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Q93MM7

- PUR5_LACSS

UniProt

Q93MM7 - PUR5_LACSS

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLSAK314315:GCKE-1227-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:LCA_0660
OrganismiLactobacillus sakei subsp. sakei (strain 23K)
Taxonomic identifieri314315 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000002707: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148218Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314315.LSA0660.

Structurei

3D structure databases

ProteinModelPortaliQ93MM7.
SMRiQ93MM7. Positions 14-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q93MM7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDAYQKAGV DVTAGYEVVA RIQKKVGADN HNIGSFGGQY ALEMAQYQKP
60 70 80 90 100
VLVSSTDGVG TKLMVAFAAD QHATIGIDCV AMCVNDIVAQ GAQPLYFLDY
110 120 130 140 150
LATGKTDPDK IEDIVAGVLE GCKQANMALI GGETAEMPGM YAAKHYDVAG
160 170 180 190 200
FAVGIAEQDA LVTGETIQAG DVLIGLASSG IHSNGYSLVR KIFFEQNNLT
210 220 230 240 250
VASQLPELPG KTLGDWLLTP TKIYVEDLQP LLQQRVIKGA AHITGGGFIE
260 270 280 290 300
NVPRMLPADL AAHLTLGSWP ILPIFKALQQ YGQLAEMEMY NIFNMGIGMV
310 320 330 340
LAVAPEAAPA VLAQLNAKQE QAYQIGTVQK RQQAAVELVT AK
Length:342
Mass (Da):36,399
Last modified:December 1, 2001 - v1
Checksum:i7F0C4561E12B266F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF401037 Genomic DNA. Translation: AAK92512.1.
CR936503 Genomic DNA. Translation: CAI54964.1.
RefSeqiWP_011374369.1. NC_007576.1.
YP_395275.1. NC_007576.1.

Genome annotation databases

EnsemblBacteriaiCAI54964; CAI54964; LCA_0660.
GeneIDi3777557.
KEGGilsa:LSA0660.
PATRICi22274140. VBILacSak116432_0638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF401037 Genomic DNA. Translation: AAK92512.1 .
CR936503 Genomic DNA. Translation: CAI54964.1 .
RefSeqi WP_011374369.1. NC_007576.1.
YP_395275.1. NC_007576.1.

3D structure databases

ProteinModelPortali Q93MM7.
SMRi Q93MM7. Positions 14-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 314315.LSA0660.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI54964 ; CAI54964 ; LCA_0660 .
GeneIDi 3777557.
KEGGi lsa:LSA0660.
PATRICi 22274140. VBILacSak116432_0638.

Phylogenomic databases

eggNOGi COG0150.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci LSAK314315:GCKE-1227-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Physical and genetic map of the Lactobacillus sakei 23K chromosome."
    Dudez A.-M., Chaillou S., Hissler L., Stentz R., Champomier-Verges M.-C., Alpert C.-A., Zagorec M.
    Microbiology 148:421-431(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 23K.

Entry informationi

Entry nameiPUR5_LACSS
AccessioniPrimary (citable) accession number: Q93MM7
Secondary accession number(s): Q38XW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3