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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-32

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-32Imported
ORF Names:CELE_F53C11.6Imported, F53C11.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF53C11.6; CE41135; WBGene00006684; twk-32.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5725HelicalSequence analysisAdd
BLAST
Transmembranei150 – 17223HelicalSequence analysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence analysisAdd
BLAST
Transmembranei275 – 29117HelicalSequence analysisAdd
BLAST
Transmembranei297 – 32428HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ93764.

Interactioni

Protein-protein interaction databases

STRINGi6239.F53C11.6.

Structurei

3D structure databases

ProteinModelPortaliQ93764.
SMRiQ93764. Positions 38-322, 394-580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini394 – 49299Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini493 – 58391Fibronectin type-IIIInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000019430.
InParanoidiQ93764.
OMAiALPHITL.
OrthoDBiEOG7W157J.
PhylomeDBiQ93764.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003280. 2pore_dom_K_chnl.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGGALLSSG LCRFSELTPG QFGLTKQLVF RLALPHITLL VVSILYAVFG
60 70 80 90 100
GWMLTLIKYS QQTTHQAIMF DQTRQNFAKR LALIGNKEEF ESIVDELVEK
110 120 130 140 150
TYDFYTMEDG HRWQEAAFNA NPLTNFTSNL FFAATTLTSI GYGIDAPESL
160 170 180 190 200
IGRVFCLVYL FFGIPLYLIT IADMAKFCTE LMNRTYTEII KYKYRVKRRY
210 220 230 240 250
KRWKSGRIRR ESMKVGQVII AGGEDEVAEF LWTHLEHAQF VEVPFLLVIG
260 270 280 290 300
ILLLYIGLSS WIISWVENWN MMDGFYFVMM SVLTIGFGDL VPRNEIFAVP
310 320 330 340 350
ILFIILAGLV LTTTCIDVVG AYYIDRLHFF GRRLDDDPLS WLKEVQQRRI
360 370 380 390 400
EAMKKEAMRK LFETVTALHH IRLTAFKQLT QNYDEHLRGK APDPPRHLIA
410 420 430 440 450
SHATADSVML RWSAPIYVDE GKRYWYTITY KPRTPQRRNN VVAVDFINKD
460 470 480 490 500
RYLVTGLKSF TLYEFSVYVT TRYGQSVPIK VQEYTEPCTV PQSVRIDAIS
510 520 530 540 550
DETATISWRA PKMNNGPESY VIQFVQEPAP QFVYWCKYKV GSSTRFTLTD
560 570 580 590 600
LHADTRYIIC VTAEHNHGLA AMSKSMRFRT KKWWGDEDST CLRIPGTSHR
610
LSIASAISTL TALR
Length:614
Mass (Da):70,707
Last modified:July 10, 2007 - v2
Checksum:i6A03AEA5F7714377
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB02119.2.
PIRiT22557.
RefSeqiNP_506416.2. NM_074015.2.
UniGeneiCel.23988.

Genome annotation databases

EnsemblMetazoaiF53C11.6; F53C11.6; WBGene00006684.
GeneIDi192075.
KEGGicel:CELE_F53C11.6.
UCSCiF53C11.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB02119.2.
PIRiT22557.
RefSeqiNP_506416.2. NM_074015.2.
UniGeneiCel.23988.

3D structure databases

ProteinModelPortaliQ93764.
SMRiQ93764. Positions 38-322, 394-580.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F53C11.6.

Proteomic databases

PaxDbiQ93764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF53C11.6; F53C11.6; WBGene00006684.
GeneIDi192075.
KEGGicel:CELE_F53C11.6.
UCSCiF53C11.6. c. elegans.

Organism-specific databases

CTDi192075.
WormBaseiF53C11.6; CE41135; WBGene00006684; twk-32.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000019430.
InParanoidiQ93764.
OMAiALPHITL.
OrthoDBiEOG7W157J.
PhylomeDBiQ93764.

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Miscellaneous databases

NextBioi951482.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003280. 2pore_dom_K_chnl.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ93764_CAEEL
AccessioniPrimary (citable) accession number: Q93764
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: July 10, 2007
Last modified: May 11, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.