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Q93JL5

- PCKG_STRCO

UniProt

Q93JL5 - PCKG_STRCO

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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene
pckG, SCO4979, 2SCK36.02
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Substrate By similarity
Binding sitei226 – 2261Substrate; via amide nitrogen By similarity
Metal bindingi233 – 2331Manganese By similarity
Binding sitei233 – 2331Substrate By similarity
Metal bindingi253 – 2531Manganese; via tele nitrogen By similarity
Binding sitei275 – 2751Substrate By similarity
Active sitei277 – 2771 By similarity
Metal bindingi300 – 3001Manganese By similarity
Binding sitei392 – 3921GTP By similarity
Binding sitei423 – 4231GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi276 – 2816GTP By similarity
Nucleotide bindingi518 – 5214GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:SCO4979
ORF Names:2SCK36.02
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609Phosphoenolpyruvate carboxykinase [GTP]UniRule annotationPRO_0000103615Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO4979.

Structurei

3D structure databases

ProteinModelPortaliQ93JL5.
SMRiQ93JL5. Positions 10-609.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni390 – 3923Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.
OrthoDBiEOG6MPWQS.
PhylomeDBiQ93JL5.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93JL5-1 [UniParc]FASTAAdd to Basket

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MARDIAAPPV PTNHQELISW VNEIAELTQP DAVVWCDGSE AEYERLCGEL    50
VEKGTFRKLD PIKRPNSYYA ASDPTDVARV EDRTFICSAK EEDAGPTNHW 100
KDPAEMRAIF TGDKGEGGLF RGSMRGRTMY VVPFCMGPLG SPLSALGVEI 150
TDSAYVAASM RTMTRMGQPV LDELGDEGFF VKAVHSVGAP LEPGQADVPW 200
PCNSTKYISH FPEDREIWSY GSGYGGNALL GKKCYALRIA SVMARDEGWL 250
AEHMLVLKLT PPTGAPKYVA AAFPSACGKT NLAMLEPTIS GWTVETIGDD 300
IAWMRFGEDG RLYAINPEAG FFGVAPGTGE HTNANAMKTL WGNSVFTNVA 350
LTDDGDVWWE GMTEETPAHL TDWKGNDWTP ESGTPAAHPN ARFTTPAAQC 400
PIIAPEWEDP RGVPISAILF GGRRATAVPL VTESFDWNHG VFLGANVASE 450
KTAAAEGKVG ELRRDPFAML PFCGYNMGDY MGHWVDVAKD KDQSKLPKIY 500
YVNWFRKDDA GRFVWPGFGE NGRVLKWIVE RLEGRADGVE TPIGVLPTKE 550
SLDTDGLDLA DADLEFLLSV DKEVWREEAA LVPEHLNTFG DHTPAELWDQ 600
YRALVRRLG 609
Length:609
Mass (Da):66,917
Last modified:December 1, 2001 - v1
Checksum:i80FF6E00B817875A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939122 Genomic DNA. Translation: CAC40592.1.
RefSeqiNP_629131.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC40592; CAC40592; CAC40592.
GeneIDi1100420.
KEGGisco:SCO4979.
PATRICi23739800. VBIStrCoe124346_5060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939122 Genomic DNA. Translation: CAC40592.1 .
RefSeqi NP_629131.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q93JL5.
SMRi Q93JL5. Positions 10-609.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO4979.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC40592 ; CAC40592 ; CAC40592 .
GeneIDi 1100420.
KEGGi sco:SCO4979.
PATRICi 23739800. VBIStrCoe124346_5060.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.
OrthoDBi EOG6MPWQS.
PhylomeDBi Q93JL5.

Enzyme and pathway databases

UniPathwayi UPA00138 .

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiPCKG_STRCO
AccessioniPrimary (citable) accession number: Q93JL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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