Reviewed, UniProtKB/Swiss-Prot Q938P0 (MSRAB_STRP3)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA/msrB
Including the following 2 domains:
    1- Recommended name:
            Peptide methionine sulfoxide reductase msrA
                Short name=Protein-methionine-S-oxide reductase
              EC=1.8.4.11
        Alternative name(s):
            Peptide-methionine (S)-S-oxide reductase
              Short name=Peptide Met(O) reductase
    2- Recommended name:
            Peptide methionine sulfoxide reductase msrB
              EC=1.8.4.12
        Alternative name(s):
            Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrAB
Synonyms:	msrA.1
Ordered Locus Names:	SpyM3_1267, SPs0596

Organism

Streptococcus pyogenes serotype M3 [Complete proteome] [HAMAP]

Taxonomic identifier

301448 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.
Sequence similarities	In the N-terminal section; belongs to the msrA Met sulfoxide reductase family. In the C-terminal section; belongs to the msrB Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Peptide methionine sulfoxide reductase msrA/msrB HAMAP MF_01400		PRO_0000138522
Regions
	Region	1 – 153	153	Peptide methionine sulfoxide reductase A HAMAP MF_01400
	Region	170 – 293	124	Peptide methionine sulfoxide reductase B HAMAP MF_01400
Sites
	Active site	8	1	By similarity
	Active site	282	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q938P0-1 [UniParc]. Last modified September 19, 2002. Version 2. Checksum: 5EC7635006D09537	FASTA	309	35,161
	10 20 30 40 50 60 MIYLAEGCFW GVEEYFSQVD GVLDAVSGYA NGRGDTTNYQ LIHQTGHAET VEVTYDANRI 70 80 90 100 110 120 SLKELLLHFF RIIDPTSLNK QGNDRGSQYR TGIYYTDKAD LAIIDEVFKE KAKDYKKKIV 130 140 150 160 170 180 VEKAPLKHFI KAEEYHQDYL KKNPNGYCHI DINQATYPVI DESKYPKPSA TEIKAKLSAD 190 200 210 220 230 240 EYRVTQKNET EKAFSNRYWD SFDAGIYVDV VTGEPLFSSK DKFESGCGWP SFSRPISPDV 250 260 270 280 290 300 VRYKEDKSFN MTRTEVRSRS GNSHLGHVFT DGPKDQGGLR YCINSLSITF IPKADMEAKG YGYLLSSVE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequence of temperate phage PhiNIH1.1." Ikebe T., Wada A., Inagaki Y., Sugama K., Tanaka D., Suzuki R., Katsukawa C., Fujinaga Y., Abe Y., Watanabe H. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NIH1 / Serotype M3,T3.
[2]	"Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence." Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed: 12122206] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-595 / MGAS315 / Serotype M3.
[3]	"Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution." Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y., Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H., Hattori M., Hamada S. Genome Res. 13:1042-1055(2003) [PubMed: 12799345] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SSI-1 / Serotype M3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY050245 Genomic DNA. Translation: AAL15042.1. Different initiation. AE014074 Genomic DNA. Translation: AAM79874.1. Different initiation. BA000034 Genomic DNA. Translation: BAC63691.1. Different initiation.
RefSeq	NP_665071.1. NP_801858.1.
3D structure databases
HSSP	HSSP built from PDB template 1L1D based on UniProtKB P14930.
ModBase	Search...
Genome annotation databases
GeneID	1009582. 1066660.
GenomeReviews	Gene locus SpyM3_1267 in contig AE014074_GR. Gene locus msrAB in contig AY050245_GR. Gene locus SPs0596 in contig BA000034_GR.
KEGG	spg:SpyM3_1267. sps:SPs0596.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q938P0.
Enzyme and pathway databases
BioCyc	SPYO193567:SPS0596-MON. SPYO198466:SPYM3_1267-MON.
Family and domain databases
HAMAP	MF_01400. Fused. [Tree] MF_01401. Fused. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR002569. MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit. G3DSA:2.170.150.20. MsrB. 1 hit.
Pfam	PF01625. PMSR. 1 hit. PF01641. SelR. 1 hit. [Graphical view]
ProDom	PD004057. DUF25. 1 hit. PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit. TIGR00357. MsrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRAB_STRP3

Accession

Primary (citable) accession number: Q938P0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	September 19, 2002
Last modified:	March 3, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)