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Protein

Zinc metalloproteinase nas-24

Gene

nas-24

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable metalloprotease.By similarity

Catalytic activityi

Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi137Zinc; catalyticPROSITE-ProRule annotation1
Active sitei138PROSITE-ProRule annotation1
Metal bindingi141Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi147Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.A39.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-24 (EC:3.4.24.21)
Alternative name(s):
Nematode astacin 24
Gene namesi
Name:nas-24
ORF Names:F20G2.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF20G2.4; CE35860; WBGene00003543; nas-24.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002892821 – 396Zinc metalloproteinase nas-24Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi229 ↔ 237By similarity
Disulfide bondi231 ↔ 251By similarity
Disulfide bondi253 ↔ 262By similarity
Glycosylationi310N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ93542.
PeptideAtlasiQ93542.

Expressioni

Gene expression databases

BgeeiWBGene00003543.

Structurei

3D structure databases

ProteinModelPortaliQ93542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini224 – 263EGF-likeAdd BLAST40

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000113731.
InParanoidiQ93542.
OMAiTHIHELM.
OrthoDBiEOG091G0MI1.
PhylomeDBiQ93542.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR017050. Metallopeptidase_nem.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PIRSFiPIRSF036365. Astacin_nematoda. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRVVHIIGA AFLLSSYAYC GLSRFNEHDI EGGDSYKRVK REFERLGSKW
60 70 80 90 100
LGGTINYYYA DNNNSVKEKV KSAIAYIANH TCIKFNEDPT HWQRLKIFTS
110 120 130 140 150
ELSHCRSTIG APGTRSGSAG ELSMETGWCA NIGSIVHEFS HSLGRYHEHT
160 170 180 190 200
RPDRDNSLKV TSTDYEARPR PWGMTTMYGP FEHGSIMMYH SSNYGVGKME
210 220 230 240 250
PYDMEYKNTM GSRRVTFYDM YKINQYYGCG CSTQLECKNG GYTSPSDCSR
260 270 280 290 300
CNCPKGFFGK LCNERRQQDS YELKATYGRW QTQTISFNYK PEPVSDGFYS
310 320 330 340 350
TFVYITGEAN STIEITMEGL ENVICTAGCT WNGVEIKSRE DSRITSPVMC
360 370 380 390
CKDEPLYKKV FKSLHNPTII ELYSKETAPS TATFKYRFMN DKIVFG
Length:396
Mass (Da):45,162
Last modified:July 5, 2004 - v2
Checksum:iD9ADF3608ADFC95A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79753 Genomic DNA. Translation: CAB02084.2.
AJ561214 mRNA. Translation: CAD99215.1.
PIRiT21166.
RefSeqiNP_506409.2. NM_074008.2.
UniGeneiCel.3976.

Genome annotation databases

EnsemblMetazoaiF20G2.4; F20G2.4; WBGene00003543.
GeneIDi184744.
KEGGicel:CELE_F20G2.4.
UCSCiF20G2.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79753 Genomic DNA. Translation: CAB02084.2.
AJ561214 mRNA. Translation: CAD99215.1.
PIRiT21166.
RefSeqiNP_506409.2. NM_074008.2.
UniGeneiCel.3976.

3D structure databases

ProteinModelPortaliQ93542.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM12.A39.

Proteomic databases

PaxDbiQ93542.
PeptideAtlasiQ93542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF20G2.4; F20G2.4; WBGene00003543.
GeneIDi184744.
KEGGicel:CELE_F20G2.4.
UCSCiF20G2.4. c. elegans.

Organism-specific databases

CTDi184744.
WormBaseiF20G2.4; CE35860; WBGene00003543; nas-24.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000113731.
InParanoidiQ93542.
OMAiTHIHELM.
OrthoDBiEOG091G0MI1.
PhylomeDBiQ93542.

Miscellaneous databases

PROiQ93542.

Gene expression databases

BgeeiWBGene00003543.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR017050. Metallopeptidase_nem.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PIRSFiPIRSF036365. Astacin_nematoda. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAS24_CAEEL
AccessioniPrimary (citable) accession number: Q93542
Secondary accession number(s): Q7Z0M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.