Q93841 (PLC1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-1
Short name=1-AGP acyltransferase
Short name=1-AGPAT
EC=2.3.1.51

Alternative name(s):
Lysophosphatidic acid acyltransferase
Short name=LPAAT

Gene names

Name:	acl-1
ORF Names:	F59F4.4

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone By similarity.
Catalytic activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-acylglycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-1		PRO_0000208202
Regions
	Transmembrane	3 – 23	21	Helical; Potential
	Transmembrane	29 – 49	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Motif	94 – 99	6	HXXXXD motif

Sequences

	Sequence		Length	Mass (Da)
	Q93841 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: 0361FE6C9710593E	FASTA	262	29,638
	10 20 30 40 50 60 MTFLAILFVI AVLLLLAQLP VIGFYIRAVY FGMCLIIGGF LGGLASIPFG KSPNNHFRMF 70 80 90 100 110 120 KIFQAMTWPM GVRFELRNSE ILHDKKPYII IANHQSALDV LGMSFAWPVD CVVMLKSSLK 130 140 150 160 170 180 YLPGFNLCAY LCDSVYINRF SKEKALKTVD TTLHEIVTKK RKVWIYPEGT RNAEPELLPF 190 200 210 220 230 240 KKGAFILAKQ AKIPIVPCVF SSHKFFYSHA EKRLTSGNCI IDILPEVDSS KFDSIDDLSA 250 260 HCRKIMQAHR EKLDAEAANL NI

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z81095, Z81089 Genomic DNA. Translation: CAB03160.1. Z81089, Z81095 Genomic DNA. Translation: CAB03139.1.
PIR	T22599.
RefSeq	NP_510606.1. NM_078205.4.
UniGene	Cel.823.
3D structure databases
ProteinModelPortal	Q93841.
ModBase	Search...
Protein-protein interaction databases
STRING	Q93841.
Proteomic databases
PRIDE	Q93841.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F59F4.4; F59F4.4; F59F4.4.
GeneID	181671.
KEGG	cel:F59F4.4.
NMPDR	fig|6239.3.peg.25503.
UCSC	F59F4.4. c. elegans.
Organism-specific databases
CTD	181671.
WormBase	F59F4.4; CE11552; WBGene00010339; acl-1.
Phylogenomic databases
eggNOG	meNOG11486.
GeneTree	EMGT00050000007043.
HOGENOM	HBG736534.
InParanoid	Q93841.
OMA	IFQAMTW.
PhylomeDB	Q93841.
Gene expression databases
ArrayExpress	Q93841.
Family and domain databases
InterPro	IPR002123. Acyltransferase. IPR004552. AGP_acyltrans. [Graphical view]
KO	K13509.
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00530. AGP_acyltrn. 1 hit.
ProtoNet	Search...
Other
NextBio	914894.

Entry information

Entry name

PLC1_CAEEL

Accession

Primary (citable) accession number: Q93841
Secondary accession number(s): Q93783

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	November 16, 2011
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project