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Protein

Glutathione peroxidase

Gene

gpx-5

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • response to reactive oxygen species Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, PeroxidaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

ReactomeiR-CEL-2142712. Synthesis of 12-eicosatetraenoic acid derivatives.
R-CEL-2142770. Synthesis of 15-eicosatetraenoic acid derivatives.
R-CEL-3299685. Detoxification of Reactive Oxygen Species.
R-CEL-5628897. TP53 Regulates Metabolic Genes.
R-CEL-74259. Purine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidaseUniRule annotation
Gene namesi
Name:gpx-5Imported
ORF Names:C11E4.1Imported, CELE_C11E4.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC11E4.1; CE08101; WBGene00007516; gpx-5.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 223206Glutathione peroxidaseSequence analysisPRO_5004320142Add
BLAST

Proteomic databases

EPDiQ93204.
PaxDbiQ93204.
PRIDEiQ93204.

Interactioni

Protein-protein interaction databases

STRINGi6239.C11E4.1.

Structurei

3D structure databases

ProteinModelPortaliQ93204.
SMRiQ93204. Positions 39-200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277055.
InParanoidiQ93204.
KOiK00432.
OMAiGVEFEIM.
OrthoDBiEOG7KQ23C.
PhylomeDBiQ93204.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWQLTFAA LFAFVAAQPG PKMVDETTRW SQCKDTNQSI YDFQVETLQG
60 70 80 90 100
EYTDLSQYRG QVLLMVNVAT FCAYTQQYTD FNPLIEKYQS QGFTLIAFPC
110 120 130 140 150
NQFYLQEPAE NHELMNGIMY VRPGNGWKPH QNLHIYGKLD TNGDNQHPIY
160 170 180 190 200
EFVKESCPQT VDKIGKTDEL MYNPIRASDI TWNFEKFLID RNGQPRFRFH
210 220
PTAWSHGDVV TPFIEQLLAE PAN
Length:223
Mass (Da):25,838
Last modified:August 21, 2007 - v3
Checksum:i73F4FED425F8E47C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAB02659.3.
RefSeqiNP_509615.3. NM_077214.4.
UniGeneiCel.11404.

Genome annotation databases

EnsemblMetazoaiC11E4.1; C11E4.1; WBGene00007516.
GeneIDi181178.
KEGGicel:CELE_C11E4.1.
UCSCiC11E4.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAB02659.3.
RefSeqiNP_509615.3. NM_077214.4.
UniGeneiCel.11404.

3D structure databases

ProteinModelPortaliQ93204.
SMRiQ93204. Positions 39-200.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C11E4.1.

Proteomic databases

EPDiQ93204.
PaxDbiQ93204.
PRIDEiQ93204.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC11E4.1; C11E4.1; WBGene00007516.
GeneIDi181178.
KEGGicel:CELE_C11E4.1.
UCSCiC11E4.1. c. elegans.

Organism-specific databases

CTDi181178.
WormBaseiC11E4.1; CE08101; WBGene00007516; gpx-5.

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277055.
InParanoidiQ93204.
KOiK00432.
OMAiGVEFEIM.
OrthoDBiEOG7KQ23C.
PhylomeDBiQ93204.

Enzyme and pathway databases

ReactomeiR-CEL-2142712. Synthesis of 12-eicosatetraenoic acid derivatives.
R-CEL-2142770. Synthesis of 15-eicosatetraenoic acid derivatives.
R-CEL-3299685. Detoxification of Reactive Oxygen Species.
R-CEL-5628897. TP53 Regulates Metabolic Genes.
R-CEL-74259. Purine catabolism.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ93204_CAEEL
AccessioniPrimary (citable) accession number: Q93204
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: August 21, 2007
Last modified: June 8, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.