Q93L51 (Q93L51_BACT4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
TetX2 protein EMBL CAC47932.1

Gene names

Name:

tetX2 EMBL CAC47932.1

Organism

Bacteroides thetaiotaomicron EMBL CAC47932.1

Taxonomic identifier

818 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Bacteroidetes/Chlorobi group › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	FAD PDB 2XDO PDB 2Y6R PDB 2Y6Q PDB 3P9U Flavoprotein PDB 2XDO PDB 2Y6R PDB 2Y6Q PDB 3P9U Nucleotide-binding PDB 2XDO PDB 2Y6R PDB 2Y6Q PDB 3P9U
Technical term	3D-structure PDB 2XYO PDB 2XDO PDB 2Y6R PDB 2Y6Q PDB 3V3N PDB 3P9U PDB 3V3O PDB 4A6N PDB 4A99 PDB 4GUV
Gene Ontology (GO)
Biological_process	oxidation-reduction process Inferred from electronic annotation. Source: GOC
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	26 – 27	2	FAD PDB 2XDO PDB 2Y6R PDB 2Y6Q PDB 3P9U
	Nucleotide binding	46 – 47	2	FAD PDB 2XDO PDB 2Y6R PDB 2Y6Q PDB 3P9U
	Nucleotide binding	321 – 324	4	FAD PDB 2XDO PDB 2Y6R PDB 2Y6Q PDB 3P9U
Sites
	Binding site	117	1	FAD PDB 2XDO PDB 2Y6R PDB 2Y6Q PDB 3P9U
	Binding site	139	1	FAD; via amide nitrogen and carbonyl oxygen PDB 2XDO PDB 2Y6R PDB 2Y6Q PDB 3P9U
	Binding site	311	1	FAD PDB 2XDO PDB 2Y6R PDB 2Y6Q PDB 3P9U

Sequences

	Sequence		Length	Mass (Da)
	Q93L51 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: C0F8976A7A82F394	FASTA	388	43,708
	10 20 30 40 50 60 MTMRIDTDKQ MNLLSDKNVA IIGGGPVGLT MAKLLQQNGI DVSVYERDND REARIFGGTL 70 80 90 100 110 120 DLHKGSGQEA MKKAGLLQTY YDLALPMGVN IADEKGNILS TKNVKPENRF DNPEINRNDL 130 140 150 160 170 180 RAILLNSLEN DTVIWDRKLV MLEPGKKKWT LTFENKPSET ADLVILANGG MSKVRKFVTD 190 200 210 220 230 240 TEVEETGTFN IQADIHQPEI NCPGFFQLCN GNRLMASHQG NLLFANPNNN GALHFGISFK 250 260 270 280 290 300 TPDEWKNQTQ VDFQNRNSVV DFLLKEFSDW DERYKELIHT TLSFVGLATR IFPLEKPWKS 310 320 330 340 350 360 KRPLPITMIG DAAHLMPPFA GQGVNSGLVD ALILSDNLAD GKFNSIEEAV KNYEQQMFIY 370 380 GKEAQEESTQ NEIEMFKPDF TFQQLLNV

References

[1]	"Characterization of the 13-kilobase ermF region of the Bacteroides conjugative transposon CTnDOT." Whittle G., Hund B.D., Shoemaker N.B., Salyers A.A. Appl. Environ. Microbiol. 67:3488-3495(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase." Volkers G., Palm G.J., Weiss M.S., Wright G.D., Hinrichs W. FEBS Lett. 585:1061-1066(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS) OF 11-388 IN COMPLEX WITH FAD.
[3]	"Structure of the Tetracycline Degrading Monooxygenase Tetx in Complex with Minocycline." Volkers G., Palm G., Hinrichs W. Submitted (NOV-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 11-388.
[4]	"Structure of the Tetracycline Degrading Monooxygenase Tetx." Volkers G., Palm G.J., Weiss M.S., Hinrichs W. Submitted (NOV-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 11-388.
[5]	"Crystal structure of TetX2 T280A: an adaptive mutant in complex with minocycline." Walkiewicz K., Shamoo Y. Submitted (DEC-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 11-388.
[6]	"Crystal structure of TetX2 T280A: an adaptive mutant in complex with tigecycline." Walkiewicz K., Shamoo Y. Submitted (DEC-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 11-388.
[7]	"Putative dioxygen binding sites and recognition of tigecycline and minocycline in the tetracycline-inactivating/degrading monooxygenase TetX." Volkers G., Palm G.J., Panjikar S., Hinrichs W. Submitted (AUG-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.73 ANGSTROMS) OF 11-388.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ311171 Genomic DNA. Translation: CAC47932.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2XDO	X-ray	2.09	A/B/C/D	11-388	[»]
2XYO	X-ray	3.00	A/B/C/D	11-388	[»]
2Y6Q	X-ray	2.37	A/B/C/D	11-388	[»]
2Y6R	X-ray	3.10	A/B/C/D	11-388	[»]
3P9U	X-ray	2.81	A/B/C/D	11-388	[»]
3V3N	X-ray	2.70	A/B/C/D	11-388	[»]
3V3O	X-ray	2.90	A/B/C/D	11-388	[»]
4A6N	X-ray	2.30	A/B/C/D	11-388	[»]
4A99	X-ray	2.18	A/B/C/D	11-388	[»]
4GUV	X-ray	2.73	A/B/C/D	11-388	[»]

ProteinModelPortal

Q93L51.

ModBase

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Protocols and materials databases

StructuralBiologyKnowledgebase

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Family and domain databases

InterPro

IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]

Pfam

PF01494. FAD_binding_3. 1 hit.
[Graphical view]

PRINTS

PR00420. RNGMNOXGNASE.

ProtoNet

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Other

EvolutionaryTrace

Q93L51.

Entry information

Entry name

Q93L51_BACT4

Accession

Primary (citable) accession number: Q93L51

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	May 29, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)