Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Gene

idhb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291SubstrateBy similarity
Binding sitei161 – 1611SubstrateBy similarity
Sitei168 – 1681Critical for catalysisBy similarity
Sitei215 – 2151Critical for catalysisBy similarity
Metal bindingi248 – 2481Magnesium or manganeseBy similarity
Binding sitei248 – 2481SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 7229NADSequence AnalysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NAD

Enzyme and pathway databases

ReactomeiREACT_287541. Citric acid cycle (TCA cycle).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit beta
NAD(+)-specific ICDH subunit beta
Gene namesi
Name:idhb-1
ORF Names:C37E2.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC37E2.1; CE08620; WBGene00007993; idhb-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131MitochondrionBy similarityAdd
BLAST
Chaini32 – 379348Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrialPRO_0000014448Add
BLAST

Proteomic databases

PaxDbiQ93353.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.By similarity

Protein-protein interaction databases

BioGridi46427. 1 interaction.
DIPiDIP-27476N.
IntActiQ93353. 1 interaction.
MINTiMINT-1058730.
STRINGi6239.C37E2.1.1.

Structurei

3D structure databases

ProteinModelPortaliQ93353.
SMRiQ93353. Positions 42-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0473.
GeneTreeiENSGT00590000083091.
HOGENOMiHOG000021113.
InParanoidiQ93353.
KOiK00030.
OMAiQMVSNPN.
PhylomeDBiQ93353.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRTVSSLS RVAPQTLGAV NAASSRQYSI TAPRPPTELN QKLKVTIIPG
60 70 80 90 100
DGVGPELIYT VQDIVKQTGI PIEFEEIFLS EVHYTRSSSI ENAVESIGRN
110 120 130 140 150
NNVALKGAIE ESAVLHTEGE LQGLNMRLRR SLDLFANVVH IKTLDGIKTR
160 170 180 190 200
HGKQLDFVIV REQTEGEYSS LEHELVPGVI ECLKISTRTK AERIAKFAFD
210 220 230 240 250
YATKTGRKKV TAVHKANIMK LGDGLFLRTC EGVAKQYPKI QFESMIIDNT
260 270 280 290 300
CMQLVSKPEQ FDVMVMPNLY GNIIDNLAAG LVGGAGVVPG QSVGRDFVIF
310 320 330 340 350
EPGSRHSFQE AMGRSIANPT AMILCAANML NHLHLDAWGN SLRQAVADVV
360 370
KEGKVRTRDL GGYATTVDFA DAVIDKFRI
Length:379
Mass (Da):41,553
Last modified:February 1, 1997 - v1
Checksum:iF099425960AB3086
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81046 Genomic DNA. Translation: CAB02822.1.
PIRiT19810.
RefSeqiNP_510362.1. NM_077961.5.
UniGeneiCel.8914.

Genome annotation databases

EnsemblMetazoaiC37E2.1.1; C37E2.1.1; WBGene00007993.
C37E2.1.2; C37E2.1.2; WBGene00007993.
GeneIDi181528.
KEGGicel:CELE_C37E2.1.
UCSCiC37E2.1.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81046 Genomic DNA. Translation: CAB02822.1.
PIRiT19810.
RefSeqiNP_510362.1. NM_077961.5.
UniGeneiCel.8914.

3D structure databases

ProteinModelPortaliQ93353.
SMRiQ93353. Positions 42-377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46427. 1 interaction.
DIPiDIP-27476N.
IntActiQ93353. 1 interaction.
MINTiMINT-1058730.
STRINGi6239.C37E2.1.1.

Proteomic databases

PaxDbiQ93353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC37E2.1.1; C37E2.1.1; WBGene00007993.
C37E2.1.2; C37E2.1.2; WBGene00007993.
GeneIDi181528.
KEGGicel:CELE_C37E2.1.
UCSCiC37E2.1.2. c. elegans.

Organism-specific databases

CTDi181528.
WormBaseiC37E2.1; CE08620; WBGene00007993; idhb-1.

Phylogenomic databases

eggNOGiCOG0473.
GeneTreeiENSGT00590000083091.
HOGENOMiHOG000021113.
InParanoidiQ93353.
KOiK00030.
OMAiQMVSNPN.
PhylomeDBiQ93353.

Enzyme and pathway databases

ReactomeiREACT_287541. Citric acid cycle (TCA cycle).

Miscellaneous databases

NextBioi914316.
PROiQ93353.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiIDH3B_CAEEL
AccessioniPrimary (citable) accession number: Q93353
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: April 1, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.