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Protein

Putative glutaminase 3

Gene

glna-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei216 – 2161SubstrateBy similarity
Binding sitei265 – 2651SubstrateBy similarity
Binding sitei311 – 3111SubstrateBy similarity
Binding sitei318 – 3181SubstrateBy similarity
Binding sitei344 – 3441SubstrateBy similarity
Binding sitei396 – 3961SubstrateBy similarity
Binding sitei414 – 4141Substrate; via amide nitrogenBy similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_285804. Amino acid synthesis and interconversion (transamination).
REACT_322471. Glutamate Neurotransmitter Release Cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glutaminase 3 (EC:3.5.1.2)
Short name:
GLS
Alternative name(s):
L-glutamine amidohydrolase
Gene namesi
Name:glna-3
ORF Names:F30F8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF30F8.2; CE28553; WBGene00009271; glna-3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 583583Putative glutaminase 3PRO_0000110585Add
BLAST

Proteomic databases

PaxDbiQ93650.
PRIDEiQ93650.

Interactioni

Protein-protein interaction databases

STRINGi6239.F30F8.2.

Structurei

3D structure databases

ProteinModelPortaliQ93650.
SMRiQ93650. Positions 74-476, 480-569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati482 – 51433ANK 1Add
BLAST
Repeati515 – 54834ANK 2Add
BLAST
Repeati549 – 58133ANK 3Add
BLAST

Sequence similaritiesi

Belongs to the glutaminase family.Curated
Contains 3 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG2066.
GeneTreeiENSGT00390000010463.
HOGENOMiHOG000216891.
InParanoidiQ93650.
KOiK01425.
OMAiLLMGHDI.
OrthoDBiEOG7S4X5F.
PhylomeDBiQ93650.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF04960. Glutaminase. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNKEKEDEE LSDELKDQPG PSEKPRTPTV VAFTKPSFYR VNTVISDVKV
60 70 80 90 100
CRSMSYDMCG NHQQELLFDL YKDETTGKVY LPRFFKALLE SGIRKDDPRI
110 120 130 140 150
DKMIQNIKDA DLLDDFVWGT QHIYLEKDTF KRYIGSSIGV VTKALKKQMI
160 170 180 190 200
IPDWERFVSD MGEIFEDVRS HNEGDLATYI PQLSRVAPDS WAMSVCTIDG
210 220 230 240 250
QRKMWGDALK PFCLQSVSKP FTYALVHDDI GPEELHAHVG QEPSGRLFND
260 270 280 290 300
ISLDHNKKPH NPLINAGAIV VASLLKNKLP LADRFDFMIH ACRKFVGSGY
310 320 330 340 350
IGFDNSVFLS ERETADRNYA LSYYMREHKV FPKDLNLQDT LDLYFQICSI
360 370 380 390 400
ETNCDSLAVM AATLANGGVN PMNGERIVNN RACRDTLSLM YSCGMYDWSG
410 420 430 440 450
QFAFHVGLPA KSGVSGDMII VIPNVMGIAL YSPRLDKLGN TVRGVKFAEQ
460 470 480 490 500
LVQKYNFHNY DSLIYSDNKK IDPRRQLKDD HDGQNRFMYA TKLGDIAAIK
510 520 530 540 550
RFLLMGHDIH CKDYDDRTVL HVAAAEGDVV TLEYVLSKWQ EDPNPCDRYD
560 570 580
RTPLDDAKHF NHTACVKLLE EAITVYNLKG QDD
Length:583
Mass (Da):66,361
Last modified:June 6, 2002 - v2
Checksum:iC09BC143CCEF9198
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81073, Z79752 Genomic DNA. Translation: CAB03030.2.
PIRiT21575.
RefSeqiNP_492162.1. NM_059761.3.
UniGeneiCel.18824.

Genome annotation databases

EnsemblMetazoaiF30F8.2; F30F8.2; WBGene00009271.
GeneIDi172547.
KEGGicel:CELE_F30F8.2.
UCSCiF30F8.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81073, Z79752 Genomic DNA. Translation: CAB03030.2.
PIRiT21575.
RefSeqiNP_492162.1. NM_059761.3.
UniGeneiCel.18824.

3D structure databases

ProteinModelPortaliQ93650.
SMRiQ93650. Positions 74-476, 480-569.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F30F8.2.

Proteomic databases

PaxDbiQ93650.
PRIDEiQ93650.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF30F8.2; F30F8.2; WBGene00009271.
GeneIDi172547.
KEGGicel:CELE_F30F8.2.
UCSCiF30F8.2. c. elegans.

Organism-specific databases

CTDi172547.
WormBaseiF30F8.2; CE28553; WBGene00009271; glna-3.

Phylogenomic databases

eggNOGiCOG2066.
GeneTreeiENSGT00390000010463.
HOGENOMiHOG000216891.
InParanoidiQ93650.
KOiK01425.
OMAiLLMGHDI.
OrthoDBiEOG7S4X5F.
PhylomeDBiQ93650.

Enzyme and pathway databases

ReactomeiREACT_285804. Amino acid synthesis and interconversion (transamination).
REACT_322471. Glutamate Neurotransmitter Release Cycle.

Miscellaneous databases

NextBioi875989.
PROiQ93650.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF04960. Glutaminase. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGLS3_CAEEL
AccessioniPrimary (citable) accession number: Q93650
Secondary accession number(s): Q95QP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: April 29, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.