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Q93413

- Q93413_CAEEL

UniProt

Q93413 - Q93413_CAEEL

Protein
Submitted name:

Protein DRH-3

Gene

drh-3

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. double-stranded RNA binding Source: WormBase
    3. helicase activity Source: UniProtKB-KW
    4. protein binding Source: IntAct
    5. RNA-dependent ATPase activity Source: WormBase
    6. RNA polymerase binding Source: WormBase
    7. single-stranded RNA binding Source: WormBase

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. production of siRNA involved in RNA interference Source: WormBase
    3. RNA interference Source: WormBase

    Keywords - Molecular functioni

    HelicaseUniRule annotation, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_183161. Negative regulators of RIG-I/MDA5 signaling.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein DRH-3Imported
    Gene namesi
    Name:drh-3Imported
    ORF Names:CELE_D2005.5Imported, D2005.5Imported
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiD2005.5; CE36120; WBGene00008400; drh-3.

    Subcellular locationi

    GO - Cellular componenti

    1. condensed nuclear chromosome Source: WormBase
    2. cytoplasm Source: WormBase
    3. metaphase plate Source: WormBase
    4. P granule Source: WormBase

    PTM / Processingi

    Proteomic databases

    PaxDbiQ93413.
    PRIDEiQ93413.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    rrf-1G5ECM12EBI-866549,EBI-7692364

    Protein-protein interaction databases

    DIPiDIP-35120N.
    IntActiQ93413. 3 interactions.
    MINTiMINT-6178703.
    STRINGi6239.D2005.5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93413.
    SMRiQ93413. Positions 345-921.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1111.
    GeneTreeiENSGT00510000046789.
    HOGENOMiHOG000018535.
    InParanoidiQ93413.
    KOiK12646.
    OMAiALISEKF.
    OrthoDBiEOG7B8S3M.
    PhylomeDBiQ93413.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR021673. RIG-I_C-RD.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF11648. RIG-I_C-RD. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q93413-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPTAIRLED YDKSKLRLPF ESPYFPAYFR LLKWKFLDVC VESTRNNDIG     50
    YFKLFESLFP PGKLEEIARM IIDEPTPVSH DPDMIKIRNA DLDVKIRKQA 100
    ETYVTLRHAH QQKVQRRRFS ECFLNTVLFD EKGLRIADEV MFNYDKELYG 150
    YSHWEDLPDG WLTAETFKNK FYDEEEVTNN PFGYQKLDRV AGAARGMIIM 200
    KHLKSNPRCV SETTILAFEV FNKGNHQLST DLVEDLLTEG PAFELKIENG 250
    EEKKYAVKKW SLHKTLTMFL AIIGFKSNDK KEKNEHEEWY YGFIDAMKND 300
    PANRAALYFL DKNWPEELEE REKERDRIRL TLLKSQRTNE EAVGEDVCTT 350
    IRPQPKDSGY NPDAVVTELV LRTYQEELVQ PALEGKNCVI VAPTGSGKTE 400
    VAIYAALKHI EERTSQGKPS RVVLLVPKIP LVGQQKDRFL KYCNGMYEVN 450
    GFHGSESSVS GTGRRDEVIA THVSVMTPQI LINMLQSVRQ NERLYVSDFS 500
    MMIFDEVHKA AKNHPYVLIN QMVQEWKYEK PQIIGLTASL SVKVDGQKDE 550
    NQMLNDIYNM LALINAPHLS TITRQSSIDE LNEHVGKPDD SVELCLPAKE 600
    NILRDYIERY LNHAHGKFLE ELASMSKSTG RNNTIPPNMI NTFKKNQPKN 650
    YEYYDSLLQG IIQELNKLNV PEKWNSQTWA KYMKVYLEAR GIVDLMPAMV 700
    AFKYMEKAIG KLNESHSETV EYSTFIKDHD TLKQTIQSVE PEIVLRLKNT 750
    LTNQFHVAPE SRVIIFVTQR STAQRVSDFL NESKVLDQFG NYGEQMVGYV 800
    LGTNKQGAVQ QTSQEQQLTL DKFNNGRLKV IVATSVVEEG LDVTACNLII 850
    KYNCSSGSAI QLVQQRGRAR AKNSRSVLLS VKSSINETET NALISEKYMR 900
    LCVKKITENG EKQLAAEVKR VAELNAAERK RNLEEQLNLR LRHENKIYKL 950
    MCSNCSKEFC KSIYIKKVFS NYMVFDPSVW RFLHVESKRK VSKYLSEDNQ 1000
    PLSDIKCFHC KLDVGRAYKI RGTYLPQLSV KALTFVQESD YSSMTKAKWS 1050
    DVEQDLFYIS EAIEDDFRIM LNALSDTEEN IEKKIVLDLD SRQHNKQLEM 1100
    KRFHIQQEPP TKGVAPEAQ 1119
    Length:1,119
    Mass (Da):129,096
    Last modified:July 5, 2004 - v3
    Checksum:iEDBDA9994166DF5A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z79752 Genomic DNA. Translation: CAB02082.3.
    PIRiT20332.
    RefSeqiNP_492161.3. NM_059760.5.
    UniGeneiCel.16985.

    Genome annotation databases

    EnsemblMetazoaiD2005.5; D2005.5; WBGene00008400.
    GeneIDi172546.
    KEGGicel:CELE_D2005.5.
    UCSCiD2005.5. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z79752 Genomic DNA. Translation: CAB02082.3 .
    PIRi T20332.
    RefSeqi NP_492161.3. NM_059760.5.
    UniGenei Cel.16985.

    3D structure databases

    ProteinModelPortali Q93413.
    SMRi Q93413. Positions 345-921.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-35120N.
    IntActi Q93413. 3 interactions.
    MINTi MINT-6178703.
    STRINGi 6239.D2005.5.

    Proteomic databases

    PaxDbi Q93413.
    PRIDEi Q93413.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai D2005.5 ; D2005.5 ; WBGene00008400 .
    GeneIDi 172546.
    KEGGi cel:CELE_D2005.5.
    UCSCi D2005.5. c. elegans.

    Organism-specific databases

    CTDi 172546.
    WormBasei D2005.5 ; CE36120 ; WBGene00008400 ; drh-3.

    Phylogenomic databases

    eggNOGi COG1111.
    GeneTreei ENSGT00510000046789.
    HOGENOMi HOG000018535.
    InParanoidi Q93413.
    KOi K12646.
    OMAi ALISEKF.
    OrthoDBi EOG7B8S3M.
    PhylomeDBi Q93413.

    Enzyme and pathway databases

    Reactomei REACT_183161. Negative regulators of RIG-I/MDA5 signaling.

    Miscellaneous databases

    NextBioi 875985.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR021673. RIG-I_C-RD.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF11648. RIG-I_C-RD. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2Imported.

    Entry informationi

    Entry nameiQ93413_CAEEL
    AccessioniPrimary (citable) accession number: Q93413
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 1, 1997
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3