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Q931T1

- RNC_STAAM

UniProt

Q931T1 - RNC_STAAM

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Protein
Ribonuclease 3
Gene
rnc, SAV1233
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+ By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Magnesium By similarity
Active sitei63 – 631 Reviewed prediction
Metal bindingi132 – 1321Magnesium By similarity
Active sitei135 – 1351 By similarity
Metal bindingi135 – 1351Magnesium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. rRNA binding Source: UniProtKB-KW
  3. ribonuclease III activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. mRNA processing Source: UniProtKB-HAMAP
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-HAMAP
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processing, rRNA processing, tRNA processing

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-1251-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3 (EC:3.1.26.3)
Alternative name(s):
Ribonuclease III
Short name:
RNase III
Gene namesi
Name:rnc
Ordered Locus Names:SAV1233
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Ribonuclease 3UniRule annotation
PRO_0000180433Add
BLAST

Proteomic databases

PRIDEiQ931T1.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi158878.SAV1233.

Structurei

3D structure databases

ProteinModelPortaliQ931T1.
SMRiQ931T1. Positions 4-239.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 146137RNase III
Add
BLAST
Domaini172 – 24170DRBM
Add
BLAST

Sequence similaritiesi

Contains 1 RNase III domain.

Phylogenomic databases

eggNOGiCOG0571.
KOiK03685.
OMAiAQKDPKT.
OrthoDBiEOG6T1WVS.
PhylomeDBiQ931T1.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q931T1-1 [UniParc]FASTAAdd to Basket

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MSKQKKSEIV NRFRKRFDTK MTELGFTYQN IDLYQQAFSH SSFINDFNMN    50
RLDHNERLEF LGDAVLELTV SRYLFDKHPN LPEGNLTKMR ATIVCEPSLV 100
IFANKIGLNE MILLGKGEEK TGGRTRPSLI SDAFEAFIGA LYLDQGLDIV 150
WKFAEKVIFP HVEQNELLGV VDFKTQFQEY VHQQNKGDVT YNLIKEEGPA 200
HHRLFTSEVI LQGEAIAEGK GKTKKESEQR AAKSAYKQLK QIK 243
Length:243
Mass (Da):27,921
Last modified:December 1, 2001 - v1
Checksum:i87503968BC3455A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB57395.1.
RefSeqiNP_371757.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB57395; BAB57395; SAV1233.
GeneIDi1121210.
KEGGisav:SAV1233.
PATRICi19563179. VBIStaAur52173_1267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB57395.1 .
RefSeqi NP_371757.1. NC_002758.2.

3D structure databases

ProteinModelPortali Q931T1.
SMRi Q931T1. Positions 4-239.
ModBasei Search...

Protein-protein interaction databases

STRINGi 158878.SAV1233.

Proteomic databases

PRIDEi Q931T1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB57395 ; BAB57395 ; SAV1233 .
GeneIDi 1121210.
KEGGi sav:SAV1233.
PATRICi 19563179. VBIStaAur52173_1267.

Phylogenomic databases

eggNOGi COG0571.
KOi K03685.
OMAi AQKDPKT.
OrthoDBi EOG6T1WVS.
PhylomeDBi Q931T1.

Enzyme and pathway databases

BioCyci SAUR158878:GJJ5-1251-MONOMER.

Family and domain databases

Gene3Di 1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPi MF_00104. RNase_III.
InterProi IPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
PANTHERi PTHR11207. PTHR11207. 1 hit.
Pfami PF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view ]
SMARTi SM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view ]
SUPFAMi SSF69065. SSF69065. 1 hit.
TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
PROSITEi PS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiRNC_STAAM
AccessioniPrimary (citable) accession number: Q931T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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