Q93NB7 (HPPA_MYXXA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative K(+)-stimulated pyrophosphate-energized sodium pump
EC=3.6.1.1

Alternative name(s):
Membrane-bound sodium-translocating pyrophosphatase
Pyrophosphate-energized inorganic pyrophosphatase
Short name=Na(+)-PPase

Gene names

Name:

hppA

Organism

Myxococcus xanthus

Taxonomic identifier

34 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus

Protein attributes

Sequence length	275 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane By similarity. HAMAP MF_01129
Catalytic activity	Diphosphate + H2O = 2 phosphate. HAMAP MF_01129
Cofactor	Magnesium By similarity. HAMAP MF_01129
Enzyme regulation	Requires K+ for maximal activity By similarity. HAMAP MF_01129
Subunit structure	Homodimer By similarity. HAMAP MF_01129
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01129.
Sequence similarities	Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Magnesium Potassium Sodium
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	proton transport Inferred from electronic annotation. Source: InterPro sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrogen-translocating pyrophosphatase activity Inferred from electronic annotation. Source: InterPro inorganic diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 275	›275	Putative K(+)-stimulated pyrophosphate-energized sodium pump HAMAP MF_01129		PRO_0000217021
Regions
	Transmembrane	51 – 71	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	163 – 182	20	Helical; Potential
	Transmembrane	189 – 211	23	Helical; Potential
	Transmembrane	254 – 274	21	Helical; Potential
Sites
	Site	49	1	Determinant of potassium dependence By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q93NB7 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: E4BA754C13706146	FASTA	275	27,791
	10 20 30 40 50 60 MLGGTAVVMT VDAYGPISDN AGGISEMSGL GPEVRAITDE LDAVGNTTAA IGKGFAIGSA 70 80 90 100 110 120 TLTVIALFSA FNLEVNHTRI AAGLPEMSLQ LTNPNVIVGL LLGSILPFLV GASTMLAVGR 130 140 150 160 170 180 AAGAIVEEIG RQFREIPGLM ELKADPDPKK IVDIATKSAL QEMVFPGIIA VAAPPLVGYL 190 200 210 220 230 240 LGPGALAGLL AGSLVVGATM ALYMANAGGA WDNAKKFIEK GKLPGHAKGS AVHKAAVVGD 250 260 270 MVGDPFKDTS GPGVAILIKV MSVVSLLVAS LIALR

References

[1]

"A large family of eukaryotic-like protein Ser/Thr kinases of Myxococcus xanthus, a developmental bacterium." Inouye S., Jain R., Ueki T., Nariya H., Xu C.Y., Hsu M.Y., Fernandez-Luque B.A., Munoz-Dorado J., Farez-Vidal E., Inouye M. Microb. Comp. Genomics 5:103-120(2000) [PubMed: 11087177] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DZF1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF377340 Genomic DNA. Translation: AAK64453.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01129. PPase-energized_pump. [Tree]
InterPro	IPR004131. PPase-energised_H-pump. [Graphical view]
Pfam	PF03030. H_PPase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HPPA_MYXXA

Accession

Primary (citable) accession number: Q93NB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	December 1, 2001
Last modified:	May 31, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program