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Q93L51

- Q93L51_BACT4

UniProt

Q93L51 - Q93L51_BACT4

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Protein
Submitted name:

TetX2 protein

Gene

tetX2

Organism
Bacteroides thetaiotaomicron
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541Sulfate 3
Binding sitei61 – 611FADImported
Binding sitei117 – 1171FADImported
Binding sitei139 – 1391FAD; via amide nitrogen and carbonyl oxygenImported
Binding sitei311 – 3111FADImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 272FADImported
Nucleotide bindingi46 – 472FADImported
Nucleotide bindingi321 – 3244FADImported

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

FADImported, Flavoprotein, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
TetX2 proteinImported
Gene namesi
Name:tetX2Imported
OrganismiBacteroides thetaiotaomicronImported
Taxonomic identifieri818 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XDOX-ray2.09A/B/C/D11-388[»]
2XYOX-ray3.00A/B/C/D11-388[»]
2Y6QX-ray2.37A/B/C/D11-388[»]
2Y6RX-ray3.10A/B/C/D11-388[»]
3P9UX-ray2.81A/B/C/D11-388[»]
3V3NX-ray2.70A/B/C/D11-388[»]
3V3OX-ray2.90A/B/C/D11-388[»]
4A6NX-ray2.30A/B/C/D11-388[»]
4A99X-ray2.18A/B/C/D11-388[»]
4GUVX-ray2.73A/B/C/D11-388[»]
ProteinModelPortaliQ93L51.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93L51.

Family & Domainsi

Family and domain databases

InterProiIPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.

Sequencei

Sequence statusi: Complete.

Q93L51-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMRIDTDKQ MNLLSDKNVA IIGGGPVGLT MAKLLQQNGI DVSVYERDND
60 70 80 90 100
REARIFGGTL DLHKGSGQEA MKKAGLLQTY YDLALPMGVN IADEKGNILS
110 120 130 140 150
TKNVKPENRF DNPEINRNDL RAILLNSLEN DTVIWDRKLV MLEPGKKKWT
160 170 180 190 200
LTFENKPSET ADLVILANGG MSKVRKFVTD TEVEETGTFN IQADIHQPEI
210 220 230 240 250
NCPGFFQLCN GNRLMASHQG NLLFANPNNN GALHFGISFK TPDEWKNQTQ
260 270 280 290 300
VDFQNRNSVV DFLLKEFSDW DERYKELIHT TLSFVGLATR IFPLEKPWKS
310 320 330 340 350
KRPLPITMIG DAAHLMPPFA GQGVNSGLVD ALILSDNLAD GKFNSIEEAV
360 370 380
KNYEQQMFIY GKEAQEESTQ NEIEMFKPDF TFQQLLNV
Length:388
Mass (Da):43,708
Last modified:December 1, 2001 - v1
Checksum:iC0F8976A7A82F394
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ311171 Genomic DNA. Translation: CAC47932.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ311171 Genomic DNA. Translation: CAC47932.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XDO X-ray 2.09 A/B/C/D 11-388 [» ]
2XYO X-ray 3.00 A/B/C/D 11-388 [» ]
2Y6Q X-ray 2.37 A/B/C/D 11-388 [» ]
2Y6R X-ray 3.10 A/B/C/D 11-388 [» ]
3P9U X-ray 2.81 A/B/C/D 11-388 [» ]
3V3N X-ray 2.70 A/B/C/D 11-388 [» ]
3V3O X-ray 2.90 A/B/C/D 11-388 [» ]
4A6N X-ray 2.30 A/B/C/D 11-388 [» ]
4A99 X-ray 2.18 A/B/C/D 11-388 [» ]
4GUV X-ray 2.73 A/B/C/D 11-388 [» ]
ProteinModelPortali Q93L51.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q93L51.

Family and domain databases

InterProi IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view ]
Pfami PF01494. FAD_binding_3. 1 hit.
[Graphical view ]
PRINTSi PR00420. RNGMNOXGNASE.
ProtoNeti Search...

Publicationsi

  1. "Characterization of the 13-kilobase ermF region of the Bacteroides conjugative transposon CTnDOT."
    Whittle G., Hund B.D., Shoemaker N.B., Salyers A.A.
    Appl. Environ. Microbiol. 67:3488-3495(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase."
    Volkers G., Palm G.J., Weiss M.S., Wright G.D., Hinrichs W.
    FEBS Lett. 585:1061-1066(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS) OF 11-388 IN COMPLEX WITH FAD.
  3. "Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 A resolution."
    Walkiewicz K., Davlieva M., Wu G., Shamoo Y.
    Proteins 79:2335-2340(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 11-388 IN COMPLEX WITH FAD.
  4. "Crystal structure of TetX2 T280A: an adaptive mutant in complex with minocycline."
    Walkiewicz K., Shamoo Y.
    Submitted (DEC-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 11-388 IN COMPLEX WITH FAD.
  5. "Crystal structure of TetX2 T280A: an adaptive mutant in complex with tigecycline."
    Walkiewicz K., Shamoo Y.
    Submitted (DEC-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 11-388 IN COMPLEX WITH FAD.
  6. "Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX."
    Volkers G., Damas J.M., Palm G.J., Panjikar S., Soares C.M., Hinrichs W.
    Acta Crystallogr. D 69:1758-1767(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 11-388 IN COMPLEX WITH FAD.

Entry informationi

Entry nameiQ93L51_BACT4
AccessioniPrimary (citable) accession number: Q93L51
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3