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Q937F6

- XPKA_LACPE

UniProt

Q937F6 - XPKA_LACPE

Protein

Xylulose-5-phosphate phosphoketolase

Gene

xpkA

Organism
Lactobacillus pentosus
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O.

    Cofactori

    Thiamine pyrophosphate.Curated

    GO - Molecular functioni

    1. phosphoketolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Thiamine pyrophosphate

    Enzyme and pathway databases

    BRENDAi4.1.2.9. 2886.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylulose-5-phosphate phosphoketolase (EC:4.1.2.9)
    Gene namesi
    Name:xpkA
    OrganismiLactobacillus pentosus
    Taxonomic identifieri1589 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 788787Xylulose-5-phosphate phosphoketolasePRO_0000193868Add
    BLAST

    Expressioni

    Inductioni

    Induced by sugars that are fermented by the phosphoketolase pathway (PKP) and repressed by glucose mediated by carbon catabolite protein A and by the mannose phosphoenolpyruvate phosphotransferase system.

    Interactioni

    Subunit structurei

    Homohexamer.Curated

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the XFP family.Curated

    Family and domain databases

    Gene3Di3.40.50.970. 1 hit.
    HAMAPiMF_01403. Phosphoketolase.
    InterProiIPR023962. Phosphoketolase.
    IPR029061. THDP-binding.
    IPR005593. Xul5P/Fru6P_PKetolase.
    IPR018969. Xul5P/Fru6P_PKetolase_C.
    IPR019790. Xul5P/Fru6P_PKetolase_CS.
    IPR018970. Xul5P/Fru6P_PKetolase_N.
    IPR019789. Xul5P/Fru6P_PKetolase_ThDP_BS.
    [Graphical view]
    PfamiPF03894. XFP. 1 hit.
    PF09363. XFP_C. 1 hit.
    PF09364. XFP_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017245. Phosphoketolase. 1 hit.
    SUPFAMiSSF52518. SSF52518. 2 hits.
    PROSITEiPS60002. PHOSPHOKETOLASE_1. 1 hit.
    PS60003. PHOSPHOKETOLASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q937F6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTDYSSPAY LQKVDKYWRA ANYLSVGQLY LKDNPLLQRP LKASDVKVHP    50
    IGHWGTIAGQ NFIYAHLNRV INKYGLKMFY VEGPGHGGQV MVSNSYLDGT 100
    YTDIYPEITQ DVEGMQKLFK QFSFPGGVAS HAAPETPGSI HEGGELGYSI 150
    SHGVGAILDN PDEIAAVVVG DGESETGPLA TSWQSTKFIN PINDGAVLPI 200
    LNLNGFKISN PTIFGRTSDE KIKQYFESMN WEPIFVEGDD PEKVHPALAK 250
    AMDEAVEKIK AIQKNAREND DATLPVWPMI VFRAPKGWTG PKSWDGDKIE 300
    GSFRAHQIPI PVDQTDMEHA DALVDWLESY QPKELFNEDG SLKDDIKEII 350
    PTGDARMAAN PITNGGVDPK ALNLPNFRDY AVDTSKHGAN VKQDMIVWSD 400
    YLRDVIKKNP DNFRLFGPDE TMSNRLYGVF ETTNRQWMED IHPDSDQYEA 450
    PAGRVLDAQL SEHQAEGWLE GYVLTGRHGL FASYEAFLRV VDSMLTQHFK 500
    WLRKANELDW RKKYPSLNII AASTVFQQDH NGYTHQDPGA LTHLAEKKPE 550
    YIREYLPADA NSLLAVGDVI FRSQEKINYV VTSKHPRQQW FSIEEAKQLV 600
    DNGLGIIDWA STDQGSEPDI VFAAAGTEPT LETLAAIQLL HDSFPDMKIR 650
    FVNVVDILKL RSPEKDPRGL SDAEFDHYFT KDKPVVFAFH GYEDLVRDIF 700
    FDRHNHNLHV HGYRENGDIT TPFDVRVMNQ MDRFDLAKSA IAAQPAMENT 750
    GAAFVQDMDN MLAKHNAYIR DAGTDLPEVN DWQWKGLK 788
    Length:788
    Mass (Da):88,705
    Last modified:January 23, 2007 - v3
    Checksum:iC9AE9E7819CF8753
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ309011 Genomic DNA. Translation: CAC84393.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ309011 Genomic DNA. Translation: CAC84393.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 4.1.2.9. 2886.

    Family and domain databases

    Gene3Di 3.40.50.970. 1 hit.
    HAMAPi MF_01403. Phosphoketolase.
    InterProi IPR023962. Phosphoketolase.
    IPR029061. THDP-binding.
    IPR005593. Xul5P/Fru6P_PKetolase.
    IPR018969. Xul5P/Fru6P_PKetolase_C.
    IPR019790. Xul5P/Fru6P_PKetolase_CS.
    IPR018970. Xul5P/Fru6P_PKetolase_N.
    IPR019789. Xul5P/Fru6P_PKetolase_ThDP_BS.
    [Graphical view ]
    Pfami PF03894. XFP. 1 hit.
    PF09363. XFP_C. 1 hit.
    PF09364. XFP_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017245. Phosphoketolase. 1 hit.
    SUPFAMi SSF52518. SSF52518. 2 hits.
    PROSITEi PS60002. PHOSPHOKETOLASE_1. 1 hit.
    PS60003. PHOSPHOKETOLASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of the xylulose 5-phosphate phosphoketolase gene, xpkA, from Lactobacillus pentosus MD363 is induced by sugars that are fermented via the phosphoketolase pathway and is repressed by glucose mediated by CcpA and the mannose phosphoenolpyruvate phosphotransferase system."
      Posthuma C.C., Bader R., Engelmann R., Postma P.W., Hengstenberg W., Pouwels P.H.
      Appl. Environ. Microbiol. 68:831-837(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-32; 478-489 AND 651-659, FUNCTION.
      Strain: MD363.

    Entry informationi

    Entry nameiXPKA_LACPE
    AccessioniPrimary (citable) accession number: Q937F6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 42 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3