Q93126 (GPR9_BALAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Probable G-protein coupled receptor No9
Organism	Balanus amphitrite (Striped barnacle)
Taxonomic identifier	1232801 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Crustacea › Maxillopoda › Thecostraca › Cirripedia › Thoracica › Sessilia › Balanidae › Amphibalanus

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Orphan G-protein coupled receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological_process	behavior Inferred from electronic annotation. Source: InterPro serotonin receptor signaling pathway Inferred from electronic annotation. Source: GOC
Cellular_component	integral to plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	adrenergic receptor activity Inferred from electronic annotation. Source: InterPro serotonin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 476	476	Probable G-protein coupled receptor No9		PRO_0000069659
Regions
	Topological domain	1 – 36	36	Extracellular Potential
	Transmembrane	37 – 60	24	Helical; Name=1; Potential
	Topological domain	61 – 69	9	Cytoplasmic Potential
	Transmembrane	70 – 93	24	Helical; Name=2; Potential
	Topological domain	94 – 103	10	Extracellular Potential
	Transmembrane	104 – 127	24	Helical; Name=3; Potential
	Topological domain	128 – 152	25	Cytoplasmic Potential
	Transmembrane	153 – 172	20	Helical; Name=4; Potential
	Topological domain	173 – 200	28	Extracellular Potential
	Transmembrane	201 – 221	21	Helical; Name=5; Potential
	Topological domain	222 – 375	154	Cytoplasmic Potential
	Transmembrane	376 – 396	21	Helical; Name=6; Potential
	Topological domain	397 – 406	10	Extracellular Potential
	Transmembrane	407 – 430	24	Helical; Name=7; Potential
	Topological domain	431 – 476	46	Cytoplasmic Potential
Sites
	Site	113	1	Implicated in ligand binding By similarity
	Site	208	1	Implicated in ligand binding By similarity
Amino acid modifications
	Glycosylation	13	1	N-linked (GlcNAc...) Potential
	Glycosylation	17	1	N-linked (GlcNAc...) Potential
	Disulfide bond	106 ↔ 192		By similarity
Experimental info
	Sequence conflict	454	1	R → A in BAA11424. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q93126 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 0F55B51595D5CD06	FASTA	476	53,246
	10 20 30 40 50 60 MEGPPLSPAP ADNVTLNVSC GRPATLFDWA DHRLISLLAL AFLNLMVVAG NLLVVMAVFV 70 80 90 100 110 120 HSKLRTVTNL FIVSLACADL LVGMLVLPFS ATLEVLDVWL YGDVWCSVWL AVDVWMCTSS 130 140 150 160 170 180 ILNLCAISLD RYLAVSQPIS YPSLMSTRRA KQLIAAVWVL SFVICFPPLV GWNDRPGTLI 190 200 210 220 230 240 GSRGSSACRL TCELTNERGY VIYSALGSFF LPSTVMLFFY GRIYRTAVST TRAIAQGFRT 250 260 270 280 290 300 TKEDEEGRLT LRIHRGRSVT QRAEQAAAGG ARAHGQVRLT LSEPGARRQN KPSFVVHCRE 310 320 330 340 350 360 DSRAKNQYEI YTVVEGDSRP GRRVPQPQRP AKKLSSASQS SEDDSRPPRF ISRVSRRNVR 370 380 390 400 410 420 HQARRFRMET KAAKTVGIIV GLFILCWLPF FVCYLVRGFC ADCVPPLLFS VFFWLGYCNS 430 440 450 460 470 AVNPCVYALC SRDFRFAFSS ILCKCVCRRG AMERRFRRTL LVGNRSQTEE DCEVAD

References

[1]	"Molecular cloning of a new member of the putative G protein-coupled receptor gene from barnacle Balanus amphitrite." Isoai A., Kawahara H., Okazaki Y., Shizuri Y. Gene 175:95-100(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Darwin.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D78363 Genomic DNA. Translation: BAA11375.1. D78587 Genomic DNA. Translation: BAA11424.1.
PIR	JC5042.
3D structure databases
ProteinModelPortal	Q93126.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002231. 5HT_rcpt. IPR002233. Adrnrgc_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24247. PTHR24247. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01103. ADRENERGICR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPR9_BALAM

Accession

Primary (citable) accession number: Q93126
Secondary accession number(s): Q93128

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 1, 1997
Last modified:	May 29, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)