Q93AR9 (HPPA2_MYCDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrophosphate-energized proton pump 2
EC=3.6.1.1

Alternative name(s):
Membrane-bound proton-translocating pyrophosphatase 2
Pyrophosphate-energized inorganic pyrophosphatase 2
Short name=H(+)-PPase 2

Gene names

Name:

hppA2

Organism

Mycoplana dimorpha

Taxonomic identifier

28320 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Mycoplana

Protein attributes

Sequence length	208 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force By similarity. HAMAP MF_01129
Catalytic activity	Diphosphate + H2O = 2 phosphate. HAMAP MF_01129
Cofactor	Magnesium By similarity. HAMAP MF_01129
Subunit structure	Homodimer By similarity. HAMAP MF_01129
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01129.
Sequence similarities	Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. [View classification]

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Magnesium
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	proton transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrogen-translocating pyrophosphatase activity Inferred from electronic annotation. Source: InterPro inorganic diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›208	›208	Pyrophosphate-energized proton pump 2 HAMAP MF_01129		PRO_0000217020
Regions
	Transmembrane	19 – 39	21	Helical; Potential
	Transmembrane	54 – 74	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	140 – 160	21	Helical; Potential
	Transmembrane	167 – 187	21	Helical; Potential
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	208	1

Sequences

	Sequence		Length	Mass (Da)
	Q93AR9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 5A5345C538A8950E	FASTA	208	20,704
	10 20 30 40 50 60 MVLAAIFFGG TPILATAMAY PLAICAACVI TSIIGTFFVK LGTNNSIMGA LYKGLIVTGA 70 80 90 100 110 120 LSILGLGAAT SFTIGWGSIG TVGGIEVRGG NLFVCGLIGL VVTALIVVIT EYYTGTNKRP 130 140 150 160 170 180 VNSIAQASVT GHGTNVIQGL AVSLESTALP AIVIVGGIIA TYQLAGLFGT AIAVTAMLGL 190 200 AGMIVALDAF GPVTDNAGGI AEMSHLSP

References

[1]

"High prevalence of the H+-proton-pumping inorganic pyrophosphatase gene in alpha proteobacteria and evidence of lateral transfer in its phylogeny." Jumas-Bilak E., Michaux-Charachon S., Teyssier C. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 4279 / DSM 7138 / JCM 20847 / NBRC 13291 / NCIMB 9439 / NRRL B-1091.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF417518 Genomic DNA. Translation: AAL18698.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01129. PPase-energized_pump. [Tree]
InterPro	IPR004131. PPase-energised_H-pump. [Graphical view]
Pfam	PF03030. H_PPase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HPPA2_MYCDI

Accession

Primary (citable) accession number: Q93AR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	December 1, 2001
Last modified:	May 31, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program