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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase subunit PurL (purL), Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ), Phosphoribosylformylglycinamidine synthase subunit PurS (purS)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLSAK314315:G1GI3-669-MONOMER
UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:LCA_0660
OrganismiLactobacillus sakei subsp. sakei (strain 23K)
Taxonomic identifieri314315 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000002707 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001482181 – 342Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST342

Interactioni

Protein-protein interaction databases

STRINGi314315.LSA0660

Structurei

3D structure databases

ProteinModelPortaliQ93MM7
SMRiQ93MM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
KOiK01933
OMAiNHCVNDI
OrthoDBiPOG091H0128

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.101 hit
3.90.650.101 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

Q93MM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDAYQKAGV DVTAGYEVVA RIQKKVGADN HNIGSFGGQY ALEMAQYQKP
60 70 80 90 100
VLVSSTDGVG TKLMVAFAAD QHATIGIDCV AMCVNDIVAQ GAQPLYFLDY
110 120 130 140 150
LATGKTDPDK IEDIVAGVLE GCKQANMALI GGETAEMPGM YAAKHYDVAG
160 170 180 190 200
FAVGIAEQDA LVTGETIQAG DVLIGLASSG IHSNGYSLVR KIFFEQNNLT
210 220 230 240 250
VASQLPELPG KTLGDWLLTP TKIYVEDLQP LLQQRVIKGA AHITGGGFIE
260 270 280 290 300
NVPRMLPADL AAHLTLGSWP ILPIFKALQQ YGQLAEMEMY NIFNMGIGMV
310 320 330 340
LAVAPEAAPA VLAQLNAKQE QAYQIGTVQK RQQAAVELVT AK
Length:342
Mass (Da):36,399
Last modified:December 1, 2001 - v1
Checksum:i7F0C4561E12B266F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401037 Genomic DNA Translation: AAK92512.1
CR936503 Genomic DNA Translation: CAI54964.1
RefSeqiWP_011374369.1, NC_007576.1

Genome annotation databases

EnsemblBacteriaiCAI54964; CAI54964; LCA_0660
GeneIDi29637119
KEGGilsa:LCA_0660

Similar proteinsi

Entry informationi

Entry nameiPUR5_LACSS
AccessioniPrimary (citable) accession number: Q93MM7
Secondary accession number(s): Q38XW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome