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Q93MM7 (PUR5_LACSS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase

EC=6.3.3.1
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
Ordered Locus Names:LCA_0660
OrganismLactobacillus sakei subsp. sakei (strain 23K) [Complete proteome] [HAMAP]
Taxonomic identifier314315 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00741.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741
PRO_0000148218

Sequences

Sequence LengthMass (Da)Tools
Q93MM7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 7F0C4561E12B266F

FASTA34236,399
        10         20         30         40         50         60 
MTDAYQKAGV DVTAGYEVVA RIQKKVGADN HNIGSFGGQY ALEMAQYQKP VLVSSTDGVG 

        70         80         90        100        110        120 
TKLMVAFAAD QHATIGIDCV AMCVNDIVAQ GAQPLYFLDY LATGKTDPDK IEDIVAGVLE 

       130        140        150        160        170        180 
GCKQANMALI GGETAEMPGM YAAKHYDVAG FAVGIAEQDA LVTGETIQAG DVLIGLASSG 

       190        200        210        220        230        240 
IHSNGYSLVR KIFFEQNNLT VASQLPELPG KTLGDWLLTP TKIYVEDLQP LLQQRVIKGA 

       250        260        270        280        290        300 
AHITGGGFIE NVPRMLPADL AAHLTLGSWP ILPIFKALQQ YGQLAEMEMY NIFNMGIGMV 

       310        320        330        340 
LAVAPEAAPA VLAQLNAKQE QAYQIGTVQK RQQAAVELVT AK 

« Hide

References

« Hide 'large scale' references
[1]"Physical and genetic map of the Lactobacillus sakei 23K chromosome."
Dudez A.-M., Chaillou S., Hissler L., Stentz R., Champomier-Verges M.-C., Alpert C.-A., Zagorec M.
Microbiology 148:421-431(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K."
Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M., Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V., Zagorec M.
Nat. Biotechnol. 23:1527-1533(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 23K.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF401037 Genomic DNA. Translation: AAK92512.1.
CR936503 Genomic DNA. Translation: CAI54964.1.
RefSeqYP_395275.1. NC_007576.1.

3D structure databases

ProteinModelPortalQ93MM7.
SMRQ93MM7. Positions 14-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING314315.LSA0660.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI54964; CAI54964; LCA_0660.
GeneID3777557.
KEGGlsa:LSA0660.
PATRIC22274140. VBILacSak116432_0638.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0150.
KOK01933.
OMAEFEMYRT.
OrthoDBEOG61CM1V.

Enzyme and pathway databases

BioCycLSAK314315:GCKE-1227-MONOMER.
UniPathwayUPA00074; UER00129.

Family and domain databases

Gene3D3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPMF_00741_B. AIRS_B.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_LACSS
AccessionPrimary (citable) accession number: Q93MM7
Secondary accession number(s): Q38XW5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways