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Protein

Translationally-controlled tumor protein homolog

Gene

tct-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in calcium binding and microtubule stabilization.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein homolog
Short name:
TCTP
Gene namesi
Name:tct-1
ORF Names:F25H2.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF25H2.11; CE09656; WBGene00009122; tct-1.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112811 – 181Translationally-controlled tumor protein homologAdd BLAST181

Proteomic databases

EPDiQ93573.
PaxDbiQ93573.
PeptideAtlasiQ93573.
PRIDEiQ93573.

2D gel databases

World-2DPAGE0020:Q93573.

PTM databases

iPTMnetiQ93573.

Expressioni

Gene expression databases

BgeeiWBGene00009122.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi38358. 4 interactors.
DIPiDIP-26025N.
IntActiQ93573. 1 interactor.
MINTiMINT-1116427.
STRINGi6239.F25H2.11.1.

Structurei

Secondary structure

1181
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Turni10 – 12Combined sources3
Beta strandi14 – 16Combined sources3
Beta strandi21 – 23Combined sources3
Turni24 – 26Combined sources3
Beta strandi27 – 31Combined sources5
Beta strandi34 – 38Combined sources5
Helixi61 – 63Combined sources3
Beta strandi65 – 68Combined sources4
Helixi69 – 72Combined sources4
Turni73 – 75Combined sources3
Beta strandi76 – 79Combined sources4
Helixi81 – 106Combined sources26
Helixi110 – 127Combined sources18
Helixi130 – 133Combined sources4
Beta strandi137 – 141Combined sources5
Helixi142 – 147Combined sources6
Beta strandi153 – 161Combined sources9
Beta strandi164 – 172Combined sources9
Turni173 – 175Combined sources3
Beta strandi176 – 179Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KWBNMR-A1-181[»]
2LOYNMR-A1-181[»]
ProteinModelPortaliQ93573.
SMRiQ93573.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93573.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 181TCTPPROSITE-ProRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation
Contains 1 TCTP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
InParanoidiQ93573.
OMAiCYEDASM.
OrthoDBiEOG091G0OTA.
PhylomeDBiQ93573.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIYKDIFTD DELSSDSFPM KLVDDLVYEF KGKHVVRKEG EIVLAGSNPS
60 70 80 90 100
AEEGAEDDGS DEHVERGIDI VLNHKLVEMN CYEDASMFKA YIKKFMKNVI
110 120 130 140 150
DHMEKNNRDK ADVDAFKKKI QGWVVSLLAK DRFKNLAFFI GERAAEGAEN
160 170 180
GQVAIIEYRD VDGTEVPTLM LVKEAIIEEK C
Length:181
Mass (Da):20,542
Last modified:February 1, 1997 - v1
Checksum:i112E23374D29DA12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79754 Genomic DNA. Translation: CAB02099.1.
PIRiT21352.
RefSeqiNP_492767.1. NM_060366.5.
UniGeneiCel.22560.

Genome annotation databases

EnsemblMetazoaiF25H2.11; F25H2.11; WBGene00009122.
GeneIDi172944.
KEGGicel:CELE_F25H2.11.
UCSCiF25H2.11.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79754 Genomic DNA. Translation: CAB02099.1.
PIRiT21352.
RefSeqiNP_492767.1. NM_060366.5.
UniGeneiCel.22560.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KWBNMR-A1-181[»]
2LOYNMR-A1-181[»]
ProteinModelPortaliQ93573.
SMRiQ93573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38358. 4 interactors.
DIPiDIP-26025N.
IntActiQ93573. 1 interactor.
MINTiMINT-1116427.
STRINGi6239.F25H2.11.1.

PTM databases

iPTMnetiQ93573.

2D gel databases

World-2DPAGE0020:Q93573.

Proteomic databases

EPDiQ93573.
PaxDbiQ93573.
PeptideAtlasiQ93573.
PRIDEiQ93573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF25H2.11; F25H2.11; WBGene00009122.
GeneIDi172944.
KEGGicel:CELE_F25H2.11.
UCSCiF25H2.11.1. c. elegans.

Organism-specific databases

CTDi172944.
WormBaseiF25H2.11; CE09656; WBGene00009122; tct-1.

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
InParanoidiQ93573.
OMAiCYEDASM.
OrthoDBiEOG091G0OTA.
PhylomeDBiQ93573.

Miscellaneous databases

EvolutionaryTraceiQ93573.
PROiQ93573.

Gene expression databases

BgeeiWBGene00009122.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCTP_CAEEL
AccessioniPrimary (citable) accession number: Q93573
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.