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Q93794 (SEL10_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box/WD repeat-containing protein sel-10
Alternative name(s):
Egg laying defective protein 41
Suppressor/enhancer of lin-12 protein 10
Gene names
Name:sel-10
Synonyms:egl-41
ORF Names:F55B12.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. May function as part of an E3 complex to target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation. Involved in sex determination by promoting female development. Potential regulator of presenilin. May have a role in egg laying. Ref.1 Ref.3 Ref.4 Ref.5

Subunit structure

Interacts with fem-1, fem-2, fem-3, intracellular domain of glp-1 and lin-12, and sel-12. Ref.1 Ref.4 Ref.5

Disruption phenotype

Worms show a weak masculinization phenotype. Moreover sel-10 mutants suppress the egg laying defective (egl) phenotype of the sel-12 mutants. Ref.3

Sequence similarities

Contains 1 F-box domain.

Contains 7 WD repeats.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: Q93794-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform b (identifier: Q93794-2)

The sequence of this isoform differs from the canonical sequence as follows:
     54-55: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587F-box/WD repeat-containing protein sel-10
PRO_0000051212

Regions

Domain121 – 16747F-box
Repeat253 – 29139WD 1
Repeat294 – 33340WD 2
Repeat336 – 37338WD 3
Repeat376 – 41540WD 4
Repeat416 – 45540WD 5
Repeat461 – 49838WD 6
Repeat501 – 53939WD 7

Natural variations

Alternative sequence54 – 552Missing in isoform b.
VSP_009813

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified April 13, 2004. Version 3.
Checksum: 2D3970B4EFAA1B8C

FASTA58765,312
        10         20         30         40         50         60 
MWPRNDVHMD DGSMTPEDQE PVTDNDMEYN DNGEESSYSN GSSSSYNADK LSSSRPLQHK 

        70         80         90        100        110        120 
LDLSASPSRN NDLNPRVEHL IALFKDLSSA EQMDAFTRLL QESNMTNIRQ LRAIIEPHFQ 

       130        140        150        160        170        180 
RDFLSCLPVE LGMKILHNLT GYDLLKVAQV SKNWKLISEI DKIWKSLGVE EFKHHPDPTD 

       190        200        210        220        230        240 
RVTGAWQGTA IAAGVTIPDH IQPCDLNVHR FLKLQKFGDI FERAADKSRY LRADKIEKNW 

       250        260        270        280        290        300 
NANPIMGSAV LRGHEDHVIT CMQIHDDVLV TGSDDNTLKV WCIDKGEVMY TLVGHTGGVW 

       310        320        330        340        350        360 
TSQISQCGRY IVSGSTDRTV KVWSTVDGSL LHTLQGHTST VRCMAMAGSI LVTGSRDTTL 

       370        380        390        400        410        420 
RVWDVESGRH LATLHGHHAA VRCVQFDGTT VVSGGYDFTV KIWNAHTGRC IRTLTGHNNR 

       430        440        450        460        470        480 
VYSLLFESER SIVCSGSLDT SIRVWDFTRP EGQECVALLQ GHTSLTSGMQ LRGNILVSCN 

       490        500        510        520        530        540 
ADSHVRVWDI HEGTCVHMLS GHRSAITSLQ WFGRNMVATS SDDGTVKLWD IERGALIRDL 

       550        560        570        580 
VTLDSGGNGG CIWRLCSTST MLACAVGSRN NTEETKVILL DFDAVYP 

« Hide

Isoform b [UniParc].

Checksum: 60F100B591F28D1B
Show »

FASTA58565,068

References

« Hide 'large scale' references
[1]"sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins."
Hubbard E.J.A., Wu G., Kitajewski J., Greenwald I.
Genes Dev. 11:3182-3193(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, INTERACTION WITH LIN-12.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
[3]"Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans."
Sundaram M., Greenwald I.
Genetics 135:765-783(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[4]"Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin."
Wu G., Hubbard E.J.A., Kitajewski J.K., Greenwald I.
Proc. Natl. Acad. Sci. U.S.A. 95:15787-15791(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH GLP-1 AND SEL-12.
[5]"The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome."
Jaeger S., Schwartz H.T., Horvitz H.R., Conradt B.
Proc. Natl. Acad. Sci. U.S.A. 101:12549-12554(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH FEM-1; FEM-2 AND FEM-3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF020788 mRNA. Translation: AAC47809.1.
Z79757 Genomic DNA. Translation: CAB02129.2.
Z79757 Genomic DNA. Translation: CAC42307.1.
PIRT22703.
RefSeqNP_001023975.1. NM_001028804.2. [Q93794-2]
NP_506421.1. NM_074020.5. [Q93794-1]
UniGeneCel.2743.

3D structure databases

ProteinModelPortalQ93794.
SMRQ93794. Positions 106-583.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid44892. 10 interactions.
IntActQ93794. 11 interactions.
MINTMINT-115740.
STRING6239.F55B12.3a.

Proteomic databases

PaxDbQ93794.
PRIDEQ93794.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF55B12.3a; F55B12.3a; WBGene00004767. [Q93794-1]
GeneID179878.
KEGGcel:CELE_F55B12.3.
UCSCF55B12.3b.1. c. elegans. [Q93794-1]

Organism-specific databases

CTD179878.
WormBaseF55B12.3a; CE25007; WBGene00004767; sel-10.
F55B12.3b; CE27762; WBGene00004767; sel-10.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00710000106459.
HOGENOMHOG000236264.
InParanoidQ93794.
KOK10260.
OMARNNTEET.
OrthoDBEOG7VX8VF.
PhylomeDBQ93794.

Enzyme and pathway databases

SignaLinkQ93794.

Family and domain databases

Gene3D2.130.10.10. 2 hits.
InterProIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00646. F-box. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio907238.
PROQ93794.

Entry information

Entry nameSEL10_CAEEL
AccessionPrimary (citable) accession number: Q93794
Secondary accession number(s): O44083, Q95ZT0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase