Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q931P4

- ISDH_STAAM

UniProt

Q931P4 - ISDH_STAAM

Protein

Iron-regulated surface determinant protein H

Gene

isdH

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone By similarity.By similarity

    Enzyme and pathway databases

    BioCyciSAUR158878:GJJ5-1747-MONOMER.

    Protein family/group databases

    TCDBi9.A.39.1.2. the gram-positive bacterial hemoglobin receptor (isd) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iron-regulated surface determinant protein H
    Alternative name(s):
    Haptoglobin receptor A
    Staphylococcus aureus surface protein I
    Gene namesi
    Name:isdH
    Synonyms:harA, sasI
    Ordered Locus Names:SAV1731
    OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
    Taxonomic identifieri158878 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002481: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cell wall Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-KW
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4040Sequence AnalysisAdd
    BLAST
    Chaini41 – 860820Iron-regulated surface determinant protein HPRO_0000285187Add
    BLAST
    Propeptidei861 – 89131Removed by sortaseSequence AnalysisPRO_0000285188Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei860 – 8601Pentaglycyl murein peptidoglycan amidated threonineSequence Analysis

    Keywords - PTMi

    Peptidoglycan-anchor

    Interactioni

    Protein-protein interaction databases

    STRINGi158878.SAV1731.

    Structurei

    Secondary structure

    1
    891
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi545 – 5506
    Beta strandi552 – 56211
    Helixi564 – 5674
    Beta strandi571 – 5788
    Beta strandi581 – 59010
    Helixi591 – 5933
    Beta strandi594 – 5996
    Beta strandi605 – 6106
    Helixi611 – 6133
    Beta strandi615 – 6217
    Beta strandi628 – 63710
    Helixi638 – 6403
    Beta strandi642 – 65211

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2E7DX-ray2.20A/B539-664[»]
    2Z6FX-ray1.90A539-664[»]
    3QUGX-ray1.70A/B539-664[»]
    3QUHX-ray2.70A/B539-664[»]
    3VTMX-ray2.80A/B543-655[»]
    3VUAX-ray1.85A/B/C/D/E/F539-664[»]
    ProteinModelPortaliQ931P4.
    SMRiQ931P4. Positions 86-227, 326-466, 543-655.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ931P4.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini105 – 232128NEAT 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini345 – 471127NEAT 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini543 – 660118NEAT 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi857 – 8615LPXTG sorting signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi698 – 77578Asp-richAdd
    BLAST

    Domaini

    The NEAT 1 domain binds with higher affinity than the NEAT 2 domain haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin.By similarity

    Sequence similaritiesi

    Belongs to the IsdH family.Curated
    Contains 3 NEAT domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000280077.
    OMAiVQTGQED.
    OrthoDBiEOG6RNQ8T.

    Family and domain databases

    InterProiIPR019930. Haptoglobin-bd_HarA.
    IPR019931. LPXTG_anchor.
    IPR006635. NEAT_dom.
    IPR005877. YSIRK_signal_dom.
    [Graphical view]
    PfamiPF05031. NEAT. 3 hits.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view]
    SMARTiSM00725. NEAT. 3 hits.
    [Graphical view]
    TIGRFAMsiTIGR03658. IsdH_HarA. 1 hit.
    TIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEiPS50978. NEAT. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q931P4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKHHPKLRS FYSIRKSTLG VASVIVSTLF LITSQHQAQA AENTNTSDKI    50
    SENQNNNATT TQQPKDTNQT QPATQPVITA KNYPAADESL KDAIKDPALE 100
    NKEHDIGPRE QVNFQLLDKN NETQYYHFFS IKDPADVYYT KKKAEVELDI 150
    NTASTWKKFE VYENNQKLPV RLVSYSPVPE DHAYIRFPVS DGTQELKIVS 200
    STQIDDGEET NYDYTKLVFA KPIYNDPSLV KSDTNDAVVT NDQSSSDASN 250
    QTNTNTSNQN TSTTNNANNQ PQATTNMSQP AQPKSSANAD QASSQPAHET 300
    NSNGNTNDKT NESSNQSDVN QQYPPADESL QDAIKNPAII DKEHTADNWR 350
    PIDFQMKNDK GERQFYHYAS TVEPATVIFT KTGPVIELGL KTASTWKKFE 400
    VYEGDKKLPV ELVSYDSDKD YAYIRFPVSN GTRDVKIVSS IEYGENIHED 450
    YDYTLMVFAQ PITNNPDDYV DEETYNLQKL LAPYHKAKTL ERQVYELEKL 500
    QEKLPEKYKA EYKKKLDQTR VELADQVKSA VTEFENVTPT NDQLTDLQEA 550
    HFVVFESEEN SESVMDGFVE HPFYTATLNG QKYVVMKTKD DSYWKDLIVE 600
    GKRVTTVSKD PKNNSRTLIF PYIPDKAVYN AIVKVVVANI GYEGQYHVRI 650
    INQDINTKDD DTSQNNTSEP LNVQTGQEGK VADTDVAENS STATNPKDAS 700
    DKADVIEPES DVVKDADNNI DKDVQHDVDH LSDMSDNNHF DKYDLKEMDT 750
    QIAKDTDRNV DNSVGMSSNV DTDKDSNKNK DKVIQLAHIA DKNNHTGKAA 800
    KLDVVKQNYN NTDKVTDKKT TEHLPSDIHK TVDKTVKTKE KAGTPSKENK 850
    LSQSKMLPKT GETTSSQSWW GLYALLGMLA LFIPKFRKES K 891
    Length:891
    Mass (Da):100,466
    Last modified:December 1, 2001 - v1
    Checksum:i7226A157FFE27123
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB57893.1.
    RefSeqiNP_372255.1. NC_002758.2.

    Genome annotation databases

    EnsemblBacteriaiBAB57893; BAB57893; SAV1731.
    GeneIDi1121706.
    KEGGisav:SAV1731.
    PATRICi19564216. VBIStaAur52173_1786.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB57893.1 .
    RefSeqi NP_372255.1. NC_002758.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2E7D X-ray 2.20 A/B 539-664 [» ]
    2Z6F X-ray 1.90 A 539-664 [» ]
    3QUG X-ray 1.70 A/B 539-664 [» ]
    3QUH X-ray 2.70 A/B 539-664 [» ]
    3VTM X-ray 2.80 A/B 543-655 [» ]
    3VUA X-ray 1.85 A/B/C/D/E/F 539-664 [» ]
    ProteinModelPortali Q931P4.
    SMRi Q931P4. Positions 86-227, 326-466, 543-655.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158878.SAV1731.

    Protein family/group databases

    TCDBi 9.A.39.1.2. the gram-positive bacterial hemoglobin receptor (isd) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB57893 ; BAB57893 ; SAV1731 .
    GeneIDi 1121706.
    KEGGi sav:SAV1731.
    PATRICi 19564216. VBIStaAur52173_1786.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000280077.
    OMAi VQTGQED.
    OrthoDBi EOG6RNQ8T.

    Enzyme and pathway databases

    BioCyci SAUR158878:GJJ5-1747-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q931P4.

    Family and domain databases

    InterProi IPR019930. Haptoglobin-bd_HarA.
    IPR019931. LPXTG_anchor.
    IPR006635. NEAT_dom.
    IPR005877. YSIRK_signal_dom.
    [Graphical view ]
    Pfami PF05031. NEAT. 3 hits.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view ]
    SMARTi SM00725. NEAT. 3 hits.
    [Graphical view ]
    TIGRFAMsi TIGR03658. IsdH_HarA. 1 hit.
    TIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEi PS50978. NEAT. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu50 / ATCC 700699.

    Entry informationi

    Entry nameiISDH_STAAM
    AccessioniPrimary (citable) accession number: Q931P4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3