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Q93GX3

- CPDA_STRAW

UniProt

Q93GX3 - CPDA_STRAW

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Metal cation 1UniRule annotation
Metal bindingi8 – 81Metal cation 1UniRule annotation
Binding sitei8 – 81cAMPUniRule annotation
Metal bindingi44 – 441Metal cation 1UniRule annotation
Metal bindingi44 – 441Metal cation 2UniRule annotation
Binding sitei44 – 441cAMPUniRule annotation
Metal bindingi74 – 741Metal cation 2UniRule annotation
Metal bindingi148 – 1481Metal cation 2UniRule annotation
Metal bindingi187 – 1871Metal cation 2UniRule annotation
Metal bindingi189 – 1891Metal cation 1UniRule annotation
Binding sitei189 – 1891cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 752cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-1254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:SAV_1247
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2572573',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413379Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_1247.

Structurei

3D structure databases

ProteinModelPortaliQ93GX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238352.
OMAiTERTLLW.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q93GX3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MAHLSDPHLT TGLLAVDRVA AFSRALRCVL ALDPRPACVV VTGDLVDRGE
60 70 80 90 100
AEEYEVLREV IARFPLPVHL VPGNHDDPGT LLEAFGGGPH TGGARAFPYA
110 120 130 140 150
VEYPNATVVV LSSTVPGAPS GRLGDEQLDR LEELLSRRPE VPAFVCLHHP
160 170 180 190 200
PVDIGIPYLD GMNLADADAF GEVIGRHPQV VRVLAGHVHR AVTGEFAGST
210 220 230 240 250
MVTAPSTYLQ SNLNLRVGGP VGYVDEPTAF LLHHLTGTGC VTHTAQVSHA

GGLIGGY
Length:257
Mass (Da):27,129
Last modified:December 1, 2001 - v1
Checksum:iC308521452EDFA66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070957 Genomic DNA. Translation: BAB69418.1.
BA000030 Genomic DNA. Translation: BAC68957.1.
RefSeqiNP_822422.1. NC_003155.4.
WP_010982685.1. NC_003155.4.

Genome annotation databases

EnsemblBacteriaiBAC68957; BAC68957; SAV_1247.
GeneIDi1210161.
KEGGisma:SAV_1247.
PATRICi23715829. VBIStrAve112782_1332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070957 Genomic DNA. Translation: BAB69418.1 .
BA000030 Genomic DNA. Translation: BAC68957.1 .
RefSeqi NP_822422.1. NC_003155.4.
WP_010982685.1. NC_003155.4.

3D structure databases

ProteinModelPortali Q93GX3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227882.SAV_1247.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC68957 ; BAC68957 ; SAV_1247 .
GeneIDi 1210161.
KEGGi sma:SAV_1247.
PATRICi 23715829. VBIStrAve112782_1332.

Phylogenomic databases

HOGENOMi HOG000238352.
OMAi TERTLLW.
OrthoDBi EOG6QG8GQ.

Enzyme and pathway databases

BioCyci SAVE227882:GJU1-1254-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiCPDA_STRAW
AccessioniPrimary (citable) accession number: Q93GX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3