Q93IC2 (Q93IC2_STAAU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Penicillin-binding protein 2' EMBL BAB47623.1

Gene names

Name:

mecA EMBL BAB47623.1

Organism

Staphylococcus aureus EMBL BAB47623.1

Taxonomic identifier

1280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus

Protein attributes

Sequence length	668 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 1MWR PDB 1MWS PDB 1MWT PDB 1MWU
Gene Ontology (GO)
Biological_process	peptidoglycan-based cell wall biogenesis Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: InterPro
Molecular_function	penicillin binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q93IC2 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 57743D053D8083D6	FASTA	668	76,189
	10 20 30 40 50 60 MKKIKIVPLI LIVVVVGFGI YFYASKDKEI NNTIDAIEDK NFKQVYKDSS YISKSDNGEV 70 80 90 100 110 120 EMTERPIKIY NSLGVKDINI QDRKIKKVSK NKKRVDAQYK IKTNYGNIDR NVQFNFVKED 130 140 150 160 170 180 GMWKLDWDHS VIIPGMQKDQ SIHIENLKSE RGKILDRNNV ELANTGTAYE IGIVPKNVSK 190 200 210 220 230 240 KDYKAIAKEL SISEDYIKQQ MDQKWVQDDT FVPLKTVKKM DEYLSDFAKK FHLTTNETES 250 260 270 280 290 300 RNYPLEKATS HLLGYVGPIN SEELKQKEYK GYKDDAVIGK KGLEKLYDKK LQHEDGYRVT 310 320 330 340 350 360 IVDDNSNTIA HTLIEKKKKD GKDIQLTIDA KVQKSIYNNM KNDYGSGTAI HPQTGELLAL 370 380 390 400 410 420 VSTPSYDVYP FMYGMSNEEY NKLTEDKKEP LLNKFQITTS PGSTQKILTA MIGLNNKTLD 430 440 450 460 470 480 DKTSYKIDGK GWQKDKSWGG YNVTRYEVVN GNIDLKQAIE SSDNIFFARV ALELGSKKFE 490 500 510 520 530 540 KGMKKLGVGE DIPSDYPFYN AQISNKNLDN EILLADSGYG QGEILINPVQ ILSIYSALEN 550 560 570 580 590 600 NGNINAPHLL KDTKNKVWKK NIISKENINL LTDGMQQVVN KTHKEDIYRS YANLIGKSGT 610 620 630 640 650 660 AELKMKQGET GRQIGWFISY DKDNPNMMMA INVKDVQDKG MASYNAKISG KVYDELYENG NKKYDIDE

References

[1]	"Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus." Ito T., Katayama Y., Asada K., Mori N., Tsutsumimoto K. Antimicrob. Agents Chemother. 45:1323-1336(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 85/2082 EMBL BAB47623.1.
[2]	"Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus." Lim D., Strynadka N.C. Nat. Struct. Biol. 9:870-876(2002) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 24-668.
[3]	"Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: genomic island SCC." Ito T., Okuma K., Xue M.X., Yuzawa H., Hiramatsu K. Drug Resist. Updat. 6:41-52(2003) Cited for: NUCLEOTIDE SEQUENCE. Strain: 85/2082 EMBL BAB47623.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB037671 Genomic DNA. Translation: BAB47623.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1MWR	X-ray	2.45	A/B	24-668	[»]
1MWS	X-ray	2.00	A/B	24-668	[»]
1MWT	X-ray	2.45	A/B	24-668	[»]
1MWU	X-ray	2.60	A/B	24-668	[»]

ProteinModelPortal

Q93IC2.

SMR

Q93IC2. Positions 27-668.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

3.40.710.10. 1 hit.

InterPro

IPR012338. Beta-lactam/transpept-like.
IPR007887. MecA_N.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]

Pfam

PF05223. MecA_N. 1 hit.
PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]

SUPFAM

SSF56519. PBP_dimer. 1 hit.
SSF56601. PBP_transp_fold. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q93IC2.

Entry information

Entry name

Q93IC2_STAAU

Accession

Primary (citable) accession number: Q93IC2

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)