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Q93714

- IDH3A_CAEEL

UniProt

Q93714 - IDH3A_CAEEL

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Protein

Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Gene

idha-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Binds 1 magnesium or manganese ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei108 – 1081SubstrateBy similarity
Binding sitei118 – 1181SubstrateBy similarity
Binding sitei139 – 1391SubstrateBy similarity
Sitei146 – 1461Critical for catalysisBy similarity
Sitei193 – 1931Critical for catalysisBy similarity
Metal bindingi226 – 2261Magnesium or manganeseBy similarity
Binding sitei226 – 2261SubstrateBy similarity
Metal bindingi250 – 2501Magnesium or manganeseBy similarity
Metal bindingi254 – 2541Magnesium or manganeseBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit alpha
NAD(+)-specific ICDH subunit alpha
Gene namesi
Name:idha-1
ORF Names:F43G9.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiF43G9.1; CE34018; WBGene00009664; idha-1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 358Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialPRO_0000014441
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PaxDbiQ93714.

2D gel databases

World-2DPAGE0020:Q93714.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.By similarity

Protein-protein interaction databases

BioGridi38088. 2 interactions.
IntActiQ93714. 2 interactions.
MINTiMINT-1058740.
STRINGi6239.F43G9.1.2.

Structurei

3D structure databases

ProteinModelPortaliQ93714.
SMRiQ93714. Positions 27-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0473.
GeneTreeiENSGT00550000074918.
HOGENOMiHOG000021113.
InParanoidiQ93714.
KOiK00030.
OMAiMCMQLVM.
PhylomeDBiQ93714.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93714 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGKCIKKAS STVGQSIRYS SGDVRRVTLI PGDGIGPEIS ASVQKIFEAA
60 70 80 90 100
DAPIAWDPVD VTPVKGRDGV FRIPSRCIEL MHANKVGLKG PLETPIGKGH
110 120 130 140 150
RSLNLAVRKE FSLYANVRPC RSLEGHKTLY DNVDVVTIRE NTEGEYSGIE
160 170 180 190 200
HEIVPGVVQS IKLITETASR NVASFAFEYA RQNGRKVVTA VHKANIMRQS
210 220 230 240 250
DGLFLSICRE QAALYPDIKF KEAYLDTVCL NMVQDPSQYD VLVMPNLYGD
260 270 280 290 300
ILSDLCAGLV GGLGVTPSGN IGKGAAVFES VHGTAPDIAG QDKANPTALL
310 320 330 340 350
LSAVMMLRYM NLPQHAARIE KAVFDAIADG RAKTGDLGGT GTCSSFTADV

CARVKDLE
Length:358
Mass (Da):38,466
Last modified:April 13, 2004 - v3
Checksum:iB175DC68C127610F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z79755 Genomic DNA. Translation: CAB02111.2.
PIRiT22149.
RefSeqiNP_492330.2. NM_059929.3.
UniGeneiCel.17675.

Genome annotation databases

EnsemblMetazoaiF43G9.1; F43G9.1; WBGene00009664.
GeneIDi172655.
KEGGicel:CELE_F43G9.1.
UCSCiF43G9.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z79755 Genomic DNA. Translation: CAB02111.2 .
PIRi T22149.
RefSeqi NP_492330.2. NM_059929.3.
UniGenei Cel.17675.

3D structure databases

ProteinModelPortali Q93714.
SMRi Q93714. Positions 27-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 38088. 2 interactions.
IntActi Q93714. 2 interactions.
MINTi MINT-1058740.
STRINGi 6239.F43G9.1.2.

2D gel databases

World-2DPAGE 0020:Q93714.

Proteomic databases

PaxDbi Q93714.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F43G9.1 ; F43G9.1 ; WBGene00009664 .
GeneIDi 172655.
KEGGi cel:CELE_F43G9.1.
UCSCi F43G9.1.1. c. elegans.

Organism-specific databases

CTDi 172655.
WormBasei F43G9.1 ; CE34018 ; WBGene00009664 ; idha-1.

Phylogenomic databases

eggNOGi COG0473.
GeneTreei ENSGT00550000074918.
HOGENOMi HOG000021113.
InParanoidi Q93714.
KOi K00030.
OMAi MCMQLVM.
PhylomeDBi Q93714.

Miscellaneous databases

NextBioi 876445.
PROi Q93714.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiIDH3A_CAEEL
AccessioniPrimary (citable) accession number: Q93714
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 13, 2004
Last modified: October 1, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3