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Q937F6

- XPKA_LACPE

UniProt

Q937F6 - XPKA_LACPE

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Protein
Xylulose-5-phosphate phosphoketolase
Gene
xpkA
Organism
Lactobacillus pentosus
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

Thiamine pyrophosphate Reviewed prediction.

GO - Molecular functioni

  1. phosphoketolase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BRENDAi4.1.2.9. 2886.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylulose-5-phosphate phosphoketolase (EC:4.1.2.9)
Gene namesi
Name:xpkA
OrganismiLactobacillus pentosus
Taxonomic identifieri1589 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 788787Xylulose-5-phosphate phosphoketolaseUniRule annotation
PRO_0000193868Add
BLAST

Expressioni

Inductioni

Induced by sugars that are fermented by the phosphoketolase pathway (PKP) and repressed by glucose mediated by carbon catabolite protein A and by the mannose phosphoenolpyruvate phosphotransferase system.UniRule annotation

Interactioni

Subunit structurei

Homohexamer Reviewed prediction.

Family & Domainsi

Sequence similaritiesi

Belongs to the XFP family.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
HAMAPiMF_01403. Phosphoketolase.
InterProiIPR023962. Phosphoketolase.
IPR029061. THDP-binding.
IPR005593. Xul5P/Fru6P_PKetolase.
IPR018969. Xul5P/Fru6P_PKetolase_C.
IPR019790. Xul5P/Fru6P_PKetolase_CS.
IPR018970. Xul5P/Fru6P_PKetolase_N.
IPR019789. Xul5P/Fru6P_PKetolase_ThDP_BS.
[Graphical view]
PfamiPF03894. XFP. 1 hit.
PF09363. XFP_C. 1 hit.
PF09364. XFP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF017245. Phosphoketolase. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
PROSITEiPS60002. PHOSPHOKETOLASE_1. 1 hit.
PS60003. PHOSPHOKETOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q937F6-1 [UniParc]FASTAAdd to Basket

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MSTDYSSPAY LQKVDKYWRA ANYLSVGQLY LKDNPLLQRP LKASDVKVHP    50
IGHWGTIAGQ NFIYAHLNRV INKYGLKMFY VEGPGHGGQV MVSNSYLDGT 100
YTDIYPEITQ DVEGMQKLFK QFSFPGGVAS HAAPETPGSI HEGGELGYSI 150
SHGVGAILDN PDEIAAVVVG DGESETGPLA TSWQSTKFIN PINDGAVLPI 200
LNLNGFKISN PTIFGRTSDE KIKQYFESMN WEPIFVEGDD PEKVHPALAK 250
AMDEAVEKIK AIQKNAREND DATLPVWPMI VFRAPKGWTG PKSWDGDKIE 300
GSFRAHQIPI PVDQTDMEHA DALVDWLESY QPKELFNEDG SLKDDIKEII 350
PTGDARMAAN PITNGGVDPK ALNLPNFRDY AVDTSKHGAN VKQDMIVWSD 400
YLRDVIKKNP DNFRLFGPDE TMSNRLYGVF ETTNRQWMED IHPDSDQYEA 450
PAGRVLDAQL SEHQAEGWLE GYVLTGRHGL FASYEAFLRV VDSMLTQHFK 500
WLRKANELDW RKKYPSLNII AASTVFQQDH NGYTHQDPGA LTHLAEKKPE 550
YIREYLPADA NSLLAVGDVI FRSQEKINYV VTSKHPRQQW FSIEEAKQLV 600
DNGLGIIDWA STDQGSEPDI VFAAAGTEPT LETLAAIQLL HDSFPDMKIR 650
FVNVVDILKL RSPEKDPRGL SDAEFDHYFT KDKPVVFAFH GYEDLVRDIF 700
FDRHNHNLHV HGYRENGDIT TPFDVRVMNQ MDRFDLAKSA IAAQPAMENT 750
GAAFVQDMDN MLAKHNAYIR DAGTDLPEVN DWQWKGLK 788
Length:788
Mass (Da):88,705
Last modified:January 23, 2007 - v3
Checksum:iC9AE9E7819CF8753
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ309011 Genomic DNA. Translation: CAC84393.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ309011 Genomic DNA. Translation: CAC84393.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 4.1.2.9. 2886.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
HAMAPi MF_01403. Phosphoketolase.
InterProi IPR023962. Phosphoketolase.
IPR029061. THDP-binding.
IPR005593. Xul5P/Fru6P_PKetolase.
IPR018969. Xul5P/Fru6P_PKetolase_C.
IPR019790. Xul5P/Fru6P_PKetolase_CS.
IPR018970. Xul5P/Fru6P_PKetolase_N.
IPR019789. Xul5P/Fru6P_PKetolase_ThDP_BS.
[Graphical view ]
Pfami PF03894. XFP. 1 hit.
PF09363. XFP_C. 1 hit.
PF09364. XFP_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF017245. Phosphoketolase. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
PROSITEi PS60002. PHOSPHOKETOLASE_1. 1 hit.
PS60003. PHOSPHOKETOLASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of the xylulose 5-phosphate phosphoketolase gene, xpkA, from Lactobacillus pentosus MD363 is induced by sugars that are fermented via the phosphoketolase pathway and is repressed by glucose mediated by CcpA and the mannose phosphoenolpyruvate phosphotransferase system."
    Posthuma C.C., Bader R., Engelmann R., Postma P.W., Hengstenberg W., Pouwels P.H.
    Appl. Environ. Microbiol. 68:831-837(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-32; 478-489 AND 651-659, FUNCTION.
    Strain: MD363.

Entry informationi

Entry nameiXPKA_LACPE
AccessioniPrimary (citable) accession number: Q937F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 41 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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