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Protein

ESAT-6 secretion machinery protein EssC

Gene

essC

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ESAT-6 secretion system (Ess). Required for the secretion of EsxA and EsxB.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi672 – 679ATPPROSITE-ProRule annotation8
Nucleotide bindingi1014 – 1021ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.7.17.1. the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ESAT-6 secretion machinery protein EssCCurated
Gene namesi
Name:essC1 Publication
Ordered Locus Names:SAV0287
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 229CytoplasmicBy similarityAdd BLAST229
Transmembranei230 – 252HelicalSequence analysisAdd BLAST23
Topological domaini253 – 256ExtracellularBy similarity4
Transmembranei257 – 279HelicalSequence analysisAdd BLAST23
Topological domaini280 – 1479CytoplasmicBy similarityAdd BLAST1200

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000983301 – 1479ESAT-6 secretion machinery protein EssCAdd BLAST1479

Proteomic databases

PaxDbiQ932J9.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV0287.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WV3X-ray1.75A1-230[»]
ProteinModelPortaliQ932J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini652 – 846FtsK 1PROSITE-ProRule annotationAdd BLAST195
Domaini997 – 1183FtsK 2PROSITE-ProRule annotationAdd BLAST187

Domaini

The N-terminal region is composed of two iterations of forkhead-associated (FHA) domain-like structures, which could interact with other proteins in the Esx secretion system.1 Publication

Sequence similaritiesi

Belongs to the EssC family.Curated
Contains 2 FtsK domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EC2. Bacteria.
COG1674. LUCA.
HOGENOMiHOG000119940.
KOiK03466.
OMAiWEWMKWL.
PhylomeDBiQ932J9.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR023839. Firmicutes_EssC_C.
IPR022206. Firmicutes_EssC_N.
IPR002543. FtsK_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF01580. FtsK_SpoIIIE. 2 hits.
PF12538. FtsK_SpoIIIE_N. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03928. T7_EssCb_Firm. 1 hit.
PROSITEiPS50901. FTSK. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q932J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKLIIKYNK QLKMLNLRDG KTYTISEDER ADITLKSLGE VIHLEQNNQG
60 70 80 90 100
TWQANHTSIN KVLVRKGDLD DITLQLYTEA DYASFAYPSI QDTMTIGPNA
110 120 130 140 150
YDDMVIQSLM NAIIIKDFQS IQESQYVRIV HDKNTDVYIN YELQEQLTNK
160 170 180 190 200
AYIGDHIYVE GIWLEVQADG LNVLSQNTVA SSLIRLTQEM PHAQADDYNT
210 220 230 240 250
YHRSPRIIHR EPTDDIKIER PPQPIQKNNT VIWRSIIPPL VMIALTVVIF
260 270 280 290 300
LVRPIGIYIL MMIGMSTVTI VFGITTYFSE KKKYNKDVEK REKDYKAYLD
310 320 330 340 350
NKSKEINKAI KAQRFSLNYH YPTVAEIKDI VETKAPRIYE KTSHHHDFLH
360 370 380 390 400
YKLGIANVEK SFKLDYQEEE FNQRRDELFD DAKELYEFYT DVEQAPLIND
410 420 430 440 450
LNHGPIAYIG ARHLILEELE KMLIQLSTFH SYHDLEFLFV TREDEVETLK
460 470 480 490 500
WARWLPHMTL RGQNIRGFVY NQRTRDQILT SIYSMIKERI QAVRERSRSN
510 520 530 540 550
EQIIFTPQLV FVITDMSLII DHVILEYVNQ DLSEYGISLI FVEDVIESLP
560 570 580 590 600
EHVDTIIDIK SRTEGELITK EKELVQLKFT PENIDNVDKE YIARRLANLI
610 620 630 640 650
HVEHLKNAIP DSITFLEMYN VKEVDQLDVV NRWRQNETYK TMAVPLGVRG
660 670 680 690 700
KDDILSLNLH EKAHGPHGLV AGTTGSGKSE IIQSYILSLA INFHPHEVAF
710 720 730 740 750
LLIDYKGGGM ANLFKDLVHL VGTITNLDGD EAMRALTSIK AELRKRQRLF
760 770 780 790 800
GEHDVNHINQ YHKLFKEGVA TEPMPHLFII SDEFAELKSE QPDFMKELVS
810 820 830 840 850
TARIGRSLGI HLILATQKPS GVVDDQIWSN SKFKLALKVQ DRQDSNEILK
860 870 880 890 900
TPDAADITLP GRAYLQVGNN EIYELFQSAW SGATYDIEGD KLEVEDKTIY
910 920 930 940 950
MINDYGQLQA INKDLSGLED EETKENQTEL EAVIDHIESI TTRLEIEEVK
960 970 980 990 1000
RPWLPPLPEN VYQEDLVETD FRKLWSDDAK EVELTLGLKD VPEEQYQGPM
1010 1020 1030 1040 1050
VLQLKKAGHI ALIGSPGYGR TTFLHNIIFD VARHHRPDQA HMYLFDFGTN
1060 1070 1080 1090 1100
GLMPVTDIPH VADYFTVDQE DKIAKAIRIF NDEIDRRKKI LSQYRVTSIS
1110 1120 1130 1140 1150
EYRKLTGETI PYVFILIDNF DAVKDSPFQE VFENMMIKMT REGLALDMQV
1160 1170 1180 1190 1200
TLTASRANAM KTPMYINMKT RIAMFLYDKS EVSNVVGQQK FAVKDVVGRA
1210 1220 1230 1240 1250
LLSSDDNVSF HIGQPFKHDE TKSYNDQIND EVSAMTEFYK GETPNDIPMM
1260 1270 1280 1290 1300
PDEIKYEDYR ESLSLPDIVA NGALPIGLDY EGVTLQKIKL TEPAMISSEN
1310 1320 1330 1340 1350
PREIAHIAEI MMKEIDILNE KYAICIADSS GEFKAYRHQV ANFAEEREDI
1360 1370 1380 1390 1400
KAIHQLMIED LKQREMDGPF EKDSLYIIND FKTYIDCTYI PEDDVKKLIT
1410 1420 1430 1440 1450
KGPELGLNIL FVGIHKELID AYDKQIDVAR KMINQFSIGI RISDQQFFKF
1460 1470
RFIQREPVIK ENEAYMVANQ AYQKIRWFK
Length:1,479
Mass (Da):170,932
Last modified:July 5, 2004 - v2
Checksum:iDD349832D2A63564
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56449.2.
RefSeqiWP_000549287.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB56449; BAB56449; SAV0287.
KEGGisav:SAV0287.
PATRICi19561188. VBIStaAur52173_0291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56449.2.
RefSeqiWP_000549287.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WV3X-ray1.75A1-230[»]
ProteinModelPortaliQ932J9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV0287.

Protein family/group databases

TCDBi3.A.7.17.1. the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family.

Proteomic databases

PaxDbiQ932J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB56449; BAB56449; SAV0287.
KEGGisav:SAV0287.
PATRICi19561188. VBIStaAur52173_0291.

Phylogenomic databases

eggNOGiENOG4105EC2. Bacteria.
COG1674. LUCA.
HOGENOMiHOG000119940.
KOiK03466.
OMAiWEWMKWL.
PhylomeDBiQ932J9.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR023839. Firmicutes_EssC_C.
IPR022206. Firmicutes_EssC_N.
IPR002543. FtsK_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF01580. FtsK_SpoIIIE. 2 hits.
PF12538. FtsK_SpoIIIE_N. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03928. T7_EssCb_Firm. 1 hit.
PROSITEiPS50901. FTSK. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESSC_STAAM
AccessioniPrimary (citable) accession number: Q932J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.