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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-32

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotationImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1299344 TWIK-related spinal cord K+ channel (TRESK)
R-CEL-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-32Imported
ORF Names:CELE_F53C11.6Imported, F53C11.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF53C11.6 ; CE41135 ; WBGene00006684 ; twk-32

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 57HelicalSequence analysisAdd BLAST25
Transmembranei150 – 172HelicalSequence analysisAdd BLAST23
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei275 – 291HelicalSequence analysisAdd BLAST17
Transmembranei297 – 324HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ93764

Expressioni

Gene expression databases

BgeeiWBGene00006684

Interactioni

Protein-protein interaction databases

STRINGi6239.F53C11.6

Structurei

3D structure databases

ProteinModelPortaliQ93764
SMRiQ93764
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini394 – 492Fibronectin type-IIIInterPro annotationAdd BLAST99
Domaini493 – 583Fibronectin type-IIIInterPro annotationAdd BLAST91

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00700000104522
HOGENOMiHOG000019430
InParanoidiQ93764
OMAiALPHITL
OrthoDBiEOG091G03LK
PhylomeDBiQ93764

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07885 Ion_trans_2, 2 hits
PRINTSiPR01333 2POREKCHANEL
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits

Sequencei

Sequence statusi: Complete.

Q93764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGGALLSSG LCRFSELTPG QFGLTKQLVF RLALPHITLL VVSILYAVFG
60 70 80 90 100
GWMLTLIKYS QQTTHQAIMF DQTRQNFAKR LALIGNKEEF ESIVDELVEK
110 120 130 140 150
TYDFYTMEDG HRWQEAAFNA NPLTNFTSNL FFAATTLTSI GYGIDAPESL
160 170 180 190 200
IGRVFCLVYL FFGIPLYLIT IADMAKFCTE LMNRTYTEII KYKYRVKRRY
210 220 230 240 250
KRWKSGRIRR ESMKVGQVII AGGEDEVAEF LWTHLEHAQF VEVPFLLVIG
260 270 280 290 300
ILLLYIGLSS WIISWVENWN MMDGFYFVMM SVLTIGFGDL VPRNEIFAVP
310 320 330 340 350
ILFIILAGLV LTTTCIDVVG AYYIDRLHFF GRRLDDDPLS WLKEVQQRRI
360 370 380 390 400
EAMKKEAMRK LFETVTALHH IRLTAFKQLT QNYDEHLRGK APDPPRHLIA
410 420 430 440 450
SHATADSVML RWSAPIYVDE GKRYWYTITY KPRTPQRRNN VVAVDFINKD
460 470 480 490 500
RYLVTGLKSF TLYEFSVYVT TRYGQSVPIK VQEYTEPCTV PQSVRIDAIS
510 520 530 540 550
DETATISWRA PKMNNGPESY VIQFVQEPAP QFVYWCKYKV GSSTRFTLTD
560 570 580 590 600
LHADTRYIIC VTAEHNHGLA AMSKSMRFRT KKWWGDEDST CLRIPGTSHR
610
LSIASAISTL TALR
Length:614
Mass (Da):70,707
Last modified:July 10, 2007 - v2
Checksum:i6A03AEA5F7714377
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB02119.2
PIRiT22557
RefSeqiNP_506416.2, NM_074015.2
UniGeneiCel.23988

Genome annotation databases

EnsemblMetazoaiF53C11.6; F53C11.6; WBGene00006684
GeneIDi192075
KEGGicel:CELE_F53C11.6
UCSCiF53C11.6 c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ93764_CAEEL
AccessioniPrimary (citable) accession number: Q93764
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: July 10, 2007
Last modified: February 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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