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Protein
Submitted name:

Dicer Related Helicase

Gene

drh-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATPase activity Source: WormBase
  • ATP binding Source: InterPro
  • double-stranded RNA binding Source: WormBase
  • helicase activity Source: UniProtKB-KW
  • RNA-dependent ATPase activity Source: WormBase
  • RNA polymerase binding Source: WormBase
  • single-stranded RNA binding Source: WormBase

GO - Biological processi

  • P granule assembly Source: WormBase
  • production of siRNA involved in RNA interference Source: WormBase
  • RNA interference Source: WormBase

Keywordsi

Molecular functionHelicaseImported, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-5689880. Ub-specific processing proteases.
R-CEL-936440. Negative regulators of DDX58/IFIH1 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Dicer Related HelicaseImported
Gene namesi
Name:drh-3Imported
ORF Names:CELE_D2005.5Imported, D2005.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiD2005.5; CE36120; WBGene00008400; drh-3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

EPDiQ93413.
PaxDbiQ93413.
PeptideAtlasiQ93413.

Expressioni

Gene expression databases

BgeeiWBGene00008400.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rrf-1G5ECM12EBI-866549,EBI-7692364

GO - Molecular functioni

  • RNA polymerase binding Source: WormBase

Protein-protein interaction databases

DIPiDIP-35120N.
IntActiQ93413. 3 interactors.
MINTiMINT-6178703.
STRINGi6239.D2005.5.

Structurei

3D structure databases

ProteinModelPortaliQ93413.
SMRiQ93413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini379 – 558Helicase ATP-bindingInterPro annotationAdd BLAST180
Domaini731 – 915Helicase C-terminalInterPro annotationAdd BLAST185
Domaini938 – 1066RLR CTRInterPro annotationAdd BLAST129

Phylogenomic databases

eggNOGiKOG0354. Eukaryota.
COG1111. LUCA.
GeneTreeiENSGT00510000046789.
HOGENOMiHOG000018535.
InParanoidiQ93413.
KOiK12646.
OMAiLIIKYNC.
OrthoDBiEOG091G01PQ.
PhylomeDBiQ93413.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RLR_CTR.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51789. RLR_CTR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q93413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPTAIRLED YDKSKLRLPF ESPYFPAYFR LLKWKFLDVC VESTRNNDIG
60 70 80 90 100
YFKLFESLFP PGKLEEIARM IIDEPTPVSH DPDMIKIRNA DLDVKIRKQA
110 120 130 140 150
ETYVTLRHAH QQKVQRRRFS ECFLNTVLFD EKGLRIADEV MFNYDKELYG
160 170 180 190 200
YSHWEDLPDG WLTAETFKNK FYDEEEVTNN PFGYQKLDRV AGAARGMIIM
210 220 230 240 250
KHLKSNPRCV SETTILAFEV FNKGNHQLST DLVEDLLTEG PAFELKIENG
260 270 280 290 300
EEKKYAVKKW SLHKTLTMFL AIIGFKSNDK KEKNEHEEWY YGFIDAMKND
310 320 330 340 350
PANRAALYFL DKNWPEELEE REKERDRIRL TLLKSQRTNE EAVGEDVCTT
360 370 380 390 400
IRPQPKDSGY NPDAVVTELV LRTYQEELVQ PALEGKNCVI VAPTGSGKTE
410 420 430 440 450
VAIYAALKHI EERTSQGKPS RVVLLVPKIP LVGQQKDRFL KYCNGMYEVN
460 470 480 490 500
GFHGSESSVS GTGRRDEVIA THVSVMTPQI LINMLQSVRQ NERLYVSDFS
510 520 530 540 550
MMIFDEVHKA AKNHPYVLIN QMVQEWKYEK PQIIGLTASL SVKVDGQKDE
560 570 580 590 600
NQMLNDIYNM LALINAPHLS TITRQSSIDE LNEHVGKPDD SVELCLPAKE
610 620 630 640 650
NILRDYIERY LNHAHGKFLE ELASMSKSTG RNNTIPPNMI NTFKKNQPKN
660 670 680 690 700
YEYYDSLLQG IIQELNKLNV PEKWNSQTWA KYMKVYLEAR GIVDLMPAMV
710 720 730 740 750
AFKYMEKAIG KLNESHSETV EYSTFIKDHD TLKQTIQSVE PEIVLRLKNT
760 770 780 790 800
LTNQFHVAPE SRVIIFVTQR STAQRVSDFL NESKVLDQFG NYGEQMVGYV
810 820 830 840 850
LGTNKQGAVQ QTSQEQQLTL DKFNNGRLKV IVATSVVEEG LDVTACNLII
860 870 880 890 900
KYNCSSGSAI QLVQQRGRAR AKNSRSVLLS VKSSINETET NALISEKYMR
910 920 930 940 950
LCVKKITENG EKQLAAEVKR VAELNAAERK RNLEEQLNLR LRHENKIYKL
960 970 980 990 1000
MCSNCSKEFC KSIYIKKVFS NYMVFDPSVW RFLHVESKRK VSKYLSEDNQ
1010 1020 1030 1040 1050
PLSDIKCFHC KLDVGRAYKI RGTYLPQLSV KALTFVQESD YSSMTKAKWS
1060 1070 1080 1090 1100
DVEQDLFYIS EAIEDDFRIM LNALSDTEEN IEKKIVLDLD SRQHNKQLEM
1110
KRFHIQQEPP TKGVAPEAQ
Length:1,119
Mass (Da):129,096
Last modified:July 5, 2004 - v3
Checksum:iEDBDA9994166DF5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB02082.3.
PIRiT20332.
RefSeqiNP_492161.3. NM_059760.5.
UniGeneiCel.16985.

Genome annotation databases

EnsemblMetazoaiD2005.5; D2005.5; WBGene00008400.
GeneIDi172546.
KEGGicel:CELE_D2005.5.
UCSCiD2005.5. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ93413_CAEEL
AccessioniPrimary (citable) accession number: Q93413
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported