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Protein

HTH-type transcriptional regulator CueR

Gene

cueR

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi112Copper(1+)By similarity1
Metal bindingi120Copper(1+)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator CueR
Alternative name(s):
Copper efflux regulator
Copper export regulator
Gene namesi
Name:cueR
Synonyms:scr
Ordered Locus Names:STM0499
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981151 – 138HTH-type transcriptional regulator CueRAdd BLAST138

Proteomic databases

PaxDbiQ93CH6.
PRIDEiQ93CH6.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi99287.STM0499.

Structurei

3D structure databases

ProteinModelPortaliQ93CH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 69HTH merR-typePROSITE-ProRule annotationAdd BLAST69

Domaini

It contains a N-terminal DNA binding region and a C-terminal metal binding region.By similarity

Phylogenomic databases

eggNOGiENOG4108Z6Z. Bacteria.
COG0789. LUCA.
HOGENOMiHOG000266076.
KOiK11923.
OMAiDENPECP.
PhylomeDBiQ93CH6.

Family and domain databases

CDDicd01108. HTH_CueR. 1 hit.
InterProiView protein in InterPro
IPR011789. CueR.
IPR009061. DNA-bd_dom_put.
IPR000551. MerR-type_HTH_dom.
PfamiView protein in Pfam
PF13411. MerR_1. 1 hit.
PRINTSiPR00040. HTHMERR.
SMARTiView protein in SMART
SM00422. HTH_MERR. 1 hit.
SUPFAMiSSF46955. SSF46955. 1 hit.
TIGRFAMsiTIGR02044. CueR. 1 hit.
PROSITEiView protein in PROSITE
PS00552. HTH_MERR_1. 1 hit.
PS50937. HTH_MERR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q93CH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISDVAKKT GLTSKAIRFY EEKGLVTPPL RSENGYRTYT QKHLNELTLL
60 70 80 90 100
RQARQVGFNL EECGELVNLF NDPRRHSADV KKRTLEKVAE IERHISELQS
110 120 130
MRDQLLALAE SCPGDDSADC PIIDNLSGCC HHKAQKPR
Length:138
Mass (Da):15,648
Last modified:December 1, 2001 - v1
Checksum:i20D6D1C23EA6D850
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF409088 Genomic DNA. Translation: AAL11724.1.
AE006468 Genomic DNA. Translation: AAL19453.1.
RefSeqiNP_459494.1. NC_003197.2.
WP_001026760.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL19453; AAL19453; STM0499.
GeneIDi1252019.
KEGGistm:STM0499.
PATRICi32379343. VBISalEnt20916_0533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF409088 Genomic DNA. Translation: AAL11724.1.
AE006468 Genomic DNA. Translation: AAL19453.1.
RefSeqiNP_459494.1. NC_003197.2.
WP_001026760.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ93CH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM0499.

Proteomic databases

PaxDbiQ93CH6.
PRIDEiQ93CH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL19453; AAL19453; STM0499.
GeneIDi1252019.
KEGGistm:STM0499.
PATRICi32379343. VBISalEnt20916_0533.

Phylogenomic databases

eggNOGiENOG4108Z6Z. Bacteria.
COG0789. LUCA.
HOGENOMiHOG000266076.
KOiK11923.
OMAiDENPECP.
PhylomeDBiQ93CH6.

Family and domain databases

CDDicd01108. HTH_CueR. 1 hit.
InterProiView protein in InterPro
IPR011789. CueR.
IPR009061. DNA-bd_dom_put.
IPR000551. MerR-type_HTH_dom.
PfamiView protein in Pfam
PF13411. MerR_1. 1 hit.
PRINTSiPR00040. HTHMERR.
SMARTiView protein in SMART
SM00422. HTH_MERR. 1 hit.
SUPFAMiSSF46955. SSF46955. 1 hit.
TIGRFAMsiTIGR02044. CueR. 1 hit.
PROSITEiView protein in PROSITE
PS00552. HTH_MERR_1. 1 hit.
PS50937. HTH_MERR_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCUER_SALTY
AccessioniPrimary (citable) accession number: Q93CH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: December 1, 2001
Last modified: February 15, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.