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Q931P4 (ISDH_STAAM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Iron-regulated surface determinant protein H
Alternative name(s):
Haptoglobin receptor A
Staphylococcus aureus surface protein I
Gene names
Name:isdH
Synonyms:harA, sasI
Ordered Locus Names:SAV1731
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length891 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone By similarity.

Subcellular location

Secretedcell wall; Peptidoglycan-anchor Potential.

Domain

The NEAT 1 domain binds with higher affinity than the NEAT 2 domain haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin By similarity.

Sequence similarities

Belongs to the IsdH family.

Contains 3 NEAT domains.

Ontologies

Keywords
   Cellular componentCell wall
Secreted
   DomainRepeat
Signal
   PTMPeptidoglycan-anchor
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Cellular_componentcell wall

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4040 Potential
Chain41 – 860820Iron-regulated surface determinant protein H
PRO_0000285187
Propeptide861 – 89131Removed by sortase Potential
PRO_0000285188

Regions

Domain105 – 232128NEAT 1
Domain345 – 471127NEAT 2
Domain543 – 660118NEAT 3
Motif857 – 8615LPXTG sorting signal Potential
Compositional bias698 – 77578Asp-rich

Amino acid modifications

Modified residue8601Pentaglycyl murein peptidoglycan amidated threonine Potential

Secondary structure

....................... 891
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q931P4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 7226A157FFE27123

FASTA891100,466
        10         20         30         40         50         60 
MNKHHPKLRS FYSIRKSTLG VASVIVSTLF LITSQHQAQA AENTNTSDKI SENQNNNATT 

        70         80         90        100        110        120 
TQQPKDTNQT QPATQPVITA KNYPAADESL KDAIKDPALE NKEHDIGPRE QVNFQLLDKN 

       130        140        150        160        170        180 
NETQYYHFFS IKDPADVYYT KKKAEVELDI NTASTWKKFE VYENNQKLPV RLVSYSPVPE 

       190        200        210        220        230        240 
DHAYIRFPVS DGTQELKIVS STQIDDGEET NYDYTKLVFA KPIYNDPSLV KSDTNDAVVT 

       250        260        270        280        290        300 
NDQSSSDASN QTNTNTSNQN TSTTNNANNQ PQATTNMSQP AQPKSSANAD QASSQPAHET 

       310        320        330        340        350        360 
NSNGNTNDKT NESSNQSDVN QQYPPADESL QDAIKNPAII DKEHTADNWR PIDFQMKNDK 

       370        380        390        400        410        420 
GERQFYHYAS TVEPATVIFT KTGPVIELGL KTASTWKKFE VYEGDKKLPV ELVSYDSDKD 

       430        440        450        460        470        480 
YAYIRFPVSN GTRDVKIVSS IEYGENIHED YDYTLMVFAQ PITNNPDDYV DEETYNLQKL 

       490        500        510        520        530        540 
LAPYHKAKTL ERQVYELEKL QEKLPEKYKA EYKKKLDQTR VELADQVKSA VTEFENVTPT 

       550        560        570        580        590        600 
NDQLTDLQEA HFVVFESEEN SESVMDGFVE HPFYTATLNG QKYVVMKTKD DSYWKDLIVE 

       610        620        630        640        650        660 
GKRVTTVSKD PKNNSRTLIF PYIPDKAVYN AIVKVVVANI GYEGQYHVRI INQDINTKDD 

       670        680        690        700        710        720 
DTSQNNTSEP LNVQTGQEGK VADTDVAENS STATNPKDAS DKADVIEPES DVVKDADNNI 

       730        740        750        760        770        780 
DKDVQHDVDH LSDMSDNNHF DKYDLKEMDT QIAKDTDRNV DNSVGMSSNV DTDKDSNKNK 

       790        800        810        820        830        840 
DKVIQLAHIA DKNNHTGKAA KLDVVKQNYN NTDKVTDKKT TEHLPSDIHK TVDKTVKTKE 

       850        860        870        880        890 
KAGTPSKENK LSQSKMLPKT GETTSSQSWW GLYALLGMLA LFIPKFRKES K 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000017 Genomic DNA. Translation: BAB57893.1.
RefSeqNP_372255.1. NC_002758.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2E7DX-ray2.20A/B539-664[»]
2Z6FX-ray1.90A539-664[»]
3QUGX-ray1.70A/B539-664[»]
3QUHX-ray2.70A/B539-664[»]
3VTMX-ray2.80A/B543-655[»]
3VUAX-ray1.85A/B/C/D/E/F539-664[»]
ProteinModelPortalQ931P4.
SMRQ931P4. Positions 86-227, 326-466, 543-655.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING158878.SAV1731.

Protein family/group databases

TCDB9.A.39.1.2. the gram-positive bacterial hemoglobin receptor (isd) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB57893; BAB57893; SAV1731.
GeneID1121706.
KEGGsav:SAV1731.
PATRIC19564216. VBIStaAur52173_1786.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000280077.
OMAVQTGQED.
OrthoDBEOG6RNQ8T.

Enzyme and pathway databases

BioCycSAUR158878:GJJ5-1747-MONOMER.

Family and domain databases

InterProIPR005877. Gpos_YSIRK.
IPR019930. Haptoglobin-bd_HarA.
IPR019931. LPXTG_anchor.
IPR006635. NEA_transpt.
[Graphical view]
PfamPF05031. NEAT. 3 hits.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTSM00725. NEAT. 3 hits.
[Graphical view]
TIGRFAMsTIGR03658. IsdH_HarA. 1 hit.
TIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEPS50978. NEAT. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ931P4.

Entry information

Entry nameISDH_STAAM
AccessionPrimary (citable) accession number: Q931P4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references