Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Iron-regulated surface determinant protein H

Gene

isdH

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone (By similarity).By similarity

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-1747-MONOMER.

Protein family/group databases

TCDBi9.A.39.1.2. the gram-positive bacterial hemoglobin receptor (isd) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-regulated surface determinant protein H
Alternative name(s):
Haptoglobin receptor A
Staphylococcus aureus surface protein I
Gene namesi
Name:isdH
Synonyms:harA, sasI
Ordered Locus Names:SAV1731
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4040Sequence AnalysisAdd
BLAST
Chaini41 – 860820Iron-regulated surface determinant protein HPRO_0000285187Add
BLAST
Propeptidei861 – 89131Removed by sortaseSequence AnalysisPRO_0000285188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei860 – 8601Pentaglycyl murein peptidoglycan amidated threonineSequence Analysis

Keywords - PTMi

Peptidoglycan-anchor

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV1731.

Structurei

Secondary structure

1
891
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi545 – 5506Combined sources
Beta strandi552 – 56211Combined sources
Helixi564 – 5674Combined sources
Beta strandi571 – 5788Combined sources
Beta strandi581 – 59010Combined sources
Helixi591 – 5933Combined sources
Beta strandi594 – 5996Combined sources
Beta strandi605 – 6106Combined sources
Helixi611 – 6133Combined sources
Beta strandi615 – 6217Combined sources
Beta strandi628 – 63710Combined sources
Helixi638 – 6403Combined sources
Beta strandi642 – 65211Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E7DX-ray2.20A/B539-664[»]
2Z6FX-ray1.90A539-664[»]
3QUGX-ray1.70A/B539-664[»]
3QUHX-ray2.70A/B539-664[»]
3VTMX-ray2.80A/B543-655[»]
3VUAX-ray1.85A/B/C/D/E/F539-664[»]
ProteinModelPortaliQ931P4.
SMRiQ931P4. Positions 86-227, 326-466, 543-655.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ931P4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 232128NEAT 1PROSITE-ProRule annotationAdd
BLAST
Domaini345 – 471127NEAT 2PROSITE-ProRule annotationAdd
BLAST
Domaini543 – 660118NEAT 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi857 – 8615LPXTG sorting signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi698 – 77578Asp-richAdd
BLAST

Domaini

The NEAT 1 domain binds with higher affinity than the NEAT 2 domain haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin.By similarity

Sequence similaritiesi

Belongs to the IsdH family.Curated
Contains 3 NEAT domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000280077.
OMAiVQTGQED.
OrthoDBiEOG6RNQ8T.

Family and domain databases

InterProiIPR019930. Haptoglobin-bd_HarA.
IPR019931. LPXTG_anchor.
IPR006635. NEAT_dom.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF05031. NEAT. 3 hits.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTiSM00725. NEAT. 3 hits.
[Graphical view]
TIGRFAMsiTIGR03658. IsdH_HarA. 1 hit.
TIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50978. NEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q931P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKHHPKLRS FYSIRKSTLG VASVIVSTLF LITSQHQAQA AENTNTSDKI
60 70 80 90 100
SENQNNNATT TQQPKDTNQT QPATQPVITA KNYPAADESL KDAIKDPALE
110 120 130 140 150
NKEHDIGPRE QVNFQLLDKN NETQYYHFFS IKDPADVYYT KKKAEVELDI
160 170 180 190 200
NTASTWKKFE VYENNQKLPV RLVSYSPVPE DHAYIRFPVS DGTQELKIVS
210 220 230 240 250
STQIDDGEET NYDYTKLVFA KPIYNDPSLV KSDTNDAVVT NDQSSSDASN
260 270 280 290 300
QTNTNTSNQN TSTTNNANNQ PQATTNMSQP AQPKSSANAD QASSQPAHET
310 320 330 340 350
NSNGNTNDKT NESSNQSDVN QQYPPADESL QDAIKNPAII DKEHTADNWR
360 370 380 390 400
PIDFQMKNDK GERQFYHYAS TVEPATVIFT KTGPVIELGL KTASTWKKFE
410 420 430 440 450
VYEGDKKLPV ELVSYDSDKD YAYIRFPVSN GTRDVKIVSS IEYGENIHED
460 470 480 490 500
YDYTLMVFAQ PITNNPDDYV DEETYNLQKL LAPYHKAKTL ERQVYELEKL
510 520 530 540 550
QEKLPEKYKA EYKKKLDQTR VELADQVKSA VTEFENVTPT NDQLTDLQEA
560 570 580 590 600
HFVVFESEEN SESVMDGFVE HPFYTATLNG QKYVVMKTKD DSYWKDLIVE
610 620 630 640 650
GKRVTTVSKD PKNNSRTLIF PYIPDKAVYN AIVKVVVANI GYEGQYHVRI
660 670 680 690 700
INQDINTKDD DTSQNNTSEP LNVQTGQEGK VADTDVAENS STATNPKDAS
710 720 730 740 750
DKADVIEPES DVVKDADNNI DKDVQHDVDH LSDMSDNNHF DKYDLKEMDT
760 770 780 790 800
QIAKDTDRNV DNSVGMSSNV DTDKDSNKNK DKVIQLAHIA DKNNHTGKAA
810 820 830 840 850
KLDVVKQNYN NTDKVTDKKT TEHLPSDIHK TVDKTVKTKE KAGTPSKENK
860 870 880 890
LSQSKMLPKT GETTSSQSWW GLYALLGMLA LFIPKFRKES K
Length:891
Mass (Da):100,466
Last modified:December 1, 2001 - v1
Checksum:i7226A157FFE27123
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB57893.1.
RefSeqiWP_001032804.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB57893; BAB57893; SAV1731.
KEGGisav:SAV1731.
PATRICi19564216. VBIStaAur52173_1786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB57893.1.
RefSeqiWP_001032804.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E7DX-ray2.20A/B539-664[»]
2Z6FX-ray1.90A539-664[»]
3QUGX-ray1.70A/B539-664[»]
3QUHX-ray2.70A/B539-664[»]
3VTMX-ray2.80A/B543-655[»]
3VUAX-ray1.85A/B/C/D/E/F539-664[»]
ProteinModelPortaliQ931P4.
SMRiQ931P4. Positions 86-227, 326-466, 543-655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV1731.

Protein family/group databases

TCDBi9.A.39.1.2. the gram-positive bacterial hemoglobin receptor (isd) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB57893; BAB57893; SAV1731.
KEGGisav:SAV1731.
PATRICi19564216. VBIStaAur52173_1786.

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000280077.
OMAiVQTGQED.
OrthoDBiEOG6RNQ8T.

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-1747-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ931P4.

Family and domain databases

InterProiIPR019930. Haptoglobin-bd_HarA.
IPR019931. LPXTG_anchor.
IPR006635. NEAT_dom.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF05031. NEAT. 3 hits.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTiSM00725. NEAT. 3 hits.
[Graphical view]
TIGRFAMsiTIGR03658. IsdH_HarA. 1 hit.
TIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50978. NEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiISDH_STAAM
AccessioniPrimary (citable) accession number: Q931P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.