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Q93249

- CAB1_CAEEL

UniProt

Q93249 - CAB1_CAEEL

Protein

Protein cab-1

Gene

cab-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 3 (30 May 2000)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. synaptic transmission Source: WormBase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein cab-1
    Gene namesi
    Name:cab-1
    ORF Names:C23H4.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiC23H4.1; CE17435; WBGene00000277; cab-1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell Source: WormBase
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Protein cab-1PRO_0000089267Add
    BLAST

    Proteomic databases

    PaxDbiQ93249.

    Expressioni

    Tissue specificityi

    Expressed in a variety of neurons.

    Interactioni

    Subunit structurei

    Binds to the RAB3 GDP/GTP exchange factor aex-3.

    Protein-protein interaction databases

    BioGridi46288. 1 interaction.
    IntActiQ93249. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93249.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei300 – 32021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni205 – 424220AEX-3-bindingAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NPDC1/cab-1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262778.
    GeneTreeiENSGT00440000038604.
    HOGENOMiHOG000020834.
    InParanoidiQ93249.
    OMAiICGEDAP.

    Family and domain databases

    InterProiIPR009635. NPDC1.
    [Graphical view]
    PANTHERiPTHR23352. PTHR23352. 1 hit.
    PfamiPF06809. NPDC1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q93249-1 [UniParc]FASTAAdd to Basket

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    MRYTFSDEKK ATTTTTSRAK SQARLLNSAS YRRAARTTLR HSYGMGMWRA    50
    VALLACLSAT HAALFTEGGA VQNGKDNKAN KYVEFAHDDK INKEDLLKYY 100
    GKEVEQYKDD DSYMEYLIEY MKSHPVPAQF PNFEQEAEQE HQDELNQWLE 150
    QLMNEQELLE PANAAVKDAE QKAPLAPVHH KQVAQKPAQE PFDLDDLLRG 200
    ELMLENEIAK ESELKKTQEK LSEQTPSAKA NVESLESAMQ TATGEPQVPQ 250
    KKGQNEFVSF VEQEPQPAKQ TISSQTVDKR RLATSAEYSG SAPRYSSSSL 300
    LLLAVGTVMC VGLIGTVAGG TYYYKNNRRT ETPDDGEYAP YAGTGPGFRK 350
    NKGNKGDETL AYKAQLHQYQ QAKQKIICGE DAPGIIESDG EDGADEENNY 400
    SVYECPGLAP TGDIEVCNPN FAAQP 425
    Length:425
    Mass (Da):47,224
    Last modified:May 30, 2000 - v3
    Checksum:i6CC2C50AEEB7A1FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF293976 mRNA. Translation: AAG17881.1.
    Z78416 Genomic DNA. Translation: CAB01682.1.
    PIRiT19415.
    RefSeqiNP_510036.1. NM_077635.4.
    UniGeneiCel.17893.

    Genome annotation databases

    EnsemblMetazoaiC23H4.1.1; C23H4.1.1; WBGene00000277.
    C23H4.1.2; C23H4.1.2; WBGene00000277.
    C23H4.1.3; C23H4.1.3; WBGene00000277.
    C23H4.1.4; C23H4.1.4; WBGene00000277.
    GeneIDi181382.
    KEGGicel:CELE_C23H4.1.
    UCSCiC23H4.1.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF293976 mRNA. Translation: AAG17881.1 .
    Z78416 Genomic DNA. Translation: CAB01682.1 .
    PIRi T19415.
    RefSeqi NP_510036.1. NM_077635.4.
    UniGenei Cel.17893.

    3D structure databases

    ProteinModelPortali Q93249.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 46288. 1 interaction.
    IntActi Q93249. 1 interaction.

    Proteomic databases

    PaxDbi Q93249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C23H4.1.1 ; C23H4.1.1 ; WBGene00000277 .
    C23H4.1.2 ; C23H4.1.2 ; WBGene00000277 .
    C23H4.1.3 ; C23H4.1.3 ; WBGene00000277 .
    C23H4.1.4 ; C23H4.1.4 ; WBGene00000277 .
    GeneIDi 181382.
    KEGGi cel:CELE_C23H4.1.
    UCSCi C23H4.1.2. c. elegans.

    Organism-specific databases

    CTDi 181382.
    WormBasei C23H4.1 ; CE17435 ; WBGene00000277 ; cab-1.

    Phylogenomic databases

    eggNOGi NOG262778.
    GeneTreei ENSGT00440000038604.
    HOGENOMi HOG000020834.
    InParanoidi Q93249.
    OMAi ICGEDAP.

    Miscellaneous databases

    NextBioi 913700.
    PROi Q93249.

    Family and domain databases

    InterProi IPR009635. NPDC1.
    [Graphical view ]
    PANTHERi PTHR23352. PTHR23352. 1 hit.
    Pfami PF06809. NPDC1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission."
      Iwasaki K., Toyonaga R.
      EMBO J. 19:4806-4816(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH AEX-3.
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiCAB1_CAEEL
    AccessioniPrimary (citable) accession number: Q93249
    Secondary accession number(s): P90751
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 89 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3