Q936V7 (OTCC_PSEME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3

Gene names

Name:

arcB

Organism

Pseudomonas mendocina

Taxonomic identifier

300 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 336	335	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000112987
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	273 – 276	4	Ornithine binding By similarity
Sites
	Binding site	108	1	Carbamoyl phosphate By similarity
	Binding site	135	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	148	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q936V7 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 19E9C0028630AFD1	FASTA	336	38,042
	10 20 30 40 50 60 MAFNMHNRNL LSLMHHSPRD VRYLLDLSRD LKRAKYTGTE QQHLKRKNIA LIFEKTSTRT 70 80 90 100 110 120 RCAFEVAAYD QGANVTYIDP NSSQIGHKES MKDTARVLGR MYDAIEYRGF KQEIVEELAT 130 140 150 160 170 180 YAGVPVFNGL TAEYHPTQML ADVLTMREHT DKPLHDITYA YLGDARNNMG NSLLLIGAKL 190 200 210 220 230 240 GMDVRIAAPK ALWPHDDHVA ACKKFAEESG ARITLTEDPK EAVKGVDFVH TDVWVSMGEP 250 260 270 280 290 300 VEAWGERIKE LLPYQVNVEI MKAAGNPRVK FMHCLPAFHN SETKVGKQIA EQYPNLKNGI 310 320 330 EVTEDVFESP WNIAFEQAEN RMHTIKAILV STLADI

References

[1]	"Ornithine transcarbamoylase from Pseudomonas." Durbecq V., Stalon V. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ417700 Genomic DNA. Translation: CAD10424.1.
3D structure databases
ProteinModelPortal	Q936V7.
SMR	Q936V7. Positions 2-336.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_PSEME

Accession

Primary (citable) accession number: Q936V7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 53 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program