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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Metal cation 1UniRule annotation1
Metal bindingi8Metal cation 1UniRule annotation1
Binding sitei8cAMPUniRule annotation1
Metal bindingi44Metal cation 1UniRule annotation1
Metal bindingi44Metal cation 2UniRule annotation1
Binding sitei44cAMPUniRule annotation1
Metal bindingi74Metal cation 2UniRule annotation1
Metal bindingi148Metal cation 2UniRule annotation1
Metal bindingi187Metal cation 2UniRule annotation1
Metal bindingi189Metal cation 1UniRule annotation1
Binding sitei189cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 75cAMPUniRule annotation2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:SAV_1247
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133791 – 2573',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST257

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_1247.

Structurei

3D structure databases

ProteinModelPortaliQ93GX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
HOGENOMiHOG000238352.
OMAiDGPYPFY.
OrthoDBiPOG091H05L5.

Family and domain databases

CDDicd07402. MPP_GpdQ. 1 hit.
Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q93GX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHLSDPHLT TGLLAVDRVA AFSRALRCVL ALDPRPACVV VTGDLVDRGE
60 70 80 90 100
AEEYEVLREV IARFPLPVHL VPGNHDDPGT LLEAFGGGPH TGGARAFPYA
110 120 130 140 150
VEYPNATVVV LSSTVPGAPS GRLGDEQLDR LEELLSRRPE VPAFVCLHHP
160 170 180 190 200
PVDIGIPYLD GMNLADADAF GEVIGRHPQV VRVLAGHVHR AVTGEFAGST
210 220 230 240 250
MVTAPSTYLQ SNLNLRVGGP VGYVDEPTAF LLHHLTGTGC VTHTAQVSHA

GGLIGGY
Length:257
Mass (Da):27,129
Last modified:December 1, 2001 - v1
Checksum:iC308521452EDFA66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070957 Genomic DNA. Translation: BAB69418.1.
BA000030 Genomic DNA. Translation: BAC68957.1.

Genome annotation databases

EnsemblBacteriaiBAC68957; BAC68957; SAVERM_1247.
KEGGisma:SAV_1247.
PATRICi23715829. VBIStrAve112782_1332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070957 Genomic DNA. Translation: BAB69418.1.
BA000030 Genomic DNA. Translation: BAC68957.1.

3D structure databases

ProteinModelPortaliQ93GX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_1247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC68957; BAC68957; SAVERM_1247.
KEGGisma:SAV_1247.
PATRICi23715829. VBIStrAve112782_1332.

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
HOGENOMiHOG000238352.
OMAiDGPYPFY.
OrthoDBiPOG091H05L5.

Family and domain databases

CDDicd07402. MPP_GpdQ. 1 hit.
Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPDA_STRAW
AccessioniPrimary (citable) accession number: Q93GX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.