7910       7920 
TTLVEPDLPF RDLGFDSLTA VDLRNQLTAA TGITLPATLV FDHPNPAALA AHLRTELLGG 

      7930       7940       7950       7960       7970       7980 
ATDTAAPVAA PAATGDDPIV IVGMACRFPG GVNSPEDLWQ LVLDEVDAVG DFPADRGWDL 

      7990       8000       8010       8020       8030       8040 
DALAGDGPGR SATDQGGFLY DATDFDPGLF GVSPREAMVM DPQQRILLEA SWEALERAGI 

      8050       8060       8070       8080       8090       8100 
DPGTLRGSGT TGVFVGGGSG DYRPPAEYGQ WQTAQSASLL SGRLAYTFGI QGPTVSVDTA 

      8110       8120       8130       8140       8150       8160 
CSSSLVALHL AAQALRSGEC SIALAGGVTV MATPVGFVEF SAQGALSPDG RCRAFSEDAN 

      8170       8180       8190       8200       8210       8220 
GTGWSEGVGM LVVERLSDAR RNGHRVLAVL RGSAINQDGA SNGLTAPSGP AQQRVIRQAL 

      8230       8240       8250       8260       8270       8280 
ANARLEAADV DAVEAHGTGT KLGDPIEAQA LLATYGQDRE RPVLVGSLKA NIGHTQAASG 

      8290       8300       8310       8320       8330       8340 
VGGVIKMVLA MQHGLLPRSL YTENPSSHVD WTAGNARLLT ELTPWPESER VRRAAVSSFG 

      8350       8360       8370       8380       8390       8400 
ASGTNAHLIL EQPEPVRQPV EGARPAEDGS PVPVLLSGRS QNALRAQARK LLAHVAGHPE 

      8410       8420       8430       8440       8450       8460 
ETVTDLARTL ATTRAVFEHR AAVTAADRDA LIAGLTAVAE GTTAAHIVEH QVERTGKHAV 

      8470       8480       8490       8500       8510       8520 
LFSGQGSQQL GMGRDLYERF PAFAEAFDAV LARLDGHLGA SLRDVVWHGD QETLNETGHT 

      8530       8540       8550       8560       8570       8580 
QPALFAFEVA LYRLVESWGV TPDFVAGHSV GEIAAAHVAG VLSLDDACRL VAARARLMQD 

      8590       8600       8610       8620       8630       8640 
LPRGGAMVAV EATEQEVAAE LTEAVSIAAV NGPTSVVLAG AEDAVLAVAA VLAERGRRTS 

      8650       8660       8670       8680       8690       8700 
RLKVSHAFHS VLMDPMLAEF RKVAESLRYE APRIAVVSNV TGDVAGADEL CDADYWVRHV 

      8710       8720       8730       8740       8750       8760 
RGTVRFADGV TALAGRGVRV LLELGPDAVL SALAEQSAPD TVSIPAQRRN RDEVETLVAA 

      8770       8780       8790       8800       8810       8820 
LGRLHVHAAG PRWDAFFDAA PGSWLDLPTY AFQRGRFWPD TLPTAPQGGA TAGEADGTDS 

      8830       8840       8850       8860       8870       8880 
AFWDAVAQED FGSLESVLDV EGDALSKVLP ALLDWRRRTS EETQLDSWRH RIVWKRLTGA 

      8890       8900       8910       8920       8930       8940 
AMAHRKPLTG TWLAVVPEGL GEDPWVTTAL DALGTRVVRA EVGADGREAM AATLREAAGE 

      8950       8960       8970       8980       8990       9000 
GTRFGGVVSL LALRETVHGD VPEGVALTGT LLQALGDAGI EAPLWCVTRS AVSANRSDRP 

      9010       9020       9030       9040       9050       9060 
RRPLQAAVWG LGRVAALEYP NRWGGLVDLP ERADERAAAG LAAVLAGLDG EDQVAVRGSA 

      9070       9080       9090       9100       9110       9120 
VLARRLVPAP DRGQSGAWDP TGTVLITGGT GAIGAHVARR LAKDGVQHLV LLSRRGAEAP 

      9130       9140       9150       9160       9170       9180 
GATALRDELQ TLGAGVTLAA CDASDRGQLA AVLDAIPDDR PLTAVLHAAG VLDDGVIDRL 

      9190       9200       9210       9220       9230       9240 
TPERYQKVFR AKVTSALLLD ELTRDLDLAA FVLFSSASSA VGNPGQANYA AANAVLDALA 

      9250       9260       9270       9280       9290       9300 
EARRVQNLPA TSVSWGAWGG GGMADGHGAD DAARRAGVAA MDPDLAVESL LRLVTGKEPT 

      9310       9320       9330       9340       9350       9360 
AVVAEVDLDR FASAFGGARP SALLREFPGY RETVAAAAPA SPEGTLADRL AGMAPARRLD 

      9370       9380       9390       9400       9410       9420 
TVVDLVRTRA AQVLGYPDID AVGAERSFRD LGVDSLGAVE LRNQLGAETG LSLPATLVFD 

      9430       9440       9450       9460       9470       9480 
HPTPLALGEF VLARLAPEEA GPAVSDEETE IRAVLASVPL DRLREIGVLE PLLQLAGRGG 

      9490       9500       9510 
GAGDDEDGES VDSMTVADLV RAALNGQSDL 

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References

[1]"Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes."
Caffrey P., Lynch S., Flood E., Finnan S., Oliynyk M.
Chem. Biol. 8:713-723(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups."
Carmody M., Murphy B., Byrne B., Power P., Rai D., Rawlings B., Caffrey P.
J. Biol. Chem. 280:34420-34426(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Structural studies of an A2-type modular polyketide synthase ketoreductase reveal features controlling ?-substituent stereochemistry."
Zheng J., Piasecki S.K., Keatinge-Clay A.T.
ACS Chem. Biol. 8:1964-1971(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 4200-4759 IN COMPLEX WITH NADP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF357202 Genomic DNA. Translation: AAK73501.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4L4XX-ray2.55A4200-4759[»]
ProteinModelPortalQ93NX9.
SMRQ93NX9. Positions 1662-1752, 6281-6371.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1200.10. 6 hits.
3.40.366.10. 12 hits.
3.40.47.10. 12 hits.
3.40.50.720. 7 hits.
InterProIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002198. DH_sc/Rdtase_SDR.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR015083. Polyketide_synth_docking.
IPR006162. PPantetheine_attach_site.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF00698. Acyl_transf_1. 6 hits.
PF00106. adh_short. 2 hits.
PF08990. Docking. 1 hit.
PF00109. ketoacyl-synt. 6 hits.
PF02801. Ketoacyl-synt_C. 6 hits.
PF08659. KR. 4 hits.
PF00550. PP-binding. 6 hits.
[Graphical view]
SMARTSM00827. PKS_AT. 6 hits.
SM00826. PKS_DH. 1 hit.
SM00822. PKS_KR. 6 hits.
SM00825. PKS_KS. 6 hits.
SM00823. PKS_PP. 6 hits.
[Graphical view]
SUPFAMSSF47336. SSF47336. 6 hits.
SSF52151. SSF52151. 12 hits.
SSF53901. SSF53901. 6 hits.
SSF55048. SSF55048. 6 hits.
PROSITEPS50075. ACP_DOMAIN. 6 hits.
PS00606. B_KETOACYL_SYNTHASE. 6 hits.
PS00012. PHOSPHOPANTETHEINE. 6 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ93NX9_9ACTO
AccessionPrimary (citable) accession number: Q93NX9
Entry history
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)