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Q931M7 (SCIN_STAAM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Staphylococcal complement inhibitor
Short name=SCIN
Gene names
Name:scn
Ordered Locus Names:SAV1942
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the SCIN family.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentSecreted
   DomainSignal
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 11685Staphylococcal complement inhibitor
PRO_0000319871

Regions

Region62 – 7918Essential for activity By similarity

Secondary structure

1 .......... 116
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q931M7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 6C30E481973D19E9

FASTA11613,067
        10         20         30         40         50         60 
MKIRKSILAG TLAIVLASPL VTNLDKNEAQ ASTSLPTSNE YQNEKLANEL KSLLDELNVN 

        70         80         90        100        110 
ELATGSLNTY YKRTIKISGQ KAMYALKSKD FKKMSEAKYQ LQKIYNEIDE ALKSKY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000017 Genomic DNA. Translation: BAB58104.1.
RefSeqNP_372466.1. NC_002758.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3L3OX-ray3.40M/P32-116[»]
3L5NX-ray7.54M32-116[»]
3NMSX-ray4.10M32-116[»]
3OHXX-ray3.50M/P32-116[»]
ProteinModelPortalQ931M7.
SMRQ931M7. Positions 33-116.
ModBaseSearch...

Protein-protein interaction databases

STRING158878.SAV1942.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB58104; BAB58104; SAV1942.
GeneID1121954.
KEGGsav:SAV1942.
PATRIC19564744. VBIStaAur52173_2012.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000232739.
KOK14199.
OMAITANEYY.
ProtClustDBCLSK884496.

Enzyme and pathway databases

BioCycSAUR158878:GJJ5-1997-MONOMER.

Family and domain databases

InterProIPR021612. CompInhib_SCIN.
[Graphical view]
PfamPF11546. CompInhib_SCIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ931M7.

Entry information

Entry nameSCIN_STAAM
AccessionPrimary (citable) accession number: Q931M7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 1, 2001
Last modified: May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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