Q93149 (ACR3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylcholine receptor subunit beta-type acr-3

Gene names

Name:	acr-3
ORF Names:	K11G12.7

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Possible acetylcholine receptor.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein By similarity. Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ionic channel Ligand-gated ion channel Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetylcholine receptor activity Inferred from direct assay Ref.1. Source: WormBase acetylcholine-activated cation-selective channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 487	467	Acetylcholine receptor subunit beta-type acr-3		PRO_0000000401
Regions
	Topological domain	21 – 231	211	Extracellular Potential
	Transmembrane	232 – 252	21	Helical; Potential
	Transmembrane	259 – 279	21	Helical; Potential
	Transmembrane	294 – 314	21	Helical; Potential
	Topological domain	315 – 439	125	Cytoplasmic Potential
	Transmembrane	440 – 460	21	Helical; Potential
Amino acid modifications
	Glycosylation	46	1	N-linked (GlcNAc...) Potential
	Disulfide bond	151 ↔ 165		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q93149 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 15D3E8D1DBF7E0F8	FASTA	487	56,245
	10 20 30 40 50 60 MQKIWLFSII TIFLITELQC YPNSAEERLL SYIFDGYNSL IRPVLNASSP PIEVFFSLAF 70 80 90 100 110 120 VLLINVDEKN QIMQTNVWPT MKWNDYQMQW DPREFDGIKT IRVPPDKVWL PDIVLFNNAD 130 140 150 160 170 180 GNYLVSFYSN VVVEHTGDML WVPPAVYKSS CLIDVEFFPF DEQVCSLTFG SWTFRKDELQ 190 200 210 220 230 240 LSYLSGKRHV ELNDYLPSGV WDLIDAPGLL IDERSKISYQ IKIRRKALFY TVILIMPTVL 250 260 270 280 290 300 MAFLSMMVFY LPAESSEKIT LAISILLALV VFLLVVSKIL PPTSSTIPLM AKYLLMTFIM 310 320 330 340 350 360 NMITIMVSVI IINVYFRGPA THIMPNWVKT VFLKFLPVLF VMRRPESTEK ELAKMKREKR 370 380 390 400 410 420 ERRSMKSALK TFFKRNDAKI SEQPKQTSRK DGSSSEEKLS SDAKKAIEAI EYITTHLTHD 430 440 450 460 470 480 NAFKRQREEW KFVSVVIDRL LLYLFFAVTT GGTVGILLSA PNVFEQVNQT SVIERLKQQA AEEMLNS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ACR-3, a Caenorhabditis elegans nicotinic acetylcholine receptor subunit. Molecular cloning and functional expression." Baylis H.A., Matsuda K., Squire M.D., Fleming J.T., Harvey R.J., Darlison M.G., Barnard E.A., Sattelle D.B. Recept. Channels 5:149-158(1997) [PubMed: 9606719] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y08637 mRNA. Translation: CAA69927.1. FO081325 Genomic DNA. Translation: CCD70799.1.
RefSeq	NP_509129.1. NM_076728.2.
UniGene	Cel.19671.
3D structure databases
ProteinModelPortal	Q93149.
SMR	Q93149. Positions 23-459.
ModBase	Search...
Protein family/group databases
TCDB	1.A.9.1.2. neurotransmitter receptor, cys loop, ligand-gated ion channel (LIC) family.
Proteomic databases
PRIDE	Q93149.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	K11G12.7; K11G12.7; K11G12.7.
GeneID	180937.
KEGG	cel:K11G12.7.
NMPDR	fig|6239.3.peg.23607.
UCSC	K11G12.7. c. elegans.
Organism-specific databases
CTD	180937.
WormBase	K11G12.7; CE28345; WBGene00000043; acr-3.
Phylogenomic databases
eggNOG	meNOG06680.
GeneTree	EMGT00050000005191.
HOGENOM	HBG387619.
InParanoid	Q93149.
OMA	HVELNDY.
PhylomeDB	Q93149.
Gene expression databases
ArrayExpress	Q93149.
Family and domain databases
InterPro	IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. IPR002394. Nicotinic_acetylcholine_rcpt. [Graphical view]
Gene3D	G3DSA:2.70.170.10. Neur_chan_lig_bd. 1 hit.
KO	K05312.
PANTHER	PTHR18945. Neur_channel. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR00254. NICOTINICR. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	911642.

Entry information

Entry name

ACR3_CAEEL

Accession

Primary (citable) accession number: Q93149

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project