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Q93L51 (Q93L51_BACT4) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:tetX2 EMBL CAC47932.1
OrganismBacteroides thetaiotaomicron EMBL CAC47932.1
Taxonomic identifier818 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding26 – 272FAD PDB 2XDO PDB 2Y6R PDB 2Y6Q PDB 3P9U PDB 3V3O PDB 4A6N PDB 4A99 PDB 4GUV
Nucleotide binding46 – 472FAD PDB 2Y6R PDB 2Y6Q PDB 3P9U PDB 3V3O PDB 4A99 PDB 4GUV
Nucleotide binding321 – 3244FAD PDB 2Y6R PDB 2Y6Q PDB 3P9U PDB 3V3O PDB 4A99 PDB 4GUV
Region77 – 782Sulfate 7 binding PDB 3V3O
Region288 – 2903Sulfate 11 binding PDB 2XYO

Sites

Binding site471Sulfate 2 PDB 2XDO PDB 2Y6Q
Binding site541Sulfate 3
Binding site541Sulfate 4 PDB 2Y6R PDB 2Y6Q
Binding site541Sulfate 5 PDB 2XDO PDB 4A6N
Binding site591Sulfate 6 PDB 3P9U
Binding site611FAD PDB 3V3O
Binding site1171FAD PDB 2Y6R PDB 2Y6Q PDB 3P9U PDB 3V3O PDB 4A99 PDB 4GUV
Binding site1371Sulfate 8 PDB 2XYO PDB 2XDO PDB 2Y6R PDB 2Y6Q PDB 3V3O PDB 4A99 PDB 4GUV
Binding site1381Sulfate 1 PDB 2Y6R
Binding site1381Sulfate 10 PDB 4GUV
Binding site1381Sulfate 9 PDB 4A6N
Binding site1391FAD; via amide nitrogen and carbonyl oxygen PDB 2Y6R PDB 2Y6Q PDB 3P9U PDB 3V3O PDB 4A99 PDB 4GUV
Binding site1561Sulfate 8 PDB 2XYO PDB 2XDO PDB 2Y6R PDB 2Y6Q PDB 3V3O PDB 4A99
Binding site3111FAD PDB 2Y6R PDB 2Y6Q PDB 3P9U PDB 3V3O PDB 4A99 PDB 4GUV

Sequences

Sequence LengthMass (Da)Tools
Q93L51 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: C0F8976A7A82F394

FASTA38843,708
        10         20         30         40         50         60 
MTMRIDTDKQ MNLLSDKNVA IIGGGPVGLT MAKLLQQNGI DVSVYERDND REARIFGGTL 

        70         80         90        100        110        120 
DLHKGSGQEA MKKAGLLQTY YDLALPMGVN IADEKGNILS TKNVKPENRF DNPEINRNDL 

       130        140        150        160        170        180 
RAILLNSLEN DTVIWDRKLV MLEPGKKKWT LTFENKPSET ADLVILANGG MSKVRKFVTD 

       190        200        210        220        230        240 
TEVEETGTFN IQADIHQPEI NCPGFFQLCN GNRLMASHQG NLLFANPNNN GALHFGISFK 

       250        260        270        280        290        300 
TPDEWKNQTQ VDFQNRNSVV DFLLKEFSDW DERYKELIHT TLSFVGLATR IFPLEKPWKS 

       310        320        330        340        350        360 
KRPLPITMIG DAAHLMPPFA GQGVNSGLVD ALILSDNLAD GKFNSIEEAV KNYEQQMFIY 

       370        380 
GKEAQEESTQ NEIEMFKPDF TFQQLLNV 

« Hide

References

[1]"Characterization of the 13-kilobase ermF region of the Bacteroides conjugative transposon CTnDOT."
Whittle G., Hund B.D., Shoemaker N.B., Salyers A.A.
Appl. Environ. Microbiol. 67:3488-3495(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase."
Volkers G., Palm G.J., Weiss M.S., Wright G.D., Hinrichs W.
FEBS Lett. 585:1061-1066(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS) OF 11-388 IN COMPLEX WITH FAD AND SULFATE.
[3]"Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 A resolution."
Walkiewicz K., Davlieva M., Wu G., Shamoo Y.
Proteins 79:2335-2340(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 11-388 IN COMPLEX WITH FAD AND SULFATE.
[4]"Crystal structure of TetX2 T280A: an adaptive mutant in complex with minocycline."
Walkiewicz K., Shamoo Y.
Submitted (DEC-2011) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 11-388 IN COMPLEX WITH FAD AND SULFATE.
[5]"Crystal structure of TetX2 T280A: an adaptive mutant in complex with tigecycline."
Walkiewicz K., Shamoo Y.
Submitted (DEC-2011) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 11-388 IN COMPLEX WITH FAD AND SULFATE.
[6]"Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX."
Volkers G., Damas J.M., Palm G.J., Panjikar S., Soares C.M., Hinrichs W.
Acta Crystallogr. D 69:1758-1767(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 11-388 IN COMPLEX WITH FAD AND SULFATE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ311171 Genomic DNA. Translation: CAC47932.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2XDOX-ray2.09A/B/C/D11-388[»]
2XYOX-ray3.00A/B/C/D11-388[»]
2Y6QX-ray2.37A/B/C/D11-388[»]
2Y6RX-ray3.10A/B/C/D11-388[»]
3P9UX-ray2.81A/B/C/D11-388[»]
3V3NX-ray2.70A/B/C/D11-388[»]
3V3OX-ray2.90A/B/C/D11-388[»]
4A6NX-ray2.30A/B/C/D11-388[»]
4A99X-ray2.18A/B/C/D11-388[»]
4GUVX-ray2.73A/B/C/D11-388[»]
ProteinModelPortalQ93L51.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSPR00420. RNGMNOXGNASE.
ProtoNetSearch...

Other

EvolutionaryTraceQ93L51.

Entry information

Entry nameQ93L51_BACT4
AccessionPrimary (citable) accession number: Q93L51
Entry history
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)