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Protein

Guanine nucleotide-binding protein alpha-6 subunit

Gene

gpa-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551MagnesiumBy similarity
Metal bindingi192 – 1921MagnesiumBy similarity
Binding sitei335 – 3351GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi48 – 558GTPBy similarity
Nucleotide bindingi186 – 1927GTPBy similarity
Nucleotide bindingi211 – 2155GTPBy similarity
Nucleotide bindingi280 – 2834GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein alpha-6 subunit
Gene namesi
Name:gpa-6
ORF Names:F48C11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF48C11.1; CE20829; WBGene00001668; gpa-6.

Subcellular locationi

GO - Cellular componenti

  • axon Source: WormBase
  • heterotrimeric G-protein complex Source: GO_Central
  • neuronal cell body Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 364363Guanine nucleotide-binding protein alpha-6 subunitPRO_0000203639Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ93743.
PaxDbiQ93743.

Expressioni

Gene expression databases

BgeeiWBGene00001668.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ93743. 1 interaction.
STRINGi6239.F48C11.1.

Structurei

3D structure databases

ProteinModelPortaliQ93743.
SMRiQ93743. Positions 1-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family.Curated

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00770000120503.
HOGENOMiHOG000038730.
InParanoidiQ93743.
OMAiHASIVLF.
OrthoDBiEOG091G09L4.
PhylomeDBiQ93743.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGATGLRG ARLSPEERAN SSKSRAIDRA LSKDHTDDLN RFKILLLGTA
60 70 80 90 100
ESGKSTIFKQ MRVLHLDGYA KEDALEYLSI IHSNCMEALT QLVDACTAFG
110 120 130 140 150
INHDITVQED VNRFEDFKRK LRDPEGLVIP VVIGRCMDRV WHSPSLQLCY
160 170 180 190 200
DTRRFRFALL DSAKYFMDNI VRLTEDNYVP SIQDIVHCRI STTGINELAF
210 220 230 240 250
NYKKMDFKMV DVGGQRSERR KWIHCFDNVD MILFIVSMSD YDQLDPEDNK
260 270 280 290 300
YNRMKQSYEI FKTIVHSDLF RHASIVLFLN KYDVFVEKLK TSPLRRSFKN
310 320 330 340 350
YEGDNSEESA REFIKKLFRR CITDRHKFFV FETTATDTGN IDLVFGSAVA
360
HIVNENLRSA GLHE
Length:364
Mass (Da):42,058
Last modified:May 1, 1999 - v2
Checksum:i14D594208714F63E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008129 mRNA. Translation: AAG32082.1.
Z80789 Genomic DNA. Translation: CAB02553.1.
PIRiT22379.
RefSeqiNP_510189.1. NM_077788.1.
UniGeneiCel.806.

Genome annotation databases

EnsemblMetazoaiF48C11.1; F48C11.1; WBGene00001668.
GeneIDi181442.
KEGGicel:CELE_F48C11.1.
UCSCiF48C11.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008129 mRNA. Translation: AAG32082.1.
Z80789 Genomic DNA. Translation: CAB02553.1.
PIRiT22379.
RefSeqiNP_510189.1. NM_077788.1.
UniGeneiCel.806.

3D structure databases

ProteinModelPortaliQ93743.
SMRiQ93743. Positions 1-362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ93743. 1 interaction.
STRINGi6239.F48C11.1.

Proteomic databases

EPDiQ93743.
PaxDbiQ93743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF48C11.1; F48C11.1; WBGene00001668.
GeneIDi181442.
KEGGicel:CELE_F48C11.1.
UCSCiF48C11.1. c. elegans.

Organism-specific databases

CTDi181442.
WormBaseiF48C11.1; CE20829; WBGene00001668; gpa-6.

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00770000120503.
HOGENOMiHOG000038730.
InParanoidiQ93743.
OMAiHASIVLF.
OrthoDBiEOG091G09L4.
PhylomeDBiQ93743.

Miscellaneous databases

PROiQ93743.

Gene expression databases

BgeeiWBGene00001668.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGPA6_CAEEL
AccessioniPrimary (citable) accession number: Q93743
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.