Q93CA2 (Q93CA2_ENTCL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Beta-lactamase AmpC EMBL AAL05857.1
EC=3.5.2.6 EMBL AAL05857.1

Gene names

Name:

ampC EMBL AAL05857.1

Organism

Enterobacter cloacae EMBL AAL05857.1

Taxonomic identifier

550 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Enterobacter › Enterobacter cloacae complex

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

Ontologies

Keywords
Domain	Signal EMBL AAL05857.1
Molecular function	Hydrolase EMBL AAL05857.1
Technical term	3D-structure PDB 1S6R
Gene Ontology (GO)
Biological process	antibiotic catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	beta-lactamase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential EMBL AAL05857.1
	Chain	21 – 381	361	beta-lactamase AmpC EMBL AAL05857.1		PRO_5000061306

Sequences

	Sequence		Length	Mass (Da)
	Q93CA2 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 31A3C4659A361921	FASTA	381	41,342
	10 20 30 40 50 60 MMRKSLCCAL LLGISCSALA TPVSEKQLAE VVANTVTPLM KAQSVPGMAV AVIYQGKPHY 70 80 90 100 110 120 YTFGKADIAA NKPVTPQTLF ELGSISKTFT GVLGGDAIAR GEISLDDPVT RYWPQLTGKQ 130 140 150 160 170 180 WQGIRMLDLA TYTAGGLPLQ VPDEVTDNAS LLRFYQNWQP QWKPGTTRLY ANASIGLFGA 190 200 210 220 230 240 LAVKPSGMPY EQAMTTRVLK PLKLDHTWIN VPKAEEAHYA WGYRDGKAVR VSPGMLDAQA 250 260 270 280 290 300 YGVKTNVQDM ANWVMANMAP ENVADASLKQ GIALAQSRYW RIGSMYQGLG WEMLNWPVEA 310 320 330 340 350 360 NTVVEGSDSK VALAPLPVVE VNPPAPPVKA SWVHKTGSTG GFGSYVAFIP EKQIGIVMLA 370 380 NTSYPNPARV EAAYHILEAL Q

References

[1]	"Dissemination of SHV-12 and characterization of new AmpC-type beta-lactamase genes among clinical isolates of enterobacter species in Korea." Lee S.H., Kim J.Y., Shin S.H., An Y.J., Choi Y.W., Jung Y.C., Jung H.I., Sohn E.S., Jeong S.H., Lee K.J. J. Clin. Microbiol. 41:2477-2482(2003) [PubMed: 12791868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: K9973 EMBL AAL05857.1.
[2]	"Biochemical characterization of type A and type B beta-lactamase from Enterobacter cloacae." Then R.L., Charnas R.L., Kocher H.P., Manneberg M., Rothlisberger U., Stocker J. Rev. Infect. Dis. 10:714-720(1988) [PubMed: 3263683] [Abstract] Cited for: PROTEIN SEQUENCE.
[3]	"Crystal structure of Enterobacter cloacae 908R class C beta-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue." Wouters J., Fonze E., Vermeire M., Frere J.M., Charlier P. Cell. Mol. Life Sci. 60:1764-1773(2003) [PubMed: 14521155] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 23-375.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF411148 Genomic DNA. Translation: AAL05857.1.

PIR

B60908.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1S6R	X-ray	2.24	A	23-375	[»]

ProteinModelPortal

Q93CA2.

SMR

Q93CA2. Positions 23-381.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]

Gene3D

G3DSA:3.40.710.10. G3DSA:3.40.710.10. 1 hit.

Pfam

PF00144. Beta-lactamase. 1 hit.
[Graphical view]

SUPFAM

SSF56601. PBP_transp_fold. 1 hit.

PROSITE

PS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q93CA2_ENTCL

Accession

Primary (citable) accession number: Q93CA2

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	April 5, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)