Q93HJ2 (Q93HJ2_STRAX) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Modular polyketide synthase EMBL BAB69195.1

Gene names

Name:

olmA6 EMBL BAB69195.1

Organism

Streptomyces avermitilis EMBL BAB69195.1

Taxonomic identifier

33903 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	4685 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Gene Ontology (GO)
Biological_process	oxidation-reduction process Inferred from electronic annotation. Source: GOC
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q93HJ2 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2FA34215A39A0DB8	FASTA	4,685	489,366
	10 20 30 40 50 60 MNSSMSEVVD ALRASLLENE RLRQQNQRLT TASAEPLAIV GIGCRYPGGV RDTEDLWRLI 70 80 90 100 110 120 TEGRDAMSGF PTDRGWDRWD IPTARTGAFL HDAGDFDPAF FRISPREAMA MDPQQRLLLE 130 140 150 160 170 180 TSWEALERAG IDPATLKGSR TGVFIGGAPQ EYGALVMNSA EGAGGYALTG APGSVLSGRI 190 200 210 220 230 240 SYVLGLEGPA VTVDTACSSS LVALHLAVKS LRTGECDLAL AGGVLVLVTP SIFAEFSATG 250 260 270 280 290 300 GSAGDGRCKA FAASADGTGW GEGAGVLAVQ RLTDARRDGH PVLAVIRGSA VNQDGASNGL 310 320 330 340 350 360 SAPNGPSQQR VIRQALANAG LSAADVDMVE AHGTGTTLGD PIEAEALLAT YGQDRPADRP 370 380 390 400 410 420 LWLGTLKSNI GHTQAAAGVS GVIKAVLSLQ HGLLPKTLHV DEPTPQVDWS AGAVELLTQA 430 440 450 460 470 480 REWPETDGPR RAGVSSFGIS GTNAHVILEQ APEPEGAEVP ESAEAPGAEG RPALSGPVPW 490 500 510 520 530 540 LVSGRTEAAL RAQAARLAEH LAGRPEATPL DVGFSLARTR SAFEQRAVVV SADRDELIAG 550 560 570 580 590 600 LRSVADSGDG AGVAGVVAGR ATADSGVVFV FPGQGSQWVG MAAELLDSAP VFRARMEECG 610 620 630 640 650 660 EALAPHVDWS LLAVVRQEEG TPSWSRVDVV QPVLWAVMVS LAAVWRSFGV EPAAVVGHSQ 670 680 690 700 710 720 GEVAAACVAG GLSLEDGARV VAVRSRLVLE KLSGKGGMVS VALPVGEVEE RLARFEGRIG 730 740 750 760 770 780 VAAVNGPGSV VVSGEPDALD ELLAECEESG VRARRIAVDY ASHSAQVDAL NEDLLRELAD 790 800 810 820 830 840 IQPRSSSVAF YSTVTGERLD TSGLDARYWV TNLRERVRFE PVVRLLAEKG SSVFVESSPH 850 860 870 880 890 900 PVLTMAVAET GEVADRAVVT VGSLRRDDGG ADRFLTSLAE AYVAGAPVDW SVLFAGMPVR 910 920 930 940 950 960 RVDLPTYAFQ HQRYWLDDVA LPGQSGFSDD PADAAFWGAV ERADVQGVAA LVDGAEPEVW 970 980 990 1000 1010 1020 EPVLSALSAW RRGRQERSVL DSWRYRTVWR SVTVPSVGRL SGTWLVVTPG GAGPVEEVRR 1030 1040 1050 1060 1070 1080 ALEAVGAEAV VLAWEAEEGR EALAGRLTGA GEVSGVVSLL GWDEEAAPVA TVTLVQALAD 1090 1100 1110 1120 1130 1140 AGVEAPLWVL TQGAASVGAE DVVHPVQTQV WALGQVAGLE QPGSWGGLVD VPGVWDERVA 1150 1160 1170 1180 1190 1200 SGLTAVLAAG EGEDQVAVRS SGAYARRLVR APLGANPAPV RDWNPHGTVL ITGGTGGIGA 1210 1220 1230 1240 1250 1260 HLARWLAKEG AERLLLVSRS GEQAEGAAEL ATELGGLGAE VTFAACDVSD RDALAHVIAG 1270 1280 1290 1300 1310 1320 IPAEHPLTAV FHTAGISGYA ELATATPEHF TDVLSARVLG ARHLDELTAE LGVELEAFVV 1330 1340 1350 1360 1370 1380 FSSGAAVWGS GSNGANAAAG GYLDGLVRRR RARGVAGTSV SWGGWQATAM AVGDTAEQLS 1390 1400 1410 1420 1430 1440 RRGVRLLDPV LAVQALRQVL EQDEVSVTVT DMDWALFTPG YAMARRRPLI EDIPEAGEAL 1450 1460 1470 1480 1490 1500 SGAAGAGETL DSAGVGLRER LAAMTETERQ ATLLGLVRGE AAQVLAHGST AEITPTRPFK 1510 1520 1530 1540 1550 1560 ELGFDSLTAM DLRNRLSKAT GLRLPATLVF DYPNPEQLAA LLRTELVDGL PGTAGPAAPA 1570 1580 1590 1600 1610 1620 VRPVDDEPLA IVGMACRYPG GVRDADDLWR LIVEGRDELS DFPTDRGWDR WGAPAVGQAG 1630 1640 1650 1660 1670 1680 FLHEAGEFDA AFFGISPREA ASMDPQQRLL LETSWEAVEQ AGIDPWSLRG SSTGVFVGGG 1690 1700 1710 1720 1730 1740 PQDYPAVLMG SAEAGGGYGM TGALGSVMSG RVSYVLGLEG PAVTVDTACS SSLVALHLAA 1750 1760 1770 1780 1790 1800 QSLNNGECEL ALAGGVTIMA TPGAFAEFDT LGGMAGDGRC KAFAASADGT GWGEGVGMVV 1810 1820 1830 1840 1850 1860 VERLSDARRN GHEVLAVIRG SAINQDGASN GLSAPNGPSQ QRVIRQALAN AGLSAADVDM 1870 1880 1890 1900 1910 1920 VEAHGTGTTL GDPIEAQALL ATYGQDRPAD RPLWLGSVKS NFGHTGAAAG VAGVIKAVLA 1930 1940 1950 1960 1970 1980 LRNGLLPKTL HVDEPTPQVD WSAGAVELLT QAREWPDAER PRRAGVSSFG ISGTNAHVIL 1990 2000 2010 2020 2030 2040 EQAPEPEGAE VPGSAEAPGA EGRPALSGPV PWLVSGRTEA ALRAQAARLA EHLAGRPEAA 2050 2060 2070 2080 2090 2100 PLDVGFSLAT TRANLEHRAV VLGSTSEELT RGLNAVAEAA ISPAVIRGNG TDTGVVFVFP 2110 2120 2130 2140 2150 2160 GQGSQWVGMG RDLWDVSPVF AESMVACERA LSPLVDWSLR DVVFRDAGDP LWSRVDVVQP 2170 2180 2190 2200 2210 2220 VLWAVMVSLA AVWRSFGVEP AAVVGHSQGE VAAACVAGGL SLEDGARVVA VRSRLVLEKL 2230 2240 2250 2260 2270 2280 SGKGGMVSVA LPVEGVEERL ARFEGRIGVA AVNGPTSVVV SGEPEALDEL LAECEGSGVR 2290 2300 2310 2320 2330 2340 ARRIAVDYAS HSAQVDALND DLLAELAGIR PKSSTVAFYS TVTGGRLDTS GLDARYWVTN 2350 2360 2370 2380 2390 2400 LRERVRFEPV VRLLADQAHG LFVEASPHPV LNMAVAETGE VADRAVVTVG SLRRDDGGAD 2410 2420 2430 2440 2450 2460 RLLTSLAEAH VAGAPVDWSV LFAGTGTRRI GLPTYAFQHQ RYWLEDAAAP GTDGVVDPVD 2470 2480 2490 2500 2510 2520 AAFWGAVERA DVQGVAALVD GADPEAWEPV LSALSAWRKG RQERSVLDSW RYRTVWRSVT 2530 2540 2550 2560 2570 2580 VPSAGRLSGT WLVVAPGEGA PAERIEEALV GAGAEVVVLA WETEEGREAL AGRLAEAGEL 2590 2600 2610 2620 2630 2640 SGVVSLLGWD EKAAPAATVT LVQGLADAGV EAPLWVLTHG AASVGSGDVI RPVQTQVWAL 2650 2660 2670 2680 2690 2700 GQIVGLEQPG SWGGLVDVPE VWDERVASGF AGVLAAGEGE DQVAVRSSGA YARRLVRAPL 2710 2720 2730 2740 2750 2760 GANPAPVRDW NPHGTVLITG GTGGIGAHLA RWLAKEGAER LLLVSRSGER AEGAAELAAE 2770 2780 2790 2800 2810 2820 LGGLGAEVTF AACDVTDRDA LAHVIAEHPP TAVFHTAGVA SYGTVRELDL ADLDAQMAAK 2830 2840 2850 2860 2870 2880 TLGARHLDEL TTERGLELDA FVVFSSGAAI WGSAGNGGYA AANAYLDGLA WDRRARGLAA 2890 2900 2910 2920 2930 2940 TSVSWGGWKA TGMATDDTAE QLARRGVRPM DPARAVEALR QALEQDETAL TVTDMDWERF 2950 2960 2970 2980 2990 3000 TPGYTMARRR PLIEDIPEVA RVLSEDSADV LGDDSAGSAL RTELAALGQA EQLDLLLDLV 3010 3020 3030 3040 3050 3060 RGEAARILAH SSTAEITPER PFKELGFDSL TAMELRNLLN TATGLRLPAT LVFDYPNPRQ 3070 3080 3090 3100 3110 3120 LAAHLRTELI GAGPDLVPAA DVVRADADEP LAIVGMACRY SGGVSSPEDL WQVVVENKDG 3130 3140 3150 3160 3170 3180 MSDFPSYRGW DRWNLASLRR AGFLHEAGDF DAGFFGISPR EAMAMDPQQR LLLEASWEAV 3190 3200 3210 3220 3230 3240 ERTGIDPHSL RGSDTGVFVG GTAVEYGALL MNSPASQGYA VTGSSGSVMS GRISYTLGLE 3250 3260 3270 3280 3290 3300 GPAVTVDTAC SSSLVALHLA AQALRGGECS LALTGGVGLM ATPGAFAEFD TLGGLSVDGR 3310 3320 3330 3340 3350 3360 TKAFAAAADG IGWGEGVGMV VVERLSDARR NGHEVLAVIR GSAINQDGAS NGLSAPNGPS 3370 3380 3390 3400 3410 3420 QQRVIRQAVA NAGLALADVD MVEAHGTGTT LGDPIEAQAL LATYGQERPA DRPLWLGSVK 3430 3440 3450 3460 3470 3480 SNIGHTGAAA GVAGVIKSVL ALRNGLLPKT LNVDEPTPKV DWSAGAVELL TQAREWPQGE 3490 3500 3510 3520 3530 3540 RPRRAGVSSF GISGTNAHVI IEEAPAAEET PAAPDEAAPA APALVTPVVP WVFSGRSSGA 3550 3560 3570 3580 3590 3600 LCGQAGRLGG LVEREPGLDV TDVAFSLATT RANLEHRAVV LGGDAAGLLD RLRSVAAREP 3610 3620 3630 3640 3650 3660 DAGVVSGTTA AGGRVVFVFP GQGSQWVGMG RDLWDVSPVF AESMVACERA LSPLVDWSLR 3670 3680 3690 3700 3710 3720 DVVFRDAGDP LWSRVDVVQP VLWAVMVSLA AVWRSFGVDP AAVVGHSQGE VAAACVAGGL 3730 3740 3750 3760 3770 3780 SLEDGARVVA VRSRLVLEKL SGKGGMVSVA LPVEGVEERL ARFEGRIGVA AVNGPTSVVV 3790 3800 3810 3820 3830 3840 SGEPDALDEL LAECEESGVR ARRIAVDYAS HSAQVDALND DLLAELADIR PKSSTVAFYS 3850 3860 3870 3880 3890 3900 TVTGDRLDTS GLDARYWVTN LRERVRFEPV VRLLAEKGSS VFVESSPHPV LTMAVAETGE 3910 3920 3930 3940 3950 3960 VADRAVVTVG SLRRDDGGAD RLLTSLAEAY VAGAPVDWSV LFAGTGARRV DLPTYAFQHQ 3970 3980 3990 4000 4010 4020 RYWLEGVSVG GEIQEASADA MDAAFWDAVE REDLADLTEV LDTSGGTGPD PAAAAEAWLP 4030 4040 4050 4060 4070 4080 ALSAWRKGRR KQTTLDSWRY RTEWRTNDRP LSARLSGTWL VVAPSDGAPT ERMERTLAGA 4090 4100 4110 4120 4130 4140 GAEVVVLAIE AGTDRAELAE RLAGTPEAAG VVSLLAWDEH TAVASTLTLI QAHGDIESAA 4150 4160 4170 4180 4190 4200 PLWVVTRGAA SVDSGDEIRP VQTQVWALGQ IVGLEQPGSW GGLVDVPEVW DERVASQVAG 4210 4220 4230 4240 4250 4260 VLAAGEGEDQ VAVRSSGAYA RRLVRAPLGA NPAPVRDWNP HGTVLITGGT GGIGAHLARW 4270 4280 4290 4300 4310 4320 LAKEGAERLL LVSRSGERAE GAAELAAELG GLGAEVTFAA CDVTDRDALA HVIAGIPAEH 4330 4340 4350 4360 4370 4380 PLTAVFHTAG VAGHGPLADL DVTDLDTQTA ARIAGARHLD ELTAELGVEL EAFVVFSSGA 4390 4400 4410 4420 4430 4440 AVWGSGSNGA NAAAGGYLDG LVRLRRARGV AGTSVSWGGW QATAMAVGDT AEQLSRRGVR 4450 4460 4470 4480 4490 4500 LLDPVLAVQA LRQALEQDEV SVTVTDMDWA LFTPGYAMAR RRPLIEDIPE AAQVLRDAEE 4510 4520 4530 4540 4550 4560 IEDGPEDGAA GADLRKRLAG LTDPERQATL LGLVRGEAAQ VLAHGSTAEI TPTRPFKELG 4570 4580 4590 4600 4610 4620 FDSLTAMDLR NRLSKATGLR LPATLVFDHP NPQRIAEHLR AGLAQDGQQG IADVLDIRRE 4630 4640 4650 4660 4670 4680 LTRIGEALNS VAPDARARED IVDHLRDLIT QLGTGTGAAE QDTTDLEAAT DDEIFDFIDR DLGVS

References

[1]

"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites." Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB070940 Genomic DNA. Translation: BAB69195.1.
3D structure databases
ProteinModelPortal	Q93HJ2.
SMR	Q93HJ2. Positions 9-917, 1561-2445.
ModBase	Search...
Protein-protein interaction databases
STRING	227882.SAV_2896.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	23719379. VBIStrAve112782_3099.
Phylogenomic databases
HOGENOM	HOG000046292.
ProtClustDB	CLSK220056.
Enzyme and pathway databases
BioCyc	SAVE227882:GJU1-2917-MONOMER.
Family and domain databases
Gene3D	1.10.1200.10. 3 hits. 3.40.366.10. 6 hits. 3.40.47.10. 6 hits. 3.40.50.720. 3 hits.
InterPro	IPR001227. Ac_transferase_dom. IPR009081. Acyl_carrier_prot-like. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR002198. DH_sc/Rdtase_SDR. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016036. Malonyl_transacylase_ACP-bd. IPR016040. NAD(P)-bd_dom. IPR020842. PKS/FAS_KR. IPR020801. PKS_acyl_transferase. IPR020841. PKS_Beta-ketoAc_synthase_dom. IPR013968. PKS_KR. IPR020806. PKS_PP-bd. IPR006162. PPantetheine_attach_site. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Pfam	PF00698. Acyl_transf_1. 3 hits. PF00106. adh_short. 2 hits. PF00109. ketoacyl-synt. 3 hits. PF02801. Ketoacyl-synt_C. 3 hits. PF08659. KR. 1 hit. PF00550. PP-binding. 3 hits. [Graphical view]
SMART	SM00827. PKS_AT. 3 hits. SM00822. PKS_KR. 3 hits. SM00825. PKS_KS. 3 hits. SM00823. PKS_PP. 3 hits. [Graphical view]
SUPFAM	SSF47336. ACP_like. 3 hits. SSF52151. Acyl_Trfase/lysoPlipase. 3 hits. SSF55048. Malonyl_transacylase_ACP-bd. 3 hits. SSF53901. Thiolase-like. 3 hits.
PROSITE	PS50075. ACP_DOMAIN. 3 hits. PS00606. B_KETOACYL_SYNTHASE. 3 hits. PS00012. PHOSPHOPANTETHEINE. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q93HJ2_STRAX

Accession

Primary (citable) accession number: Q93HJ2

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)