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Q93353

- IDH3B_CAEEL

UniProt

Q93353 - IDH3B_CAEEL

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Protein
Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Gene
idhb-1, C37E2.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291Substrate By similarity
Binding sitei161 – 1611Substrate By similarity
Sitei168 – 1681Critical for catalysis By similarity
Sitei215 – 2151Critical for catalysis By similarity
Metal bindingi248 – 2481Magnesium or manganese By similarity
Binding sitei248 – 2481Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 7229NAD Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit beta
NAD(+)-specific ICDH subunit beta
Gene namesi
Name:idhb-1
ORF Names:C37E2.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC37E2.1; CE08620; WBGene00007993; idhb-1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131Mitochondrion By similarity
Add
BLAST
Chaini32 – 379348Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
PRO_0000014448Add
BLAST

Proteomic databases

PaxDbiQ93353.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 By similarity.

Protein-protein interaction databases

BioGridi46427. 1 interaction.
DIPiDIP-27476N.
IntActiQ93353. 1 interaction.
MINTiMINT-1058730.
STRINGi6239.C37E2.1.1.

Structurei

3D structure databases

ProteinModelPortaliQ93353.
SMRiQ93353. Positions 42-377.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0473.
GeneTreeiENSGT00590000083091.
HOGENOMiHOG000021113.
InParanoidiQ93353.
KOiK00030.
OMAiPSIAYNE.
PhylomeDBiQ93353.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93353-1 [UniParc]FASTAAdd to Basket

« Hide

MLSRTVSSLS RVAPQTLGAV NAASSRQYSI TAPRPPTELN QKLKVTIIPG    50
DGVGPELIYT VQDIVKQTGI PIEFEEIFLS EVHYTRSSSI ENAVESIGRN 100
NNVALKGAIE ESAVLHTEGE LQGLNMRLRR SLDLFANVVH IKTLDGIKTR 150
HGKQLDFVIV REQTEGEYSS LEHELVPGVI ECLKISTRTK AERIAKFAFD 200
YATKTGRKKV TAVHKANIMK LGDGLFLRTC EGVAKQYPKI QFESMIIDNT 250
CMQLVSKPEQ FDVMVMPNLY GNIIDNLAAG LVGGAGVVPG QSVGRDFVIF 300
EPGSRHSFQE AMGRSIANPT AMILCAANML NHLHLDAWGN SLRQAVADVV 350
KEGKVRTRDL GGYATTVDFA DAVIDKFRI 379
Length:379
Mass (Da):41,553
Last modified:February 1, 1997 - v1
Checksum:iF099425960AB3086
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z81046 Genomic DNA. Translation: CAB02822.1.
PIRiT19810.
RefSeqiNP_510362.1. NM_077961.5.
UniGeneiCel.8914.

Genome annotation databases

EnsemblMetazoaiC37E2.1.1; C37E2.1.1; WBGene00007993.
C37E2.1.2; C37E2.1.2; WBGene00007993.
GeneIDi181528.
KEGGicel:CELE_C37E2.1.
UCSCiC37E2.1.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z81046 Genomic DNA. Translation: CAB02822.1 .
PIRi T19810.
RefSeqi NP_510362.1. NM_077961.5.
UniGenei Cel.8914.

3D structure databases

ProteinModelPortali Q93353.
SMRi Q93353. Positions 42-377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 46427. 1 interaction.
DIPi DIP-27476N.
IntActi Q93353. 1 interaction.
MINTi MINT-1058730.
STRINGi 6239.C37E2.1.1.

Proteomic databases

PaxDbi Q93353.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C37E2.1.1 ; C37E2.1.1 ; WBGene00007993 .
C37E2.1.2 ; C37E2.1.2 ; WBGene00007993 .
GeneIDi 181528.
KEGGi cel:CELE_C37E2.1.
UCSCi C37E2.1.2. c. elegans.

Organism-specific databases

CTDi 181528.
WormBasei C37E2.1 ; CE08620 ; WBGene00007993 ; idhb-1.

Phylogenomic databases

eggNOGi COG0473.
GeneTreei ENSGT00590000083091.
HOGENOMi HOG000021113.
InParanoidi Q93353.
KOi K00030.
OMAi PSIAYNE.
PhylomeDBi Q93353.

Miscellaneous databases

NextBioi 914316.
PROi Q93353.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiIDH3B_CAEEL
AccessioniPrimary (citable) accession number: Q93353
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi