Reviewed, UniProtKB/Swiss-Prot Q93KF3 (MSRAB_CAMFE)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA/msrB
Including the following 2 domains:
    1- Recommended name:
            Peptide methionine sulfoxide reductase msrA
                Short name=Protein-methionine-S-oxide reductase
              EC=1.8.4.11
        Alternative name(s):
            Peptide-methionine (S)-S-oxide reductase
              Short name=Peptide Met(O) reductase
    2- Recommended name:
            Peptide methionine sulfoxide reductase msrB
              EC=1.8.4.12
        Alternative name(s):
            Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrAB
Synonyms:	msrA

Organism

Campylobacter fetus

Taxonomic identifier

196 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin. L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin. Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin.
Sequence similarities	In the N-terminal section; belongs to the msrA Met sulfoxide reductase family. In the C-terminal section; belongs to the msrB Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Multifunctional enzyme
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Peptide methionine sulfoxide reductase msrA/msrB		PRO_0000138512
Regions
	Region	28 – 181	154	Peptide methionine sulfoxide reductase A
	Region	198 – 321	124	Peptide methionine sulfoxide reductase B
Sites
	Active site	36	1	By similarity
	Active site	310	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q93KF3-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 4406FA3CC4BC236F	FASTA	337	38,342
	10 20 30 40 50 60 MKKILFVVAT IFMALFLNAK ENDMRNLKDI YLAGGCFWGT QAYFDKIRGV IKTDVGYANG 70 80 90 100 110 120 KSDKTDYHSL HYSGHAETVH ITFDENIVSL AEILAHYFRI IDPFSVNKQG NDVGSQYRTG 130 140 150 160 170 180 IYYNDSSLKN SISEFIKHEQ TKYDKKIAVE VEPLKNYVLA EDYHQKYLDK NPGGYCHVDL 190 200 210 220 230 240 SLADKPLYNE SKFKAPSKDE LKAKLSDLQY SVTQEKATER PYSSEYDKFD KKGIYVDIVS 250 260 270 280 290 300 KKPLFSSSDK FDAGCGWPSF TKPITTDALG YNRDLSHGME RVEVTSNLAN SHLGHVFTDG 310 320 330 PKDKGGLRYC INGASLKFIP LEDMEKEGYK DYIIYVK

References

[1]	"Identification of genes encoding exported proteins in Campylobacter jejuni and C. fetus." Thies F.L., Trotha R., Koenig W. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 27374 / CIP 5396 / DSM 5361 / LMG 6442 / NCTC 10842.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ312325 Genomic DNA. Translation: CAC42492.1.
3D structure databases
HSSP	HSSP built from PDB template 1L1D based on UniProtKB P14930.
ModBase	Search...
Family and domain databases
HAMAP	MF_01400. Fused. [Tree] MF_01401. Fused. [Tree]
InterPro	IPR002569. MsrA. IPR002579. MsrB. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit. G3DSA:2.170.150.20. MsrB. 1 hit.
Pfam	PF01625. PMSR. 1 hit. PF01641. SelR. 1 hit. [Graphical view]
ProDom	PD004057. DUF25. 1 hit. PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit. TIGR00357. MsrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRAB_CAMFE

Accession

Primary (citable) accession number: Q93KF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	December 1, 2001
Last modified:	November 4, 2008
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)