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Q93324

- MANBA_CAEEL

UniProt

Q93324 - MANBA_CAEEL

Protein

Probable beta-mannosidase

Gene

C33G3.4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei463 – 4631Proton donorBy similarity

    GO - Molecular functioni

    1. beta-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mannan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH2. Glycoside Hydrolase Family 2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-mannosidase (EC:3.2.1.25)
    Alternative name(s):
    Mannanase
    Short name:
    Mannase
    Gene namesi
    ORF Names:C33G3.4
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiC33G3.4; CE08560; WBGene00007904.

    Subcellular locationi

    Lysosome Curated

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 900879Probable beta-mannosidasePRO_0000012167Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi131 – 1311N-linked (GlcNAc...)1 Publication
    Glycosylationi477 – 4771N-linked (GlcNAc...)1 Publication
    Glycosylationi576 – 5761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi661 – 6611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi738 – 7381N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ93324.
    PRIDEiQ93324.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.C33G3.4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93324.
    SMRiQ93324. Positions 28-771.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3250.
    GeneTreeiENSGT00390000001670.
    HOGENOMiHOG000186862.
    InParanoidiQ93324.
    KOiK01192.
    OMAiYGARTIE.
    OrthoDBiEOG7S7SD2.
    PhylomeDBiQ93324.

    Family and domain databases

    Gene3Di2.60.120.260. 2 hits.
    2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    InterProiIPR008979. Galactose-bd-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR028369. Mannanase.
    [Graphical view]
    PANTHERiPTHR10066:SF12. PTHR10066:SF12. 1 hit.
    PfamiPF00703. Glyco_hydro_2. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF49303. SSF49303. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q93324-1 [UniParc]FASTAAdd to Basket

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    MRTSLVVCLF WLLFQLHTTH GYNTLVNLAG NWEFSSSNKT VNGTGTVPGD    50
    IYSDLYASGI IDNPLFGENH LNLKWIAEDD WTYSRKFRLI DLDDTVGAFL 100
    EIESVDTIAT VYVNGQKVLH SRNQFLPYHV NVTDIIALGE NDITIKFKSS 150
    VKYAEKRADE YKKIFGHSLP PDCNPDIYHG ECHQNFIRKA QYSFAWDWGP 200
    SFPTVGIPST ITINIYRGQY FHDFNWKTRF AHGKWKVAFE FDTFHYGART 250
    IEYSVQIPEL GIKESDYYRL SATKSLQTRS KNIMSLSIPM EHEPERWWPN 300
    GMGEQKLYDV VVSMGGQVKE KKIGFKTVEL VQDLIDPKKP EKGRNFYFKI 350
    NDEPVFLKGT NWIPVSMFRS DRENIAKTEF LLDSVAEVGM NAIRVWGGGF 400
    YESNHFYYYA SKKGILVWQD LMFACALYPT TEEFIQNAEE EVSYNVDRIS 450
    QHTSVIVFSG NNENEAAIRG HWWKASNYTE SQQVKDYVLL YQRLAKIAKK 500
    VAPTIPFIMS SPSNGVETEE EGGVSKNPYD VRYGDIHYYN EFVNLWRDDT 550
    YLTPRCASEY GVQSYPMKET MLNWINESDW EYTSKAMFHR QHHPGGIATN 600
    LLMIFQHLPI PAECGSKSVS DVPSCKYISS ASYMSRLAYF SQVHQSIALK 650
    TQTLHYRRFR NTTTNEGLGN TMCAMYWQLN DVWAAPTWST IDFEQNWKMA 700
    HYEARRFFSN VAVYSFADET DFNLKVFLLN DNPYLLHNIT VNVQMLSWGN 750
    GLDPILTNEF HIDSVPAGSS EVLKTGITFS KITELSEYLY VSTLYDSSGV 800
    KIHEDVLVPD FLFEVDFNTF GDVQISDVQR IDEKTYDLTI TTDRVSPFTW 850
    ITCKKPFTGW FSDNGFHMIQ RLRKIRLIAK FEVDLEKSDF TVCNLKNCYV 900
    Length:900
    Mass (Da):103,978
    Last modified:February 1, 1997 - v1
    Checksum:iC6B90C25517579C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z78540 Genomic DNA. Translation: CAB01737.1.
    PIRiT19689.
    RefSeqiNP_510342.1. NM_077941.5.
    UniGeneiCel.5667.

    Genome annotation databases

    EnsemblMetazoaiC33G3.4; C33G3.4; WBGene00007904.
    GeneIDi181517.
    KEGGicel:CELE_C33G3.4.
    UCSCiC33G3.4. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z78540 Genomic DNA. Translation: CAB01737.1 .
    PIRi T19689.
    RefSeqi NP_510342.1. NM_077941.5.
    UniGenei Cel.5667.

    3D structure databases

    ProteinModelPortali Q93324.
    SMRi Q93324. Positions 28-771.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.C33G3.4.

    Protein family/group databases

    CAZyi GH2. Glycoside Hydrolase Family 2.

    Proteomic databases

    PaxDbi Q93324.
    PRIDEi Q93324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C33G3.4 ; C33G3.4 ; WBGene00007904 .
    GeneIDi 181517.
    KEGGi cel:CELE_C33G3.4.
    UCSCi C33G3.4. c. elegans.

    Organism-specific databases

    CTDi 181517.
    WormBasei C33G3.4 ; CE08560 ; WBGene00007904 .

    Phylogenomic databases

    eggNOGi COG3250.
    GeneTreei ENSGT00390000001670.
    HOGENOMi HOG000186862.
    InParanoidi Q93324.
    KOi K01192.
    OMAi YGARTIE.
    OrthoDBi EOG7S7SD2.
    PhylomeDBi Q93324.

    Miscellaneous databases

    NextBioi 914270.
    PROi Q93324.

    Family and domain databases

    Gene3Di 2.60.120.260. 2 hits.
    2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    InterProi IPR008979. Galactose-bd-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR028369. Mannanase.
    [Graphical view ]
    PANTHERi PTHR10066:SF12. PTHR10066:SF12. 1 hit.
    Pfami PF00703. Glyco_hydro_2. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49303. SSF49303. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
      Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
      Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131 AND ASN-477, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiMANBA_CAEEL
    AccessioniPrimary (citable) accession number: Q93324
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3