Reviewed, UniProtKB/Swiss-Prot Q934J6 (PHON_SALTI)

Names and origin

Protein names

Recommended name:
    Non-specific acid phosphatase
      Short name=NSAP
    EC=3.1.3.2

Gene names

Name:	phoN
Ordered Locus Names:	STY4519, t4225

Organism

Salmonella typhi [Complete proteome] [HAMAP]

Taxonomic identifier

90370 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Subunit structure	Homodimer By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the class A bacterial acid phosphatase family.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	membrane Inferred from electronic annotation. Source: InterPro outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	acid phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 250	230	Non-specific acid phosphatase		PRO_0000024001

Sequences

	Sequence		Length	Mass (Da)
	Q934J6-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 02B92D2035F4FE82	FASTA	250	28,459
	10 20 30 40 50 60 MKSRYLLFFL PLIVAKYTSA ATMQPFHSPE ESVNSQFYLP PPPGNDDPAF RYDKEAYFKG 70 80 90 100 110 120 YAIKGSPRWK QAAEDADISV ENIARIFSPV VGAKINPKDT PETWNMLQNL LKMGGYYATA 130 140 150 160 170 180 SAKKYYMRTR PFVLFNHSTC RPEDENTLRK DGSYPSGHTA YSTLLALVLS QARPERAQEL 190 200 210 220 230 240 ARRGWEFGQS RVICGAHWQS DVDAGRYVGA VEFARLQTIP AFQKSLAKVR EELNDKNNLL 250 SKEERPELNY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"phoN, a gene for acid phosphatase from Salmonella typhi." Rao A.S., Mukhopadhyaya R., Mahajan S.K. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18.
[3]	"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF366353 Genomic DNA. Translation: AAK50861.1. AL627282 Genomic DNA. Translation: CAD09303.1. AE014613 Genomic DNA. Translation: AAO71687.1.
RefSeq	NP_458615.1. NP_807827.1.
3D structure databases
HSSP	HSSP built from PDB template 1IW8 based on UniProtKB Q9S1A6.
SMR	Q934J6. Positions 23-241.
ModBase	Search...
Genome annotation databases
GeneID	1068505. 1250732.
GenomeReviews	Gene locus t4225 in contig AE014613_GR. Gene locus STY4519 in contig AL513382_GR.
KEGG	stt:t4225. sty:STY4519.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q934J6.
OMA	SPRWKQA.
Enzyme and pathway databases
BioCyc	SENT209261:T4225-MON. SENT220341:STY4519-MON.
BRENDA	3.1.3.2. 3716.
Family and domain databases
InterPro	IPR011158. Acid_Pase_ClassA. IPR001011. Acid_Pase_classA_bac. IPR018296. Acid_Pase_classA_bac_CS. IPR016118. P_Acid_Pase/Cl_peroxidase_N. IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Gene3D	G3DSA:1.20.144.10. P_Acid_Pase/Cl_peroxidase_N. 1 hit.
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
PIRSF	PIRSF000897. Acid_Ptase_ClsA. 1 hit.
PRINTS	PR00483. BACPHPHTASE.
ProDom	PD009838. Bac_AcPataseA. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
PROSITE	PS01157. ACID_PHOSPH_CL_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHON_SALTI

Accession

Primary (citable) accession number: Q934J6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2002
Last sequence update:	December 1, 2001
Last modified:	November 3, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)