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Q93650

- GLS3_CAEEL

UniProt

Q93650 - GLS3_CAEEL

Protein

Putative glutaminase 3

Gene

glna-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei216 – 2161SubstrateBy similarity
    Binding sitei265 – 2651SubstrateBy similarity
    Binding sitei311 – 3111SubstrateBy similarity
    Binding sitei318 – 3181SubstrateBy similarity
    Binding sitei344 – 3441SubstrateBy similarity
    Binding sitei396 – 3961SubstrateBy similarity
    Binding sitei414 – 4141Substrate; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative glutaminase 3 (EC:3.5.1.2)
    Short name:
    GLS
    Alternative name(s):
    L-glutamine amidohydrolase
    Gene namesi
    Name:glna-3
    ORF Names:F30F8.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiF30F8.2; CE28553; WBGene00009271; glna-3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 583583Putative glutaminase 3PRO_0000110585Add
    BLAST

    Proteomic databases

    PaxDbiQ93650.
    PRIDEiQ93650.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.F30F8.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93650.
    SMRiQ93650. Positions 74-476, 480-569.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati482 – 51433ANK 1Add
    BLAST
    Repeati515 – 54834ANK 2Add
    BLAST
    Repeati549 – 58133ANK 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the glutaminase family.Curated
    Contains 3 ANK repeats.Curated

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG2066.
    GeneTreeiENSGT00390000010463.
    HOGENOMiHOG000216891.
    InParanoidiQ93650.
    KOiK01425.
    OMAiYRVNTVI.
    OrthoDBiEOG7S4X5F.
    PhylomeDBiQ93650.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF04960. Glutaminase. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q93650-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNKEKEDEE LSDELKDQPG PSEKPRTPTV VAFTKPSFYR VNTVISDVKV    50
    CRSMSYDMCG NHQQELLFDL YKDETTGKVY LPRFFKALLE SGIRKDDPRI 100
    DKMIQNIKDA DLLDDFVWGT QHIYLEKDTF KRYIGSSIGV VTKALKKQMI 150
    IPDWERFVSD MGEIFEDVRS HNEGDLATYI PQLSRVAPDS WAMSVCTIDG 200
    QRKMWGDALK PFCLQSVSKP FTYALVHDDI GPEELHAHVG QEPSGRLFND 250
    ISLDHNKKPH NPLINAGAIV VASLLKNKLP LADRFDFMIH ACRKFVGSGY 300
    IGFDNSVFLS ERETADRNYA LSYYMREHKV FPKDLNLQDT LDLYFQICSI 350
    ETNCDSLAVM AATLANGGVN PMNGERIVNN RACRDTLSLM YSCGMYDWSG 400
    QFAFHVGLPA KSGVSGDMII VIPNVMGIAL YSPRLDKLGN TVRGVKFAEQ 450
    LVQKYNFHNY DSLIYSDNKK IDPRRQLKDD HDGQNRFMYA TKLGDIAAIK 500
    RFLLMGHDIH CKDYDDRTVL HVAAAEGDVV TLEYVLSKWQ EDPNPCDRYD 550
    RTPLDDAKHF NHTACVKLLE EAITVYNLKG QDD 583
    Length:583
    Mass (Da):66,361
    Last modified:June 6, 2002 - v2
    Checksum:iC09BC143CCEF9198
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81073, Z79752 Genomic DNA. Translation: CAB03030.2.
    PIRiT21575.
    RefSeqiNP_492162.1. NM_059761.3.
    UniGeneiCel.18824.

    Genome annotation databases

    EnsemblMetazoaiF30F8.2; F30F8.2; WBGene00009271.
    GeneIDi172547.
    KEGGicel:CELE_F30F8.2.
    UCSCiF30F8.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81073 , Z79752 Genomic DNA. Translation: CAB03030.2 .
    PIRi T21575.
    RefSeqi NP_492162.1. NM_059761.3.
    UniGenei Cel.18824.

    3D structure databases

    ProteinModelPortali Q93650.
    SMRi Q93650. Positions 74-476, 480-569.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F30F8.2.

    Proteomic databases

    PaxDbi Q93650.
    PRIDEi Q93650.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F30F8.2 ; F30F8.2 ; WBGene00009271 .
    GeneIDi 172547.
    KEGGi cel:CELE_F30F8.2.
    UCSCi F30F8.2. c. elegans.

    Organism-specific databases

    CTDi 172547.
    WormBasei F30F8.2 ; CE28553 ; WBGene00009271 ; glna-3.

    Phylogenomic databases

    eggNOGi COG2066.
    GeneTreei ENSGT00390000010463.
    HOGENOMi HOG000216891.
    InParanoidi Q93650.
    KOi K01425.
    OMAi YRVNTVI.
    OrthoDBi EOG7S4X5F.
    PhylomeDBi Q93650.

    Miscellaneous databases

    NextBioi 875989.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF12796. Ank_2. 1 hit.
    PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGLS3_CAEEL
    AccessioniPrimary (citable) accession number: Q93650
    Secondary accession number(s): Q95QP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3