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Q93413

- Q93413_CAEEL

UniProt

Q93413 - Q93413_CAEEL

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Protein
Submitted name:

Protein DRH-3

Gene

drh-3

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. double-stranded RNA binding Source: WormBase
  3. helicase activity Source: UniProtKB-KW
  4. RNA-dependent ATPase activity Source: WormBase
  5. RNA polymerase binding Source: WormBase
  6. single-stranded RNA binding Source: WormBase

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. production of siRNA involved in RNA interference Source: WormBase
  3. RNA interference Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

HelicaseUniRule annotation, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_183161. Negative regulators of RIG-I/MDA5 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein DRH-3Imported
Gene namesi
Name:drh-3Imported
ORF Names:CELE_D2005.5Imported, D2005.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiD2005.5; CE36120; WBGene00008400; drh-3.

Subcellular locationi

GO - Cellular componenti

  1. condensed nuclear chromosome Source: WormBase
  2. cytoplasm Source: WormBase
  3. metaphase plate Source: WormBase
  4. P granule Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ93413.
PRIDEiQ93413.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rrf-1G5ECM12EBI-866549,EBI-7692364

Protein-protein interaction databases

DIPiDIP-35120N.
IntActiQ93413. 3 interactions.
MINTiMINT-6178703.
STRINGi6239.D2005.5.

Structurei

3D structure databases

ProteinModelPortaliQ93413.
SMRiQ93413. Positions 345-921.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1111.
GeneTreeiENSGT00510000046789.
HOGENOMiHOG000018535.
InParanoidiQ93413.
KOiK12646.
OMAiALISEKF.
OrthoDBiEOG7B8S3M.
PhylomeDBiQ93413.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RIG-I_C-RD.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93413-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPTAIRLED YDKSKLRLPF ESPYFPAYFR LLKWKFLDVC VESTRNNDIG
60 70 80 90 100
YFKLFESLFP PGKLEEIARM IIDEPTPVSH DPDMIKIRNA DLDVKIRKQA
110 120 130 140 150
ETYVTLRHAH QQKVQRRRFS ECFLNTVLFD EKGLRIADEV MFNYDKELYG
160 170 180 190 200
YSHWEDLPDG WLTAETFKNK FYDEEEVTNN PFGYQKLDRV AGAARGMIIM
210 220 230 240 250
KHLKSNPRCV SETTILAFEV FNKGNHQLST DLVEDLLTEG PAFELKIENG
260 270 280 290 300
EEKKYAVKKW SLHKTLTMFL AIIGFKSNDK KEKNEHEEWY YGFIDAMKND
310 320 330 340 350
PANRAALYFL DKNWPEELEE REKERDRIRL TLLKSQRTNE EAVGEDVCTT
360 370 380 390 400
IRPQPKDSGY NPDAVVTELV LRTYQEELVQ PALEGKNCVI VAPTGSGKTE
410 420 430 440 450
VAIYAALKHI EERTSQGKPS RVVLLVPKIP LVGQQKDRFL KYCNGMYEVN
460 470 480 490 500
GFHGSESSVS GTGRRDEVIA THVSVMTPQI LINMLQSVRQ NERLYVSDFS
510 520 530 540 550
MMIFDEVHKA AKNHPYVLIN QMVQEWKYEK PQIIGLTASL SVKVDGQKDE
560 570 580 590 600
NQMLNDIYNM LALINAPHLS TITRQSSIDE LNEHVGKPDD SVELCLPAKE
610 620 630 640 650
NILRDYIERY LNHAHGKFLE ELASMSKSTG RNNTIPPNMI NTFKKNQPKN
660 670 680 690 700
YEYYDSLLQG IIQELNKLNV PEKWNSQTWA KYMKVYLEAR GIVDLMPAMV
710 720 730 740 750
AFKYMEKAIG KLNESHSETV EYSTFIKDHD TLKQTIQSVE PEIVLRLKNT
760 770 780 790 800
LTNQFHVAPE SRVIIFVTQR STAQRVSDFL NESKVLDQFG NYGEQMVGYV
810 820 830 840 850
LGTNKQGAVQ QTSQEQQLTL DKFNNGRLKV IVATSVVEEG LDVTACNLII
860 870 880 890 900
KYNCSSGSAI QLVQQRGRAR AKNSRSVLLS VKSSINETET NALISEKYMR
910 920 930 940 950
LCVKKITENG EKQLAAEVKR VAELNAAERK RNLEEQLNLR LRHENKIYKL
960 970 980 990 1000
MCSNCSKEFC KSIYIKKVFS NYMVFDPSVW RFLHVESKRK VSKYLSEDNQ
1010 1020 1030 1040 1050
PLSDIKCFHC KLDVGRAYKI RGTYLPQLSV KALTFVQESD YSSMTKAKWS
1060 1070 1080 1090 1100
DVEQDLFYIS EAIEDDFRIM LNALSDTEEN IEKKIVLDLD SRQHNKQLEM
1110
KRFHIQQEPP TKGVAPEAQ
Length:1,119
Mass (Da):129,096
Last modified:July 5, 2004 - v3
Checksum:iEDBDA9994166DF5A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z79752 Genomic DNA. Translation: CAB02082.3.
PIRiT20332.
RefSeqiNP_492161.3. NM_059760.5.
UniGeneiCel.16985.

Genome annotation databases

EnsemblMetazoaiD2005.5; D2005.5; WBGene00008400.
GeneIDi172546.
KEGGicel:CELE_D2005.5.
UCSCiD2005.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z79752 Genomic DNA. Translation: CAB02082.3 .
PIRi T20332.
RefSeqi NP_492161.3. NM_059760.5.
UniGenei Cel.16985.

3D structure databases

ProteinModelPortali Q93413.
SMRi Q93413. Positions 345-921.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-35120N.
IntActi Q93413. 3 interactions.
MINTi MINT-6178703.
STRINGi 6239.D2005.5.

Proteomic databases

PaxDbi Q93413.
PRIDEi Q93413.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai D2005.5 ; D2005.5 ; WBGene00008400 .
GeneIDi 172546.
KEGGi cel:CELE_D2005.5.
UCSCi D2005.5. c. elegans.

Organism-specific databases

CTDi 172546.
WormBasei D2005.5 ; CE36120 ; WBGene00008400 ; drh-3.

Phylogenomic databases

eggNOGi COG1111.
GeneTreei ENSGT00510000046789.
HOGENOMi HOG000018535.
InParanoidi Q93413.
KOi K12646.
OMAi ALISEKF.
OrthoDBi EOG7B8S3M.
PhylomeDBi Q93413.

Enzyme and pathway databases

Reactomei REACT_183161. Negative regulators of RIG-I/MDA5 signaling.

Miscellaneous databases

NextBioi 875985.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RIG-I_C-RD.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ93413_CAEEL
AccessioniPrimary (citable) accession number: Q93413
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3