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Protein

Protein EssC

Gene

essC

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for secretion of EsxA and EsxB.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-288-MONOMER.

Protein family/group databases

TCDBi3.A.7.17.1. the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein EssC
Gene namesi
Name:essC
Ordered Locus Names:SAV0287
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST
Transmembranei261 – 28121HelicalSequence analysisAdd
BLAST
Transmembranei503 – 52321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14791479Protein EssCPRO_0000098330Add
BLAST

Proteomic databases

PaxDbiQ932J9.
PRIDEiQ932J9.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV0287.

Structurei

3D structure databases

ProteinModelPortaliQ932J9.
SMRiQ932J9. Positions 1-186, 627-857, 959-1188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini652 – 846195FtsK 1PROSITE-ProRule annotationAdd
BLAST
Domaini997 – 1183187FtsK 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 FtsK domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EC2. Bacteria.
COG1674. LUCA.
HOGENOMiHOG000119940.
KOiK03466.
OMAiQYQKLYK.
OrthoDBiEOG6S52GD.
PhylomeDBiQ932J9.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR023839. Firmicutes_EssC_C.
IPR022206. Firmicutes_EssC_N.
IPR002543. FtsK_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF01580. FtsK_SpoIIIE. 2 hits.
PF12538. FtsK_SpoIIIE_N. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03928. T7_EssCb_Firm. 1 hit.
PROSITEiPS50901. FTSK. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q932J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKLIIKYNK QLKMLNLRDG KTYTISEDER ADITLKSLGE VIHLEQNNQG
60 70 80 90 100
TWQANHTSIN KVLVRKGDLD DITLQLYTEA DYASFAYPSI QDTMTIGPNA
110 120 130 140 150
YDDMVIQSLM NAIIIKDFQS IQESQYVRIV HDKNTDVYIN YELQEQLTNK
160 170 180 190 200
AYIGDHIYVE GIWLEVQADG LNVLSQNTVA SSLIRLTQEM PHAQADDYNT
210 220 230 240 250
YHRSPRIIHR EPTDDIKIER PPQPIQKNNT VIWRSIIPPL VMIALTVVIF
260 270 280 290 300
LVRPIGIYIL MMIGMSTVTI VFGITTYFSE KKKYNKDVEK REKDYKAYLD
310 320 330 340 350
NKSKEINKAI KAQRFSLNYH YPTVAEIKDI VETKAPRIYE KTSHHHDFLH
360 370 380 390 400
YKLGIANVEK SFKLDYQEEE FNQRRDELFD DAKELYEFYT DVEQAPLIND
410 420 430 440 450
LNHGPIAYIG ARHLILEELE KMLIQLSTFH SYHDLEFLFV TREDEVETLK
460 470 480 490 500
WARWLPHMTL RGQNIRGFVY NQRTRDQILT SIYSMIKERI QAVRERSRSN
510 520 530 540 550
EQIIFTPQLV FVITDMSLII DHVILEYVNQ DLSEYGISLI FVEDVIESLP
560 570 580 590 600
EHVDTIIDIK SRTEGELITK EKELVQLKFT PENIDNVDKE YIARRLANLI
610 620 630 640 650
HVEHLKNAIP DSITFLEMYN VKEVDQLDVV NRWRQNETYK TMAVPLGVRG
660 670 680 690 700
KDDILSLNLH EKAHGPHGLV AGTTGSGKSE IIQSYILSLA INFHPHEVAF
710 720 730 740 750
LLIDYKGGGM ANLFKDLVHL VGTITNLDGD EAMRALTSIK AELRKRQRLF
760 770 780 790 800
GEHDVNHINQ YHKLFKEGVA TEPMPHLFII SDEFAELKSE QPDFMKELVS
810 820 830 840 850
TARIGRSLGI HLILATQKPS GVVDDQIWSN SKFKLALKVQ DRQDSNEILK
860 870 880 890 900
TPDAADITLP GRAYLQVGNN EIYELFQSAW SGATYDIEGD KLEVEDKTIY
910 920 930 940 950
MINDYGQLQA INKDLSGLED EETKENQTEL EAVIDHIESI TTRLEIEEVK
960 970 980 990 1000
RPWLPPLPEN VYQEDLVETD FRKLWSDDAK EVELTLGLKD VPEEQYQGPM
1010 1020 1030 1040 1050
VLQLKKAGHI ALIGSPGYGR TTFLHNIIFD VARHHRPDQA HMYLFDFGTN
1060 1070 1080 1090 1100
GLMPVTDIPH VADYFTVDQE DKIAKAIRIF NDEIDRRKKI LSQYRVTSIS
1110 1120 1130 1140 1150
EYRKLTGETI PYVFILIDNF DAVKDSPFQE VFENMMIKMT REGLALDMQV
1160 1170 1180 1190 1200
TLTASRANAM KTPMYINMKT RIAMFLYDKS EVSNVVGQQK FAVKDVVGRA
1210 1220 1230 1240 1250
LLSSDDNVSF HIGQPFKHDE TKSYNDQIND EVSAMTEFYK GETPNDIPMM
1260 1270 1280 1290 1300
PDEIKYEDYR ESLSLPDIVA NGALPIGLDY EGVTLQKIKL TEPAMISSEN
1310 1320 1330 1340 1350
PREIAHIAEI MMKEIDILNE KYAICIADSS GEFKAYRHQV ANFAEEREDI
1360 1370 1380 1390 1400
KAIHQLMIED LKQREMDGPF EKDSLYIIND FKTYIDCTYI PEDDVKKLIT
1410 1420 1430 1440 1450
KGPELGLNIL FVGIHKELID AYDKQIDVAR KMINQFSIGI RISDQQFFKF
1460 1470
RFIQREPVIK ENEAYMVANQ AYQKIRWFK
Length:1,479
Mass (Da):170,932
Last modified:July 5, 2004 - v2
Checksum:iDD349832D2A63564
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56449.2.
RefSeqiWP_000549287.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB56449; BAB56449; SAV0287.
KEGGisav:SAV0287.
PATRICi19561188. VBIStaAur52173_0291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB56449.2.
RefSeqiWP_000549287.1. NC_002758.2.

3D structure databases

ProteinModelPortaliQ932J9.
SMRiQ932J9. Positions 1-186, 627-857, 959-1188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV0287.

Protein family/group databases

TCDBi3.A.7.17.1. the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family.

Proteomic databases

PaxDbiQ932J9.
PRIDEiQ932J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB56449; BAB56449; SAV0287.
KEGGisav:SAV0287.
PATRICi19561188. VBIStaAur52173_0291.

Phylogenomic databases

eggNOGiENOG4105EC2. Bacteria.
COG1674. LUCA.
HOGENOMiHOG000119940.
KOiK03466.
OMAiQYQKLYK.
OrthoDBiEOG6S52GD.
PhylomeDBiQ932J9.

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-288-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR023839. Firmicutes_EssC_C.
IPR022206. Firmicutes_EssC_N.
IPR002543. FtsK_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF01580. FtsK_SpoIIIE. 2 hits.
PF12538. FtsK_SpoIIIE_N. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03928. T7_EssCb_Firm. 1 hit.
PROSITEiPS50901. FTSK. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiESSC_STAAM
AccessioniPrimary (citable) accession number: Q932J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.