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Protein

Probable beta-mannosidase

Gene

C33G3.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei463Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.
R-CEL-8853383. Lysosomal oligosaccharide catabolism.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-mannosidase (EC:3.2.1.25)
Alternative name(s):
Mannanase
Short name:
Mannase
Gene namesi
ORF Names:C33G3.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC33G3.4; CE08560; WBGene00007904.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001216722 – 900Probable beta-mannosidaseAdd BLAST879

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Glycosylationi131N-linked (GlcNAc...)1 Publication1
Glycosylationi477N-linked (GlcNAc...)1 Publication1
Glycosylationi576N-linked (GlcNAc...)Sequence analysis1
Glycosylationi661N-linked (GlcNAc...)Sequence analysis1
Glycosylationi738N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ93324.
PaxDbiQ93324.
PeptideAtlasiQ93324.

Expressioni

Gene expression databases

BgeeiWBGene00007904.

Interactioni

Protein-protein interaction databases

STRINGi6239.C33G3.4.

Structurei

3D structure databases

ProteinModelPortaliQ93324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2230. Eukaryota.
COG3250. LUCA.
GeneTreeiENSGT00390000001670.
HOGENOMiHOG000186862.
InParanoidiQ93324.
KOiK01192.
OMAiDIHYYNE.
OrthoDBiEOG091G02FY.
PhylomeDBiQ93324.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTSLVVCLF WLLFQLHTTH GYNTLVNLAG NWEFSSSNKT VNGTGTVPGD
60 70 80 90 100
IYSDLYASGI IDNPLFGENH LNLKWIAEDD WTYSRKFRLI DLDDTVGAFL
110 120 130 140 150
EIESVDTIAT VYVNGQKVLH SRNQFLPYHV NVTDIIALGE NDITIKFKSS
160 170 180 190 200
VKYAEKRADE YKKIFGHSLP PDCNPDIYHG ECHQNFIRKA QYSFAWDWGP
210 220 230 240 250
SFPTVGIPST ITINIYRGQY FHDFNWKTRF AHGKWKVAFE FDTFHYGART
260 270 280 290 300
IEYSVQIPEL GIKESDYYRL SATKSLQTRS KNIMSLSIPM EHEPERWWPN
310 320 330 340 350
GMGEQKLYDV VVSMGGQVKE KKIGFKTVEL VQDLIDPKKP EKGRNFYFKI
360 370 380 390 400
NDEPVFLKGT NWIPVSMFRS DRENIAKTEF LLDSVAEVGM NAIRVWGGGF
410 420 430 440 450
YESNHFYYYA SKKGILVWQD LMFACALYPT TEEFIQNAEE EVSYNVDRIS
460 470 480 490 500
QHTSVIVFSG NNENEAAIRG HWWKASNYTE SQQVKDYVLL YQRLAKIAKK
510 520 530 540 550
VAPTIPFIMS SPSNGVETEE EGGVSKNPYD VRYGDIHYYN EFVNLWRDDT
560 570 580 590 600
YLTPRCASEY GVQSYPMKET MLNWINESDW EYTSKAMFHR QHHPGGIATN
610 620 630 640 650
LLMIFQHLPI PAECGSKSVS DVPSCKYISS ASYMSRLAYF SQVHQSIALK
660 670 680 690 700
TQTLHYRRFR NTTTNEGLGN TMCAMYWQLN DVWAAPTWST IDFEQNWKMA
710 720 730 740 750
HYEARRFFSN VAVYSFADET DFNLKVFLLN DNPYLLHNIT VNVQMLSWGN
760 770 780 790 800
GLDPILTNEF HIDSVPAGSS EVLKTGITFS KITELSEYLY VSTLYDSSGV
810 820 830 840 850
KIHEDVLVPD FLFEVDFNTF GDVQISDVQR IDEKTYDLTI TTDRVSPFTW
860 870 880 890 900
ITCKKPFTGW FSDNGFHMIQ RLRKIRLIAK FEVDLEKSDF TVCNLKNCYV
Length:900
Mass (Da):103,978
Last modified:February 1, 1997 - v1
Checksum:iC6B90C25517579C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z78540 Genomic DNA. Translation: CAB01737.1.
PIRiT19689.
RefSeqiNP_510342.1. NM_077941.5.
UniGeneiCel.5667.

Genome annotation databases

EnsemblMetazoaiC33G3.4; C33G3.4; WBGene00007904.
GeneIDi181517.
KEGGicel:CELE_C33G3.4.
UCSCiC33G3.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z78540 Genomic DNA. Translation: CAB01737.1.
PIRiT19689.
RefSeqiNP_510342.1. NM_077941.5.
UniGeneiCel.5667.

3D structure databases

ProteinModelPortaliQ93324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C33G3.4.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Proteomic databases

EPDiQ93324.
PaxDbiQ93324.
PeptideAtlasiQ93324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC33G3.4; C33G3.4; WBGene00007904.
GeneIDi181517.
KEGGicel:CELE_C33G3.4.
UCSCiC33G3.4. c. elegans.

Organism-specific databases

CTDi181517.
WormBaseiC33G3.4; CE08560; WBGene00007904.

Phylogenomic databases

eggNOGiKOG2230. Eukaryota.
COG3250. LUCA.
GeneTreeiENSGT00390000001670.
HOGENOMiHOG000186862.
InParanoidiQ93324.
KOiK01192.
OMAiDIHYYNE.
OrthoDBiEOG091G02FY.
PhylomeDBiQ93324.

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.
R-CEL-8853383. Lysosomal oligosaccharide catabolism.

Miscellaneous databases

PROiQ93324.

Gene expression databases

BgeeiWBGene00007904.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMANBA_CAEEL
AccessioniPrimary (citable) accession number: Q93324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.