Reviewed, UniProtKB/Swiss-Prot Q93841 (PLC1_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-1
      Short name=1-AGP acyltransferase
      Short name=1-AGPAT
    EC=2.3.1.51
Alternative name(s):
    Lysophosphatidic acid acyltransferase
      Short name=LPAAT

Gene names

Name:	acl-1
ORF Names:	F59F4.4

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone By similarity.
Catalytic activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-acylglycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-1		PRO_0000208202
Regions
	Transmembrane	3 – 23	21	Potential
	Transmembrane	29 – 49	21	Potential
	Transmembrane	89 – 109	21	Potential
	Motif	94 – 99	6	HXXXXD motif

Sequences

	Sequence		Length	Mass (Da)
	Q93841-1 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: 0361FE6C9710593E	FASTA	262	29,638
	10 20 30 40 50 60 MTFLAILFVI AVLLLLAQLP VIGFYIRAVY FGMCLIIGGF LGGLASIPFG KSPNNHFRMF 70 80 90 100 110 120 KIFQAMTWPM GVRFELRNSE ILHDKKPYII IANHQSALDV LGMSFAWPVD CVVMLKSSLK 130 140 150 160 170 180 YLPGFNLCAY LCDSVYINRF SKEKALKTVD TTLHEIVTKK RKVWIYPEGT RNAEPELLPF 190 200 210 220 230 240 KKGAFILAKQ AKIPIVPCVF SSHKFFYSHA EKRLTSGNCI IDILPEVDSS KFDSIDDLSA 250 260 HCRKIMQAHR EKLDAEAANL NI

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z81095, Z81089 Genomic DNA. Translation: CAB03160.1. Z81089, Z81095 Genomic DNA. Translation: CAB03139.1.
PIR	T22599.
RefSeq	NP_510606.1.
UniGene	Cel.823
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q93841.
Genome annotation databases
Ensembl	F59F4.4; F59F4.4; F59F4.4; Caenorhabditis elegans. [Genome view]
GeneID	181671.
KEGG	cel:F59F4.4.
NMPDR	fig|6239.3.peg.25503.
UCSC	F59F4.4. c. elegans.
Organism-specific databases
CTD	181671.
WormBase	WBGene00010339. acl-1.
WormPep	F59F4.4. CE11552. [WorfDB]
Phylogenomic databases
eggNOG	meNOG11486.
HOGENOM	HBG736534.
InParanoid	Q93841.
OMA	FNLCAYL.
PhylomeDB	Q93841.
Enzyme and pathway databases
BRENDA	2.3.1.51. 672.
Gene expression databases
ArrayExpress	Q93841.
Family and domain databases
InterPro	IPR002123. Acyltransferase. IPR004552. AGP_acyltrans. [Graphical view]
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00530. AGP_acyltrn. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	914894.

Entry information

Entry name

PLC1_CAEEL

Accession

Primary (citable) accession number: Q93841
Secondary accession number(s): Q93783

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	February 9, 2010
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project