Reviewed,
UniProtKB/Swiss-Prot Q93714 (IDH3A_CAEEL)
Last modified
June 16, 2009.
Version 67.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial EC=1.1.1.41 Alternative name(s): Isocitric dehydrogenase NAD(+)-specific ICDH | ||
| Gene names |
| ||
| Organism | Caenorhabditis elegans [Complete proteome] | ||
| Taxonomic identifier | 6239 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 358 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH. |
| Cofactor | Binds 1 magnesium or manganese ion per subunit By similarity. |
| Subunit structure | Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 By similarity. |
| Subcellular location | Mitochondrion By similarity. |
| Sequence similarities | Belongs to the isocitrate and isopropylmalate dehydrogenases family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion Potential | |||||||
| Chain | ? – 358 | Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | PRO_0000014441 | ||||||
Sites | |||||||||
| Metal binding | 226 | 1 | Magnesium or manganese By similarity | ||||||
| Metal binding | 250 | 1 | Magnesium or manganese By similarity | ||||||
| Metal binding | 254 | 1 | Magnesium or manganese By similarity | ||||||
| Binding site | 108 | 1 | Substrate By similarity | ||||||
| Binding site | 118 | 1 | Substrate By similarity | ||||||
| Binding site | 139 | 1 | Substrate By similarity | ||||||
| Binding site | 226 | 1 | Substrate By similarity | ||||||
| Site | 146 | 1 | Critical for catalysis By similarity | ||||||
| Site | 193 | 1 | Critical for catalysis By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
Cross-references
Sequence databases | |
|---|---|
| Z79755 Genomic DNA. Translation: CAB02111.2. | |
| PIR | T22149. |
| RefSeq | NP_492330.2. |
| UniGene | Cel.17675 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1PB1 based on UniProtKB P08200. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q93714. 6 interactions. |
Genome annotation databases | |
| Ensembl | F43G9.1. Caenorhabditis elegans. [Contig view] |
| GeneID | 172655. |
| KEGG | cel:F43G9.1. |
Organism-specific databases | |
| WormBase | WBGene00009664. F43G9.1. |
| WormPep | F43G9.1. CE34018. [WorfDB] |
Phylogenomic databases | |
| OMA | Q93714. GGNSKCS. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.41. 672. |
Gene expression databases | |
| ArrayExpress | Q93714. |
Family and domain databases | |
| InterPro | IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR004434. Isocitrate_DH_NAD_mit. [Graphical view] |
| Gene3D | G3DSA:3.40.718.10. IDH_IMDH. 1 hit. |
| PANTHER | PTHR11835. IDH_IMDH_dimeric. 1 hit. |
| Pfam | PF00180. Iso_dh. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00175. mito_nad_idh. 1 hit. |
| PROSITE | PS00470. IDH_IMDH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 876445. |
Entry information
| Entry name | IDH3A_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q93714 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

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