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Q93112

- GST1C_ANOGA

UniProt

Q93112 - GST1C_ANOGA

Protein

Glutathione S-transferase 1, isoform C

Gene

GstD1

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (16 May 2006)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has DDT dehydrochlorinase activity.1 Publication

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.1 Publication
    1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei9 – 91GlutathioneBy similarity

    GO - Molecular functioni

    1. DDT-dehydrochlorinase activity Source: UniProtKB-EC
    2. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase 1, isoform C (EC:2.5.1.18, EC:4.5.1.1)
    Alternative name(s):
    AgGst1-alpha
    Aggst1-5
    DDT-dehydrochlorinase
    GST class-theta
    Gene namesi
    Name:GstD1
    Synonyms:GST1a
    ORF Names:AGAP004164
    OrganismiAnopheles gambiae (African malaria mosquito)
    Taxonomic identifieri7165 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
    ProteomesiUP000007062: Chromosome 2R

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Glutathione S-transferase 1, isoform CPRO_0000185961Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ93112.
    SMRiQ93112. Positions 1-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8080GST N-terminalAdd
    BLAST
    Domaini86 – 207122GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni50 – 523Glutathione bindingBy similarity
    Regioni64 – 663Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Theta family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    HOGENOMiHOG000125741.
    KOiK00799.
    OMAiNEADYLA.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform C (identifier: Q93112-1) [UniParc]FASTAAdd to Basket

    Also known as: 1-5

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDFYYLPGSA PCRAVQMTAA AVGVELNLKL TDLMKGEHMK PEFLKINPQH    50
    CIPTLVDNGF ALWESRAICT YLAEKYGKDD KLYPKDPQKR AVVNQRMYFD 100
    MGTLYQRFAD YYYPQIFAKQ PANPENEQKM KDAVGFLNSF LDGHKYVAGD 150
    SLTIADLSIL ATISTYDVAG FDLAKYQHVA AWYENIRKEA PGAAINQAGI 200
    EEFKKYFEK 209
    Length:209
    Mass (Da):23,783
    Last modified:May 16, 2006 - v2
    Checksum:iED01B322C2715409
    GO
    Isoform A (identifier: O77462-1) [UniParc]FASTAAdd to Basket

    Also known as: 1-3

    The sequence of this isoform can be found in the external entry O77462.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:186
    Mass (Da):21,255
    GO
    Isoform B (identifier: O77473-1) [UniParc]FASTAAdd to Basket

    Also known as: 1-4

    The sequence of this isoform can be found in the external entry O77473.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:216
    Mass (Da):24,492
    GO
    Isoform D (identifier: Q93113-1) [UniParc]FASTAAdd to Basket

    Also known as: 1-1, 1-6, 2-1

    The sequence of this isoform can be found in the external entry Q93113.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:209
    Mass (Da):23,445
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti135 – 1351G → D in CAB03592. (PubMed:9038148)Curated
    Sequence conflicti139 – 1391S → T in CAB03592. (PubMed:9038148)Curated
    Sequence conflicti181 – 1811A → V in CAB03592. (PubMed:9038148)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81291 mRNA. Translation: CAB03592.1.
    AF071160 Genomic DNA. Translation: AAC79993.1.
    AAAB01008880 Genomic DNA. Translation: EAA08605.2.
    RefSeqiXP_313049.1. XM_313049.4.

    Genome annotation databases

    EnsemblMetazoaiAGAP004164-RA; AGAP004164-PA; AGAP004164. [Q93112-1]
    GeneIDi1273988.
    KEGGiaga:AgaP_AGAP004164.
    VectorBaseiAGAP004163. Anopheles gambiae.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81291 mRNA. Translation: CAB03592.1 .
    AF071160 Genomic DNA. Translation: AAC79993.1 .
    AAAB01008880 Genomic DNA. Translation: EAA08605.2 .
    RefSeqi XP_313049.1. XM_313049.4.

    3D structure databases

    ProteinModelPortali Q93112.
    SMRi Q93112. Positions 1-207.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    DrugBanki DB00143. Glutathione.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai AGAP004164-RA ; AGAP004164-PA ; AGAP004164 . [Q93112-1 ]
    GeneIDi 1273988.
    KEGGi aga:AgaP_AGAP004164.
    VectorBasei AGAP004163. Anopheles gambiae.

    Organism-specific databases

    CTDi 1273988.

    Phylogenomic databases

    HOGENOMi HOG000125741.
    KOi K00799.
    OMAi NEADYLA.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and localization of a glutathione S-transferase class I gene from Anopheles gambiae."
      Ranson H., Cornel A.J., Fournier D., Vaughan A., Collins F.H., Hemingway J.
      J. Biol. Chem. 272:5464-5468(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Zands.
      Tissue: Larva.
    2. "The role of alternative mRNA splicing in generating heterogeneity within the Anopheles gambiae class I glutathione S-transferase family."
      Ranson H., Collins F.H., Hemingway J.
      Proc. Natl. Acad. Sci. U.S.A. 95:14284-14289(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: ZAN/U.
    3. "The genome sequence of the malaria mosquito Anopheles gambiae."
      Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
      , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
      Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PEST.
    4. "Cloning and characterization of two glutathione S-transferases from a DDT-resistant strain of Anopheles gambiae."
      Ranson H., Prapanthadara L., Hemingway J.
      Biochem. J. 324:97-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY.
      Strain: Zands.

    Entry informationi

    Entry nameiGST1C_ANOGA
    AccessioniPrimary (citable) accession number: Q93112
    Secondary accession number(s): O76482, Q7PQM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3