ID   GLGA_SYNE7              Reviewed;         465 AA.
AC   Q935Y7; Q31K71;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 3.
DT   27-MAR-2024, entry version 103.
DE   RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE            EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE   AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN   Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484};
GN   OrderedLocusNames=Synpcc7942_2518; ORFNames=sea0009;
OS   Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805)
OS   (Anacystis nidulans R2).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC   Synechococcus.
OX   NCBI_TaxID=1140;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Holtman C.K., Socias T., Mohler B.J., Chen Y., Min H., Golden S.S.,
RA   Youderian P.;
RT   "Synechococcus elongatus PCC7942 genome sequence, cosmid 7H1.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33912 / PCC 7942 / FACHB-805;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Lykidis A., Golden S., Richardson P.;
RT   "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00484}.
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DR   EMBL; U30252; AAL03921.2; -; Genomic_DNA.
DR   EMBL; CP000100; ABB58548.1; -; Genomic_DNA.
DR   RefSeq; WP_011378498.1; NZ_JACJTX010000001.1.
DR   AlphaFoldDB; Q935Y7; -.
DR   SMR; Q935Y7; -.
DR   STRING; 1140.Synpcc7942_2518; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   PaxDb; 1140-Synpcc7942_2518; -.
DR   GeneID; 76401243; -.
DR   KEGG; syf:Synpcc7942_2518; -.
DR   eggNOG; COG0297; Bacteria.
DR   HOGENOM; CLU_009583_18_2_3; -.
DR   OrthoDB; 9808590at2; -.
DR   BioCyc; SYNEL:SYNPCC7942_2518-MONOMER; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000889800; Chromosome.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd03791; GT5_Glycogen_synthase_DULL1-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   NCBIfam; TIGR02095; glgA; 1.
DR   PANTHER; PTHR45825; GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC/AMYLOPLASTIC; 1.
DR   PANTHER; PTHR45825:SF11; STARCH SYNTHASE 1, CHLOROPLASTIC_AMYLOPLASTIC; 1.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..465
FT                   /note="Glycogen synthase"
FT                   /id="PRO_0000188653"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
FT   CONFLICT        33..34
FT                   /note="LG -> SA (in Ref. 1; AAL03921)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        38
FT                   /note="R -> G (in Ref. 1; AAL03921)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        42
FT                   /note="P -> R (in Ref. 1; AAL03921)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        48
FT                   /note="N -> T (in Ref. 1; AAL03921)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        251..252
FT                   /note="DK -> IA (in Ref. 1; AAL03921)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        257
FT                   /note="K -> R (in Ref. 1; AAL03921)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   465 AA;  53347 MW;  F49F080B462B922B CRC64;
     MRILFVAAEC APFAKVGGMG DVVGSLPKVL KALGHDVRIF MPYYGFLNSK LDIPAEPIWW
     GYAMFNHFAV YETQLPGSDV PLYLMGHPAF DPHRIYSGED EDWRFTFFAN GAAEFSWNYW
     KPQVIHCHDW HTGMIPVWMH QSPDISTVFT IHNLAYQGPW RWKLEKITWC PWYMQGDSTM
     AAALLYADRV NTVSPTYAQQ IQTPTYGEKL EGLLSFISGK LSGILNGIDV DSYNPATDTR
     IVANYDRDTL DKRLNNKLAL QKEMGLEVNP DRFLIGFVAR LVEQKGIDLL LQILDRFLSY
     SDAQFVVLGT GERYYETQLW ELATRYPGRM STYLMYDEGL SRRIYAGSDA FLVPSRFEPC
     GITQMLALRY GSVPIVRRTG GLVDTVFHHD PRHAEGNGYC FDRYEPLDLY TCLVRAWESY
     QYQPQWQKLQ QRGMAVDLSW KQSAIAYEQL YAEAIGLPID VLQEA
//