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Protein

Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Gene

idha-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei108 – 1081SubstrateBy similarity
Binding sitei118 – 1181SubstrateBy similarity
Binding sitei139 – 1391SubstrateBy similarity
Sitei146 – 1461Critical for catalysisBy similarity
Sitei193 – 1931Critical for catalysisBy similarity
Metal bindingi226 – 2261Magnesium or manganeseBy similarity
Binding sitei226 – 2261SubstrateBy similarity
Metal bindingi250 – 2501Magnesium or manganeseBy similarity
Metal bindingi254 – 2541Magnesium or manganeseBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NAD

Enzyme and pathway databases

ReactomeiREACT_287541. Citric acid cycle (TCA cycle).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit alpha
NAD(+)-specific ICDH subunit alpha
Gene namesi
Name:idha-1
ORF Names:F43G9.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF43G9.1; CE34018; WBGene00009664; idha-1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 358Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialPRO_0000014441
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PaxDbiQ93714.

2D gel databases

World-2DPAGE0020:Q93714.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.By similarity

Protein-protein interaction databases

BioGridi38088. 2 interactions.
IntActiQ93714. 2 interactions.
MINTiMINT-1058740.
STRINGi6239.F43G9.1.2.

Structurei

3D structure databases

ProteinModelPortaliQ93714.
SMRiQ93714. Positions 27-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0473.
GeneTreeiENSGT00550000074918.
HOGENOMiHOG000021113.
InParanoidiQ93714.
KOiK00030.
OMAiHPERVNM.
PhylomeDBiQ93714.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKCIKKAS STVGQSIRYS SGDVRRVTLI PGDGIGPEIS ASVQKIFEAA
60 70 80 90 100
DAPIAWDPVD VTPVKGRDGV FRIPSRCIEL MHANKVGLKG PLETPIGKGH
110 120 130 140 150
RSLNLAVRKE FSLYANVRPC RSLEGHKTLY DNVDVVTIRE NTEGEYSGIE
160 170 180 190 200
HEIVPGVVQS IKLITETASR NVASFAFEYA RQNGRKVVTA VHKANIMRQS
210 220 230 240 250
DGLFLSICRE QAALYPDIKF KEAYLDTVCL NMVQDPSQYD VLVMPNLYGD
260 270 280 290 300
ILSDLCAGLV GGLGVTPSGN IGKGAAVFES VHGTAPDIAG QDKANPTALL
310 320 330 340 350
LSAVMMLRYM NLPQHAARIE KAVFDAIADG RAKTGDLGGT GTCSSFTADV

CARVKDLE
Length:358
Mass (Da):38,466
Last modified:April 13, 2004 - v3
Checksum:iB175DC68C127610F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79755 Genomic DNA. Translation: CAB02111.2.
PIRiT22149.
RefSeqiNP_492330.2. NM_059929.3.
UniGeneiCel.17675.

Genome annotation databases

EnsemblMetazoaiF43G9.1; F43G9.1; WBGene00009664.
GeneIDi172655.
KEGGicel:CELE_F43G9.1.
UCSCiF43G9.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79755 Genomic DNA. Translation: CAB02111.2.
PIRiT22149.
RefSeqiNP_492330.2. NM_059929.3.
UniGeneiCel.17675.

3D structure databases

ProteinModelPortaliQ93714.
SMRiQ93714. Positions 27-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38088. 2 interactions.
IntActiQ93714. 2 interactions.
MINTiMINT-1058740.
STRINGi6239.F43G9.1.2.

2D gel databases

World-2DPAGE0020:Q93714.

Proteomic databases

PaxDbiQ93714.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF43G9.1; F43G9.1; WBGene00009664.
GeneIDi172655.
KEGGicel:CELE_F43G9.1.
UCSCiF43G9.1.1. c. elegans.

Organism-specific databases

CTDi172655.
WormBaseiF43G9.1; CE34018; WBGene00009664; idha-1.

Phylogenomic databases

eggNOGiCOG0473.
GeneTreeiENSGT00550000074918.
HOGENOMiHOG000021113.
InParanoidiQ93714.
KOiK00030.
OMAiHPERVNM.
PhylomeDBiQ93714.

Enzyme and pathway databases

ReactomeiREACT_287541. Citric acid cycle (TCA cycle).

Miscellaneous databases

NextBioi876445.
PROiQ93714.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiIDH3A_CAEEL
AccessioniPrimary (citable) accession number: Q93714
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 13, 2004
Last modified: July 22, 2015
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.