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Q937F6

- XPKA_LACPE

UniProt

Q937F6 - XPKA_LACPE

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Protein

Xylulose-5-phosphate phosphoketolase

Gene

xpkA

Organism
Lactobacillus pentosus
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O.

Cofactori

Thiamine pyrophosphate.Curated

GO - Molecular functioni

  1. phosphoketolase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BRENDAi4.1.2.9. 2886.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylulose-5-phosphate phosphoketolase (EC:4.1.2.9)
Gene namesi
Name:xpkA
OrganismiLactobacillus pentosus
Taxonomic identifieri1589 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 788787Xylulose-5-phosphate phosphoketolasePRO_0000193868Add
BLAST

Expressioni

Inductioni

Induced by sugars that are fermented by the phosphoketolase pathway (PKP) and repressed by glucose mediated by carbon catabolite protein A and by the mannose phosphoenolpyruvate phosphotransferase system.

Interactioni

Subunit structurei

Homohexamer.Curated

Family & Domainsi

Sequence similaritiesi

Belongs to the XFP family.Curated

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
HAMAPiMF_01403. Phosphoketolase.
InterProiIPR023962. Phosphoketolase.
IPR029061. THDP-binding.
IPR005593. Xul5P/Fru6P_PKetolase.
IPR018969. Xul5P/Fru6P_PKetolase_C.
IPR019790. Xul5P/Fru6P_PKetolase_CS.
IPR018970. Xul5P/Fru6P_PKetolase_N.
IPR019789. Xul5P/Fru6P_PKetolase_ThDP_BS.
[Graphical view]
PfamiPF03894. XFP. 1 hit.
PF09363. XFP_C. 1 hit.
PF09364. XFP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF017245. Phosphoketolase. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
PROSITEiPS60002. PHOSPHOKETOLASE_1. 1 hit.
PS60003. PHOSPHOKETOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q937F6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTDYSSPAY LQKVDKYWRA ANYLSVGQLY LKDNPLLQRP LKASDVKVHP
60 70 80 90 100
IGHWGTIAGQ NFIYAHLNRV INKYGLKMFY VEGPGHGGQV MVSNSYLDGT
110 120 130 140 150
YTDIYPEITQ DVEGMQKLFK QFSFPGGVAS HAAPETPGSI HEGGELGYSI
160 170 180 190 200
SHGVGAILDN PDEIAAVVVG DGESETGPLA TSWQSTKFIN PINDGAVLPI
210 220 230 240 250
LNLNGFKISN PTIFGRTSDE KIKQYFESMN WEPIFVEGDD PEKVHPALAK
260 270 280 290 300
AMDEAVEKIK AIQKNAREND DATLPVWPMI VFRAPKGWTG PKSWDGDKIE
310 320 330 340 350
GSFRAHQIPI PVDQTDMEHA DALVDWLESY QPKELFNEDG SLKDDIKEII
360 370 380 390 400
PTGDARMAAN PITNGGVDPK ALNLPNFRDY AVDTSKHGAN VKQDMIVWSD
410 420 430 440 450
YLRDVIKKNP DNFRLFGPDE TMSNRLYGVF ETTNRQWMED IHPDSDQYEA
460 470 480 490 500
PAGRVLDAQL SEHQAEGWLE GYVLTGRHGL FASYEAFLRV VDSMLTQHFK
510 520 530 540 550
WLRKANELDW RKKYPSLNII AASTVFQQDH NGYTHQDPGA LTHLAEKKPE
560 570 580 590 600
YIREYLPADA NSLLAVGDVI FRSQEKINYV VTSKHPRQQW FSIEEAKQLV
610 620 630 640 650
DNGLGIIDWA STDQGSEPDI VFAAAGTEPT LETLAAIQLL HDSFPDMKIR
660 670 680 690 700
FVNVVDILKL RSPEKDPRGL SDAEFDHYFT KDKPVVFAFH GYEDLVRDIF
710 720 730 740 750
FDRHNHNLHV HGYRENGDIT TPFDVRVMNQ MDRFDLAKSA IAAQPAMENT
760 770 780
GAAFVQDMDN MLAKHNAYIR DAGTDLPEVN DWQWKGLK
Length:788
Mass (Da):88,705
Last modified:January 23, 2007 - v3
Checksum:iC9AE9E7819CF8753
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ309011 Genomic DNA. Translation: CAC84393.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ309011 Genomic DNA. Translation: CAC84393.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 4.1.2.9. 2886.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
HAMAPi MF_01403. Phosphoketolase.
InterProi IPR023962. Phosphoketolase.
IPR029061. THDP-binding.
IPR005593. Xul5P/Fru6P_PKetolase.
IPR018969. Xul5P/Fru6P_PKetolase_C.
IPR019790. Xul5P/Fru6P_PKetolase_CS.
IPR018970. Xul5P/Fru6P_PKetolase_N.
IPR019789. Xul5P/Fru6P_PKetolase_ThDP_BS.
[Graphical view ]
Pfami PF03894. XFP. 1 hit.
PF09363. XFP_C. 1 hit.
PF09364. XFP_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF017245. Phosphoketolase. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
PROSITEi PS60002. PHOSPHOKETOLASE_1. 1 hit.
PS60003. PHOSPHOKETOLASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of the xylulose 5-phosphate phosphoketolase gene, xpkA, from Lactobacillus pentosus MD363 is induced by sugars that are fermented via the phosphoketolase pathway and is repressed by glucose mediated by CcpA and the mannose phosphoenolpyruvate phosphotransferase system."
    Posthuma C.C., Bader R., Engelmann R., Postma P.W., Hengstenberg W., Pouwels P.H.
    Appl. Environ. Microbiol. 68:831-837(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-32; 478-489 AND 651-659, FUNCTION.
    Strain: MD363.

Entry informationi

Entry nameiXPKA_LACPE
AccessioniPrimary (citable) accession number: Q937F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 42 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3