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Q93650 (GLS3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative glutaminase 3

Short name=GLS
EC=3.5.1.2
Alternative name(s):
L-glutamine amidohydrolase
Gene names
Name:glna-3
ORF Names:F30F8.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length583 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Sequence similarities

Belongs to the glutaminase family.

Contains 3 ANK repeats.

Ontologies

Keywords
   DomainANK repeat
Repeat
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 583583Putative glutaminase 3 HAMAP-Rule MF_00313
PRO_0000110585

Regions

Repeat482 – 51433ANK 1 HAMAP-Rule MF_00313
Repeat515 – 54834ANK 2 HAMAP-Rule MF_00313
Repeat549 – 58133ANK 3 HAMAP-Rule MF_00313

Sites

Binding site2161Substrate By similarity
Binding site2651Substrate By similarity
Binding site3111Substrate By similarity
Binding site3181Substrate By similarity
Binding site3441Substrate By similarity
Binding site3961Substrate By similarity
Binding site4141Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q93650 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: C09BC143CCEF9198

FASTA58366,361
        10         20         30         40         50         60 
MDNKEKEDEE LSDELKDQPG PSEKPRTPTV VAFTKPSFYR VNTVISDVKV CRSMSYDMCG 

        70         80         90        100        110        120 
NHQQELLFDL YKDETTGKVY LPRFFKALLE SGIRKDDPRI DKMIQNIKDA DLLDDFVWGT 

       130        140        150        160        170        180 
QHIYLEKDTF KRYIGSSIGV VTKALKKQMI IPDWERFVSD MGEIFEDVRS HNEGDLATYI 

       190        200        210        220        230        240 
PQLSRVAPDS WAMSVCTIDG QRKMWGDALK PFCLQSVSKP FTYALVHDDI GPEELHAHVG 

       250        260        270        280        290        300 
QEPSGRLFND ISLDHNKKPH NPLINAGAIV VASLLKNKLP LADRFDFMIH ACRKFVGSGY 

       310        320        330        340        350        360 
IGFDNSVFLS ERETADRNYA LSYYMREHKV FPKDLNLQDT LDLYFQICSI ETNCDSLAVM 

       370        380        390        400        410        420 
AATLANGGVN PMNGERIVNN RACRDTLSLM YSCGMYDWSG QFAFHVGLPA KSGVSGDMII 

       430        440        450        460        470        480 
VIPNVMGIAL YSPRLDKLGN TVRGVKFAEQ LVQKYNFHNY DSLIYSDNKK IDPRRQLKDD 

       490        500        510        520        530        540 
HDGQNRFMYA TKLGDIAAIK RFLLMGHDIH CKDYDDRTVL HVAAAEGDVV TLEYVLSKWQ 

       550        560        570        580 
EDPNPCDRYD RTPLDDAKHF NHTACVKLLE EAITVYNLKG QDD 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z81073, Z79752 Genomic DNA. Translation: CAB03030.2.
PIRT21575.
RefSeqNP_492162.1. NM_059761.3.
UniGeneCel.18824.

3D structure databases

ProteinModelPortalQ93650.
SMRQ93650. Positions 74-569.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.F30F8.2.

Proteomic databases

PaxDbQ93650.
PRIDEQ93650.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF30F8.2; F30F8.2; F30F8.2.
GeneID172547.
KEGGcel:CELE_F30F8.2.
UCSCF30F8.2. c. elegans.

Organism-specific databases

CTD172547.
WormBaseF30F8.2; CE28553; WBGene00009271; glna-3.

Phylogenomic databases

eggNOGCOG2066.
HOGENOMHOG000216891.
InParanoidQ93650.
KOK01425.
OMAFRRCVGN.
OrthoDBEOG7S4X5F.
PhylomeDBQ93650.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF12796. Ank_2. 1 hit.
PF04960. Glutaminase. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio875989.

Entry information

Entry nameGLS3_CAEEL
AccessionPrimary (citable) accession number: Q93650
Secondary accession number(s): Q95QP4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: April 16, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase