Reviewed, UniProtKB/Swiss-Prot Q93341 (DYR_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative dihydrofolate reductase
    EC=1.5.1.3

Gene names

ORF Names:

C36B1.7

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; tetrahydrofolate from dihydrofolate: step 1/1.
Miscellaneous	The reaction catalyzed by this enzyme represents an essential step for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
Sequence similarities	Belongs to the dihydrofolate reductase family. Contains 1 DHFR (dihydrofolate reductase) domain.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase glycine biosynthetic process Inferred from electronic annotation. Source: InterPro nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon compound metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro dihydrofolate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Putative dihydrofolate reductase		PRO_0000186372
Regions
	Domain	3 – 185	183	DHFR

Sequences

	Sequence		Length	Mass (Da)
	Q93341-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: C1642558E097725F	FASTA	189	21,602
	10 20 30 40 50 60 MRKMNLIVAM DAEGGIGKNG VLPWRIKKDM QYFASVTKNV SDQSKRNAVL MGRKCWESIP 70 80 90 100 110 120 VTRRPLAGRL NIVLSRQLPA QKSDDYIVVN SLEAAMKLLS EPPFVDSIET IWNIGGAEIY 130 140 150 160 170 180 DLALRENLVD EIHLTRIFKN FEADVHLKSL DFSKMEKVQN AEVSSENSEI FEENGLKFEF CKWKVVENH

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z80215 Genomic DNA. Translation: CAB02272.1.
PIR	T19778.
RefSeq	NP_492364.1.
UniGene	Cel.19146
3D structure databases
HSSP	HSSP built from PDB template 1J3K based on UniProtKB P13922.
ModBase	Search...
Genome annotation databases
Ensembl	C36B1.7. Caenorhabditis elegans. [Contig view]
GeneID	172681.
KEGG	cel:C36B1.7.
NMPDR	fig|6239.3.peg.2297.
Organism-specific databases
WormBase	WBGene00007974. C36B1.7.
WormPep	C36B1.7. CE05374. [WorfDB]
Phylogenomic databases
OMA	Q93341. PLNCIVA.
Enzyme and pathway databases
BRENDA	1.5.1.3. 672.
Gene expression databases
ArrayExpress	Q93341.
Family and domain databases
InterPro	IPR012259. DHFR. IPR001796. DHFR_reg. IPR017925. Dihydrofolate_reductase_CS. [Graphical view]
PANTHER	PTHR11549:SF1. DHFR. 1 hit.
Pfam	PF00186. DHFR_1. 1 hit. [Graphical view]
PRINTS	PR00070. DHFR.
PROSITE	PS00075. DHFR_1. 1 hit. PS51330. DHFR_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	876555.

Entry information

Entry name

DYR_CAEEL

Accession

Primary (citable) accession number: Q93341

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project