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Q93GX3

- CPDA_STRAW

UniProt

Q93GX3 - CPDA_STRAW

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi6 – 61Metal cation 1UniRule annotation
    Metal bindingi8 – 81Metal cation 1UniRule annotation
    Binding sitei8 – 81cAMPUniRule annotation
    Metal bindingi44 – 441Metal cation 1UniRule annotation
    Metal bindingi44 – 441Metal cation 2UniRule annotation
    Binding sitei44 – 441cAMPUniRule annotation
    Metal bindingi74 – 741Metal cation 2UniRule annotation
    Metal bindingi148 – 1481Metal cation 2UniRule annotation
    Metal bindingi187 – 1871Metal cation 2UniRule annotation
    Metal bindingi189 – 1891Metal cation 1UniRule annotation
    Binding sitei189 – 1891cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi74 – 752cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAVE227882:GJU1-1254-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:SAV_1247
    OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
    Taxonomic identifieri227882 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000000428: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2572573',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413379Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi227882.SAV_1247.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93GX3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000238352.
    OMAiTERTLLW.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q93GX3-1 [UniParc]FASTAAdd to Basket

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    MAHLSDPHLT TGLLAVDRVA AFSRALRCVL ALDPRPACVV VTGDLVDRGE    50
    AEEYEVLREV IARFPLPVHL VPGNHDDPGT LLEAFGGGPH TGGARAFPYA 100
    VEYPNATVVV LSSTVPGAPS GRLGDEQLDR LEELLSRRPE VPAFVCLHHP 150
    PVDIGIPYLD GMNLADADAF GEVIGRHPQV VRVLAGHVHR AVTGEFAGST 200
    MVTAPSTYLQ SNLNLRVGGP VGYVDEPTAF LLHHLTGTGC VTHTAQVSHA 250
    GGLIGGY 257
    Length:257
    Mass (Da):27,129
    Last modified:December 1, 2001 - v1
    Checksum:iC308521452EDFA66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070957 Genomic DNA. Translation: BAB69418.1.
    BA000030 Genomic DNA. Translation: BAC68957.1.
    RefSeqiNP_822422.1. NC_003155.4.
    WP_010982685.1. NC_003155.4.

    Genome annotation databases

    EnsemblBacteriaiBAC68957; BAC68957; SAV_1247.
    GeneIDi1210161.
    KEGGisma:SAV_1247.
    PATRICi23715829. VBIStrAve112782_1332.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070957 Genomic DNA. Translation: BAB69418.1 .
    BA000030 Genomic DNA. Translation: BAC68957.1 .
    RefSeqi NP_822422.1. NC_003155.4.
    WP_010982685.1. NC_003155.4.

    3D structure databases

    ProteinModelPortali Q93GX3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227882.SAV_1247.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC68957 ; BAC68957 ; SAV_1247 .
    GeneIDi 1210161.
    KEGGi sma:SAV_1247.
    PATRICi 23715829. VBIStrAve112782_1332.

    Phylogenomic databases

    HOGENOMi HOG000238352.
    OMAi TERTLLW.
    OrthoDBi EOG6QG8GQ.

    Enzyme and pathway databases

    BioCyci SAVE227882:GJU1-1254-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
      Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
      Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
    2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
      Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
      Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

    Entry informationi

    Entry nameiCPDA_STRAW
    AccessioniPrimary (citable) accession number: Q93GX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3