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Protein
Submitted name:

Dicer Related Helicase

Gene

drh-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATPase activity Source: WormBase
  • ATP binding Source: InterPro
  • double-stranded RNA binding Source: WormBase
  • helicase activity Source: UniProtKB-KW
  • RNA-dependent ATPase activity Source: WormBase
  • RNA polymerase binding Source: WormBase
  • single-stranded RNA binding Source: WormBase

GO - Biological processi

  • P granule assembly Source: WormBase
  • production of siRNA involved in RNA interference Source: WormBase
  • RNA interference Source: WormBase

Keywordsi

Molecular functionHelicaseImported, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-1169408 ISG15 antiviral mechanism
R-CEL-5689880 Ub-specific processing proteases
R-CEL-936440 Negative regulators of DDX58/IFIH1 signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Dicer Related HelicaseImported
Gene namesi
Name:drh-3Imported
ORF Names:CELE_D2005.5Imported, D2005.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiD2005.5 ; CE36120 ; WBGene00008400 ; drh-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

EPDiQ93413
PaxDbiQ93413
PeptideAtlasiQ93413

Expressioni

Gene expression databases

BgeeiWBGene00008400

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • RNA polymerase binding Source: WormBase

Protein-protein interaction databases

DIPiDIP-35120N
IntActiQ93413, 5 interactors
MINTiQ93413
STRINGi6239.D2005.5

Structurei

3D structure databases

ProteinModelPortaliQ93413
SMRiQ93413
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini379 – 558Helicase ATP-bindingInterPro annotationAdd BLAST180
Domaini731 – 915Helicase C-terminalInterPro annotationAdd BLAST185
Domaini938 – 1066RLR CTRInterPro annotationAdd BLAST129

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili924 – 944Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0354 Eukaryota
COG1111 LUCA
GeneTreeiENSGT00510000046789
HOGENOMiHOG000018535
InParanoidiQ93413
KOiK12646
OMAiIIKYNCS
OrthoDBiEOG091G01PQ
PhylomeDBiQ93413

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di2.170.150.30, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038557 RLR_C_sf
IPR021673 RLR_CTR
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF11648 RIG-I_C-RD, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51789 RLR_CTR, 1 hit

Sequencei

Sequence statusi: Complete.

Q93413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPTAIRLED YDKSKLRLPF ESPYFPAYFR LLKWKFLDVC VESTRNNDIG
60 70 80 90 100
YFKLFESLFP PGKLEEIARM IIDEPTPVSH DPDMIKIRNA DLDVKIRKQA
110 120 130 140 150
ETYVTLRHAH QQKVQRRRFS ECFLNTVLFD EKGLRIADEV MFNYDKELYG
160 170 180 190 200
YSHWEDLPDG WLTAETFKNK FYDEEEVTNN PFGYQKLDRV AGAARGMIIM
210 220 230 240 250
KHLKSNPRCV SETTILAFEV FNKGNHQLST DLVEDLLTEG PAFELKIENG
260 270 280 290 300
EEKKYAVKKW SLHKTLTMFL AIIGFKSNDK KEKNEHEEWY YGFIDAMKND
310 320 330 340 350
PANRAALYFL DKNWPEELEE REKERDRIRL TLLKSQRTNE EAVGEDVCTT
360 370 380 390 400
IRPQPKDSGY NPDAVVTELV LRTYQEELVQ PALEGKNCVI VAPTGSGKTE
410 420 430 440 450
VAIYAALKHI EERTSQGKPS RVVLLVPKIP LVGQQKDRFL KYCNGMYEVN
460 470 480 490 500
GFHGSESSVS GTGRRDEVIA THVSVMTPQI LINMLQSVRQ NERLYVSDFS
510 520 530 540 550
MMIFDEVHKA AKNHPYVLIN QMVQEWKYEK PQIIGLTASL SVKVDGQKDE
560 570 580 590 600
NQMLNDIYNM LALINAPHLS TITRQSSIDE LNEHVGKPDD SVELCLPAKE
610 620 630 640 650
NILRDYIERY LNHAHGKFLE ELASMSKSTG RNNTIPPNMI NTFKKNQPKN
660 670 680 690 700
YEYYDSLLQG IIQELNKLNV PEKWNSQTWA KYMKVYLEAR GIVDLMPAMV
710 720 730 740 750
AFKYMEKAIG KLNESHSETV EYSTFIKDHD TLKQTIQSVE PEIVLRLKNT
760 770 780 790 800
LTNQFHVAPE SRVIIFVTQR STAQRVSDFL NESKVLDQFG NYGEQMVGYV
810 820 830 840 850
LGTNKQGAVQ QTSQEQQLTL DKFNNGRLKV IVATSVVEEG LDVTACNLII
860 870 880 890 900
KYNCSSGSAI QLVQQRGRAR AKNSRSVLLS VKSSINETET NALISEKYMR
910 920 930 940 950
LCVKKITENG EKQLAAEVKR VAELNAAERK RNLEEQLNLR LRHENKIYKL
960 970 980 990 1000
MCSNCSKEFC KSIYIKKVFS NYMVFDPSVW RFLHVESKRK VSKYLSEDNQ
1010 1020 1030 1040 1050
PLSDIKCFHC KLDVGRAYKI RGTYLPQLSV KALTFVQESD YSSMTKAKWS
1060 1070 1080 1090 1100
DVEQDLFYIS EAIEDDFRIM LNALSDTEEN IEKKIVLDLD SRQHNKQLEM
1110
KRFHIQQEPP TKGVAPEAQ
Length:1,119
Mass (Da):129,096
Last modified:July 5, 2004 - v3
Checksum:iEDBDA9994166DF5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB02082.3
PIRiT20332
RefSeqiNP_492161.3, NM_059760.5
UniGeneiCel.16985

Genome annotation databases

EnsemblMetazoaiD2005.5; D2005.5; WBGene00008400
GeneIDi172546
KEGGicel:CELE_D2005.5
UCSCiD2005.5 c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ93413_CAEEL
AccessioniPrimary (citable) accession number: Q93413
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health