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Q93714

- IDH3A_CAEEL

UniProt

Q93714 - IDH3A_CAEEL

Protein

Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Gene

idha-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei108 – 1081SubstrateBy similarity
    Binding sitei118 – 1181SubstrateBy similarity
    Binding sitei139 – 1391SubstrateBy similarity
    Sitei146 – 1461Critical for catalysisBy similarity
    Sitei193 – 1931Critical for catalysisBy similarity
    Metal bindingi226 – 2261Magnesium or manganeseBy similarity
    Binding sitei226 – 2261SubstrateBy similarity
    Metal bindingi250 – 2501Magnesium or manganeseBy similarity
    Metal bindingi254 – 2541Magnesium or manganeseBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC:1.1.1.41)
    Alternative name(s):
    Isocitric dehydrogenase subunit alpha
    NAD(+)-specific ICDH subunit alpha
    Gene namesi
    Name:idha-1
    ORF Names:F43G9.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiF43G9.1; CE34018; WBGene00009664; idha-1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: WormBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 358Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialPRO_0000014441
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiQ93714.

    2D gel databases

    World-2DPAGE0020:Q93714.

    Interactioni

    Subunit structurei

    Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.By similarity

    Protein-protein interaction databases

    BioGridi38088. 2 interactions.
    IntActiQ93714. 2 interactions.
    MINTiMINT-1058740.
    STRINGi6239.F43G9.1.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93714.
    SMRiQ93714. Positions 27-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0473.
    GeneTreeiENSGT00550000074918.
    HOGENOMiHOG000021113.
    InParanoidiQ93714.
    KOiK00030.
    OMAiMCMQLVM.
    PhylomeDBiQ93714.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q93714-1 [UniParc]FASTAAdd to Basket

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    MLGKCIKKAS STVGQSIRYS SGDVRRVTLI PGDGIGPEIS ASVQKIFEAA    50
    DAPIAWDPVD VTPVKGRDGV FRIPSRCIEL MHANKVGLKG PLETPIGKGH 100
    RSLNLAVRKE FSLYANVRPC RSLEGHKTLY DNVDVVTIRE NTEGEYSGIE 150
    HEIVPGVVQS IKLITETASR NVASFAFEYA RQNGRKVVTA VHKANIMRQS 200
    DGLFLSICRE QAALYPDIKF KEAYLDTVCL NMVQDPSQYD VLVMPNLYGD 250
    ILSDLCAGLV GGLGVTPSGN IGKGAAVFES VHGTAPDIAG QDKANPTALL 300
    LSAVMMLRYM NLPQHAARIE KAVFDAIADG RAKTGDLGGT GTCSSFTADV 350
    CARVKDLE 358
    Length:358
    Mass (Da):38,466
    Last modified:April 13, 2004 - v3
    Checksum:iB175DC68C127610F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z79755 Genomic DNA. Translation: CAB02111.2.
    PIRiT22149.
    RefSeqiNP_492330.2. NM_059929.3.
    UniGeneiCel.17675.

    Genome annotation databases

    EnsemblMetazoaiF43G9.1; F43G9.1; WBGene00009664.
    GeneIDi172655.
    KEGGicel:CELE_F43G9.1.
    UCSCiF43G9.1.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z79755 Genomic DNA. Translation: CAB02111.2 .
    PIRi T22149.
    RefSeqi NP_492330.2. NM_059929.3.
    UniGenei Cel.17675.

    3D structure databases

    ProteinModelPortali Q93714.
    SMRi Q93714. Positions 27-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 38088. 2 interactions.
    IntActi Q93714. 2 interactions.
    MINTi MINT-1058740.
    STRINGi 6239.F43G9.1.2.

    2D gel databases

    World-2DPAGE 0020:Q93714.

    Proteomic databases

    PaxDbi Q93714.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F43G9.1 ; F43G9.1 ; WBGene00009664 .
    GeneIDi 172655.
    KEGGi cel:CELE_F43G9.1.
    UCSCi F43G9.1.1. c. elegans.

    Organism-specific databases

    CTDi 172655.
    WormBasei F43G9.1 ; CE34018 ; WBGene00009664 ; idha-1.

    Phylogenomic databases

    eggNOGi COG0473.
    GeneTreei ENSGT00550000074918.
    HOGENOMi HOG000021113.
    InParanoidi Q93714.
    KOi K00030.
    OMAi MCMQLVM.
    PhylomeDBi Q93714.

    Miscellaneous databases

    NextBioi 876445.
    PROi Q93714.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiIDH3A_CAEEL
    AccessioniPrimary (citable) accession number: Q93714
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3