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Q93873

- NDUS2_CAEEL

UniProt

Q93873 - NDUS2_CAEEL

Protein

Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

Gene

gas-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    Cofactori

    Binds 1 4Fe-4S cluster.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi345 – 3451Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi351 – 3511Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi366 – 3661Iron-sulfur (4Fe-4S)Sequence Analysis

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. NAD binding Source: InterPro
    4. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    5. quinone binding Source: InterPro

    GO - Biological processi

    1. mitochondrial electron transport, NADH to ubiquinone Source: WormBase
    2. response to drug Source: WormBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-49kD
    Short name:
    CI-49kD
    NADH-ubiquinone oxidoreductase 49 kDa subunit
    Gene namesi
    Name:gas-1
    ORF Names:K09A9.5
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiK09A9.5; CE11980; WBGene00001520; gas-1.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. intracellular membrane-bounded organelle Source: WormBase
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 482Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialPRO_0000019983
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiQ93873.
    PRIDEiQ93873.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme By similarity.By similarity

    Protein-protein interaction databases

    STRINGi6239.K09A9.5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93873.
    SMRiQ93873. Positions 99-482.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 49 kDa subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0649.
    GeneTreeiENSGT00390000009529.
    HOGENOMiHOG000228264.
    InParanoidiQ93873.
    KOiK03935.
    OMAiARFTINY.
    OrthoDBiEOG7WT411.
    PhylomeDBiQ93873.

    Family and domain databases

    Gene3Di1.10.645.10. 1 hit.
    HAMAPiMF_01358. NDH1_NuoD.
    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    TIGRFAMsiTIGR01962. NuoD. 1 hit.
    PROSITEiPS00535. COMPLEX1_49K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q93873-1 [UniParc]FASTAAdd to Basket

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    MLGRKIAGTC LRANVPSVAA TSSTPATQTR NSHTIWYPDA KFERQFKTGG    50
    TLGKLWMSER VSDFDEKIGL DKLEKLAYSD PVMSDNYSGK QREKNLENMI 100
    LNFGPQHPAA HGVLRLVLKL EGEVIIKAIP HIGLLHRATE KLIEHKTYTQ 150
    ALPYFDRLDY VSMMCNEQAW SLAVEKLLGI DIPTRAKYIR TLMGELTRIQ 200
    NHIMGITTHA LDVGAMTPFF WMFEEREKLF EFSERVSGAR MHANYVRPGG 250
    VAWDLPIGLM DDIYDWAIKF PERIDELEDM LTENRIWKAR TIDIGLVSAA 300
    DALNWGFSGV MVRGSGIKQD VRKTEPYDAY ADMEFDVPIG TKGDCYDRYL 350
    CRIEEMRQSL NIVHQCLNKM PAGEIKVDDH KVVPPKRAEM KENMESLIHH 400
    FKFFTEGFQV PPGATYVPIE APKGEFGVYL VADGTGKPYR CFIRAPGFAH 450
    LAAIHDVCYM SLIADIVAVI GTMDIVFGEV DR 482
    Length:482
    Mass (Da):54,563
    Last modified:January 1, 1998 - v2
    Checksum:iACF06535338418B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z79601 Genomic DNA. Translation: CAB01886.1.
    PIRiT23532.
    RefSeqiNP_510569.1. NM_078168.4.
    UniGeneiCel.8011.

    Genome annotation databases

    EnsemblMetazoaiK09A9.5; K09A9.5; WBGene00001520.
    GeneIDi181646.
    KEGGicel:CELE_K09A9.5.
    UCSCiK09A9.5. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z79601 Genomic DNA. Translation: CAB01886.1 .
    PIRi T23532.
    RefSeqi NP_510569.1. NM_078168.4.
    UniGenei Cel.8011.

    3D structure databases

    ProteinModelPortali Q93873.
    SMRi Q93873. Positions 99-482.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.K09A9.5.

    Proteomic databases

    PaxDbi Q93873.
    PRIDEi Q93873.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai K09A9.5 ; K09A9.5 ; WBGene00001520 .
    GeneIDi 181646.
    KEGGi cel:CELE_K09A9.5.
    UCSCi K09A9.5. c. elegans.

    Organism-specific databases

    CTDi 181646.
    WormBasei K09A9.5 ; CE11980 ; WBGene00001520 ; gas-1.

    Phylogenomic databases

    eggNOGi COG0649.
    GeneTreei ENSGT00390000009529.
    HOGENOMi HOG000228264.
    InParanoidi Q93873.
    KOi K03935.
    OMAi ARFTINY.
    OrthoDBi EOG7WT411.
    PhylomeDBi Q93873.

    Miscellaneous databases

    NextBioi 914808.

    Family and domain databases

    Gene3Di 1.10.645.10. 1 hit.
    HAMAPi MF_01358. NDH1_NuoD.
    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    TIGRFAMsi TIGR01962. NuoD. 1 hit.
    PROSITEi PS00535. COMPLEX1_49K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiNDUS2_CAEEL
    AccessioniPrimary (citable) accession number: Q93873
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3