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Q93353

- IDH3B_CAEEL

UniProt

Q93353 - IDH3B_CAEEL

Protein

Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Gene

idhb-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei129 – 1291SubstrateBy similarity
    Binding sitei161 – 1611SubstrateBy similarity
    Sitei168 – 1681Critical for catalysisBy similarity
    Sitei215 – 2151Critical for catalysisBy similarity
    Metal bindingi248 – 2481Magnesium or manganeseBy similarity
    Binding sitei248 – 2481SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi44 – 7229NADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (EC:1.1.1.41)
    Alternative name(s):
    Isocitric dehydrogenase subunit beta
    NAD(+)-specific ICDH subunit beta
    Gene namesi
    Name:idhb-1
    ORF Names:C37E2.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiC37E2.1; CE08620; WBGene00007993; idhb-1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3131MitochondrionBy similarityAdd
    BLAST
    Chaini32 – 379348Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrialPRO_0000014448Add
    BLAST

    Proteomic databases

    PaxDbiQ93353.

    Interactioni

    Subunit structurei

    Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.By similarity

    Protein-protein interaction databases

    BioGridi46427. 1 interaction.
    DIPiDIP-27476N.
    IntActiQ93353. 1 interaction.
    MINTiMINT-1058730.
    STRINGi6239.C37E2.1.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93353.
    SMRiQ93353. Positions 42-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0473.
    GeneTreeiENSGT00590000083091.
    HOGENOMiHOG000021113.
    InParanoidiQ93353.
    KOiK00030.
    OMAiPSIAYNE.
    PhylomeDBiQ93353.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q93353-1 [UniParc]FASTAAdd to Basket

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    MLSRTVSSLS RVAPQTLGAV NAASSRQYSI TAPRPPTELN QKLKVTIIPG    50
    DGVGPELIYT VQDIVKQTGI PIEFEEIFLS EVHYTRSSSI ENAVESIGRN 100
    NNVALKGAIE ESAVLHTEGE LQGLNMRLRR SLDLFANVVH IKTLDGIKTR 150
    HGKQLDFVIV REQTEGEYSS LEHELVPGVI ECLKISTRTK AERIAKFAFD 200
    YATKTGRKKV TAVHKANIMK LGDGLFLRTC EGVAKQYPKI QFESMIIDNT 250
    CMQLVSKPEQ FDVMVMPNLY GNIIDNLAAG LVGGAGVVPG QSVGRDFVIF 300
    EPGSRHSFQE AMGRSIANPT AMILCAANML NHLHLDAWGN SLRQAVADVV 350
    KEGKVRTRDL GGYATTVDFA DAVIDKFRI 379
    Length:379
    Mass (Da):41,553
    Last modified:February 1, 1997 - v1
    Checksum:iF099425960AB3086
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81046 Genomic DNA. Translation: CAB02822.1.
    PIRiT19810.
    RefSeqiNP_510362.1. NM_077961.5.
    UniGeneiCel.8914.

    Genome annotation databases

    EnsemblMetazoaiC37E2.1.1; C37E2.1.1; WBGene00007993.
    C37E2.1.2; C37E2.1.2; WBGene00007993.
    GeneIDi181528.
    KEGGicel:CELE_C37E2.1.
    UCSCiC37E2.1.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81046 Genomic DNA. Translation: CAB02822.1 .
    PIRi T19810.
    RefSeqi NP_510362.1. NM_077961.5.
    UniGenei Cel.8914.

    3D structure databases

    ProteinModelPortali Q93353.
    SMRi Q93353. Positions 42-377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 46427. 1 interaction.
    DIPi DIP-27476N.
    IntActi Q93353. 1 interaction.
    MINTi MINT-1058730.
    STRINGi 6239.C37E2.1.1.

    Proteomic databases

    PaxDbi Q93353.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C37E2.1.1 ; C37E2.1.1 ; WBGene00007993 .
    C37E2.1.2 ; C37E2.1.2 ; WBGene00007993 .
    GeneIDi 181528.
    KEGGi cel:CELE_C37E2.1.
    UCSCi C37E2.1.2. c. elegans.

    Organism-specific databases

    CTDi 181528.
    WormBasei C37E2.1 ; CE08620 ; WBGene00007993 ; idhb-1.

    Phylogenomic databases

    eggNOGi COG0473.
    GeneTreei ENSGT00590000083091.
    HOGENOMi HOG000021113.
    InParanoidi Q93353.
    KOi K00030.
    OMAi PSIAYNE.
    PhylomeDBi Q93353.

    Miscellaneous databases

    NextBioi 914316.
    PROi Q93353.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiIDH3B_CAEEL
    AccessioniPrimary (citable) accession number: Q93353
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3