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Q93MM7

- PUR5_LACSS

UniProt

Q93MM7 - PUR5_LACSS

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, LCA_0660
Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLSAK314315:GCKE-1227-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:LCA_0660
OrganismiLactobacillus sakei subsp. sakei (strain 23K)
Taxonomic identifieri314315 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000002707: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_0000148218Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314315.LSA0660.

Structurei

3D structure databases

ProteinModelPortaliQ93MM7.
SMRiQ93MM7. Positions 14-332.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q93MM7-1 [UniParc]FASTAAdd to Basket

« Hide

MTDAYQKAGV DVTAGYEVVA RIQKKVGADN HNIGSFGGQY ALEMAQYQKP    50
VLVSSTDGVG TKLMVAFAAD QHATIGIDCV AMCVNDIVAQ GAQPLYFLDY 100
LATGKTDPDK IEDIVAGVLE GCKQANMALI GGETAEMPGM YAAKHYDVAG 150
FAVGIAEQDA LVTGETIQAG DVLIGLASSG IHSNGYSLVR KIFFEQNNLT 200
VASQLPELPG KTLGDWLLTP TKIYVEDLQP LLQQRVIKGA AHITGGGFIE 250
NVPRMLPADL AAHLTLGSWP ILPIFKALQQ YGQLAEMEMY NIFNMGIGMV 300
LAVAPEAAPA VLAQLNAKQE QAYQIGTVQK RQQAAVELVT AK 342
Length:342
Mass (Da):36,399
Last modified:December 1, 2001 - v1
Checksum:i7F0C4561E12B266F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF401037 Genomic DNA. Translation: AAK92512.1.
CR936503 Genomic DNA. Translation: CAI54964.1.
RefSeqiWP_011374369.1. NC_007576.1.
YP_395275.1. NC_007576.1.

Genome annotation databases

EnsemblBacteriaiCAI54964; CAI54964; LCA_0660.
GeneIDi3777557.
KEGGilsa:LSA0660.
PATRICi22274140. VBILacSak116432_0638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF401037 Genomic DNA. Translation: AAK92512.1 .
CR936503 Genomic DNA. Translation: CAI54964.1 .
RefSeqi WP_011374369.1. NC_007576.1.
YP_395275.1. NC_007576.1.

3D structure databases

ProteinModelPortali Q93MM7.
SMRi Q93MM7. Positions 14-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 314315.LSA0660.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI54964 ; CAI54964 ; LCA_0660 .
GeneIDi 3777557.
KEGGi lsa:LSA0660.
PATRICi 22274140. VBILacSak116432_0638.

Phylogenomic databases

eggNOGi COG0150.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci LSAK314315:GCKE-1227-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Physical and genetic map of the Lactobacillus sakei 23K chromosome."
    Dudez A.-M., Chaillou S., Hissler L., Stentz R., Champomier-Verges M.-C., Alpert C.-A., Zagorec M.
    Microbiology 148:421-431(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 23K.

Entry informationi

Entry nameiPUR5_LACSS
AccessioniPrimary (citable) accession number: Q93MM7
Secondary accession number(s): Q38XW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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