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Q93341

- DYR_CAEEL

UniProt

Q93341 - DYR_CAEEL

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Protein

Putative dihydrofolate reductase

Gene
dhfr-1, C36B1.7
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis By similarity.

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei69 – 691Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 217NADP By similarity
Nucleotide bindingi53 – 553NADP By similarity
Nucleotide bindingi75 – 773NADP By similarity
Nucleotide bindingi115 – 1228NADP By similarity

GO - Molecular functioni

  1. dihydrofolate reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. glycine biosynthetic process Source: InterPro
  2. nucleotide biosynthetic process Source: InterPro
  3. one-carbon metabolic process Source: UniProtKB-KW
  4. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_183103. G1/S-Specific Transcription.
REACT_183242. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
UniPathwayiUPA00077; UER00158.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dihydrofolate reductase (EC:1.5.1.3)
Gene namesi
Name:dhfr-1
ORF Names:C36B1.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiC36B1.7; CE05374; WBGene00007974; dhfr-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Putative dihydrofolate reductasePRO_0000186372Add
BLAST

Proteomic databases

PaxDbiQ93341.
PRIDEiQ93341.

Interactioni

Protein-protein interaction databases

BioGridi38114. 1 interaction.
IntActiQ93341. 1 interaction.
STRINGi6239.C36B1.7.

Structurei

3D structure databases

ProteinModelPortaliQ93341.
SMRiQ93341. Positions 1-185.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 185183DHFRAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 346Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0262.
GeneTreeiENSGT00390000010283.
HOGENOMiHOG000040235.
InParanoidiQ93341.
KOiK00287.
OMAiIKKDMQY.
OrthoDBiEOG7V1FS3.
PhylomeDBiQ93341.

Family and domain databases

Gene3Di3.40.430.10. 1 hit.
InterProiIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamiPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSiPR00070. DHFR.
SUPFAMiSSF53597. SSF53597. 1 hit.
PROSITEiPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93341-1 [UniParc]FASTAAdd to Basket

« Hide

MRKMNLIVAM DAEGGIGKNG VLPWRIKKDM QYFASVTKNV SDQSKRNAVL    50
MGRKCWESIP VTRRPLAGRL NIVLSRQLPA QKSDDYIVVN SLEAAMKLLS 100
EPPFVDSIET IWNIGGAEIY DLALRENLVD EIHLTRIFKN FEADVHLKSL 150
DFSKMEKVQN AEVSSENSEI FEENGLKFEF CKWKVVENH 189
Length:189
Mass (Da):21,602
Last modified:February 1, 1997 - v1
Checksum:iC1642558E097725F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z80215 Genomic DNA. Translation: CAB02272.1.
PIRiT19778.
RefSeqiNP_492364.1. NM_059963.3.
UniGeneiCel.19146.

Genome annotation databases

EnsemblMetazoaiC36B1.7; C36B1.7; WBGene00007974.
GeneIDi172681.
KEGGicel:CELE_C36B1.7.
UCSCiC36B1.7. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z80215 Genomic DNA. Translation: CAB02272.1 .
PIRi T19778.
RefSeqi NP_492364.1. NM_059963.3.
UniGenei Cel.19146.

3D structure databases

ProteinModelPortali Q93341.
SMRi Q93341. Positions 1-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 38114. 1 interaction.
IntActi Q93341. 1 interaction.
STRINGi 6239.C36B1.7.

Proteomic databases

PaxDbi Q93341.
PRIDEi Q93341.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C36B1.7 ; C36B1.7 ; WBGene00007974 .
GeneIDi 172681.
KEGGi cel:CELE_C36B1.7.
UCSCi C36B1.7. c. elegans.

Organism-specific databases

CTDi 172681.
WormBasei C36B1.7 ; CE05374 ; WBGene00007974 ; dhfr-1.

Phylogenomic databases

eggNOGi COG0262.
GeneTreei ENSGT00390000010283.
HOGENOMi HOG000040235.
InParanoidi Q93341.
KOi K00287.
OMAi IKKDMQY.
OrthoDBi EOG7V1FS3.
PhylomeDBi Q93341.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00158 .
Reactomei REACT_183103. G1/S-Specific Transcription.
REACT_183242. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.

Miscellaneous databases

NextBioi 876555.
PROi Q93341.

Family and domain databases

Gene3Di 3.40.430.10. 1 hit.
InterProi IPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view ]
Pfami PF00186. DHFR_1. 1 hit.
[Graphical view ]
PRINTSi PR00070. DHFR.
SUPFAMi SSF53597. SSF53597. 1 hit.
PROSITEi PS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiDYR_CAEEL
AccessioniPrimary (citable) accession number: Q93341
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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