Q938W0 (HIS22_BRAJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-ATP pyrophosphatase 2
Short name=PRA-PH 2
EC=3.6.1.31

Gene names

Name:	hisE2
Synonyms:	his2
Ordered Locus Names:	blr1323

Organism

Bradyrhizobium japonicum

Taxonomic identifier

375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity HAMAP MF_01020.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 134	134	Phosphoribosyl-ATP pyrophosphatase 2 HAMAP MF_01020		PRO_0000136351

Sequences

	Sequence		Length	Mass (Da)
	Q938W0 [UniParc]. Last modified February 28, 2003. Version 2. Checksum: 5702192AE3F55077	FASTA	134	14,894
	10 20 30 40 50 60 MSDSLERLYL AVLAARDLDP ATSRTARLFQ RGPSKMAKKL AEEAIEVVID AVNGDTDAVV 70 80 90 100 110 120 RESADLLYNL TVLWASAGVR PEDVWREMTR REDMLGIAEK LPKSAMKLPK VASPRVAARR 130 PIVALEGRTA RKRH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A TnKPK2 insertion in the B. japonicum aspA gene causes the formation of inflated symbiosomes within infected soybean nodule cells." Mueller P. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: USDA 110spc4.
[2]	"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110." Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S. DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA 110.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY046315 Genomic DNA. Translation: AAL02318.2. BA000040 Genomic DNA. Translation: BAC46588.1.
RefSeq	NP_767963.1. NC_004463.1.
3D structure databases
ProteinModelPortal	Q938W0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1053380.
GenomeReviews	Gene locus blr1323 in contig BA000040_GR.
KEGG	bja:blr1323.
NMPDR	fig|224911.1.peg.1323.
PATRIC	21186200. VBIBraJap65052_1368.
Phylogenomic databases
HOGENOM	HBG646527.
OMA	DDVWAEM.
ProtClustDB	CLSK818515.
Enzyme and pathway databases
BioCyc	BJAP224911:BLR1323-MONOMER.
Family and domain databases
HAMAP	MF_01020. HisE. [Tree]
InterPro	IPR008179. PRib-ATP_PPHydrolase. IPR021130. PRib-ATP_PPHydrolase-like. [Graphical view]
KO	K01523.
Pfam	PF01503. PRA-PH. 1 hit. [Graphical view]
TIGRFAMs	TIGR03188. Histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS22_BRAJA

Accession

Primary (citable) accession number: Q938W0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	February 28, 2003
Last modified:	January 25, 2012
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program