Q93IM5 (GLK_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucokinase
EC=2.7.1.2

Alternative name(s):
Glucose kinase

Gene names

Name:	glk
Ordered Locus Names:	STM2403

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP-Rule MF_00524
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00524.
Sequence similarities	Belongs to the bacterial glucokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP glucokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Glucokinase HAMAP-Rule MF_00524		PRO_0000215138
Regions
	Nucleotide binding	8 – 13	6	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q93IM5 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 0ECD9CC77D8C6C8A	FASTA	321	34,595
	10 20 30 40 50 60 MTKYALVGDV GGTNARLALC DIASGEISQA KTYSGLDYPS LEAVVRVYLD EHSVSVEDGC 70 80 90 100 110 120 IAIACPITGD WVAMTNHTWA FSIAEMKKNL GFSHLEIIND FTAVSMAIPM LKKEHLIQFG 130 140 150 160 170 180 GGEPVDGKPI AVYGAGTGLG VAHLVHVDKR WISLPGEGGH VDFAPNSEEE AMILEILRAE 190 200 210 220 230 240 IGHVSAERVL SGPGLVNLYR AIVKSDNRLP ENLRPKDITE RALADSCIDC RRALSLFCVI 250 260 270 280 290 300 MGRFGGDLAL TMGTFGGVYI AGGIVPRFLE FFKASGFRGG FEDKGRFKDY VHGIPVYLIV 310 320 HDNPGLLGSG AHLRQTLGHI L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the Salmonella typhimurium ipd gene encoding a putative indole-3-pyruvate decarboxylase." Norel F. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C52.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ401270 Genomic DNA. Translation: CAC48241.1. AE006468 Genomic DNA. Translation: AAL21303.1.
RefSeq	NP_461344.1. NC_003197.1.
3D structure databases
ProteinModelPortal	Q93IM5.
SMR	Q93IM5. Positions 2-321.
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM2403.
Proteomic databases
PaxDb	Q93IM5.
PRIDE	Q93IM5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL21303; AAL21303; STM2403.
GeneID	1253925.
KEGG	stm:STM2403.
PATRIC	32383433. VBISalEnt20916_2545.
Phylogenomic databases
eggNOG	COG0837.
HOGENOM	HOG000274469.
KO	K00845.
OMA	EAVIRHY.
ProtClustDB	PRK00292.
Enzyme and pathway databases
BioCyc	SENT99287:GCTI-2418-MONOMER.
Family and domain databases
HAMAP	MF_00524. Glucokinase.
InterPro	IPR003836. Glucokinase. [Graphical view]
Pfam	PF02685. Glucokinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00749. glk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLK_SALTY

Accession

Primary (citable) accession number: Q93IM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	December 1, 2001
Last modified:	May 29, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program