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Protein
Submitted name:

Glutathione diSulfide Reductase

Gene

gsr-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • cellular oxidant detoxification Source: GOC
  • ecdysis, collagen and cuticulin-based cuticle Source: WormBase
  • glutathione metabolic process Source: InterPro
  • oxidation-reduction process Source: WormBase
  • response to superoxide Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

ReactomeiR-CEL-3299685. Detoxification of Reactive Oxygen Species.
R-CEL-499943. Synthesis and interconversion of nucleotide di- and triphosphates.
R-CEL-5628897. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Submitted name:
Glutathione diSulfide ReductaseImported
Gene namesi
Name:gsr-1Imported
ORF Names:C46F11.2Imported, CELE_C46F11.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC46F11.2a; CE17558; WBGene00008117; gsr-1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ93379.
PaxDbiQ93379.
PRIDEiQ93379.

Expressioni

Gene expression databases

ExpressionAtlasiQ93379. baseline and differential.

Interactioni

Protein-protein interaction databases

DIPiDIP-27224N.
MINTiMINT-1098913.
STRINGi6239.C46F11.2a.

Structurei

3D structure databases

ProteinModelPortaliQ93379.
SMRiQ93379. Positions 17-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 335315FAD/NAD-binding_domInterPro annotationAdd
BLAST
Domaini356 – 466111Pyr_redox_dimInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiKOG0405. Eukaryota.
COG1249. LUCA.
GeneTreeiENSGT00390000007578.
HOGENOMiHOG000276712.
InParanoidiQ93379.
OMAiYAEDYGF.
PhylomeDBiQ93379.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01421. gluta_reduc_1. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRFRCILST SRSIMSGVKE FDYLVIGGGS GGIASARRAR EFGVSVGLIE
60 70 80 90 100
SGRLGGTCVN VGCVPKKVMY NCSLHAEFIR DHADYGFDVT LNKFDWKVIK
110 120 130 140 150
KSRDEYIKRL NGLYESGLKG SSVEYIRGRA TFAEDGTVEV NGAKYRGKNT
160 170 180 190 200
LIAVGGKPTI PNIKGAEHGI DSDGFFDLED LPSRTVVVGA GYIAVEIAGV
210 220 230 240 250
LANLGSDTHL LIRYDKVLRT FDKMLSDELT ADMDEETNPL HLHKNTQVTE
260 270 280 290 300
VIKGDDGLLT IKTTTGVIEK VQTLIWAIGR DPLTKELNLE RVGVKTDKSG
310 320 330 340 350
HIIVDEYQNT SAPGILSVGD DTGKFLLTPV AIAAGRRLSH RLFNGETDNK
360 370 380 390 400
LTYENIATVV FSHPLIGTVG LTEAEAVEKY GKDEVTLYKS RFNPMLFAVT
410 420 430 440 450
KHKEKAAMKL VCVGKDEKVV GVHVFGVGSD EMLQGFAVAV TMGATKKQFD
460 470
QTVAIHPTSA EELVTMRGGV KPE
Length:473
Mass (Da):51,467
Last modified:August 1, 1998 - v2
Checksum:iE1DAA50758109D80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAB03763.1.
PIRiT19972.
RefSeqiNP_001021220.1. NM_001026049.5.
UniGeneiCel.10704.

Genome annotation databases

EnsemblMetazoaiC46F11.2a; C46F11.2a; WBGene00008117.
GeneIDi175467.
KEGGicel:CELE_C46F11.2.
UCSCiC46F11.2a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAB03763.1.
PIRiT19972.
RefSeqiNP_001021220.1. NM_001026049.5.
UniGeneiCel.10704.

3D structure databases

ProteinModelPortaliQ93379.
SMRiQ93379. Positions 17-467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-27224N.
MINTiMINT-1098913.
STRINGi6239.C46F11.2a.

Proteomic databases

EPDiQ93379.
PaxDbiQ93379.
PRIDEiQ93379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC46F11.2a; C46F11.2a; WBGene00008117.
GeneIDi175467.
KEGGicel:CELE_C46F11.2.
UCSCiC46F11.2a. c. elegans.

Organism-specific databases

CTDi175467.
WormBaseiC46F11.2a; CE17558; WBGene00008117; gsr-1.

Phylogenomic databases

eggNOGiKOG0405. Eukaryota.
COG1249. LUCA.
GeneTreeiENSGT00390000007578.
HOGENOMiHOG000276712.
InParanoidiQ93379.
OMAiYAEDYGF.
PhylomeDBiQ93379.

Enzyme and pathway databases

ReactomeiR-CEL-3299685. Detoxification of Reactive Oxygen Species.
R-CEL-499943. Synthesis and interconversion of nucleotide di- and triphosphates.
R-CEL-5628897. TP53 Regulates Metabolic Genes.

Miscellaneous databases

NextBioi888288.

Gene expression databases

ExpressionAtlasiQ93379. baseline and differential.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01421. gluta_reduc_1. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ93379_CAEEL
AccessioniPrimary (citable) accession number: Q93379
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.