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Q93794

- SEL10_CAEEL

UniProt

Q93794 - SEL10_CAEEL

Protein

F-box/WD repeat-containing protein sel-10

Gene

sel-10

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. May function as part of an E3 complex to target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation. Involved in sex determination by promoting female development. Potential regulator of presenilin. May have a role in egg laying.4 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. female sex differentiation Source: UniProtKB
    2. negative regulation of Notch signaling pathway Source: UniProtKB
    3. regulation of Notch signaling pathway Source: WormBase
    4. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: RefGenome

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    SignaLinkiQ93794.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/WD repeat-containing protein sel-10
    Alternative name(s):
    Egg laying defective protein 41
    Suppressor/enhancer of lin-12 protein 10
    Gene namesi
    Name:sel-10
    Synonyms:egl-41
    ORF Names:F55B12.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiF55B12.3a; CE25007; WBGene00004767; sel-10.
    F55B12.3b; CE27762; WBGene00004767; sel-10.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. cytoplasm Source: WormBase

    Pathology & Biotechi

    Disruption phenotypei

    Worms show a weak masculinization phenotype. Moreover sel-10 mutants suppress the egg laying defective (egl) phenotype of the sel-12 mutants.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 587587F-box/WD repeat-containing protein sel-10PRO_0000051212Add
    BLAST

    Proteomic databases

    PaxDbiQ93794.
    PRIDEiQ93794.

    Interactioni

    Subunit structurei

    Interacts with fem-1, fem-2, fem-3, intracellular domain of glp-1 and lin-12, and sel-12.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    fem-1P172212EBI-323098,EBI-1998155
    fem-2P495942EBI-323098,EBI-1998402
    fem-3P346912EBI-323098,EBI-445465
    lin-12P145853EBI-323098,EBI-326049
    Notch4P316952EBI-323098,EBI-643670From a different organism.
    skr-1G5ECU15EBI-323098,EBI-323117

    Protein-protein interaction databases

    BioGridi44892. 11 interactions.
    IntActiQ93794. 11 interactions.
    MINTiMINT-115740.
    STRINGi6239.F55B12.3a.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93794.
    SMRiQ93794. Positions 106-583.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini121 – 16747F-boxPROSITE-ProRule annotationAdd
    BLAST
    Repeati253 – 29139WD 1Add
    BLAST
    Repeati294 – 33340WD 2Add
    BLAST
    Repeati336 – 37338WD 3Add
    BLAST
    Repeati376 – 41540WD 4Add
    BLAST
    Repeati416 – 45540WD 5Add
    BLAST
    Repeati461 – 49838WD 6Add
    BLAST
    Repeati501 – 53939WD 7Add
    BLAST

    Sequence similaritiesi

    Contains 1 F-box domain.PROSITE-ProRule annotation
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00710000106459.
    HOGENOMiHOG000236264.
    InParanoidiQ93794.
    KOiK10260.
    OMAiRNNTEET.
    OrthoDBiEOG7VX8VF.
    PhylomeDBiQ93794.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR001810. F-box_dom.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00646. F-box. 1 hit.
    PF00400. WD40. 7 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00256. FBOX. 1 hit.
    SM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEiPS50181. FBOX. 1 hit.
    PS00678. WD_REPEATS_1. 5 hits.
    PS50082. WD_REPEATS_2. 7 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q93794-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWPRNDVHMD DGSMTPEDQE PVTDNDMEYN DNGEESSYSN GSSSSYNADK    50
    LSSSRPLQHK LDLSASPSRN NDLNPRVEHL IALFKDLSSA EQMDAFTRLL 100
    QESNMTNIRQ LRAIIEPHFQ RDFLSCLPVE LGMKILHNLT GYDLLKVAQV 150
    SKNWKLISEI DKIWKSLGVE EFKHHPDPTD RVTGAWQGTA IAAGVTIPDH 200
    IQPCDLNVHR FLKLQKFGDI FERAADKSRY LRADKIEKNW NANPIMGSAV 250
    LRGHEDHVIT CMQIHDDVLV TGSDDNTLKV WCIDKGEVMY TLVGHTGGVW 300
    TSQISQCGRY IVSGSTDRTV KVWSTVDGSL LHTLQGHTST VRCMAMAGSI 350
    LVTGSRDTTL RVWDVESGRH LATLHGHHAA VRCVQFDGTT VVSGGYDFTV 400
    KIWNAHTGRC IRTLTGHNNR VYSLLFESER SIVCSGSLDT SIRVWDFTRP 450
    EGQECVALLQ GHTSLTSGMQ LRGNILVSCN ADSHVRVWDI HEGTCVHMLS 500
    GHRSAITSLQ WFGRNMVATS SDDGTVKLWD IERGALIRDL VTLDSGGNGG 550
    CIWRLCSTST MLACAVGSRN NTEETKVILL DFDAVYP 587
    Length:587
    Mass (Da):65,312
    Last modified:April 13, 2004 - v3
    Checksum:i2D3970B4EFAA1B8C
    GO
    Isoform b (identifier: Q93794-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         54-55: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:585
    Mass (Da):65,068
    Checksum:i60F100B591F28D1B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei54 – 552Missing in isoform b. CuratedVSP_009813

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020788 mRNA. Translation: AAC47809.1.
    Z79757 Genomic DNA. Translation: CAB02129.2.
    Z79757 Genomic DNA. Translation: CAC42307.1.
    PIRiT22703.
    RefSeqiNP_001023975.1. NM_001028804.2. [Q93794-2]
    NP_506421.1. NM_074020.5. [Q93794-1]
    UniGeneiCel.2743.

    Genome annotation databases

    EnsemblMetazoaiF55B12.3a; F55B12.3a; WBGene00004767. [Q93794-1]
    GeneIDi179878.
    KEGGicel:CELE_F55B12.3.
    UCSCiF55B12.3b.1. c. elegans. [Q93794-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020788 mRNA. Translation: AAC47809.1 .
    Z79757 Genomic DNA. Translation: CAB02129.2 .
    Z79757 Genomic DNA. Translation: CAC42307.1 .
    PIRi T22703.
    RefSeqi NP_001023975.1. NM_001028804.2. [Q93794-2 ]
    NP_506421.1. NM_074020.5. [Q93794-1 ]
    UniGenei Cel.2743.

    3D structure databases

    ProteinModelPortali Q93794.
    SMRi Q93794. Positions 106-583.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 44892. 11 interactions.
    IntActi Q93794. 11 interactions.
    MINTi MINT-115740.
    STRINGi 6239.F55B12.3a.

    Proteomic databases

    PaxDbi Q93794.
    PRIDEi Q93794.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F55B12.3a ; F55B12.3a ; WBGene00004767 . [Q93794-1 ]
    GeneIDi 179878.
    KEGGi cel:CELE_F55B12.3.
    UCSCi F55B12.3b.1. c. elegans. [Q93794-1 ]

    Organism-specific databases

    CTDi 179878.
    WormBasei F55B12.3a ; CE25007 ; WBGene00004767 ; sel-10.
    F55B12.3b ; CE27762 ; WBGene00004767 ; sel-10.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00710000106459.
    HOGENOMi HOG000236264.
    InParanoidi Q93794.
    KOi K10260.
    OMAi RNNTEET.
    OrthoDBi EOG7VX8VF.
    PhylomeDBi Q93794.

    Enzyme and pathway databases

    SignaLinki Q93794.

    Miscellaneous databases

    NextBioi 907238.
    PROi Q93794.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR001810. F-box_dom.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00646. F-box. 1 hit.
    PF00400. WD40. 7 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00256. FBOX. 1 hit.
    SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEi PS50181. FBOX. 1 hit.
    PS00678. WD_REPEATS_1. 5 hits.
    PS50082. WD_REPEATS_2. 7 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins."
      Hubbard E.J.A., Wu G., Kitajewski J., Greenwald I.
      Genes Dev. 11:3182-3193(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, INTERACTION WITH LIN-12.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.
    3. "Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans."
      Sundaram M., Greenwald I.
      Genetics 135:765-783(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    4. "Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin."
      Wu G., Hubbard E.J.A., Kitajewski J.K., Greenwald I.
      Proc. Natl. Acad. Sci. U.S.A. 95:15787-15791(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GLP-1 AND SEL-12.
    5. "The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome."
      Jaeger S., Schwartz H.T., Horvitz H.R., Conradt B.
      Proc. Natl. Acad. Sci. U.S.A. 101:12549-12554(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH FEM-1; FEM-2 AND FEM-3.

    Entry informationi

    Entry nameiSEL10_CAEEL
    AccessioniPrimary (citable) accession number: Q93794
    Secondary accession number(s): O44083, Q95ZT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3