Q93249 (CAB1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein cab-1

Gene names

Name:	cab-1
ORF Names:	C23H4.1

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Binds to the RAB3 GDP/GTP exchange factor aex-3. Ref.1
Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Expressed in a variety of neurons.
Sequence similarities	Belongs to the NPDC1/cab-1 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	synaptic transmission Inferred from mutant phenotype Ref.1. Source: WormBase
Cellular_component	cell Inferred from direct assay Ref.1. Source: WormBase integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 425	425	Protein cab-1		PRO_0000089267
Regions
	Transmembrane	300 – 320	21	Helical; Potential
	Region	205 – 424	220	AEX-3-binding

Sequences

	Sequence		Length	Mass (Da)
	Q93249 [UniParc]. Last modified May 30, 2000. Version 3. Checksum: 6CC2C50AEEB7A1FA	FASTA	425	47,224
	10 20 30 40 50 60 MRYTFSDEKK ATTTTTSRAK SQARLLNSAS YRRAARTTLR HSYGMGMWRA VALLACLSAT 70 80 90 100 110 120 HAALFTEGGA VQNGKDNKAN KYVEFAHDDK INKEDLLKYY GKEVEQYKDD DSYMEYLIEY 130 140 150 160 170 180 MKSHPVPAQF PNFEQEAEQE HQDELNQWLE QLMNEQELLE PANAAVKDAE QKAPLAPVHH 190 200 210 220 230 240 KQVAQKPAQE PFDLDDLLRG ELMLENEIAK ESELKKTQEK LSEQTPSAKA NVESLESAMQ 250 260 270 280 290 300 TATGEPQVPQ KKGQNEFVSF VEQEPQPAKQ TISSQTVDKR RLATSAEYSG SAPRYSSSSL 310 320 330 340 350 360 LLLAVGTVMC VGLIGTVAGG TYYYKNNRRT ETPDDGEYAP YAGTGPGFRK NKGNKGDETL 370 380 390 400 410 420 AYKAQLHQYQ QAKQKIICGE DAPGIIESDG EDGADEENNY SVYECPGLAP TGDIEVCNPN FAAQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission." Iwasaki K., Toyonaga R. EMBO J. 19:4806-4816(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH AEX-3. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF293976 mRNA. Translation: AAG17881.1. Z78416 Genomic DNA. Translation: CAB01682.1.
PIR	T19415.
RefSeq	NP_510036.1. NM_077635.4.
UniGene	Cel.17893.
3D structure databases
ProteinModelPortal	Q93249.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q93249. 1 interaction.
Proteomic databases
PaxDb	Q93249.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C23H4.1.1; C23H4.1.1; C23H4.1. C23H4.1.2; C23H4.1.2; C23H4.1. C23H4.1.3; C23H4.1.3; C23H4.1. C23H4.1.4; C23H4.1.4; C23H4.1. C23H4.1.5; C23H4.1.5; C23H4.1.
GeneID	181382.
KEGG	cel:CELE_C23H4.1.
UCSC	C23H4.1.2. c. elegans.
Organism-specific databases
CTD	181382.
WormBase	C23H4.1; CE17435; WBGene00000277; cab-1.
Phylogenomic databases
eggNOG	NOG262778.
GeneTree	ENSGT00440000038604.
HOGENOM	HOG000020834.
InParanoid	Q93249.
OMA	ICGEDAP.
Family and domain databases
InterPro	IPR009635. NPDC1. [Graphical view]
PANTHER	PTHR23352. PTHR23352. 1 hit.
Pfam	PF06809. NPDC1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	913700.

Entry information

Entry name

CAB1_CAEEL

Accession

Primary (citable) accession number: Q93249
Secondary accession number(s): P90751

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 30, 2000
Last modified:	May 1, 2013
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project