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Protein

Putative formate dehydrogenase SAV2309

Gene

SAV2309

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi37Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi48Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi51Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi63Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi95Iron-sulfur 2 (4Fe-4S); via tele nitrogenBy similarity1
Metal bindingi99Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi102Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi109Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi147Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi150Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi153Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi157Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi190Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi193Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi196Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi200Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi264Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi267Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi271Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi299Iron-sulfur 5 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2366-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate dehydrogenase SAV2309 (EC:1.2.1.2)
Gene namesi
Ordered Locus Names:SAV2309
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003041321 – 984Putative formate dehydrogenase SAV2309Add BLAST984

Proteomic databases

PaxDbiQ931G2.
PRIDEiQ931G2.

2D gel databases

World-2DPAGE0002:Q931G2.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2309.

Structurei

3D structure databases

ProteinModelPortaliQ931G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 792Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST77
Domaini138 – 1654Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST28
Domaini181 – 2114Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST31
Domaini257 – 3134Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni252 – 984Formate dehydrogenaseAdd BLAST733

Sequence similaritiesi

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated
Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation
Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108HIZ. Bacteria.
COG3383. LUCA.
HOGENOMiHOG000031440.
KOiK00123.
OMAiWGVTLQP.
PhylomeDBiQ931G2.

Family and domain databases

CDDicd00207. fer2. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036643. FDH_alpha. 1 hit.
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q931G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEHLVVTLD GKDYLVEPGT NLLEFIKSQD TFVPSICYNE SMGPIQTCDT
60 70 80 90 100
CTVEIDGKIE RSCSTVIDRP MTVNTVNNDV KDAQKEALDR ILEKHMLYCT
110 120 130 140 150
VCDYNNGDCE IHNTMDAWGL QHQTYEYKEK PYEKDYGPFY RYDPNQCILC
160 170 180 190 200
GRCVEACQDI EVNETIRIDW DREHPRVIWD NDVPINESSC VSCGQCATVC
210 220 230 240 250
PCNAMMEVNM EGNAGYMTDT EPGSLAAMID LTKKAEPGYG PLFAISDSEA
260 270 280 290 300
EMRKERIKKT KTVCTYCGVG CSFEVWTKDR EILKVQPSHD SPANKIVTCV
310 320 330 340 350
KGKFSWGHIN SDQRLTKPLV RKNGEFHEVE WDEALNVIAD NFTSIKEKYG
360 370 380 390 400
PDALSFISSS KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR
410 420 430 440 450
TVGHGGDSGS IEDLEKAAMS VLIGTNTAEA HPVIASRMKR AQKLFGQKIH
460 470 480 490 500
VFDIRKHEMA ERADRFYQPK PGTDLAWLSA VTKYIIDHDL HDKAFIDEWV
510 520 530 540 550
DDFDEYYKSL ETFTMAFAEE ATGIPESELI KFAEECAKAE SVVICWAMGI
560 570 580 590 600
TQQDIGSDSS TAISNLLLVT GNYRRPGTGA YPLRGHNNVQ GCSDMGSMPD
610 620 630 640 650
KITGYQSIEA DDIRAKFEKE YGVKLNPKAG KDNHEMVEGI HDGEVHSLYL
660 670 680 690 700
YGEDTGIVDS NINFVQAAFE KLDFMVVQDE FLTFTATYAD VVLPASPSLE
710 720 730 740 750
KDGTFTNTER RIQRLYQALE PLGDSKPDWK IFQAIANRLG FDWNYKHPSE
760 770 780 790 800
IMDEVARLTP LYAGVSYDRL EGFNSLQWPV QPDGTDEPIL YLEGFNFDNG
810 820 830 840 850
KAKLFPLSFD NYFKQDEIYD IHVNNGRLLE HFHEGNMTYQ TPMIKYKVPR
860 870 880 890 900
AFVEISPELA EDRGIHEGAE VKLISETGEA VLQVHVTDRV KGKEIYIPLN
910 920 930 940 950
NDAMENGDLG AINLLTNSDV DQYTDTPSYK RTSCRLEVIT KRGKSPLNPN
960 970 980
NFRVNKKRHP QYSVQVQKKW ERSDYVFPGN QVDK
Length:984
Mass (Da):111,323
Last modified:December 1, 2001 - v1
Checksum:iB4FB4538B4B2B15A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58471.1.
RefSeqiWP_001155288.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58471; BAB58471; SAV2309.
KEGGisav:SAV2309.
PATRICi19565526. VBIStaAur52173_2389.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58471.1.
RefSeqiWP_001155288.1. NC_002758.2.

3D structure databases

ProteinModelPortaliQ931G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV2309.

2D gel databases

World-2DPAGE0002:Q931G2.

Proteomic databases

PaxDbiQ931G2.
PRIDEiQ931G2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58471; BAB58471; SAV2309.
KEGGisav:SAV2309.
PATRICi19565526. VBIStaAur52173_2389.

Phylogenomic databases

eggNOGiENOG4108HIZ. Bacteria.
COG3383. LUCA.
HOGENOMiHOG000031440.
KOiK00123.
OMAiWGVTLQP.
PhylomeDBiQ931G2.

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2366-MONOMER.

Family and domain databases

CDDicd00207. fer2. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036643. FDH_alpha. 1 hit.
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFDHL_STAAM
AccessioniPrimary (citable) accession number: Q931G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.