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Protein
Submitted name:

Putative glycosyltransferase

Gene

aviGT4

Organism
Streptomyces viridochromogenes Tue57
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei220 – 2201UDP; via amide nitrogen and carbonyl oxygenCombined sources
Binding sitei225 – 2251UDPCombined sources
Binding sitei252 – 2521UDPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 303UDPCombined sources
Nucleotide bindingi256 – 2605UDPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Keywords - Ligandi

Nucleotide-bindingCombined sources

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative glycosyltransferaseImported
Gene namesi
Name:aviGT4Imported
OrganismiStreptomyces viridochromogenes Tue57Imported
Taxonomic identifieri1160705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IUYX-ray2.10A/B1-342[»]
2IV3X-ray2.30A/B/C/D1-342[»]
ProteinModelPortaliQ93KV2.
SMRiQ93KV2. Positions 3-342.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93KV2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 280121Glycos_transf_1InterPro annotationAdd
BLAST

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93KV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLKVALVN IPLRVPGSDA WISVPPQGYG GIQWVVANLM DGLLELGHEV
60 70 80 90 100
FLLGAPGSPA GRPGLTVVPA GEPEEIERWL RTADVDVVHD HSGGVIGPAG
110 120 130 140 150
LPPGTAFISS HHFTTRPVNP VGCTYSSRAQ RAHCGGGDDA PVIPIPVDPA
160 170 180 190 200
RYRSAADQVA KEDFLLFMGR VSPHKGALEA AAFAHACGRR LVLAGPAWEP
210 220 230 240 250
EYFDEITRRY GSTVEPIGEV GGERRLDLLA SAHAVLAMSQ AVTGPWGGIW
260 270 280 290 300
CEPGATVVSE AAVSGTPVVG TGNGCLAEIV PSVGEVVGYG TDFAPDEARR
310 320 330 340
TLAGLPASDE VRRAAVRLWG HVTIAERYVE QYRRLLAGAT WK
Length:342
Mass (Da):36,102
Last modified:December 1, 2001 - v1
Checksum:iB30126E4E6782151
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333038 Genomic DNA. Translation: AAK83193.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333038 Genomic DNA. Translation: AAK83193.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IUYX-ray2.10A/B1-342[»]
2IV3X-ray2.30A/B/C/D1-342[»]
ProteinModelPortaliQ93KV2.
SMRiQ93KV2. Positions 3-342.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ93KV2.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics."
    Weitnauer G., Muhlenweg A., Trefzer A., Hoffmeister D., Sussmuth R.D., Jung G., Welzel K., Vente A., Girreser U., Bechthold A.
    Chem. Biol. 8:569-581(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Tue57Imported.
  2. "Novel avilamycin derivatives with improved polarity generated by targeted gene disruption."
    Weitnauer G., Hauser G., Hofmann C., Linder U., Boll R., Pelz K., Glaser S.J., Bechthold A.
    Chem. Biol. 11:1403-1411(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Tue57Imported.
  3. "Insights into the synthesis of lipopolysaccharide and antibiotics through the structures of two retaining glycosyltransferases from family GT4."
    Martinez-Fleites C., Proctor M., Roberts S., Bolam D.N., Gilbert H.J., Davies G.J.
    Chem. Biol. 13:1143-1152(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH UDP.

Entry informationi

Entry nameiQ93KV2_STRVR
AccessioniPrimary (citable) accession number: Q93KV2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.