Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q93AR9 (HPPA2_MYCDI)

Last modified January 19, 2010. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Pyrophosphate-energized proton pump 2
    EC=3.6.1.1
Alternative name(s):
    Pyrophosphate-energized inorganic pyrophosphatase 2
      Short name=H(+)-PPase 2
    Membrane-bound proton-translocating pyrophosphatase 2
Gene names
Name: hppA2
OrganismMycoplana dimorpha
Taxonomic identifier28320 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeMycoplana

Protein attributes

Sequence length208 AA.
Sequence statusFragment.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Generates a proton motive force; it probably catalyzes a fully reversible reaction, thus being able to synthesize pyrophosphate when the proton motive force is sufficient By similarity. HAMAP MF_01130

Catalytic activity

Diphosphate + H2O = 2 phosphate. HAMAP MF_01130

Cofactor

Magnesium By similarity. HAMAP MF_01130

Subunit structure

Homodimer Potential. HAMAP MF_01130

Subcellular location

Cell membrane; Multi-pass membrane protein Probable HAMAP MF_01130.

Sequence similarities

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. Type 2 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›208›208Pyrophosphate-energized proton pump 2 HAMAP MF_01130
PRO_0000217020

Regions

Transmembrane20 – 4223 Potential
Transmembrane55 – 7723 Potential
Transmembrane87 – 10923 Potential
Transmembrane164 – 18623 Potential

Experimental info

Non-terminal residue11
Non-terminal residue2081

Sequences

Sequence LengthMass (Da)Tools
Q93AR9-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5A5345C538A8950E

FASTA20820,704
        10         20         30         40         50         60 
MVLAAIFFGG TPILATAMAY PLAICAACVI TSIIGTFFVK LGTNNSIMGA LYKGLIVTGA 

        70         80         90        100        110        120 
LSILGLGAAT SFTIGWGSIG TVGGIEVRGG NLFVCGLIGL VVTALIVVIT EYYTGTNKRP 

       130        140        150        160        170        180 
VNSIAQASVT GHGTNVIQGL AVSLESTALP AIVIVGGIIA TYQLAGLFGT AIAVTAMLGL 

       190        200 
AGMIVALDAF GPVTDNAGGI AEMSHLSP 

« Hide

References

[1]"High prevalence of the H+-proton-pumping inorganic pyrophosphatase gene in alpha proteobacteria and evidence of lateral transfer in its phylogeny."
Jumas-Bilak E., Michaux-Charachon S., Teyssier C.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 4279 / DSM 7138 / IFO 13291 / NCIMB 9439.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF417518 Genomic DNA. Translation: AAL18698.1.

3D structure databases

ModBaseSearch...

Enzyme and pathway databases

BRENDA3.6.1.1. 66799.

Family and domain databases

HAMAPMF_01130. H_PPase_type2.
[Tree]
InterProIPR004131. H_PPase.
[Graphical view]
PfamPF03030. H_PPase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHPPA2_MYCDI
AccessionPrimary (citable) accession number: Q93AR9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: December 1, 2001
Last modified: January 19, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents