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Protein

Iron-regulated surface determinant protein H

Gene

isdH

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone (By similarity).By similarity

GO - Molecular functioni

Enzyme and pathway databases

BioCyciSAUR158878:G1G22-1880-MONOMER

Protein family/group databases

TCDBi9.A.39.1.2 the gram-positive bacterial hemoglobin receptor (isd) family

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-regulated surface determinant protein H
Alternative name(s):
Haptoglobin receptor A
Staphylococcus aureus surface protein I
Gene namesi
Name:isdH
Synonyms:harA, sasI
Ordered Locus Names:SAV1731
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 40Sequence analysisAdd BLAST40
ChainiPRO_000028518741 – 860Iron-regulated surface determinant protein HAdd BLAST820
PropeptideiPRO_0000285188861 – 891Removed by sortaseSequence analysisAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei860Pentaglycyl murein peptidoglycan amidated threonineSequence analysis1

Keywords - PTMi

Peptidoglycan-anchor

Proteomic databases

PaxDbiQ931P4
PRIDEiQ931P4

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV1731

Structurei

Secondary structure

1891
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi545 – 550Combined sources6
Beta strandi552 – 562Combined sources11
Helixi564 – 567Combined sources4
Beta strandi571 – 578Combined sources8
Beta strandi581 – 590Combined sources10
Helixi591 – 593Combined sources3
Beta strandi594 – 599Combined sources6
Beta strandi605 – 610Combined sources6
Helixi611 – 613Combined sources3
Beta strandi615 – 621Combined sources7
Beta strandi628 – 637Combined sources10
Helixi638 – 640Combined sources3
Beta strandi642 – 652Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E7DX-ray2.20A/B539-664[»]
2Z6FX-ray1.90A539-664[»]
3QUGX-ray1.70A/B539-664[»]
3QUHX-ray2.70A/B539-664[»]
3VTMX-ray2.80A/B543-655[»]
3VUAX-ray1.85A/B/C/D/E/F539-664[»]
ProteinModelPortaliQ931P4
SMRiQ931P4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ931P4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 232NEAT 1PROSITE-ProRule annotationAdd BLAST128
Domaini345 – 471NEAT 2PROSITE-ProRule annotationAdd BLAST127
Domaini543 – 660NEAT 3PROSITE-ProRule annotationAdd BLAST118

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi857 – 861LPXTG sorting signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi698 – 775Asp-richAdd BLAST78

Domaini

The NEAT 1 domain binds with higher affinity than the NEAT 2 domain haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin.By similarity

Sequence similaritiesi

Belongs to the IsdH family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000280077
OMAiVQTGQED

Family and domain databases

CDDicd06920 NEAT, 1 hit
InterProiView protein in InterPro
IPR019930 Haptoglobin-bd_HarA
IPR006635 NEAT_dom
IPR037250 NEAT_dom_sf
IPR005877 YSIRK_signal_dom
PfamiView protein in Pfam
PF05031 NEAT, 3 hits
PF04650 YSIRK_signal, 1 hit
SMARTiView protein in SMART
SM00725 NEAT, 3 hits
SUPFAMiSSF158911 SSF158911, 3 hits
TIGRFAMsiTIGR03658 IsdH_HarA, 1 hit
TIGR01168 YSIRK_signal, 1 hit
PROSITEiView protein in PROSITE
PS50978 NEAT, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q931P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKHHPKLRS FYSIRKSTLG VASVIVSTLF LITSQHQAQA AENTNTSDKI
60 70 80 90 100
SENQNNNATT TQQPKDTNQT QPATQPVITA KNYPAADESL KDAIKDPALE
110 120 130 140 150
NKEHDIGPRE QVNFQLLDKN NETQYYHFFS IKDPADVYYT KKKAEVELDI
160 170 180 190 200
NTASTWKKFE VYENNQKLPV RLVSYSPVPE DHAYIRFPVS DGTQELKIVS
210 220 230 240 250
STQIDDGEET NYDYTKLVFA KPIYNDPSLV KSDTNDAVVT NDQSSSDASN
260 270 280 290 300
QTNTNTSNQN TSTTNNANNQ PQATTNMSQP AQPKSSANAD QASSQPAHET
310 320 330 340 350
NSNGNTNDKT NESSNQSDVN QQYPPADESL QDAIKNPAII DKEHTADNWR
360 370 380 390 400
PIDFQMKNDK GERQFYHYAS TVEPATVIFT KTGPVIELGL KTASTWKKFE
410 420 430 440 450
VYEGDKKLPV ELVSYDSDKD YAYIRFPVSN GTRDVKIVSS IEYGENIHED
460 470 480 490 500
YDYTLMVFAQ PITNNPDDYV DEETYNLQKL LAPYHKAKTL ERQVYELEKL
510 520 530 540 550
QEKLPEKYKA EYKKKLDQTR VELADQVKSA VTEFENVTPT NDQLTDLQEA
560 570 580 590 600
HFVVFESEEN SESVMDGFVE HPFYTATLNG QKYVVMKTKD DSYWKDLIVE
610 620 630 640 650
GKRVTTVSKD PKNNSRTLIF PYIPDKAVYN AIVKVVVANI GYEGQYHVRI
660 670 680 690 700
INQDINTKDD DTSQNNTSEP LNVQTGQEGK VADTDVAENS STATNPKDAS
710 720 730 740 750
DKADVIEPES DVVKDADNNI DKDVQHDVDH LSDMSDNNHF DKYDLKEMDT
760 770 780 790 800
QIAKDTDRNV DNSVGMSSNV DTDKDSNKNK DKVIQLAHIA DKNNHTGKAA
810 820 830 840 850
KLDVVKQNYN NTDKVTDKKT TEHLPSDIHK TVDKTVKTKE KAGTPSKENK
860 870 880 890
LSQSKMLPKT GETTSSQSWW GLYALLGMLA LFIPKFRKES K
Length:891
Mass (Da):100,466
Last modified:December 1, 2001 - v1
Checksum:i7226A157FFE27123
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB57893.1
RefSeqiWP_001032804.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB57893; BAB57893; SAV1731
KEGGisav:SAV1731

Similar proteinsi

Entry informationi

Entry nameiISDH_STAAM
AccessioniPrimary (citable) accession number: Q931P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome
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Main funding by: National Institutes of Health