Q93AR8 (HPPA1_MYCDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrophosphate-energized proton pump 1
EC=3.6.1.1

Alternative name(s):
Membrane-bound proton-translocating pyrophosphatase 1
Pyrophosphate-energized inorganic pyrophosphatase 1
Short name=H(+)-PPase 1

Gene names

Name:

hppA1

Organism

Mycoplana dimorpha

Taxonomic identifier

28320 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Mycoplana

Protein attributes

Sequence length	225 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force By similarity. HAMAP MF_01129
Catalytic activity	Diphosphate + H2O = 2 phosphate. HAMAP MF_01129
Cofactor	Magnesium By similarity. HAMAP MF_01129
Subunit structure	Homodimer By similarity. HAMAP MF_01129
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01129.
Sequence similarities	Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. [View classification]

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Magnesium
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	proton transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrogen-translocating pyrophosphatase activity Inferred from electronic annotation. Source: InterPro inorganic diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›225	›225	Pyrophosphate-energized proton pump 1 HAMAP MF_01129		PRO_0000217019
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	47 – 67	21	Helical; Potential
	Transmembrane	116 – 136	21	Helical; Potential
	Transmembrane	143 – 163	21	Helical; Potential
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	225	1

Sequences

	Sequence		Length	Mass (Da)
	Q93AR8 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 74C9181011D85377	FASTA	225	23,382
	10 20 30 40 50 60 AIGSAGLGAL VLFAAYSNDL SYFAANGDKY PYFANIGEIS FDLSNPYVVA GLIFGGLIPY 70 80 90 100 110 120 LFGGIAMTAV GRAAGSIVEE VRRQFKEKPG IMQGKDKPNY GRAVDLLTKA AIREMIVPSL 130 140 150 160 170 180 LPVLAPLVVY FGVLLISGSK ASAFAALGAS LLGVIVNGLF VAISMTSGGG AWDNAKKSFE 190 200 210 220 DGFVDKDGQR HMKGSEAHKA SVTGDTVGDP YKDTAGPAVN PAIKI

References

[1]

"High prevalence of the H+-proton-pumping inorganic pyrophosphatase gene in alpha proteobacteria and evidence of lateral transfer in its phylogeny." Jumas-Bilak E., Michaux-Charachon S., Teyssier C. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 4279 / DSM 7138 / JCM 20847 / NBRC 13291 / NCIMB 9439 / NRRL B-1091.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF417519 Genomic DNA. Translation: AAL18699.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01129. PPase-energized_pump. [Tree]
InterPro	IPR004131. PPase-energised_H-pump. [Graphical view]
Pfam	PF03030. H_PPase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HPPA1_MYCDI

Accession

Primary (citable) accession number: Q93AR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	December 1, 2001
Last modified:	May 31, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program