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Q937F6 (XPKA_LACPE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xylulose-5-phosphate phosphoketolase

EC=4.1.2.9
Gene names
Name:xpkA
OrganismLactobacillus pentosus
Taxonomic identifier1589 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length788 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_01403

Cofactor

Thiamine pyrophosphate Potential.

Subunit structure

Homohexamer Potential.

Induction

Induced by sugars that are fermented by the phosphoketolase pathway (PKP) and repressed by glucose mediated by carbon catabolite protein A and by the mannose phosphoenolpyruvate phosphotransferase system. HAMAP-Rule MF_01403

Sequence similarities

Belongs to the XFP family.

Ontologies

Keywords
   LigandThiamine pyrophosphate
   Molecular functionLyase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionphosphoketolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 788787Xylulose-5-phosphate phosphoketolase HAMAP-Rule MF_01403
PRO_0000193868

Sequences

Sequence LengthMass (Da)Tools
Q937F6 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: C9AE9E7819CF8753

FASTA78888,705
        10         20         30         40         50         60 
MSTDYSSPAY LQKVDKYWRA ANYLSVGQLY LKDNPLLQRP LKASDVKVHP IGHWGTIAGQ 

        70         80         90        100        110        120 
NFIYAHLNRV INKYGLKMFY VEGPGHGGQV MVSNSYLDGT YTDIYPEITQ DVEGMQKLFK 

       130        140        150        160        170        180 
QFSFPGGVAS HAAPETPGSI HEGGELGYSI SHGVGAILDN PDEIAAVVVG DGESETGPLA 

       190        200        210        220        230        240 
TSWQSTKFIN PINDGAVLPI LNLNGFKISN PTIFGRTSDE KIKQYFESMN WEPIFVEGDD 

       250        260        270        280        290        300 
PEKVHPALAK AMDEAVEKIK AIQKNAREND DATLPVWPMI VFRAPKGWTG PKSWDGDKIE 

       310        320        330        340        350        360 
GSFRAHQIPI PVDQTDMEHA DALVDWLESY QPKELFNEDG SLKDDIKEII PTGDARMAAN 

       370        380        390        400        410        420 
PITNGGVDPK ALNLPNFRDY AVDTSKHGAN VKQDMIVWSD YLRDVIKKNP DNFRLFGPDE 

       430        440        450        460        470        480 
TMSNRLYGVF ETTNRQWMED IHPDSDQYEA PAGRVLDAQL SEHQAEGWLE GYVLTGRHGL 

       490        500        510        520        530        540 
FASYEAFLRV VDSMLTQHFK WLRKANELDW RKKYPSLNII AASTVFQQDH NGYTHQDPGA 

       550        560        570        580        590        600 
LTHLAEKKPE YIREYLPADA NSLLAVGDVI FRSQEKINYV VTSKHPRQQW FSIEEAKQLV 

       610        620        630        640        650        660 
DNGLGIIDWA STDQGSEPDI VFAAAGTEPT LETLAAIQLL HDSFPDMKIR FVNVVDILKL 

       670        680        690        700        710        720 
RSPEKDPRGL SDAEFDHYFT KDKPVVFAFH GYEDLVRDIF FDRHNHNLHV HGYRENGDIT 

       730        740        750        760        770        780 
TPFDVRVMNQ MDRFDLAKSA IAAQPAMENT GAAFVQDMDN MLAKHNAYIR DAGTDLPEVN 


DWQWKGLK 

« Hide

References

[1]"Expression of the xylulose 5-phosphate phosphoketolase gene, xpkA, from Lactobacillus pentosus MD363 is induced by sugars that are fermented via the phosphoketolase pathway and is repressed by glucose mediated by CcpA and the mannose phosphoenolpyruvate phosphotransferase system."
Posthuma C.C., Bader R., Engelmann R., Postma P.W., Hengstenberg W., Pouwels P.H.
Appl. Environ. Microbiol. 68:831-837(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-32; 478-489 AND 651-659, FUNCTION.
Strain: MD363.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ309011 Genomic DNA. Translation: CAC84393.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA4.1.2.9. 2886.

Family and domain databases

HAMAPMF_01403. Phosphoketolase.
InterProIPR023962. Phosphoketolase.
IPR005593. Xul5P/Fru6P_PKetolase.
IPR018969. Xul5P/Fru6P_PKetolase_C.
IPR019790. Xul5P/Fru6P_PKetolase_CS.
IPR018970. Xul5P/Fru6P_PKetolase_N.
IPR019789. Xul5P/Fru6P_PKetolase_ThDP_BS.
[Graphical view]
PfamPF03894. XFP. 1 hit.
PF09363. XFP_C. 1 hit.
PF09364. XFP_N. 1 hit.
[Graphical view]
PIRSFPIRSF017245. Phosphoketolase. 1 hit.
PROSITEPS60002. PHOSPHOKETOLASE_1. 1 hit.
PS60003. PHOSPHOKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXPKA_LACPE
AccessionPrimary (citable) accession number: Q937F6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 40 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families