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Protein

B lymphocyte-induced maturation protein 1 homolog

Gene

blmp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage (PubMed:24613396). Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning (PubMed:24968003).2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri508 – 53023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri536 – 55823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri564 – 58623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri592 – 61423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri620 – 64223C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • enhancer sequence-specific DNA binding Source: WormBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • dauer entry Source: UniProtKB
  • determination of adult lifespan Source: UniProtKB
  • hermaphrodite genitalia development Source: UniProtKB
  • negative regulation of distal tip cell migration Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of epidermis development Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B lymphocyte-induced maturation protein 1 homologImported
Gene namesi
Name:blmp-1Imported
ORF Names:F25D7.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF25D7.3a; CE09631; WBGene00003847; blmp-1.
F25D7.3b; CE43409; WBGene00003847; blmp-1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Gonadal migration defects with premature dorsal turning of distal tip cells in the hermaphrodite gonad (PubMed:24613396, PubMed:24968003). Defective dauer formation, shortened lifespan and retarded terminal differentiation of seam cells with incomplete adult alae synthesis (PubMed:24613396). Suppresses the precocious seam cell terminal differentiation and gonadal migration defects seen in dre-1 mutants (PubMed:24613396). Weak dumpy phenotype and partially penetrant embryonic lethality (PubMed:24968003).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 817817B lymphocyte-induced maturation protein 1 homologCuratedPRO_0000430670Add
BLAST

Post-translational modificationi

Ubiquitinated by the SCF(dre-1) complex, leading to its degradation by the proteasome.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ93560.
PaxDbiQ93560.

Expressioni

Tissue specificityi

Expressed in hypodermal, vulval, intestinal and distal tip cells.1 Publication

Developmental stagei

In distal tip cells, expressed from mid-L2 when gonadal outgrowth initiates (PubMed:24613396). By mid-L3, just prior to the dorsal gonadal turn, levels drop dramatically (PubMed:24968003). In seam and hypodermal cells, levels are largely constant throughout larval development except for a transient peak early in L4 (PubMed:24613396).2 Publications

Gene expression databases

ExpressionAtlasiQ93560. baseline and differential.

Interactioni

Subunit structurei

Interacts with dre-1; the interaction targets blmp-1 for proteasomal degradation.2 Publications

Protein-protein interaction databases

BioGridi38333. 1 interaction.
IntActiQ93560. 12 interactions.
STRINGi6239.F25D7.3a.

Structurei

3D structure databases

ProteinModelPortaliQ93560.
SMRiQ93560. Positions 54-255, 499-646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 241139SETPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 5944Ser-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi712 – 79382Gln-richPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SET domain.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri508 – 53023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri536 – 55823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri564 – 58623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri592 – 61423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri620 – 64223C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2461. Eukaryota.
ENOG410ZFVU. LUCA.
GeneTreeiENSGT00830000128336.
HOGENOMiHOG000016658.
InParanoidiQ93560.
OMAiKTRYACK.
OrthoDBiEOG7060Q3.
PhylomeDBiQ93560.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q93560-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQGSGDDGV PPAPFSSAAA AAHSPPHSPL SVGVSSASSA TSSSSTPPSS
60 70 80 90 100
TSPAGVSASG ARNVETDWKQ SGDENLAELC IFHVPDKSVS LPNPKRAECT
110 120 130 140 150
LPMNLILKSS SKNRKKSSIW SSDHIPRGVR FGPLVGEIRL VDVDTALVCP
160 170 180 190 200
AEASMAGGGP AQEDVPFDEA PEEWKIYSPS GGRLNKTICV KDDARSNWMK
210 220 230 240 250
YVAAAEEEDF QNLVAAQIGN DIYFYTVKKI EANTELSFWF SRDYARKLNY
260 270 280 290 300
STRPYVRVRR PATQLIPSAP PASASTAIAS LAETIVAIDY SVKKLIESPI
310 320 330 340 350
DTLSTDASSA SDEEMIDVEE QESCTRPVAE VTRPNVIQNP VVRPVATKVN
360 370 380 390 400
NFPGIPVRLG NFYASPLVDF KEFMRKSLQL KLVDTSMFVS PVAQTTAAIT
410 420 430 440 450
ATGGRSGQPI DVQPVLAATA GAHFGNYAAI YGSQDFQHEL SKPLYTSASP
460 470 480 490 500
AFGGGGGMGG GFGMGGSAHT SSFHQLPFVN HSSSSHNDSS FNGVPNYVQQ
510 520 530 540 550
QENGKTRYAC KDCNKTFGQL SNLKVHVRTH TGERPFKCEI CTKEFTQLAH
560 570 580 590 600
LQKHHLVHTG ERPHRCDICD KRFSSTSNLK THLRLHNGQK PYTCDVCDAK
610 620 630 640 650
FTQYVHLRLH KRLHANERPY SCGTCGKKYI SPSGLRTHWK TTTCKEEDMK
660 670 680 690 700
DSMRDDLMDI KGEIDEGSMS GSGYGNLGIF ENTLNSELKR PLMPIETIYS
710 720 730 740 750
KYNLPNASLL GQGPSGMQEQ QAPPPTSQQQ QHMMYGNTMG HMGQGSHLQG
760 770 780 790 800
PPPPPQHFQM DHSGMQNGGG IPHQHQLIQG GPSSGSGQQQ HPQHNGIHRL
810
PDLKNPLLPS LGLPHYP
Note: No experimental confirmation available.Curated
Length:817
Mass (Da):88,639
Last modified:February 1, 1997 - v1
Checksum:i4B74F5263A9594FA
GO
Isoform 2 (identifier: Q93560-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     685-700: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:801
Mass (Da):86,766
Checksum:i7B7B22C98D91DEB7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei685 – 70016Missing in isoform 2. 1 PublicationVSP_057061Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z78418 Genomic DNA. Translation: CAB01695.1.
Z78418 Genomic DNA. Translation: CAV31771.1.
PIRiT21336.
RefSeqiNP_001251370.1. NM_001264441.1. [Q93560-1]
NP_001251371.1. NM_001264442.1. [Q93560-2]
UniGeneiCel.18891.

Genome annotation databases

EnsemblMetazoaiF25D7.3a; F25D7.3a; WBGene00003847. [Q93560-1]
GeneIDi172917.
KEGGicel:CELE_F25D7.3.
UCSCiF25D7.3. c. elegans. [Q93560-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z78418 Genomic DNA. Translation: CAB01695.1.
Z78418 Genomic DNA. Translation: CAV31771.1.
PIRiT21336.
RefSeqiNP_001251370.1. NM_001264441.1. [Q93560-1]
NP_001251371.1. NM_001264442.1. [Q93560-2]
UniGeneiCel.18891.

3D structure databases

ProteinModelPortaliQ93560.
SMRiQ93560. Positions 54-255, 499-646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38333. 1 interaction.
IntActiQ93560. 12 interactions.
STRINGi6239.F25D7.3a.

Proteomic databases

EPDiQ93560.
PaxDbiQ93560.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF25D7.3a; F25D7.3a; WBGene00003847. [Q93560-1]
GeneIDi172917.
KEGGicel:CELE_F25D7.3.
UCSCiF25D7.3. c. elegans. [Q93560-1]

Organism-specific databases

CTDi172917.
WormBaseiF25D7.3a; CE09631; WBGene00003847; blmp-1.
F25D7.3b; CE43409; WBGene00003847; blmp-1.

Phylogenomic databases

eggNOGiKOG2461. Eukaryota.
ENOG410ZFVU. LUCA.
GeneTreeiENSGT00830000128336.
HOGENOMiHOG000016658.
InParanoidiQ93560.
OMAiKTRYACK.
OrthoDBiEOG7060Q3.
PhylomeDBiQ93560.

Miscellaneous databases

NextBioi877519.
PROiQ93560.

Gene expression databases

ExpressionAtlasiQ93560. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2Imported.
  2. "DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation."
    Horn M., Geisen C., Cermak L., Becker B., Nakamura S., Klein C., Pagano M., Antebi A.
    Dev. Cell 28:697-710(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DRE-1, DEVELOPMENTAL STAGE, UBIQUITINATION, DISRUPTION PHENOTYPE.
  3. "BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans."
    Huang T.F., Cho C.Y., Cheng Y.T., Huang J.W., Wu Y.Z., Yeh A.Y., Nishiwaki K., Chang S.C., Wu Y.C.
    PLoS Genet. 10:E1004428-E1004428(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DRE-1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiBLMP1_CAEEL
AccessioniPrimary (citable) accession number: Q93560
Secondary accession number(s): B7WN98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.