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Q93249

- CAB1_CAEEL

UniProt

Q93249 - CAB1_CAEEL

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Protein

Protein cab-1

Gene

cab-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. synaptic transmission Source: WormBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cab-1
Gene namesi
Name:cab-1
ORF Names:C23H4.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC23H4.1; CE17435; WBGene00000277; cab-1.

Subcellular locationi

GO - Cellular componenti

  1. cell Source: WormBase
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Protein cab-1PRO_0000089267Add
BLAST

Proteomic databases

PaxDbiQ93249.

Expressioni

Tissue specificityi

Expressed in a variety of neurons.

Interactioni

Subunit structurei

Binds to the RAB3 GDP/GTP exchange factor aex-3.

Protein-protein interaction databases

BioGridi46288. 1 interaction.
IntActiQ93249. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ93249.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei300 – 32021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni205 – 424220AEX-3-bindingAdd
BLAST

Sequence similaritiesi

Belongs to the NPDC1/cab-1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262778.
GeneTreeiENSGT00440000038604.
HOGENOMiHOG000020834.
InParanoidiQ93249.
OMAiICGEDAP.

Family and domain databases

InterProiIPR009635. NPDC1.
[Graphical view]
PANTHERiPTHR23352. PTHR23352. 1 hit.
PfamiPF06809. NPDC1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93249 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MRYTFSDEKK ATTTTTSRAK SQARLLNSAS YRRAARTTLR HSYGMGMWRA
60 70 80 90 100
VALLACLSAT HAALFTEGGA VQNGKDNKAN KYVEFAHDDK INKEDLLKYY
110 120 130 140 150
GKEVEQYKDD DSYMEYLIEY MKSHPVPAQF PNFEQEAEQE HQDELNQWLE
160 170 180 190 200
QLMNEQELLE PANAAVKDAE QKAPLAPVHH KQVAQKPAQE PFDLDDLLRG
210 220 230 240 250
ELMLENEIAK ESELKKTQEK LSEQTPSAKA NVESLESAMQ TATGEPQVPQ
260 270 280 290 300
KKGQNEFVSF VEQEPQPAKQ TISSQTVDKR RLATSAEYSG SAPRYSSSSL
310 320 330 340 350
LLLAVGTVMC VGLIGTVAGG TYYYKNNRRT ETPDDGEYAP YAGTGPGFRK
360 370 380 390 400
NKGNKGDETL AYKAQLHQYQ QAKQKIICGE DAPGIIESDG EDGADEENNY
410 420
SVYECPGLAP TGDIEVCNPN FAAQP
Length:425
Mass (Da):47,224
Last modified:May 30, 2000 - v3
Checksum:i6CC2C50AEEB7A1FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF293976 mRNA. Translation: AAG17881.1.
Z78416 Genomic DNA. Translation: CAB01682.1.
PIRiT19415.
RefSeqiNP_510036.1. NM_077635.4.
UniGeneiCel.17893.

Genome annotation databases

EnsemblMetazoaiC23H4.1.1; C23H4.1.1; WBGene00000277.
C23H4.1.2; C23H4.1.2; WBGene00000277.
C23H4.1.3; C23H4.1.3; WBGene00000277.
C23H4.1.4; C23H4.1.4; WBGene00000277.
GeneIDi181382.
KEGGicel:CELE_C23H4.1.
UCSCiC23H4.1.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF293976 mRNA. Translation: AAG17881.1 .
Z78416 Genomic DNA. Translation: CAB01682.1 .
PIRi T19415.
RefSeqi NP_510036.1. NM_077635.4.
UniGenei Cel.17893.

3D structure databases

ProteinModelPortali Q93249.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 46288. 1 interaction.
IntActi Q93249. 1 interaction.

Proteomic databases

PaxDbi Q93249.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C23H4.1.1 ; C23H4.1.1 ; WBGene00000277 .
C23H4.1.2 ; C23H4.1.2 ; WBGene00000277 .
C23H4.1.3 ; C23H4.1.3 ; WBGene00000277 .
C23H4.1.4 ; C23H4.1.4 ; WBGene00000277 .
GeneIDi 181382.
KEGGi cel:CELE_C23H4.1.
UCSCi C23H4.1.2. c. elegans.

Organism-specific databases

CTDi 181382.
WormBasei C23H4.1 ; CE17435 ; WBGene00000277 ; cab-1.

Phylogenomic databases

eggNOGi NOG262778.
GeneTreei ENSGT00440000038604.
HOGENOMi HOG000020834.
InParanoidi Q93249.
OMAi ICGEDAP.

Miscellaneous databases

NextBioi 913700.
PROi Q93249.

Family and domain databases

InterProi IPR009635. NPDC1.
[Graphical view ]
PANTHERi PTHR23352. PTHR23352. 1 hit.
Pfami PF06809. NPDC1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission."
    Iwasaki K., Toyonaga R.
    EMBO J. 19:4806-4816(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH AEX-3.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiCAB1_CAEEL
AccessioniPrimary (citable) accession number: Q93249
Secondary accession number(s): P90751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: October 1, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3