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Protein

Translationally-controlled tumor protein homolog

Gene

tct-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in calcium binding and microtubule stabilization.By similarity

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein homolog
Short name:
TCTP
Gene namesi
Name:tct-1
ORF Names:F25H2.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF25H2.11; CE09656; WBGene00009122; tct-1.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Translationally-controlled tumor protein homologPRO_0000211281Add
BLAST

Proteomic databases

EPDiQ93573.
PaxDbiQ93573.

2D gel databases

World-2DPAGE0020:Q93573.

PTM databases

iPTMnetiQ93573.

Interactioni

Protein-protein interaction databases

BioGridi38358. 4 interactions.
DIPiDIP-26025N.
IntActiQ93573. 1 interaction.
MINTiMINT-1116427.
STRINGi6239.F25H2.11.1.

Structurei

Secondary structure

1
181
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 87Combined sources
Turni10 – 123Combined sources
Beta strandi14 – 163Combined sources
Beta strandi21 – 233Combined sources
Turni24 – 263Combined sources
Beta strandi27 – 315Combined sources
Beta strandi34 – 385Combined sources
Helixi61 – 633Combined sources
Beta strandi65 – 684Combined sources
Helixi69 – 724Combined sources
Turni73 – 753Combined sources
Beta strandi76 – 794Combined sources
Helixi81 – 10626Combined sources
Helixi110 – 12718Combined sources
Helixi130 – 1334Combined sources
Beta strandi137 – 1415Combined sources
Helixi142 – 1476Combined sources
Beta strandi153 – 1619Combined sources
Beta strandi164 – 1729Combined sources
Turni173 – 1753Combined sources
Beta strandi176 – 1794Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KWBNMR-A1-181[»]
2LOYNMR-A1-181[»]
ProteinModelPortaliQ93573.
SMRiQ93573. Positions 1-181.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93573.

Family & Domainsi

Sequence similaritiesi

Belongs to the TCTP family.Curated

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
InParanoidiQ93573.
OMAiCAMIEEG.
OrthoDBiEOG7SJD61.
PhylomeDBiQ93573.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIYKDIFTD DELSSDSFPM KLVDDLVYEF KGKHVVRKEG EIVLAGSNPS
60 70 80 90 100
AEEGAEDDGS DEHVERGIDI VLNHKLVEMN CYEDASMFKA YIKKFMKNVI
110 120 130 140 150
DHMEKNNRDK ADVDAFKKKI QGWVVSLLAK DRFKNLAFFI GERAAEGAEN
160 170 180
GQVAIIEYRD VDGTEVPTLM LVKEAIIEEK C
Length:181
Mass (Da):20,542
Last modified:February 1, 1997 - v1
Checksum:i112E23374D29DA12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79754 Genomic DNA. Translation: CAB02099.1.
PIRiT21352.
RefSeqiNP_492767.1. NM_060366.5.
UniGeneiCel.22560.

Genome annotation databases

EnsemblMetazoaiF25H2.11; F25H2.11; WBGene00009122.
GeneIDi172944.
KEGGicel:CELE_F25H2.11.
UCSCiF25H2.11.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79754 Genomic DNA. Translation: CAB02099.1.
PIRiT21352.
RefSeqiNP_492767.1. NM_060366.5.
UniGeneiCel.22560.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KWBNMR-A1-181[»]
2LOYNMR-A1-181[»]
ProteinModelPortaliQ93573.
SMRiQ93573. Positions 1-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38358. 4 interactions.
DIPiDIP-26025N.
IntActiQ93573. 1 interaction.
MINTiMINT-1116427.
STRINGi6239.F25H2.11.1.

PTM databases

iPTMnetiQ93573.

2D gel databases

World-2DPAGE0020:Q93573.

Proteomic databases

EPDiQ93573.
PaxDbiQ93573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF25H2.11; F25H2.11; WBGene00009122.
GeneIDi172944.
KEGGicel:CELE_F25H2.11.
UCSCiF25H2.11.1. c. elegans.

Organism-specific databases

CTDi172944.
WormBaseiF25H2.11; CE09656; WBGene00009122; tct-1.

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
InParanoidiQ93573.
OMAiCAMIEEG.
OrthoDBiEOG7SJD61.
PhylomeDBiQ93573.

Miscellaneous databases

EvolutionaryTraceiQ93573.
NextBioi877625.
PROiQ93573.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Two-dimensional gel electrophoresis of Caenorhabditis elegans homogenates and identification of protein spots by microsequencing."
    Bini L., Heid H., Liberatori S., Geier G., Pallini V., Zwilling R.
    Electrophoresis 18:557-562(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-19.
    Strain: Bristol N2.

Entry informationi

Entry nameiTCTP_CAEEL
AccessioniPrimary (citable) accession number: Q93573
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.