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Q93J59 (METE_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
EC=2.1.1.14
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene names
Name:metE
Ordered Locus Names:SCO0985
ORF Names:SCBAC19F3.12
OrganismStreptomyces coelicolor
Taxonomic identifier1902 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length772 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7727725-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
PRO_0000098669

Sites

Metal binding6561Zinc By similarity
Metal binding6581Zinc By similarity
Metal binding7411Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q93J59 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 1D732E3D4076FA65

FASTA77283,666
        10         20         30         40         50         60 
MTAKSAAAAA RATVYGYPRQ GPNRELKKAI EGYWKGRVSA PELRSLAADL RAANWRRLAD 

        70         80         90        100        110        120 
AGIDEVPAGD FSYYDHVLDT TVMVGAIPER HRAAVAADAL DGYFAMARGT QEVAPLEMTK 

       130        140        150        160        170        180 
WFDTNYHYLV PELGPDTVFT ADSTKQVTEL AEAVALGLTA RPVLVGPVTY LLLAKPAPGA 

       190        200        210        220        230        240 
PADFEPLTLL DRLLPVYAEV LTDLRAAGAE WVQLDEPAFV QDRTPAELNA LERAYRELGA 

       250        260        270        280        290        300 
LTDRPKLLVA SYFDRLGDAL PVLAKAPIEG LALDFTDAAA TNLDALAAVG GLPGKRLVAG 

       310        320        330        340        350        360 
VVNGRNIWIN DLQKSLSTLG TLLGLADRVD VSASCSLLHV PLDTGAERDI EPQILRWLAF 

       370        380        390        400        410        420 
ARQKTAEIVT LAKGLAQGTD AITGELAASR ADMASRAGSP ITRNPAVRAR AEAVTDDDAR 

       430        440        450        460        470        480 
RSQPYAERTA AQRAHLGLPP LPTTTIGSFP QTGEIRAARA DLRDGRIDIA GYEERIRAEI 

       490        500        510        520        530        540 
QEVISFQEKT GLDVLVHGEP ERNDMVQYFA EQLTGYLATQ HGWVQSYGTR YVRPPILAGD 

       550        560        570        580        590        600 
ISRPEPMTVR WTTYAQSLTE KPVKGMLTGP VTMLAWSFVR DDQPLGDTAR QVALALRDEV 

       610        620        630        640        650        660 
NDLEAAGTSV IQVDEPALRE TLPLRAADHT AYLAWATEAF RLTTSGVRPD TQIHTHMCYA 

       670        680        690        700        710        720 
EFGDIVQAID DLDADVISLE AARSHMQVAH ELATHGYPRE AGPGVYDIHS PRVPSAEEAA 

       730        740        750        760        770 
ALLRTGLKAI PAERLWVNPD CGLKTRGWPE TRASLENLVA TARTLRGELS AS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL939107 Genomic DNA. Translation: CAC44335.1.
RefSeqNP_625281.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ93J59.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1096408.
GenomeReviewsGene locus SCO0985 in contig AL645882_GR.
KEGGsco:SCO0985.
NMPDRfig|100226.1.peg.952.
PATRIC23731522. VBIStrCoe124346_0983.

Phylogenomic databases

HOGENOMHBG287495.
OMARNIWRAN.
PhylomeDBQ93J59.
ProtClustDBPRK05222.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETE_STRCO
AccessionPrimary (citable) accession number: Q93J59
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: December 1, 2001
Last modified: January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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