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Q93249 (CAB1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein cab-1
Gene names
Name:cab-1
ORF Names:C23H4.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Binds to the RAB3 GDP/GTP exchange factor aex-3. Ref.1

Subcellular location

Membrane; Single-pass membrane protein Potential.

Tissue specificity

Expressed in a variety of neurons.

Sequence similarities

Belongs to the NPDC1/cab-1 family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsynaptic transmission

Inferred from mutant phenotype Ref.1. Source: WormBase

   Cellular_componentcell

Inferred from direct assay Ref.1. Source: WormBase

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Protein cab-1
PRO_0000089267

Regions

Transmembrane300 – 32021Helical; Potential
Region205 – 424220AEX-3-binding

Sequences

Sequence LengthMass (Da)Tools
Q93249 [UniParc].

Last modified May 30, 2000. Version 3.
Checksum: 6CC2C50AEEB7A1FA

FASTA42547,224
        10         20         30         40         50         60 
MRYTFSDEKK ATTTTTSRAK SQARLLNSAS YRRAARTTLR HSYGMGMWRA VALLACLSAT 

        70         80         90        100        110        120 
HAALFTEGGA VQNGKDNKAN KYVEFAHDDK INKEDLLKYY GKEVEQYKDD DSYMEYLIEY 

       130        140        150        160        170        180 
MKSHPVPAQF PNFEQEAEQE HQDELNQWLE QLMNEQELLE PANAAVKDAE QKAPLAPVHH 

       190        200        210        220        230        240 
KQVAQKPAQE PFDLDDLLRG ELMLENEIAK ESELKKTQEK LSEQTPSAKA NVESLESAMQ 

       250        260        270        280        290        300 
TATGEPQVPQ KKGQNEFVSF VEQEPQPAKQ TISSQTVDKR RLATSAEYSG SAPRYSSSSL 

       310        320        330        340        350        360 
LLLAVGTVMC VGLIGTVAGG TYYYKNNRRT ETPDDGEYAP YAGTGPGFRK NKGNKGDETL 

       370        380        390        400        410        420 
AYKAQLHQYQ QAKQKIICGE DAPGIIESDG EDGADEENNY SVYECPGLAP TGDIEVCNPN 


FAAQP 

« Hide

References

« Hide 'large scale' references
[1]"The rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission."
Iwasaki K., Toyonaga R.
EMBO J. 19:4806-4816(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH AEX-3.
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF293976 mRNA. Translation: AAG17881.1.
Z78416 Genomic DNA. Translation: CAB01682.1.
PIRT19415.
RefSeqNP_510036.1. NM_077635.4.
UniGeneCel.17893.

3D structure databases

ProteinModelPortalQ93249.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid46288. 1 interaction.
IntActQ93249. 1 interaction.

Proteomic databases

PaxDbQ93249.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC23H4.1.1; C23H4.1.1; C23H4.1.
C23H4.1.2; C23H4.1.2; C23H4.1.
C23H4.1.3; C23H4.1.3; C23H4.1.
C23H4.1.4; C23H4.1.4; C23H4.1.
C23H4.1.5; C23H4.1.5; C23H4.1.
GeneID181382.
KEGGcel:CELE_C23H4.1.
UCSCC23H4.1.2. c. elegans.

Organism-specific databases

CTD181382.
WormBaseC23H4.1; CE17435; WBGene00000277; cab-1.

Phylogenomic databases

eggNOGNOG262778.
HOGENOMHOG000020834.
InParanoidQ93249.
OMAICGEDAP.

Family and domain databases

InterProIPR009635. NPDC1.
[Graphical view]
PANTHERPTHR23352. PTHR23352. 1 hit.
PfamPF06809. NPDC1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio913700.
PROQ93249.

Entry information

Entry nameCAB1_CAEEL
AccessionPrimary (citable) accession number: Q93249
Secondary accession number(s): P90751
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: April 16, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase