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Q93794

- SEL10_CAEEL

UniProt

Q93794 - SEL10_CAEEL

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Protein
F-box/WD repeat-containing protein sel-10
Gene
sel-10, egl-41, F55B12.3
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. May function as part of an E3 complex to target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation. Involved in sex determination by promoting female development. Potential regulator of presenilin. May have a role in egg laying.4 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: RefGenome
  2. female sex differentiation Source: UniProtKB
  3. negative regulation of Notch signaling pathway Source: UniProtKB
  4. regulation of Notch signaling pathway Source: WormBase
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ93794.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein sel-10
Alternative name(s):
Egg laying defective protein 41
Suppressor/enhancer of lin-12 protein 10
Gene namesi
Name:sel-10
Synonyms:egl-41
ORF Names:F55B12.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiF55B12.3a; CE25007; WBGene00004767; sel-10.
F55B12.3b; CE27762; WBGene00004767; sel-10.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. cytoplasm Source: WormBase
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Worms show a weak masculinization phenotype. Moreover sel-10 mutants suppress the egg laying defective (egl) phenotype of the sel-12 mutants.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587F-box/WD repeat-containing protein sel-10
PRO_0000051212Add
BLAST

Proteomic databases

PaxDbiQ93794.
PRIDEiQ93794.

Interactioni

Subunit structurei

Interacts with fem-1, fem-2, fem-3, intracellular domain of glp-1 and lin-12, and sel-12.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
fem-1P172212EBI-323098,EBI-1998155
fem-2P495942EBI-323098,EBI-1998402
fem-3P346912EBI-323098,EBI-445465
lin-12P145853EBI-323098,EBI-326049
Notch4P316952EBI-323098,EBI-643670From a different organism.
skr-1G5ECU15EBI-323098,EBI-323117

Protein-protein interaction databases

BioGridi44892. 10 interactions.
IntActiQ93794. 11 interactions.
MINTiMINT-115740.
STRINGi6239.F55B12.3a.

Structurei

3D structure databases

ProteinModelPortaliQ93794.
SMRiQ93794. Positions 106-583.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 16747F-box
Add
BLAST
Repeati253 – 29139WD 1
Add
BLAST
Repeati294 – 33340WD 2
Add
BLAST
Repeati336 – 37338WD 3
Add
BLAST
Repeati376 – 41540WD 4
Add
BLAST
Repeati416 – 45540WD 5
Add
BLAST
Repeati461 – 49838WD 6
Add
BLAST
Repeati501 – 53939WD 7
Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.
Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00710000106459.
HOGENOMiHOG000236264.
InParanoidiQ93794.
KOiK10260.
OMAiRNNTEET.
OrthoDBiEOG7VX8VF.
PhylomeDBiQ93794.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q93794-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWPRNDVHMD DGSMTPEDQE PVTDNDMEYN DNGEESSYSN GSSSSYNADK    50
LSSSRPLQHK LDLSASPSRN NDLNPRVEHL IALFKDLSSA EQMDAFTRLL 100
QESNMTNIRQ LRAIIEPHFQ RDFLSCLPVE LGMKILHNLT GYDLLKVAQV 150
SKNWKLISEI DKIWKSLGVE EFKHHPDPTD RVTGAWQGTA IAAGVTIPDH 200
IQPCDLNVHR FLKLQKFGDI FERAADKSRY LRADKIEKNW NANPIMGSAV 250
LRGHEDHVIT CMQIHDDVLV TGSDDNTLKV WCIDKGEVMY TLVGHTGGVW 300
TSQISQCGRY IVSGSTDRTV KVWSTVDGSL LHTLQGHTST VRCMAMAGSI 350
LVTGSRDTTL RVWDVESGRH LATLHGHHAA VRCVQFDGTT VVSGGYDFTV 400
KIWNAHTGRC IRTLTGHNNR VYSLLFESER SIVCSGSLDT SIRVWDFTRP 450
EGQECVALLQ GHTSLTSGMQ LRGNILVSCN ADSHVRVWDI HEGTCVHMLS 500
GHRSAITSLQ WFGRNMVATS SDDGTVKLWD IERGALIRDL VTLDSGGNGG 550
CIWRLCSTST MLACAVGSRN NTEETKVILL DFDAVYP 587
Length:587
Mass (Da):65,312
Last modified:April 13, 2004 - v3
Checksum:i2D3970B4EFAA1B8C
GO
Isoform b (identifier: Q93794-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-55: Missing.

Note: No experimental confirmation available.

Show »
Length:585
Mass (Da):65,068
Checksum:i60F100B591F28D1B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei54 – 552Missing in isoform b.
VSP_009813

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF020788 mRNA. Translation: AAC47809.1.
Z79757 Genomic DNA. Translation: CAB02129.2.
Z79757 Genomic DNA. Translation: CAC42307.1.
PIRiT22703.
RefSeqiNP_001023975.1. NM_001028804.2. [Q93794-2]
NP_506421.1. NM_074020.5. [Q93794-1]
UniGeneiCel.2743.

Genome annotation databases

EnsemblMetazoaiF55B12.3a; F55B12.3a; WBGene00004767. [Q93794-1]
GeneIDi179878.
KEGGicel:CELE_F55B12.3.
UCSCiF55B12.3b.1. c. elegans. [Q93794-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF020788 mRNA. Translation: AAC47809.1 .
Z79757 Genomic DNA. Translation: CAB02129.2 .
Z79757 Genomic DNA. Translation: CAC42307.1 .
PIRi T22703.
RefSeqi NP_001023975.1. NM_001028804.2. [Q93794-2 ]
NP_506421.1. NM_074020.5. [Q93794-1 ]
UniGenei Cel.2743.

3D structure databases

ProteinModelPortali Q93794.
SMRi Q93794. Positions 106-583.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 44892. 10 interactions.
IntActi Q93794. 11 interactions.
MINTi MINT-115740.
STRINGi 6239.F55B12.3a.

Proteomic databases

PaxDbi Q93794.
PRIDEi Q93794.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F55B12.3a ; F55B12.3a ; WBGene00004767 . [Q93794-1 ]
GeneIDi 179878.
KEGGi cel:CELE_F55B12.3.
UCSCi F55B12.3b.1. c. elegans. [Q93794-1 ]

Organism-specific databases

CTDi 179878.
WormBasei F55B12.3a ; CE25007 ; WBGene00004767 ; sel-10.
F55B12.3b ; CE27762 ; WBGene00004767 ; sel-10.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00710000106459.
HOGENOMi HOG000236264.
InParanoidi Q93794.
KOi K10260.
OMAi RNNTEET.
OrthoDBi EOG7VX8VF.
PhylomeDBi Q93794.

Enzyme and pathway databases

SignaLinki Q93794.

Miscellaneous databases

NextBioi 907238.
PROi Q93794.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00646. F-box. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins."
    Hubbard E.J.A., Wu G., Kitajewski J., Greenwald I.
    Genes Dev. 11:3182-3193(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, INTERACTION WITH LIN-12.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  3. "Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans."
    Sundaram M., Greenwald I.
    Genetics 135:765-783(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. "Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin."
    Wu G., Hubbard E.J.A., Kitajewski J.K., Greenwald I.
    Proc. Natl. Acad. Sci. U.S.A. 95:15787-15791(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GLP-1 AND SEL-12.
  5. "The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome."
    Jaeger S., Schwartz H.T., Horvitz H.R., Conradt B.
    Proc. Natl. Acad. Sci. U.S.A. 101:12549-12554(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FEM-1; FEM-2 AND FEM-3.

Entry informationi

Entry nameiSEL10_CAEEL
AccessioniPrimary (citable) accession number: Q93794
Secondary accession number(s): O44083, Q95ZT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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